Hompes Method. Practitioner Training Level II. Lesson Twenty-Two Supporting Phase II Detoxification

Transcription

1 Hompes Method Practitioner Training Level II Lesson Twenty-Two Supporting Phase II Detoxification Health for the People Ltd not for reuse without expressed permission Hompes Method is a trading name of Health For The People Ltt Registered in England & Wales Company # VAT #

2 Supporting Phase II - Introduction Once a client/patient s toxin exposure levels have been reduced (foods, water, skin, gut) it s pertinent to begin supporting detoxification pathways to help the body begin reducing its toxin stockpile.

3 Supporting Phase II - Introduction As previously discussed, it s important to support phase II pathways before jumping in and trying to up regulate phase I. There s a myriad of products out there that can help us in this task!

4 Supporting Phase II - Introduction Remember the pathways we re looking to support: Glutathione conjugation Amino acid conjugation Sulfation Methylation Glucuronidation

5 Supporting Phase II - Introduction You re going to naturally up regulate these pathways by optimizing nutrition: Many people need to eat more protein (obviously you need to ensure it s being digested effectively) Bone broth / powdered gelatin and collagen Sulphur foods (garlic, onions, etc.) Well cooked cruciferous vegetables (undercooked can irritate gut and may suppress thyroid)

6 Supporting Phase II - Glutathione Glutathione is one of the most powerful antioxidants known for its ability to protect the body against the damages caused by heavy metal toxicity and environmental toxins. It s important during acute infections, inflammatory bowel conditions, autoimmune disorders and all other conditions involving free radical stress.

7 Supporting Phase II - Glutathione In humans, Glutathione is found in all tissues, with the highest levels found in the liver, eyes, spleen, pancreas, and kidneys. Research shows that glutathione is the single most protective antioxidant in virtually every tissue of the body. Glutathione Powder has a bland taste that dissolves quickly in water or other beverage for easy daily intake.

8 Supporting Phase II - Glutathione Depleted tissue GSH levels have been observed in several disease conditions. The restoration of cell GSH levels in a number of these conditions is beneficial. Thus, strategies to boost cell glutathione level are of marked therapeutic significance (in our present context of detoxification and well beyond )

9 Supporting Phase II - Glutathione Orally, glutathione has been used for treating cataracts, glaucoma, preventing aging, treating or preventing alcoholism, asthma, cancer, heart disease (atherosclerosis and hypercholesterolemia), hepatitis, liver disease, immunosuppression (including AIDS and chronic fatigue syndrome), maintaining immune function, memory loss, Alzheimer s disease, osteoarthritis, Parkinson s disease, detoxifying metals and drugs.

10 Supporting Phase II - Glutathione Inhaled, glutathione is used for treating lung diseases, including idiopathic pulmonary fibrosis, cystic fibrosis, and lung disease in individuals with HIV disease. Intramuscularly: glutathione is used for preventing toxicity of chemotherapy and for treating male infertility.

11 Supporting Phase II - Glutathione Intravenously: glutathione is used for preventing anaemia in patients undergoing haemodialysis, preventing renal dysfunction after coronary bypass surgery, treating Parkinson s disease, improving blood flow and decreasing clotting in individuals with atherosclerosis, treating diabetes, and preventing toxicity of chemotherapy.

12 Supporting Phase II - Glutathione Oral consumption may not provide optimal availability. GSH has a short life in human plasma (<3 min) and difficulty in crossing cell membranes, so administration of high doses is necessary to reach a therapeutic value.

13 Supporting Phase II - Glutathione A common mistaken belief is that glutathione is not well absorbed when it's taken orally, but significant data confirms it is efficiently absorbed across the intestinal epithelium by a specific uptake system. (study done on rats)

14 Supporting Phase II - Glutathione Plasma glutathione (GSH) concentration in rats increased from approximately 15 to 30 microm after administration of GSH either as a liquid bolus (30 mumol) or mixed ( mg/g) in AIN-76 semisynthetic diet. GSH concentration was maximal at min after GSH administration and remained high for over 3 h. Administration of the amino acid precursors of GSH had little or no effect on plasma GSH values, indicating that GSH catabolism and resynthesis do not account for the increased GSH concentration seen. Inhibition of GSH synthesis and degradation by L-buthionine-[S,R]-sulfoximine and acivicin showed that the increased plasma GSH came mostly from absorption of intact GSH instead of from its metabolism. Plasma protein-bound GSH also increased after GSH administration, with a time course similar to that observed for free plasma GSH. Thus dietary GSH can be absorbed intact and results in a substantial increase in blood plasma GSH. This indicates that oral supplementation may be useful to enhance tissue availability of GSH.

15 Supporting Phase II - Glutathione A great deal of controversy still exists regarding the bioavailabiity of oral glutathione. Thankfully, there are a couple of other options (over and above IV, which would need to be administered by a physician).

16 Supporting Phase II - Glutathione Acetyl-glutathione is orally active, unlike plain glutathione, and is stable in the intestine and plasma when absorbed and delivered directly to the cells for natural de-acetylation intracellularly. Plain glutathione delivered to the plasma by precursors, liposomal products or intravenously must be broken down by enzymes to the basic amino acid components for absorption into the cell and require more energy expenditure to be re-constructed back to rgsh.

17 Supporting Phase II - Glutathione It is known that disease states can block the reassimilation of components into rgsh. Therefore, it is a better dietary/therapeutic decision to provide the orally active and absorbed. Acetyl-glutathione which increases intracellular rgsh directly and naturally without increased energy expenditure and without being compromised from disease states.

18 Supporting Phase II - Glutathione In his thyroid book, Dr. Datis Kharrazian recommends the use of a transdermal form of glutathione, via a product called Oxicell. He states that the transdermal delivery system is superior to the oral route.

19 Supporting Phase II - Glutathione In his more recent book on brain function entitled Why Isn t My Brain Working, he also discusses acetylglutathione. Here s what he has to say

20 Supporting Phase II - Glutathione In the thyroid book I recommend a liposomal glutathione cream because oral glutathione is difficult to absorb Now we have access to a new form of glutathione known as s-acetyl-glutathione, which the gastrointestinal tract can efficiently absorb. Oral doses can start at 300mg/day and go up to several thousand milligrams if necessary with certain inflammatory conditions. I suggest about 1000mg/day in most cases. Dr. Datis Kharrazian: Why Isn t My Brain Working? P.426.

21 Supporting Phase II - Glutathione Oxicell is a the glutathione cream recommended by Dr. Kharrazian at 1-2 pumps per day, rubbed into the skin on the underside of feet and inside the wrist and elbows. Good for people with compromised guts.

22 Supporting Phase II - Glutathione Acetyl-Glutathione is a novel oral glutathione formulation that is stable in the stomach and gastrointestinal tract, well absorbed, and able to enter the cells directly and present to the cytosol for mitochondrial entry.

23 Supporting Phase II - Glutathione AC-Glutathione is Apex s version of s- acetyl-glutathione - well absorbed, and able to enter the cells directly and present to the cytosol for mitochondrial entry.

24 Supporting Phase II - Glutathione Absorption of oral glutathione can be affected by stomach acid or enzymes in the duodenum. However, the sustained-release properties of Glutathione- SR protect it from stomach acid and digestive enzymes, allowing slower release and a more steady level in the blood of this essential nutrient.

25 Supporting Phase II - Glutathione Reduced glutathione is offered by many companies, including Vital Nutrients and DFH. It s available in both capsule and powder form.

26 Supporting Phase II - Glutathione Glutathione Recycler provides compounds that aid in glutathione activity, support glutathione peroxidase and super oxide dismutase enzyme activity, helps support favorable reduced:oxidized glutathione ratios. 1 capsule contains NAC, Cordyceps, Gotu Kola, Milk thistle, L- glutamine and ALA.

27 Supporting Phase II - Glutathione N-Acetyl Cysteine provides several benefits, most notably its ability to support glutathione production (DFH product available in the US from Moss Nutrition).

28 Supporting Phase II - Glutathione Milk thistle (Silymarin) has been shown to increase the liver's content of glutathione. Silybin, one of the primary constituents of milk thistle, supports the liver's efforts to remove chemicals, drugs, alcohol, and other exogenous toxins.

29 Supporting Phase II - Glycine Glycine plays a key role in CNS function, phase II liver detoxification (direct effect on toxin elimination or via its effect on increasing glutathione). Glycine is necessary for the healthy DNA and RNA it plays an important role in ensuring healthy cell function throughout the body.

30 Supporting Phase II - Glycine Bone broths and collagen supplements contain a rich array of amino acids (noninflammatory). Glycine is a primary constituent and arginine is also present (ammonia clearance).

31 Supporting Phase II - Methylation Trimethylglycine (TMG) is an effective methylation enhancing agent. After TMG converts toxic homocysteine into methionine and SAMe, it becomes DMG (dimethylglycine).

32 Supporting Phase II - Methylation SAMe supports methylation and is found naturally in every cell in the human body. It increases levels of neurotransmitters such as serotonin and dopamine, and helps protect the liver from fat infiltration (expensive).

33 Supporting Phase II - Methylation Vitamins B 12, B 6 and folic acid can be helpful in upregulating the methylation pathways. Because of poor cephalic response and damage to parietal cells (gluten, H. pylori, etc.) there may be a lack of intrinsic factor, which will impact B 12 absorption even when high dose oral supplements are used.

34 Supporting Phase II - Methylation Methyl Factors from Biogenesis is a liquid form that can be used sublingually to deliver: B6 2mg B mcg Folic acid 400mcg

35 Supporting Phase II - Methylation Sublingual B 6 liquid by Designs For Health offers improved bioavailability for people whose digestion is compromised.

36 Supporting Phase II - Methylation B12 Boost Spray offers a neat little delivery system that allows oral absorption of B 12.

37 Supporting Phase II - Methylation B 12 may be absorbed by an alternate mechanism without reliance on intrinsic factor when high amounts of 1,000 mcg or more are taken. Thus, individuals without adequate intrinsic factor can still obtain adequate amounts of B 12 if extra amounts are ingested.

38 Supporting Phase II - Methylation HomocysteX Plus: B 2 B 6 B 12 Folic acid TMG

39 Supporting Phase II - Methylation Standard B-complex formulas are readily available: B-Supreme (DFH) Ultra-B Complex (Biogenesis) B Complex number 5, 6, etc. (Thorne)

40 Supporting Urea Cycle L-arginine is the product of choice when the urea cycle needs to be supported. Gelatin products do contain quite good levels of arginine, so individual arginine supplementation may not be needed in some cases.

41 Supporting Phase II - Estrogen Calcium D-Glucarate lowers blood and tissue levels of Betaglucuronidase and supports detoxification of estrogens, androgens, "used" T4, some steroids, bilirubin, bile salts, certain drugs, xenobiotics, environmental toxins.

42 Supporting Phase II - Estrogen Diindolylmethane (DIM) is an indole - plant compounds in cruciferous vegetables such as broccoli, cabbage, cauliflower & Brussels sprouts. It pushes estrogen into more of the protective 2-OH rather than the proliferative 16-a-OH.

43 Supporting Phase II - General Liver Nutrients provides several key phase II nutrients: Milk thistle NAC ALA L-methionine L-cysteine Taurine TMG

44 Supporting Phase II - General Amino-D-Tox does not contain botanicals: Glutamine 500 mg Glycine 500 mg Methylsulfonylmethane 400 mg N-Acetyl L-Cysteine 250 mg Taurine 250 mg Alpha Ketoglutarate 200 mg Glutathione 200 mg Methionine 200 mg Ornithine 200 mg Calcium-D-Glucarate 200 mg

45 Supporting Phase II - General Support Liver: Vitamin C 9 mg L-Methionine 300 mg, Lemon Pure Form Bioflavonoid Complex 345 mg N-Acetyl-Cysteine 150 mg, Taurine 75 mg L-Glutathione (reduced) 75 mg

46 Supporting Phase II Organic Acid Results The Metametrix, Genova and US Biotek organic acids profiles all come complete with specific supplement guidelines and recommendations, which makes your programme design task much easier. Let s look at an example

47 Supporting Phase II Organic Acid Results

48 2-Methylhippurate If you see high 2-methylhippurate: Indicates xylene exposure, so see whether exposure levels can be reduced. Glycine is the intervention option.

49 Glucarate High glucarate indicates general liver stress and exposure to higher levels of pesticides, etc. Organic food / fix gut General detoxification treatment - gently introduce phase II then phase I: Amino Dtox, Liver Nutrients, Support Liver Then consider adding phase I and support such as LV/GB Complex,

50 a-hydroxybutyrate If high a-hydroxybutyrate, support glutathione production: Glutathione products Glycine (bone broth and consider collagen hydrosylate powder as well as glycine supps) NAC Milk Thistle (Silymarin) Support Liver, Liver Nutrients, etc.

51 Pyroglutamate If high pyroglutamate shows up it s because of glutathione wasting: Remove exposure, reduce sources of toxicity, inflammation and oxidative stress Glutathione products Glycine NAC Milk thistle Support Liver, Liver Nutrients, etc.

52 Sulfate Sulfate imbalances indicate either excessive phase II activity or depletion: Glutathione products Glycine (bone broth and consider collagen hydrosylate powder as well as glycine supps) NAC Milk Thistle (Silymarin) Support Liver, Liver Nutrients, etc.

53 Orotate If orotate is high: L-arginine Bone broth and collagen/gelatin also contain quite a lot of arginine per unit mass. Note: other organic acid markers can indicate ammonia toxicity to be discussed when we cover other sections of the organic acids tests.

54 Methylation If methylation (methylmalonate / FIGLU) markers are elevated: B 12 Folic acid B 6 TMG SAMe May be advisable to check SNPs.

55 Supporting Phase II - Summary As I keep stating, it s generally appropriate to support phase II prior to up-regulating phase I. This can be done very effectively by using individual products such as NAC, glutathione in the correct form, glycine, milk thistle and others. Compound products such as Support Liver, Amino D-Tox and Liver Nutrients can also be used.

56 Thank You! Thanks a million for tuning in I hope this lesson was informative and helpful. In lesson 13, part 3, we ll look at supporting phase I, antioxidant support and general liver-support products that up-regulate both phases.