Index. Note: Page numbers of article titles are in boldface type.

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1 Index Note: Page numbers of article titles are in boldface type. A Absolute monocyte counts, in necrotizing enterocolitis, 576 Adhesions, platelet, 627 Afibrinogenemia, 629 Age of Red Blood Cells in Premature Infants (ARIPI), 502 Aggregometry, platelet, Anemia in necrotizing enterocolitis, prevention of, darbepoietin for, Antibody screen, umbilical cord blood for, Anticoagulant proteins, 652 Anticoagulant therapy, for thrombosis, Antiphospholipid antibody panel, Antithrombin, measurement of, Apoptosis biomarkers for, neuroprotection from, ARIPI (Age of Red Blood Cells in Premature Infants), 502 Arterial thromboses, Arteriotomy, for thrombosis, 665 Aspirin, platelet dysfunction due to, 628, 630 Autophagy, neuroprotection from, B B cells, in necrotizing enterocolitis, Bacterial overgrowth, in necrotizing enterocolitis, 568 Basophils, in necrotizing enterocolitis, 576 Beclin 1 protein, in necrosis, 472 Bernard-Soulier syndrome, Biomarkers, of oxidative stress, Bite cells, in hemolysis, Bleeding time, for platelet evaluation, Blister cells, in hemolysis, Blood culture, of umbilical cord blood, 548, 550 Blood pressure, maintenance of, after delayed cord clamping/milking, 545 Brain Imaging and Developmental Follow-up of Infants Treated with Erythropoietin or Placebo (BRITE), 475 Brain injury neuroprotection for, oxidative stress in, stem cell transplantation for, Clin Perinatol 42 (2015) perinatology.theclinics.com /15/$ see front matter ª 2015 Elsevier Inc. All rights reserved.

2 676 Index BRITE (Brain Imaging and Developmental Follow-up of Infants Treated with Erythropoietin or Placebo), 475 Bronchopulmonary dysplasia, stem cell transplantation for, 604 C Candida, in sepsis, 590, 592 Carbon monoxide, end-tidal, for hemolysis, Catalase, in oxidative stress, Catheters, arterial thrombosis in, CCL compounds, in necrotizing enterocolitis, 573 Central venous catheters, thrombosis due to, Cerebral sinovenous thrombosis, 654, 657 Chédiak-Higashi syndrome, 628 Chemokines, in necrotizing enterocolitis, 573 Clostridia, in necrotizing enterocolitis, 568 Closure time, for platelet evaluation, Clotting times, fresh frozen plasma dose and, Coagulation, platelet function in, 627 Coagulation system, function of, 652 Coagulopathy, in necrotizing enterocolitis, 574 Collagen receptor deficiency, 629 Colostrum, secretory immunoglobulins in, 571 Complete blood count of umbilical cord blood, , 550 reference intervals for, Cone and platelet analyzer, Congenital heart disease, venous thrombosis related to, 654, CXCL compounds, in necrotizing enterocolitis, 573 Cytokines in necrosis, 472 in necrotizing enterocolitis, 573 in oxidative stress, 534 in platelets, 626 Cytomegalovirus infections, , 592 D DANCE (Darbe Administration in Newborns Undergoing Cooling for Encephalopathy), 476, Darbepoetin, clinical studies of, dosing of, for neuroprotection, pharmacokinetics of, Delayed cord clamping/milking, Dendritic cells, in necrotizing enterocolitis, 569 Dense granule deficiency, 628 Developmental hemostasis, 645 Diabetes mellitus, platelet dysfunction in, 628 Disseminated intravascular coagulation, in necrotizing enterocolitis, 574

3 Index 677 Docosahexaenoic acid, in oxidative stress, Down syndrome, oxidative stress biomarkers in, 533 Dysbiosis, in necrotizing enterocolitis, 568 E Echinocytes, in hemolysis, Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO), 501 Efficacy of Erythropoietin to Improve Survival and Neurologic Outcome in Hypoxic Ischemic Encephalopathy (Neurepo), Eicosopentaenoic acid, in oxidative stress, 531 Elliptocytes, in hemolysis, EMA flow cytometry, for hemolysis, Embolectomy, for thrombosis, 665 Endothelial colony-forming cells, Endothelial progenitors, End-tidal carbon monoxide test, for hemolysis, Enterobacteriaceae, in necrotizing enterocolitis, 568 Enterocolitis, necrotizing. See Necrotizing enterocolitis. Eosin-5 -maleimide flow cytometry, for hemolysis, 520 Eosinophils in necrotizing enterocolitis, 576 reference intervals for, Epithelial cells, in necrotizing enterocolitis, Erythrocytes. See Red blood cells. Erythropoiesis, tests for, 517 Erythropoietin, for neuroprotection, , ETTNO (Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants), 501 Extracorporeal membrane oxygenation, 631 F Factor V Leiden, measurement of, Fetal circulation, transition to neonatal circulation, Flow cytometry for hemolysis, 520 for platelet evaluation, FOXP31 T regulatory cells, in necrotizing enterocolitis, 570 Free radicals, biomarkers of, Fresh frozen plasma, clotting time dose and, compliance improvement for, hemostasis assessment for, recommendations for, use of, statistics for, 640 G Gammaproteobacteria, in necrotizing enterocolitis, 568 Genes, mutations of, in hemolysis, 523

4 678 Index Glanzmann thrombasthenia, Glutathione peroxidase, in oxidative stress, Goblet cells, in necrotizing enterocolitis, 569 GPIIb/IIIa, platelet function and, 627 Granulocyte colony stimulating factor, in sepsis, 590 Gray platelet syndrome, 628 H Heart congenital disease of, 654, thromboses in, 656 Hematocrit, reference intervals for, Hematology and transfusion medicine darbepoietin, erythropoietin neuroprotection, fresh frozen plasma administration, hyperbilirubinemia, in necrotizing enterocolitis. See Necrotizing enterocolitis. in sepsis, infection prevention for, optimal platelet threshold for, oxidative stress biomarkers, platelet function, platelet transfusions, red blood cell storage and, 503 red blood cell threshold for, reference intervals for, research questions in, stem cells, thromboses, umbilical cord blood as resource in, Hematopoietic stem cells, , 605 Hemoglobin concentration of, reference intervals for, degradation of, tests for, 517 Hemolytic disorders, causes of, genes involved in, 523 identification of, in necrotizing enterocolitis, pathophysiology of, tests for, Hemostasis evaluation of, for fresh frozen plasma use, platelet function in, , thromboses and, 652 Heparin preparations, for thrombosis, Hermansky-Pudlak syndrome, 628 Hyperbilirubinemia delayed cord clamping/milking and,

5 Index 679 hemolytic causes of, platelet dysfunction in, 631 Hyperglycemia, platelet dysfunction in, 628 Hyperinsulinemia, platelet dysfunction in, 628 Hypoxic-ischemic encephalopathy biomarkers of, neuroprotection for, stem cell transplantation for, 603 I Iatrogenic arterial thrombosis, Iatrogenic venous thrombosis, 654 Ibuprofen, 628 Immune response, platelet function in, 626 Immunoglobulins, in necrotizing enterocolitis, Inducible pluripotent stem cells, 602 Infections sepsis as, transfusion-related, Inflammation biomarkers for, platelet function in, 626 INTERCEPT Blood System, Interleukin-1 receptor-associated kinase, in necrotizing enterocolitis, 569 Intestinal epithelial cells, in necrotizing enterocolitis, Intestinal injury, stem cell transplantation for, 604 Intracardiac thromboses, 656 Intraepithelial compartments, in necrotizing enterocolitis, 570 IPEX syndrome, 570 Isofurans, in oxidative stress, Isoprostanes, in oxidative stress, J Jaundice, hemolytic causes of, K Kidney failure, platelet dysfunction in, 631 L Lamina propria, in necrotizing enterocolitis, 570 Leukocytes, in sepsis, Lipid peroxidation, in oxidative stress, 534 Lung injury, stem cell transplantation for, 604 Lymphocytes in necrotizing enterocolitis, 576 in sepsis, reference intervals for, Lymphopenia, in sepsis, 591

6 680 Index M Macrophages, in necrotizing enterocolitis, 569, Mammalian target of rapamycin pathway, in necrosis, 472 MCH (mean corpuscular hemoglobin), reference intervals for, 488 MCHC (mean corpuscular hemoglobin concentration), reference intervals for, 488 MCV (mean corpuscular volume), reference intervals for, 488 Mean platelet volume (MPV), reference intervals for, 491 Megakaryocytes, platelet development from, Mesenchymal stem cells, 601, Metabolic screen, umbilical cord blood for, Microspherocytes, in hemolysis, Monocytes in necrotizing enterocolitis, reference intervals for, MPV (mean platelet volume), reference intervals for, 491 Mucosa-associated lymphoid tissue (MALT), in necrotizing enterocolitis, Mucosal sensitivity, to bacterial products, in necrotizing enterocolitis, 568 Myeloid differentiation primary response gene 88, in necrotizing enterocolitis, N NEAT trials, 476 Necrosis, neuroprotection from, Necrotizing enterocolitis, hematological manifestations of, immunologic aspects of, stem cell transplantation for, 604 thrombocytopenia in, 618 transfusion-related, Neurepo (Efficacy of Erythropoietin to Improve Survival and Neurologic Outcome in Hypoxic Ischemic Encephalopathy), Neurofuroans, in oxidative stress, Neuroprostanes, in oxidative stress, Neuroprotection, cell death mechanisms and, conditions useful for, darbepoetin for, erythropoietin for, , Neutropenia, in sepsis, Neutrophils in necrotizing enterocolitis, 575 in sepsis, reference intervals for, Next-generation sequencing, for hemolysis, 522 Nitric oxide in necrotizing enterocolitis, in oxidative stress, platelet dysfunction and, 631 Nitroglycerin, for thrombosis, 662

7 Index 681 Non protein bound iron compounds, in oxidative stress, Northern Neonatal Nursing Initiative Trial, 641 NRBC (nucleated red blood cell) levels, reference intervals for, 489 Nuclear factor kappa B, in necrotizing enterocolitis, 569 Nucleated red blood cell (NRBC) levels in necrotizing enterocolitis, reference intervals for, 489 O Octaplas, for infection reduction, Oxidative stress, biomarkers of, P PAEAN (Preventing Adverse Outcomes of Neonatal Encephalopathy with Erythropoietin) study, 476 Paneth cells, in necrotizing enterocolitis, 569 Partial exchange transfusions, 641 PENUT (Preterm Epo Neuroprotection) trial, Percutaneous intravenous central catheters, thrombosis due to, Perinatal arterial ischemic stroke, Peripheral smear, for platelet evaluation, 632 Peroxynitrite, in oxidative stress, 534 Peyer patches, in necrotizing enterocolitis, PlaNeT-2 study, Plasminogen, measurement of, Platelet(s), disorders of, function of, , laboratory testing of, production of, Platelet aggregometry, Platelet analyzer, Platelet count in necrotizing enterocolitis, in sepsis, reference intervals for, 490 Platelet transfusions, current recommendations for, 619 efficacy of, hemostasis mechanisms and, optimal platelet threshold for, practices for, Platelet-activating factor, in necrotizing enterocolitis, 571 Platelets for Neonatal Transfusion, 502 Pluripotent stem cells, , 602 Polycythemia, thrombosis in, 655 Portal vein thrombosis, 656 Preeclampsia, sepsis and, 590

8 682 Index Pregnancy-induced hypertension, platelet dysfunction in, Premature Infants in Need of Transfusion trial, Preterm Epo Neuroprotection (PENUT) trial, Preterm infants, brain injury in, Preventing Adverse Outcomes of Neonatal Encephalopathy with Erythropoietin (PAEAN) study, 476 Prostanoids, in oxidative stress, Protein C, Protein S, Prothrombin, measurement of, Prothrombotic state, 652 Pseudomonadaceae, in necrotizing enterocolitis, 568 R RDW (red cell distribution width), reference intervals for, 489 Reactive oxygen species, in necrotizing enterocolitis, 572 Red blood cells in sepsis, 588 morphology of, in hemolysis, nucleated, in necrotizing enterocolitis, transfusion of storage effects on, 503 threshold for, Red cell distribution width (RDW), reference intervals for, 489 Reference intervals, for neonatal hematology, Renal vein thrombosis, 654, 656 Reoxygenation, oxidative stress in, 533 Resuscitation, delayed cord clamping/milking effects on, 546 RIP proteins, in necrosis, 472 Rotating thromboelastography, 634 S Schistocytes, in hemolysis, Scott syndrome, 630 Secretory immunoglobulins, in necrotizing enterocolitis, Sepsis, Spherocytes, in hemolysis, Spontaneous arterial thrombosis, Stem cell transplantation, biology of, for postinsult injury, utility of, Stroke neuroprotection for, perinatal arterial ischemic, stem cell transplantation for, Superoxide dismutase, in oxidative stress,

9 Index 683 T T lymphocytes, in necrotizing enterocolitis, 570 T regulatory cells, in necrotizing enterocolitis, 570 Thomsen-Friedenreich cryptantigen, in necrotizing enterocolitis, Thrombocytopenia in necrotizing enterocolitis, in sepsis, platelet transfusions for, thrombopoietin levels in, Thromboelastography, 632, 634, 646 Thrombolysis, 665 Thrombopoietin in necrotizing enterocolitis, 574 levels of, Thrombosis(es), arterial, in congenital heart disease, laboratory evaluation for, mechanisms of, 652 risk for, 651, treatment of, venous, Thrombotic microangiopathy, in necrotizing enterocolitis, Tissue plasminogen activator, , 665 Tissue-specific somatic stem cells, Toll-interacting protein, in necrotizing enterocolitis, 569 Toll-like receptors, in necrotizing enterocolitis, TOP (Transfusion of Prematures) trial, 501 Transforming growth factor-beta, in necrotizing enterocolitis, 569, 572 Transfusion of Prematures (TOP) trial, 501 Transplantation, stem cell, Tumor necrosis factor receptor superfamily, in necrosis, in necrosis, 472 Tumor necrosis factor receptor-associated factor 6, in necrotizing enterocolitis, Typing, umbilical cord blood for, U Umbilical cord blood, delayed cord clamping/milking of benefits of, 546 blood volume after, obstetric acceptance of, outcomes of, physiologic changes and, 545 risks of, transition from fetal to neonatal circulation and, laboratory testing of, platelet function in, 616, 627 transplantation of, Umbilical venous catheters, thrombosis due to, University of Iowa trial, of red blood cell transfusions,

10 684 Index V Venous thromboses, von Willebrand disease, platelet type, 629 von Willebrand factor, platelet adhesion and, 627 X Xanthine oxidase/dehydrogenase, in necrotizing enterocolitis, 572