ADVENTURES IN THE LIPIDOME

Transcription

1 Organizing Committee: INTERNATIONAL SCHOOL OF PHARMACOLOGY ADVENTURES IN THE LIPIDOME Erice, Sicily, 26 th - 30 th September 2017 Garret FitzGerald, Philadelphia, USA Pietro Minuz, Verona, Italy Carlo Patrono, Rome, Italy Giampaolo Velo, Verona, Italy Scientfic Advisory Board: Site: Jane Armitage, Oxford, UK Valerie O Donnell, Cardiff, UK David Sacerdoti, Padova, Italy Ettore Majorana Foundation and Centre for Scientific Culture, Erice, Trapani (Italy) International School of Pharmacology Dates: Arrival on 26 th Sept. 2017, scientific sessions from 27 th to 29 th Sept. 2017, departure on 30 th Sept.2017 Aim of the Course: The recent identification of a high interplay among cancer cells, inflammatory cells and platelets mediated by bioactive lipids opened new fields of research linking different pathophysiological mechanisms in a more complex scenario. Three years after the previous course on Eicosanoids, part of a series of 9 courses on the topic since in 1976, the interest has broadened to the concept of lipid mediators (including a variety of bioactive compounds from prostanoids to recently identified bioactive sphingolipids) in a wider sense. Aim of the Course is to focus on the role of lipid mediators in cardiovascular medicine, oncology and inflammation related disorders, with high quality speakers that could inspire and lead young researchers in

2 this exciting and multifaced topic. Young participants will be encouraged to actively participate to discussion and to present the results of their scientific work. Participation: A total of around 60 participants can be accommodated. The cost of the Course is which includes the participation in the course, airport transfers in Sicily, and living expenses in Erice. We are pleased to be able to offer scholarships of each to 25 students, which will cover a substantial part of the cost of the Course. The remaining part ( 100.-) will need to be paid locally. For information and registration please contact the Secretariat of the International School of Pharmacology at the following address: hayleylouise.salt@univr.it PROGRAMME Tuesday 26 th September 2017 Arrival of participants Marsala and Sicilian cakes in S. Rocco cellar Wednesday 27 th September Welcome and introductory remarks SESSION 1: CARDIOVASCULAR- BASIC MECHANISMS AND CLINICAL IMPLICATIONS CHAIRPERSONS: Edward Fisher and Ingrid Fleming Molecular Clocks, Cardio-Metabolism and Variability in Drug Response Garret FitzGerald, University of Pennsylvania, Philadelphia, USA Proteomics, Lipidomics and MicroRNAs Manuel Mayr, King's British Heart Foundation Centre, King's College, London, UK Coffee break

3 SESSION 2: CARDIOVASCULAR- BASIC MECHANISMS AND CLINICAL IMPLICATIONS CHAIRPERSONS: Gerhard Krӧnke and Manuel Mayr Control of eicosanoid formation by mirnas Beatrix Süβ, Dept. Biology, Technische Universität Darmstadt, Germany Uncovering the 20-HETE Receptor Victor Garcia, New York Medical College, Yale University, Valhalla, NY, USA Lunch SESSION 3: CARDIOVASCULAR- BASIC MECHANISMS AND CLINICAL IMPLICATIONS CHAIRPERSONS: Garret FitGerald and Beatrix Süβ ,20-DHDP the identification of a new player in physiology and pathophysiology Ingrid Fleming, Vascular Research Centre, Frankfurt, Germany Regression of atherosclerosis: insights about mechanisms and therapies from novel mouse models Edward Fisher, School of Medicine, New York University, New York, USA Coffee break SESSION 4: CARDIOVASCULAR- BASIC MECHANISMS AND CLINICAL IMPLICATIONS CHAIRPERSON: Marielle S. Kӧberlin and Luca Vanella Role of oxidized polyunsaturated fatty acids in the expansion of necrotic core in atherosclerotic plaques Anna Fratta Pasini, Department of Medicine, University of Verona, Italy The role of polyunsaturated fatty acids (PUFA) metabolites in endothelial cell specification Giorgia Ciliberti, Institute for Vascular Signalling, Goethe University, Frankfurt, D GUIDED DISCUSSIONS: Adventures in the lipidome: how new bioactive compounds can be identified? and Lipid mediators as biomarkers of disease, old and new Jane Armitage, Garret FitzGerald, Ingrid Fleming, Marielle S. Kӧberlin, Pietro Minuz, Carlo Patrono, David Sacerdoti and Dieter Steinhilber Dinner

4 20.30 Marsala and Sicilian cakes in S. Rocco cellar Thursday 28 th September 2017 SESSION 5: CARDIOVASCULAR- BASIC MECHANISMS AND CLINICAL IMPLICATIONS CHAIRPERSONS: Bianca Rocca and Dieter Steinhilber Metabolites and risk of cardiovascular disease subtypes Michael Holmes, Nuffield Department of Population Health, University of Oxford, UK LOXs in inflammation in skin and cardiovascular system Chris Thomas, School of Pharmacy, Cardiff, UK Omega-3 fatty acids, nutrition and cardiovascular damage in children Cristiano Fava, Department of Medicine, University of Verona, Italy Coffee break SESSION 6: CARDIOVASCULAR- BASIC MECHANISMS AND CLINICAL IMPLICATIONS CHAIRPERSONS: Michael Holmes and Paola Patrignani PK/PD determinants of the interindividual variability in response to aspirin Bianca Rocca, Università Cattolica del Sacro Cuore, Rome, Italy Antiplatelet agents in diabetes mellitus Jane Armitage, Oxford University, Oxford, UK Lunch SESSION 7: INFLAMMATION-RELATED DISEASES CHAIRPERSONS: David Sacerdoti and Chris Thomas A conserved network of co-regulated lipids modulates innate immune and receptor responses Marielle S. Kӧberlin, Stanford University, USA Enzymatic lipid oxidation by 15-Lipoxygenase during the control of immunity and hemostasis Gerhard Krӧenke, Dept. Internal Medicine 3, University Clinic of Erlangen, Germany Coffee break

5 SESSION 8: INFLAMMATION-RELATED DISEASES INTERNATIONAL SCHOOL OF PHARMACOLOGY CHAIRPERSONS: Victor Garcia and Santiago Zelenay Novel insights into the role of prostanoids in intestinal inflammation Paola Patrignani, Dept. Neuroscience, Imaging and Clinical Sciences and CeSi-MeT, G. d Annunzio University, Chieti, Italy EETs, metabolic syndrome and NAFLD David Sacerdoti, Padova University, Padua, Italy Social Dinner Friday 29 th September Epoxyeicosatrienoic Acids: a new class of lipids against metabolic syndrome Luca Vanella, University of Catania, Italy SESSION 9: ONCOLOGY CHAIRPERSONS: Jane Armitage and Carlo Patrono Reducing prostaglandin E2 to raise cancer immunogenicity Santiago Zelenay, Cancer Research UK Manchester Institute, University of Manchester, UK Coffee break Lipoxygenase is a p53 effector and regulator Dieter Steinhilber, Institute Pharmacueutical Chemistry, University of Frankfurt, Germany Eicosanoids and Phospholipid-esterified eicosanoids in the cross-talk of platelets and cancer cells Melania Dovizio, Dept. Neuroscience, Imaging and Clinical Sciences and CeSi-MeT, G. d Annunzio University, Chieti, Italy SESSION 10: CLINICAL APPLICATIONS GUIDED DISCUSSION: New therapeutic targets? Jane Armitage, Garret FitzGerald, Pietro Minuz, Carlo Patrono and David Sacerdoti Lunch

6 VISIT TO AN ANCIENT SICILIAN HISTORICAL SITE (MOTHIA?) Dinner Marsala and Sicilian cakes in S. Rocco cellar Saturday 30 th September 2017 Departure of participants