Chair: Susan Clark, The Garvan Institute of Medical Research, AU. Undercover: gene control by metabolic enzymes in development and disease

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1 23 rd October SESSION 1. EPIGENETIC MECHANISMS Chair: Susan Clark, The Garvan Institute of Medical Research, AU Opening remarks Peter Verrijzer, Erasmus Medical Centre, NL Undercover: gene control by metabolic enzymes in development and disease Lars Jansen, Gulbenkian Institute of Science, PT Chromatin inheritance at the centromere and beyond Oral presentations selected from abstracts Emilie Bonnaud, INSERM, FR Bornavirus phosphoprotein interferes with histone acetylation in primary neurons in a PKC dependent manner Abderrahmane Kaidi, University of Cambridge, UK mechanism for sensing chromatin alterations in mammalian cells Coffee break & Poster Setup Oral presentations selected from abstracts Zachary Kaminsky, Johns Hopkins University School of Medicine, US Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors Bertille Montibus, GReD CNRS UMR6293, FR Bivalency is a common mechanism to control neural lineage- specific imprinting. Adele Murrell, University of Bath, UK Transcriptional interference by the long non-coding RNA GNG12-AS1 modulates DIRAS3 an imprinted tumor suppressor Gonca Bayraktar, RG Neuroplasticity, Leibniz-Institute for Neurobiology, DE Synaptic GLuN2A NMDA receptor-activation leads to degradation of the de novo DNA methyltransferase DNMT3a1 in the nucleus of hippocampal neurons Lunch at Institute s Lobby Poster discussion

2 23 rd October SESSION 2. DEVELOPMENTAL (RE)PROGRAMMING Chair: Hongjun Song, Johns Hopkins University, US Maria Elena Torres-Padilla, IGBMC Strasbourg, FR (EpiGeneSys Speaker) Novel chromatin pathways to induce totipotency Hakan Bagci, Imperial College London, UK Epigenetic Programming and Reprogramming during Development Myriam Hemberger, Babraham Institute, UK Programming and reprogramming of trophoblast lineage Coffee break and Poster Viewing Oral presentations selected from abstracts António Mateus-Pinheiro, ICVS - University of Minho, PT Epigenetic control of post-natal neuroplasticity in the healthy and stressed brain: exploring methylation and hydroxymethylation landscapes Irene Pappa, Erasmus University Rotterdam, NL Implications of Maternal Psychopathology in the Genome-wide Epigenome of Neonates Marijn Schouten, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, NL Mitochondrial pro-apoptotic proteins are target of cooperative microrna regulation in early stages of adult hippocampal neurogenesis induction after status epilepticus Zinah Wassouf, Institute of Medical Genetics and Applied Genomics, DE Characterizing Epigenetic Signatures in Parkinson s Disease under the Influence of Chronic Stress 20:00 Gala Dinner at Restaurant Expositor

3 24 th October SESSION 3. FROM NEUROGENESIS TO NEURONAL PLASTICITY Chair: Joseph Costello, University of California, San Francisco, US Hongjun Song, Johns Hopkins University, US (EpiGeneSys Speaker) Adult neurogenesis and Epigenetic DNA modifications Sacri Ferrón, University of Valencia, SP Genomic imprinting in neurogenesis Brian Dias, Emory University, US Transgenerational inheritance of ancestral olfactory experience Coffee break & Poster discussion Oral presentations selected from abstracts Svitlana Bach, Wake Forest School of Medicine, US The ubiquitin-proteasome pathway modulates transcription-favoring epigenetic modifications in hippocampal longterm synaptic plasticity Elena Battaglioli, University of Milan, IT LSD1 modulates emotional behavior in mice through the regulation of stress-related transcriptional plasticity Philipp Mews, University of Pennsylvania - Perelman School of Medicine, US AceCS1: Linking Intermediary Metabolism _to Neuronal Chromatin Remodeling Nael Nadif Kasri, Donders Institute for Brain, Behavior and Cognition, NL EHMT1-mediated epigenetic dynamic control of homeostatic synaptic plasticity Joana Viana, University of Exeter Medical School, UK Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia Yabin Wei, Neurogenetics Unit, Karolinska Institutet, SE Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene Lunch at Institute s Lobby

4 24 th October SESSION 4. NEUROEPIGENETIC HALLMARKS OF DISEASE Chair: Peter Verrijzer, Erasmus Medical School, NL Jonathan Mill, Exeter University & King's College London, UK Role of epigenetic processes in mediating the interplay between genes and the environment in neuropsychiatric disorders Nuno Sousa, ICVS University of Minho, PT From stress to neuronal plasticity: when genes meet the environment Andre Fischer, German Center for Neurodegenerative Diseases, DE Reading the code: Epigenetic mechanisms in Alzheimer's disease Coffee break & Poster viewing 16:00 16:30 Marcelo Wood, University of California, US The role of nucleosome remodeling in synaptic plasticity, memory, and intellectual disability disorders 16:30-17:00 Giuseppe Testa, European Institute of Oncology, IT Disease avatars: modeling epigenetic dysfunction in neurodevelopmental disorders 17:00 Visit to Braga City center & Dinner at Restaurant Dom Ribeiro

5 25 th October SESSION 5. EPIGENETIC LANDSCAPE IN NEURO-ONCOLOGY Chair: Nuno Sousa, ICVS, University of Minho, PT Joseph Costello, UCSF, US Co-evolution of brain tumor genomes and epigenomes Carmen Jerónimo, IPO, PT Diagnostic and prognostic epigenetic biomarkers in cancer Coffee break & Poster wrap-up 10:45-11:30 Susan Clark, The Garvan Institute of Medical Research, AU Epigenome remodelling in cancer: what are the implications Wolf Reik, Babraham Institute, UK (EpiGeneSys Speaker) Epigenetic reprogramming in mammalian development Closing remarks Light Lunch and Departure