GENOROOT. Metabolism Monitor Report. Renu Singh. Laboratory Findings. Fri, 19 Jun Page No. 1 of 11. Nutrifit

Transcription

1 GENOROOT Nutrifit Laboratory Findings D R AF T Metabolism Monitor Report Renu Singh Fri, 19 Jun 2015 Page No. 1 of 11

2 B Fri, 19 Jun 2015 GENOROOT metabolism Patient Name Renu Singh Collected On Sun, 7 Jun 2015 Age 45 Years Received On Mon, 8 Jun 2015 Referred By Self Report Date Fri, 19 Jun 2015 The present blood and urine sample were analyzed for the Metabolic Markers enlisted in the Section-A of this report. Value of Biotin Deficiency markers have been detected in broderline range, which implies the need of Biotin Supplements. A standard recommendation is about 2-5 mg/day for about 4 weeks. Rest all metabolic markers were located within the Normal Range which is based on the standardized metabolic profile of healthy controls. (Refer: Graphical Representations). You may also refer to the Section-B of this report which illustrates the sources of various essential vitamins and minerals which help maintain a good metabolism. The results have to be correlated with other clinical findings by a medical practitioner. Approved By Dr. Mahesh Hampe MD (Biochemistry) Conditions of Reporting The analysis of urine sample is done on various Chromatographic Methods under license of PreventiNe Life Care ( India) The metabolic markers and health conditions mapping is not mutually unique and there can be other forms in which a problem with metabolism may be apparent. Similarly, a particular health condition may not exclusively be an outcome of the abnormal levels of metabolic markers in consideration. Isolated laboratory investigations do not confirm the final diagnosis of a health condition or a disease. They help in arriving at a diagnosis in conjunction with clinical presentation and other related investigations. It is important to monitor your health and take a proactive approach should there be any unhealthy condition(s) within or beyond scope of this test. Genoroot - Metabolism Monitor analyzes a sample for limited metabolites/markers and their effects on human health. It is presumed that the specimen belongs to the person named or identified in the Test Request Form. All investigations have their limitations which are imposed by the limits of sensitivity and specificity of individual assay procedures as well as the quality of specimen received by the laboratory. A possibility of 1% error is there leading to a false positive or a false negative result. Genoroot test is not intended to replace the medical advice and/or treatment obtained from a qualified healthcare practitioner. A test requested might not be performed or may not yield best results for the following reasons: a. Insufficient quantity of specimen (inadequate collection/ pilferage in transit) b. Specimen quality (contaminated, fungal growth) c. Incorrect specimen type Page No. 2 of 11

3 Understanding your report Your GENOROOT - Metabolism Monitor Report has TWO Sections: Section A - The technical report which gives a Graphical Representation of various metabolic markers in your sample(s). Section B - A general guide for quick reference of nutritional component in various dietary sources. Definitions Metabolites - Metabolites in your urine/blood samples are the Markers of Metabolism which act as the health indicators. They characterize your state of metabolism and help make inferences in case of non-specific health conditions which can be an outcome of problems with your metabolism. Tracking the levels of these metabolites during a dietary and lifestyle change helps ensure that there is no negative impact on your health. Control Values - The Normal Limit within which the value of a metabolic marker should ideally fall. Observed (your) Value - The Actual Value of a Metabolic Marker in your sample. Risk Bar - The horizontal bar with Green Zone at left end and Red Zone at right end. The bar is a pictorial representation of the observed values of the metabolic markers against the control values. Safe Zone (Green Color)- If the value of markers measured in your sample fall in this region (signified by the green zone), you can relax and maintain the lifestyle you have. Risk Zone (Red Color) - If the value of marker(s) measured in your sample falls in this region (signified by the red zone), it will be a matter of concern. You must consult your family physician or a metabolism expert. Medium Zone (color transition zone) - If the value of a marker measured in your sample falls in this region (signified by the color transition from green to red), you may need to bring in minor changes in your lifestyle, specially diet, for a better health. There is not much reason to worry; yet you may consider getting counseled by your family physician or a metabolism expert. ND - Non Detected. This implies that the marker was not detected; and hence not in the Risk Zone. Understanding the Graphical Representation In the technical report section, you will see the graphic representation of all metabolic markers in the scope of the test conducted on your sample(s) and interpreted by our metabolic experts. The metabolic markers have been clubbed under various classes like - Carbohydrate Metabolism, Fatty Acid Metabolism, Vitamins Metabolism, Muscles Catabolism etc. Metabolite Control Value Observed Value Representation Phenylalanine ND Observed value Safe Zone Medium Zone Risk Zone Page No. 3 of 11

4 Section A - Metabolic Markers and Their Values Metabolite Control Value Observed Value Representation Muscles Catabolism Methyl-histidine Taurine Cysteine Lysine Proline Valine Fatty Acid Metabolism 1-Methylhistidine Methylhistidine C C4OH Carnitine Adipate Suberate EMA sebacate Me-succinate Vitamin B12 and folic acid metabolism Glycine Beta-AminoIsoButyric Acid Sarcosine Methionine Cystathionine Histidine Page No. 4 of 11

5 Vitamin B12 and folic acid metabolism MMA Uracil Formiminoglutamate Carbohydrate Metabolism Lactate Pyruvate Glutamic Acid Pyruvate Lactate KG HB Neurotransmitter Metabolism Methionine Phenylalanine Tyrosine Tryptophan GABA HVA VMA Qinolinate kynurate HindoleAA Page No. 5 of 11

6 Vitamin Metabolism Histidine Anserine Carnosine Beta-AminoIsoButyric Acid beta-alanine Threonine Glycine Serine Sarcosine Methionine HMG Pyruvate Adipate Malate Suberate EMA kynurate Succinate VitC vitb AB Glutarate Fumarate Glutamine Leucine isoleucine PyroGlu Energy Production Markers GABA Valine Carnitine Lactate Pyruvate Alanine Page No. 6 of 11

7 Energy Production Markers Citrate Malate Succinate Cisaconate Analog Cit HMG Nutritional Markers Histidine Leucine Phenylalanine Glycine Threonine beta-alanine Lysine Leucine isoleucine Histidine Phenylalanine beta-alanine Serine Threonine Glycine Lysine Nutrition - Protein Intake Markers Histidine Leucine Phenylalanine Glycine Threonine beta-alanine Lysine Page No. 7 of 11

8 Dysbiosis and Gastrointestinal Markers Anserine Carnosine Aminoadipic Acid beta-alanine Valine Threonine HydroxyIsoCaproate Hydroxy Benzoate HPL hippurate Benzoate Indole3AA Hhippurate tartarate arabinose Hhippurate HPA HP3HP HM2F HPA Oxidative Stress and Detoxification Markers Taurine beta-alanine Glutamine PyroGlu Mandelate Orotate Cysteine Cystine Technical Details The reference ranges for metabolic markers were established using samples collected from typical individuals of all ages and both the genders.the individuals were known to be with no known physiological or psychological disorders. The ranges were determined by calculating the mean and standard deviation (SD) and are defined as +/-2SD of the mean. Reference ranges are age and gender specific. The graph represents whether the value of the patient is within the reference (normal) range, defined as the mean plus or minus two standard deviations. Page No. 8 of 11

9 Section B - Food Guide A Vitamin A Needed for vision, healthy skin and mucous membranes, bone and tooth growth, immune system health Folic Folic Acid Folate promotes normal digestion; essential for development of red blood cells. Liver and fish liver oil, egg yolks, whole milk, cream, butter Spinach, kale, beet greens, beets, chard, asparagus, broccoli, liver, brewer ' s yeast, whole grains E Vitamin E An antioxidant. It helps to slow down processes that damage cells. C Vitamin C Needed for the growth and repair of tissues Cold-pressed vegetable, seed and nut oils, wheat germ oil, whole grains, soybeans, uncooked green peas, spinach, asparagus, kale, cucumber Citrus fruits, strawberries, mango, papaya, watermelon, tomatoes, broccoli. Brussels sprouts, cauliflower, cabbage, spinach B1 Vitamin B1 (Thiamin) Needed for healthy skin, hair, eyes, and liver. They also help the nervous system function properly, and are needed for good brain function. Whole or enriched grain products, brown rice, brewers yeast, blackstrap molasses, spinach, cauliflower, most nuts, sunflower seeds, peanuts, peas, beans, avocado, pork. B3 Vitamin B3 ( Niacin ) Plays an important role in maintaining muscle tone along the digestive tract. B2 Vitamin B2 (Riboflavin) Works as an antioxidant by fighting damaging particles in the body known as free radicals which damage cells and DNA, and may contribute to the aging process. Whole or enriched grain products, brewer s yeast, organ meats, mackerel, trout, shad, eggs, shellfish, millet, wild rice, dried peas, beans, sunflower seeds, asparagus, collards, broccoli, spinach, mushrooms, avocado B5 Vitamin B5 (Pantothenic Acid) Helps treat dietary deficiencies. Synthesized from the amino acid tryptophan, Liver and other organ meats, poultry, fish, peanuts, brewer s yeast, dried beans and peas, wheat germ, whole grains, avocado, dates. Organ meats, chicken, beef, brewer s yeast, egg yolks, fish, chicken, whole grains, cheese, peanuts, dried beans, sweet potato, green peas, broccoli, avocado, cauliflower. B6 Vitamin B6 (Pyridoxine) Helps the body make neurotransmitters. These are chemicals that carry signals from one nerve cell to another and are needed for normal brain development and function. Liver and other organ meats, fish, poultry, egg yolk, whole wheat, wheat germ, soybeans and other dried beans, peanuts, wal- nuts, banana, prunes, potatoes, cauliflower, cabbage, avocado B12 Vitamin B12 Is important for metabolism and helps in the formation of red blood cells and maintenance of the central nervous system. Whole grains, organ meats, trout, herring, mackerel, crab, oysters, egg yolk, yogurt, tempeh K Vitamin K Is necessary for normal blood clotting and synthesis of proteins found in plasma, bone and kidneys. Probiotics Food containing live bacteria which have health benefitting properties. Synthesized by intestinal bacteria, dark leafy greens, blackstrap molasses, liver, milk, yogurt, egg yolks, fish liver oils Page No. 9 of 11 Kefir, yogurt, fermented vegetables, branded-supplements

10 Cr Chromium Important in the metabolism of fats and carb. Stimulates fatty acid and cholesterol synthesis, which are important for brain function and other body processes. Important in the breakdown of insulin. Brewer's yeast, beef, liver, whole wheat, wheat germ, rye, fresh chillies, oysters, potatoes, green peppers, eggs, chicken, apples, butter, bananas, spinach Cu Copper Works with iron to help the body form red blood cells. It also helps keep the blood vessels, nerves, immune system, and bones healthy. Buckwheat, whole wheat, shrimp, liver, brazil nuts, almonds, hazelnuts, walnuts, pecans, soybeans, dark leafy greens, prunes, cocoa Fe Iron Needed to make part of blood cell and also make up part of many proteins in the body. Beef, liver, kidney, pork, lamb, chicken, clams, oysters, egg yolks, salmon, whole wheat, millet, oats, brown rice, lima beans, soybeans, kidney beans, green peas, almonds, brazil nuts, walnuts, pine nuts, pumpkin seeds, sesame seeds, sunflower Mg Mangnese Helps the body form connective tissue, bones, blood clotting factors, and sex hormones. Plays a role in fat and carbohydrate metabolism, calcium absorption, and blood sugar regulation. Also necessary for normal brain and nerve function. Pecans, almonds, whole grains, egg yolks, seeds, peas, beans, spinach Mn Magnesium Contributes to the structural development of bone. Plays role in active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction and normal heart functioning. Dark green vegetables, almonds, pecans, cashews, brazil nuts, seeds, legumes, soy products, wheat bran and germ, millet, brown rice, avocado, dried apricots L-Tyrosine Used in the synthesis of structural proteins, used in the production of neurotransmitters. Synthesized from the amino acid phenylalanine, soy products, chicken, fish, almonds, avocado, bananas, dairy products, lima beans, pumpkin seeds, sesame seeds Se Selenium Helps the body with making special proteins, called antioxidant enzymes, which play a role in preventing cell damage Brewer's yeast, wheat germ, barley, oats, brown rice, whole wheat, liver, butter, scallops, lobster, shrimp, clams, crab, oysters, lamb, garlic, onions, mushrooms, broccoli, Swiss chard, radishes Glycine An amino acid, a building block for protein. Used for treating schizophrenia, stroke and some rare inherited metabolic disorders. High-protein foods, fish, meat and dairy. Vegetarian glycine sources include soybeans, spinach, kale, cauliflower, cabbage, pumpkin, banana, kiwi fruit, cucumber and beans. L-Phenylalanine Contraindicated with concomitant use of MAO inhibitors or Tricyclic antidepressants Beef, pork, poultry, lamb, fish, eggs, cheese. Vegetarian sources of proteins must be combined to maintain adequate levels of essential amino acids - whole grains, legumes, nuts and seeds. L-Carnitine Helps the body produce energy. It is important for heart and brain function, muscle movement, and many other body processes. Synthesized by the liver and kidneys, red meats, fish. L-Glutamine Can minimize breakdown of muscle and improve protein metabolism. Taurine An amino acid which helps in anxiety control and stress management. It lowers cortisol levels. Abundant in both animal and vegetable protein. Lean meats, fish. Page No. 10 of 11

11 Inositol Helps balance certain chemicals in the body to help conditions such as panic disorder, depression and polycystic ovary syndrome. Synthesized from glucose, liver, lecithin, whole grains, wheat germ, lima beans, peanuts, brewer s yeast, cabbage, citrus fruits ( Except lemons ), cantaloupe, raisins, unrefined molasses Biotin Supports healthy skin through proper fat production, helsp body make efficient use of sugar and maintain an energy supply in the nerve cells. Egg yolks, liver, brewer s yeast, nuts, milk, unpolished rice Note: The supplements mentioned above do not represent a complete list of all that is required by the human body. The need of protein and essential nutrients depends on several factors like: age, weight, health, body composition and physical activities being undertaken. It is important to maintain a balanced diet, healthy lifestyle, enough of sleep and exercises in order to ensure a good metabolism. References 1. Goodman SI, Markey SP: Diagnosis of organic acidemias by gas chromatography-mass spectrometry. New York, Alan R Liss, Sweetman L: Organic acid analysis. In Techniques in Diagnostic Human Biochemical Genetics. Edited by FA Hommes. Wiley-Liss, New York, 1991, pp Lehotay DC, Clarke JT: Organic acidurias and related abnormalities. Crit Rev Clin Lab Sci 1995;32: Seashore MR: The Organic Acidemias: An Overview. Available from Reviewed December 22, Part 9, Organic Acids. In Scriver CR, Beaudet AL, Sly WS, et al, eds. The Metabolic and Molecular Basis of Inherited Disease. 8th ed. New York, NY: McGraw-Hill, Inc; 2001: Kushnir MM, Komaromy-Hiller G. Rapid screening for urine organic acids by GC-MS. Clin Chem. 1999;45:A21. GENOROOT metabolism We welcome all questions and concerns. The questions pertaining to your analysis shall be answered by our experts (medical / nutritional). You may post your queries on - genoroot@preventine.com. Please mention your Name, Date of Birth and the Customer ID in the query. Customer satisfaction is our core goal. It is important for us to learn about what our customers think about our service and how we can improve it. If you have any suggestion or complaint, whatsoever, we request you to contact us and report it on: info@preventine.com Contact: