COMPOUND LIBRARIES. Target Molecule Corp Drug Screening Expert (Inhibitors, Libraries, Natural Compounds)

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1 COMPOUND LIBRARIES Target Molecule Corp. ---Drug Screening Expert (Inhibitors, Libraries, Natural )

2 About us Target Molecule Corp. (TargetMol) is a global high-tech enterprise, specializing in chemical and biological research products and service to meet the research needs of global customers. With the help of fast and efficient global supply chain, professional and rigorous procurement process and timely dynamic news of products, you will save more time with less cost and lead in drug discovery and screening. Our Product Portfolio Inhibitor Targetmol supplies over 3000 compounds used in the study of cell signaling pathways and drug discovery.track the latest scientific research and promptly offer the newest and most popular inhibitors. 50~100 new inhibitors per month. NMR and HPLC validated to ensure high purity. All compounds are in stock. INHIBITORS Targets include: JAK p38 MAPK AMPK Aurora Kinase Syk PERK PDK-1 DNA-PK GSK-3 ALK Bcr-Abl Aurora Kinase MEK JNK ERK ROCK PLK Histone Demethylase CDK LRRK ATPase Raf Rho Epigenetic Reader domain HDAC Pim EGFR MAO HAT DNA Methyltransferase ATM/ATR HIF FLT3 STAT p53 DNA Demethylase PARP Sirt CDK PKC Bcl-2 Histone Methyltransferase Src FAK BTK IAP Wnt/beta-catenin Hedgehog/Smoothened more

3 Compound Libraries Targetmol provides more than 32 types of compound libraries.they are available for cell induction, signaling pathway and HTS. Compound libraries are useful professional tools for drug discovery and new indication research. Customers can customize individual libraries by selecting specific molecules, quantities, concentrations, and format. Hot libraries: Approved Drug Library(1700 compounds) Inhibitor Library(2672 compounds) Natural Compound Library(623 compounds) CADD Target Library(1.5 million) Clinical Compound Library(432 compounds) Anti-cancer Library(933 compounds) Bioactive (3071 compounds) Bioactive Lipid Library(112 compounds) Stem Cell Library(150 compounds) Apoptosis Compound Library(78 compounds) Protease Inhibitor Library(69 compounds) Epigenetics Inhibitor Library(135 compounds) PI3K/Akt/mTOR Library(109 compounds) MAPK Inhibitor Library(56 compounds) GPCR Compound Library(356 compounds) Kinase Inhibitors Library(481 compounds) HTS Library(5 million) Anti-virus Compound Library(116 compounds) Anti-infection Compound Library(423 compounds) Anti-diabetic Library(69 compounds) Tyrosine Kinase Inhibitors Library(159 compounds) Ion Channel Inhibitor Library(263 compounds) Endocrinology-Hormones Library(186 compounds) Human Endogenous Ligand Library(200 compounds) CNS Library(600 compounds) Adrenergic Library(129 compounds) Serotonin Library(114 compounds) Oxidation-Reduction Library(71 compounds) The Hematopoietic Toxicity Library(104 compounds) Autophagy Library(254 compounds) Histamine & melatonin Library(93 compounds) FDA-apprared tibrary(1080 compounds) more Customize your library You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Select compounds Quantity 96 Well Plate Concentration Format (dry/solid or DMSO) Please contact us at to customize your library.

4 Contents L1000 Approved Drug Library...5 L2000 Inhibitor Library...6 L2100 Anti-cancer Library...8 L4000 Known Bioactive Compound Library...9 L6000 Natural Compound Library L4200 FDA-approved Drug Library L1100 Protease Inhibitor Library L1200 Epigenetics Library L1300 PI3K/Akt/mTOR Inhibitor Library L1400 MAPK Inhibitor Library L1500 GPCR Compound Library L1600 Kinase Inhibitor Library L1700 Anti-virus Compound Library L1800 Anti-infection Compound Library L1900 Anti-diabetic Library L2200 Tyrosine Kinase Inhibitor Library L2300 Ion Channel Inhibitor Library L2400 Endocrinology/Hormones Library L9000 Apoptosis Compound Library L2600 CNS Library L2700 Adrenergic Library L2800 Serotonin Library L2900 Oxidation-Reduction Library L3000 CADD Target Library L3100 The Hematopoietic Toxicity Library L3200 Autophagy Library L3300 Histamine & Melatonin Library L3400 Clinical Compound Library L4700 Anti-inflammation Library L5000 HTS Library L7000 Bioactive Lipid Library L8000 Stem Cell Library L2500 The Human Endogenous Ligand Library Tel: (857)

5 Cat.No. L1000 Approved Drug Library 1,700 approved drugs, for use in discovering alternate functions and new target mechanisms, as well as being suitable for research into known functions, and positive compound comparison. Each drug has pharmacological activity, sources and references for high-throughput screening and high-content screening. A unique collection of 1,700 approved drugs for high throughput screening (HTS) and highcontent screening (HCS). All compounds are approved by the FDA, CFDA, or EMEA, with known pharmacology and toxicology information. An effective tool for drug screening and to identify new targets for previously discovered drugs. have applications in a wide range of fields, including oncology, cardiology, immunology, endocrinology, etc. Detailed compound information, including structure, target, activity, IC50 value, and brief introduction. NMR- and HPLC-validated to ensure high purity and quality Research Areas of Approved Endocrine system 7% Cancer 8% Others 10% Cardiovascular System 11% Metabolism system 13% Respiratory system 3% Immunology 26% Nervous system 22% Approved Compound library Composition Mar DNA/RNA Synthesis Antibiotic Adrenergic Receptor AChR modulator COX Histamine Receptor antagonist Dopamine Receptor Sodium Channel Calmodulin Antibacterial Estrogen/Progestogen Receptor modulator Potassium Channel Topoisomerase Glucocorticoid Receptor PDE s GABAR potentiator PPAR agonist ChE Reactivator MRP NF-κB Androgen Receptor antagonist Antifungal RAAS Serotonin uptake VB Dehydrogenase substrate Antiviral Dopamine uptake ATPase Noradrenaline uptake Reverse Transcriptase Amino Acids and Derivatives Opioid Receptor Carbonic anhydrase, beta Catenin Microtubule Associated Intermediates ROS VEGFR Chelator EGFR GluR potentiator MAO HDAC Drug Screening Expert (Inhibitors, Libraries, Natural ) 5

6 Cat.No. L1000/L2000 Approved Compound library Composition Mar Antibiotic Adrenergic Receptor AChR modulator COX Histamine Receptor antagonist Dopamine Receptor Sodium Channel Calmodulin Antibacterial Estrogen/Progestogen Receptor modulator Potassium Channel Topoisomerase DNA/RNA Synthesis Glucocorticoid Receptor PDE s GABAR potentiator PPAR agonist ChE Reactivator MRP NF-κB Androgen Receptor antagonist Antifungal RAAS Serotonin uptake VB Dehydrogenase substrate Antiviral Dopamine uptake ATPase Noradrenaline uptake Reverse Transcriptase Amino Acids and Derivatives Opioid Receptor Carbonic anhydrase, beta Catenin Microtubule Associated Intermediates ROS VEGFR Chelator EGFR GluR potentiator MAO HDAC Inhibitor Library Cat.No. L2000 The inhibitors library contains over 2,672 active compounds with a diversity of structures. Most products have reported biological and pharmacological activity, which can be used in specific research, high-throughput screening, and high-content screening. A unique collection of over 2,672 small molecule inhibitors for HTS and HCS. Compound bioactivity and safety have been validated by preclinical research and clinical trials. Some of the inhibitors have approval by the FDA. Targets include: MAPK, PI3K, and JAK/STAT signaling pathways, HDAC, Aurora kinases, CDK and cell cycle regulatory proteins, integrase/protease. An effective tool for drug screening and to identify new targets for previously discovered drugs. Detailed compound information, including structure, target, activity, IC50 value, and brief introduction. Structurally diverse, medicinally active, and cell permeable. NMR- and HPLC-validated to ensure high purity and quality Tel: (857) info@targetmol.com

7 Cat.No. L Inhibitor library Composition Mar MMP MRP Antifungal mtor ATPase NF-κB Antiviral ChE GluR Carbonic anhydrase MAO Opioid Receptor ACE GSK-3 Bcl-2 CYP Akt Wnt/beta-catenin Bcr-Abl AChE c-met Aurora Kinase c-kit DPP-4 Noradrenaline uptake AMPAR Neuroscience Microbiology&Viro... Others Metabolism Antibiotic Adrenergic Receptor AChR modulator COX 5-HT receptor Dopamine Receptor Histamine Receptor Antibacterial Estrogen/Progestogen DNA/RNA Synthesis Topoisomerase Calcium Channel Glucocorticoid GABAR Antiparasitic ATM/ATR TGF-beta/Smad Calmodulin Dehydrogenase DHPS EGFR Epigenetic Read.. HDAC FAK CDK FGFR Microtubule Assoc... HIV Protease JAK HSP Androgen Receptor Immunologic Fac... VEGFR TRP/TRPV Histone Methyltra... Autophagy DNA Alkylating GPR Hedgehog/Smooth.. ḢIF IκB/IKK MEK AGTR AhR Annexin A Biliation Cannabinoid Rec MembraneTransport... Endocrinology/Hor... FLT3 HMG-CoA STAT Thyroid Hormone... Apoptosis inducer Aromatase BET bromodomain CFTR IGF-1R IL Src Xanthine Oxidase Antiprotozoal Beta Amyloid BTK CaMK CK CXCR antagonist DUB Factor Xa HAP antagonist ERKJNK DNADamage/DNA Repair GPCR/G Protein TyrosineKinase/Ad... CellCycle/Checkpoint Immunology/Inflam... Apoptosis PI3K/Akt/mTORSign... Chromatin/Epigenetic Enzyme Proteases/Proteasome MAPKSignaling JAK/STATSignaling StemCell Ubquitination Vitamin MAPK Mdm2 TXA2 CSF-1R Targeted Research Areas of Inhibitor Others 23% Immunology 22% Respiratory system 3% Endocrine system 6% Nervous system 19% Cardiovascular System 9% Cancer 18% Drug Screening Expert (Inhibitors, Libraries, Natural ) 7

8 Cat.No. L2100 Anti-cancer Library A unique collection of 933 compounds for use in cancer-related research and for high-throughput screening and high-content screening. A unique collection of 933 anti-cancer compounds for HTS and HCS. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Effective tools for research into the mechanisms of carcinogenesis, and for anti-tumor drug screening. Targets include PI3K, HDAC, mtor, CDK, Aurora kinase, JAK, etc. 933 Targeted Pathways of Anti-Cancer Compound Library Tyrosine Kinase/Adaptors DNA Damage/DNA Repair Cell Cycle/Checkpoint Immunology/Inflammation PI3K/Akt/mTOR Signaling Chromatin/Epigenetic Angiogensis MAPK Signaling Proteases/Proteasome JAK/STAT Signaling Microbiology & Virology Apoptosis Stem Cell Metabolism Neuroscience Ubiquitination Endocrinology/ Hormones GPCR/G Protein Membrane Transporter/Ion C... Enzyme Vitamin 8 Tel: (857) info@targetmol.com

9 Cat.No. L2100/L4000 Anti-Cancer Compound Library Composition Mar Topoisomerase PI3K DNA/RNASynthesis HDAC CDK NF-κB Histone Methyltransferase DNASynthesis Raf GSK-3 Bcl-2 HER2 Bcr-Abl p38mapk Akt ACE p53 DPP-4 Antiviral PPAR HSP FAK COX STAT IκB/IKK PotassiumChannel PDE IGF-1R DNA Alkylating Rho Immunologic Factors DNA Methyltransferase BET bromodomain AGTR PLK PDK MAPK Histamine Receptor Adrenergic Receptor antagonist TAMReceptor SodiumChannel Plasminogen JNK BTK Trk receptor MAO PLA TNF-alpha Known Bioactive Compound Library Cat.No. L4000 The bioactive compound library contains more than 3,071 small molecule compounds, paying close attention to their targets. Each compound has a target description, which is key to drug screening. A unique collection of 3,071 bioactive compounds with known targets for high throughput screening (HTS) and high content screening (HCS); All compounds have clarified target and corresponding target description; An effective tool for drug screening and discovering new with old drugs; Covers various areas, such as GPCR/G protein, Neuroscience, Membrane Transporter/Ion Channel, Microbiology & Virology, Immunology/Inflammation, Tyrosine Kinase/Adaptors, etc; More detailed compound information with structure, target, activity, IC50 value, and brief introduction; Structurally diverse, medicinally active, and cell permeable; NMR and HPLC validated to ensure high purity and quality; 3071 Drug Screening Expert (Inhibitors, Libraries, Natural ) 9

10 Cat.No. L4000/L6000 Targeted Pathways of Bioactive Company A Neuroscience Microbiology & Virology Metabolism Membrane Transporter... DNA Damage/DNA Repair Endocrinology/ Hormones GPCR/G protein Tyrosine Kinase/Adap... Immunology/Inflammation Cell Cycle/Checkpoint Bioacitve Compound Library Data Analysis Taregtmol 3071 PI3K/Akt/mTOR Signaling Chromatin/Epigenetic Enzyme Angiogensis Proteases/Proteasome MAPK Signaling JAK/STAT Signaling Apoptosis Targeted Research Areas of Bioactive Others 29% Cancer 14% 683 Vitamin Stem Cell Amino Acids & Buildi.. Ubiquitination Others Cardiovascular System 7% Endocrine system 5% Company B 2100 Respiratory system 2% Nervous system 15% Metabolism system Immunology 19% Natural Compound Library Cat.No. L6000 The library contains more than 623 compounds, derived from the nature of biological separation, and extraction of organic compounds in the body. Literature reports have demonstrated pharmacological activity and medicinal value of the compounds, but the specific target mechanisms are still unclear. These compounds are likely to be very important tools for drug screening and research. More than 623 natural compounds, to be used for HTS and HCS. Detailed compound information, including structure, target, activity, IC50 value, and brief introduction. 10 Tel: (857) info@targetmol.com

11 Cat.No. L Principle Research Areas of Natural Compound Library Classfication of Natural Cardiovascular System Endocrine 4% Respiratory system 1% system Cancer 5% 10% Others 42% Others 34% Alkaloids 12% Glycosides 11% Terpenoids 10% Immunology 14% Saccharides 3% Quinones 4% Flavonoids 9% Nervous system 24% Phenylpropanoids 4% Steroids 6% Phenols 7% Antibiotic AChR VB NF-κB CYP Estrogen/Progestogen Microtubule Associated Amino Acids and Derivatives Natural Compound Library Composition Mar Metabolism Neuroscience Microbiology & Virology Immunology/Inflammation Vitamin Endocrinology/ Hormones DNA Damage/DNA Repair Cell Cycle/Checkpoint Androgen Receptor agonist ROS Topoisomerase Adrenergic Receptor GABAR PDE Biliation activator COX DNA Synthesis EGFR MMP p38 MAPK PKC Antibacterial Bcl-2 TNF-alpha Membrane Transporter/Ion Channel VEGF Akt Apoptosis inducer MRP mtor p53 activator Potassium Channel ROS TGF-beta/Smad VA VCVD Amino Acids & Building Blocks PI3K/Akt/mTOR Signaling Enzyme GPCR/G Protein MAPK Signaling Proteases/Proteasome Tyrosine Kinase/Adaptors Angiogensis Apoptosis Chromatin/Epigenetic STAT VE 5-HT Receptor antagonist Wnt/beta-catenin Ubiquitination JAK/STAT Signaling 1 Stem Cell Drug Screening Expert (Inhibitors, Libraries, Natural ) 11

12 Cat.No. L4200 FDA-approved Drug Library Cat.No. L4200 1,068 FDA-approved drugs are used to discover their more function, suitable for old drug research, new targets mechanism and positive compound comparison and so on. A unique collection of 1,068 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS) ; All compounds have been approved by FDA; An effective tool for drug screening and discovering new with old drugs; Including multiple field, such as oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, etc; More detailed compound information with structure, target, activity, IC50 value, and brief introduction; Structurally diverse, medicinally active, and cell permeable; NMR and HPLC validated to ensure high purity and quality; 1068 Principle Research Areas of FDA-Approved Compound Library Endocrine system Respiratory system Immunology Cancer Metabolism system Nervous system Cardiovascular System Others 12 Tel: (857) info@targetmol.com

13 Cat.No. L4200 FDA-Approved Compound Library Composition Mar Antibiotic AChR antagonist Adrenergic Receptor antagonist 5-HT Receptor antagonist Histamine Receptor antagonist COX Estrogen/Progestogen Receptor agonist Antibacterial Sodium Channel Glucocorticoid Receptor Topoisomerase DNA/RNA Synthesis Potassium Channel Dopamine Receptor antagonist PDE GABAR Calcium Channel RAAS Androgen Receptor antagonist Carbonic anhydrase Antiviral VB Antifungal ATPase Dehydrogenase Microtubule Associated Targeted Pathways of FDA-Approved PPAR agonist Reverse Transcriptase Chelator DNA Alkylating ChE NF-κB AChE Annexin A... EGFR Thyroid Ho... Aromatase Biliation HDAC MAO MRP P2 Recepto... Factor Xa GluR antag... Influenza... Plasminogen RNA synthesis TNF-alpha AhR agonist Antiprotozoal Bcr-Abl Progestero.. VKOR 5-Lipoxyge... AKR Endocrinology/ Hormones Microbiology & Virology Others Membrane Transporter/Ion C... Metabolism GPCR/G protein Enzyme Chromatin/Epigenetic Angiogensis Immunology/Inflammation Proteases/Proteasome Tyrosine Kinase/Adaptors Vitamin JAK/STAT Signaling PI3K/Akt/mTOR Signaling Ubiquitination Apoptosis MAPK Signaling Amino Acids & Building Blocks Drug Screening Expert (Inhibitors, Libraries, Natural ) 13

14 Cat.No. L1100 Protease Inhibitor Library The protease inhibitor library contains 69 small molecule inhibitors associated with proteases and proteasomes, for use in scientific research and drug screening. A unique collection of 69 types of bioactive compounds for HTS and HCS. Targets include DPP-4, serine proteases, cysteine proteases, MMPs, aspartic proteases, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Several of the inhibitors have been approved by the FDA MMP DPP-4 HIV Integ... Autophagy DUB Gamma-sec... Proteasome Protease Inhibitor Library Composition Mar Beta Amyloid Caspase a... Cysteine... Serine Pr... Antiviral Autophagy DNA/RNA S... HCV Integrase p97 PPAR agonist Protease Aspartic... BACE Histamine... NF-κB PAI RAAS TLR antag... TNF Topoisome... Antiviral 14 Tel: (857) info@targetmol.com

15 Cat.No. L1200 Epigenetics Library The epigenetics library contains 135 compounds for epigenetic research, related testing, HTS and HCS. A unique collection of 135 compounds related to epigenetics for HTS and HCS. Targets include HDAC, Sirt/Sirtuin, HAT, HMT, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Some of the compounds have been approved by the FDA. 135 Epigenetics Inhibitor Library Composition Mar HDAC JAK Histone Methyltransferase Epigenetic Reader Domain HIF Aurora Kinase FLT3 BET bromodomain PARP DNA Methyltransferase Pim Sirtuin JAK FGFR Adenosine Receptor antago... Histone Demethylase Adenosine receptor antag... Aurora Kinase EGFR Drug Screening Expert (Inhibitors, Libraries, Natural ) 15

16 Cat.No. L1300 PI3K/Akt/mTOR Inhibitor Library The PI3K/Akt/mTOR inhibitor library consists of 109 small molecular compounds; they are used in the study of the PI3K/Akt/mTOR signaling pathway, and for relevant drug screening. A unique collection of 109 biologically active compounds associated with PI3K/Akt/mTOR. An effective way of studying cell/tumor cell growth, proliferation, apoptosis, etc. 109 PI3K/Akt/mTOR Library Composition Mar PI3K mtor GSK-3 15 Akt ATM/ATR DNA-PK S6Kinase PDK AMPK FGFR PKA PKC EGFR HDAC JAK MEK PotassiumChannel ROCK SEC14-likeprotein Sirtuin Src TGF-beta/Smad Tyk 16 Tel: (857) info@targetmol.com

17 Cat.No. L1400 MAPK Inhibitor Library The MAPK inhibitor library contains 56 bioactive compounds related to the MAPK pathway for use in research and drug screening. A unique collection of 56 types of bioactive compounds associated with MAPK inhibition for HTS and HCS. Targets include MAPK, ERK, JNK, MEK, p38, Raf, RSK, MNK, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Some compounds in the library are approved by the FDA. 56 MAPK Inhibitor Library Composition Mar Raf 13 9 p38 MAPK MEK MAPK ERK JNK Bcr-Abl CaMK NO agonist PDGFR Src VEGFR Akt CDK c-met EGFR FGFR HER2 Mast/stem cell GFR Kit Rho TGF-beta/Smad Drug Screening Expert (Inhibitors, Libraries, Natural ) 17

18 Cat.No. L1500 GPCR Compound Library This library contains 356 active compounds associated with G-proteins and GPCRs, used in research of GPCR-targeted drugs, and drug screening. A unique collection of 356 compounds for GPCR-targeted drug screening. have demonstrated good biological and pharmaceutical activity. The GPCR compound library consists of small molecules associated with receptors, such as 5-HT receptor, dopamine receptor, opioid receptor, adrenergic receptor, cannabinoid receptor, mglur, ETA-receptor, etc. It is estimated that approximately 200 orphan GPCRs are functionally unknown; use of this library for screening these GPCRs with unknown function may yield new GPCR-based drug candidates. 356 GPCR Compound Library Composition Mar Adrenergic Receptor 5-HT Receptor Histamine Receptor Dopamine Receptor Opioid Receptor AChR antagonist Adenosine Receptor Cannabinoid antagonist Hedgehog/Smoothened CXCR Potassium Channel Serotonin Calcium Channel SGLT P2 Receptor PDE Calmodulin CaSR antagonist Endothelin GPR Noradrenaline OX Receptor Sigma receptor Vasopressin AMPAR modulators Antibiotic Antifungal Apoptosis inducer ATPase S1P Receptor agonist TGF-beta/Smad Xanthine Oxidase 18 Tel: (857) info@targetmol.com

19 Cat.No. L1600 Kinase Inhibitor Library The kinase inhibitor library contains 481 varieties of inhibitor targeted to specific protein kinases, for use in HTS and HCS. A unique collection of 481 types of kinase inhibitor for HTS and HCS. Targets numerous kinases, such as MAPK, PI3K, JAK, STAT, CDK, MEK, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Several kinase inhibitors have been approved by the FDA. Most inhibitors of the library are ATP-competitive. 481 Kinase Inhibitor Library Composition Mar PI3K EGFR JAK TGF-beta/Smad c-kit FLT3 PDGFR Pim PLK AMPK 19 VEGFR CDK NF-κB GSK-3 Raf Akt mtor p38 MAPK Bcr-Abl c-met Aurora Kinase FAK BTK ERK IGF-1R MAPK PDK PKD Src HER ROCK ATM/ATR PKC Plasminogen TAM Receptor Adrenergic HIF IκB/IKK Factor Xa FGFR Rho STAT Dynamin NO agonist Potassium C... TNF-alpha 1 Trk Wnt/beta-ca... Drug Screening Expert (Inhibitors, Libraries, Natural ) 19

20 Cat.No. L1700 Anti-virus Compound Library The antivirus compound library contains 116 varieties of molecule for drug research and other pharmaceutical development fields. A unique collection of 116 compounds for HTS and HCS. include anti-cmv, anti-hiv, anti-influenza virus, etc. biological activity and safety have been verified through preliminary clinical studies and clinical trials. An effective tool for research institutes, and for pharmaceutical development and pharmaceutical engineering. Some of the antiviral drugs have FDA approval Anti-virus Compound Library Composition Mar DNA/RNA Synthesis Reverse Transcriptase Antiviral Antibiotic HIV Protease Nucleoside Antimetabolite/A... Influenza Virus Integrase Thymidylate synthase Topoisomerase Autophagy activator HCV Histamine Receptor HIV integrase Phosphorylase ADK activator Caspase activator HCMV HDAC activator HSP Rhinovirus STAT 20 Tel: (857) info@targetmol.com

21 Cat.No. L1800 Anti-infection Compound Library The anti-infection compound library contains 423 types of antiviral, antibacterial, and antiparisitic drugs for HTS and HCS. A unique collection of 423 anti-infection compounds for HTS and HCS. include antibacterial, antifungal, anti-cmv, anti-hiv, anti-influenza virus, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. An effective tool for research institutes, pharmaceutical development, pharmaceutical engineering, etc. Some anti-infection drugs have FDA approval. 423 Anti-infection Compound Library Composition Mar Antibiotic Antibacterial DNA/RNA Synthesis Topoisomerase Antifungal Antiviral Reverse Transcriptase Antiparasitic HIV Protease Antiprotozoal DHPS DHFR Influenza Virus Nucleoside Antimetabolite/Ana... Integrase HCV Histamine Receptor Others Potassium Channel AChR antagonist AntiVirus ATM/ATR Biliation activator Carbonic anhydrase, beta Catenin Caspase activator CCR Chelator Dehydrogenase DNA damage Fe(II)-protoporphyrin IX HCMV IL antagonist MAO Microtubule Associated Purine nucleoside phosphorylase Rac1 Rhinovirus Thymidylate synthase UMP-CMP kinase Drug Screening Expert (Inhibitors, Libraries, Natural ) 21

22 Cat.No. L1900 Anti-diabetic Library The anti-diabetic library contains 69 bioactive compounds aliquoted to 96-well plates; these are ideal for screening, and for research into the mechanisms of neurodegenerative diseases. A unique collection of 69 compounds for drug screening. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Targets include SGLT, PPAR, DPP-4, OC receptor, AMPK, etc PPAR DPP-4 NF-κB Potassium Channel ROS 3 SGLT Others GPR antagonist IGF-1R Anti-diabetic Library Composition Mar MMP AMPK activator Antibiotic Calcium Channel antago... COX Dehydrogenase ERK GABAR agonist HDAC activator MGA p38 MAPK RAAS TGF-beta/Smad Thrombomodulin TLR TNF-alpha Wnt/beta-catenin Xanthine Oxidase 22 Tel: (857) info@targetmol.com

23 Cat.No. L2200 Tyrosine Kinase Inhibitor Library The tyrosine kinase inhibitor library consists of 159 compounds, which are used for drug screening, and to research diseases associated with tyrosine kinase activity. A unique collection of 159 types of tyrosine kinase inhibitor for HTS and HCS. Targets include c-kit, c-met, HGFR, EGFR, FGFR, insulin receptor, JAK, PDGFR, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Several of the tyrosine kinase inhibitors have been FDA-approved. 159 Tyrosine Kinase Inhibitor Library Composition Mar EGFR VEGFR TGF-beta/Smad PDGFR c-kit FLT3 HER2 c-met FGFR Bcr-Abl IGF-1R JAK Src MEK Raf TAM CDK AuroraKinase AuroraKinase CSF-1R EPHAantagonist Mast/stemcellGFRKit mtor RTK Trkreceptor Sodium Channel Tie-2 Topoisomerase Abl Drug Screening Expert (Inhibitors, Libraries, Natural ) 23

24 Cat.No. L2300 Ion Channel Inhibitor Library The ion channel inhibitor library contains 263 small molecule inhibitors of ion channels; they can be used for HTS and HCS. A unique collection of 263 compounds associated with ion channels for use in HTS and HCS. Targets include K+ channels, Ca2+ channels, Na+ channels, proton pumps, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Some of the active compounds have FDA approval. 263 Ion Channel Inhibitor Library Composition Mar Sodium Channel Calcium Channel GABAR Potassium Channel ATPase Others TRP/TRPV Proton Pump CFTR SGLT 5-HT Receptor Calmodulin Carbonic anhydrase AChR antagonist AMPAR modulator GluR MRP NKCC cotransporter Adenosine receptor AhR Androgen Receptor ChE COX CTFR Dopamine Receptor EGFR Histamine Receptor ABC AMPK activator PPAR agonist Thrombomodulin 24 Tel: (857) info@targetmol.com

25 Cat.No. L2400 Endocrinology/Hormones Library This library contains 186 compounds related to endocrinology/hormone signaling pathways, used for the study of the human endocrine system, and for HTS and HCS. A unique collection of 186 compounds associated with the endocrine system for HTS and HCS. An effective means of studying diseases of the human endocrine system. Targets include estrogen receptor, androgen receptor, norepinephrine receptor, etc. 186 Endocrinology/ Hormones Library Mar Estrogen/Proges... Androgen Receptor GPR Glucocorticoid Others Opioid Receptor RAAS ACE AGTR antagonist Norepinephrine Progesterone CCK GluR PGE Synthase 5-HT Receptor Drug Screening Expert (Inhibitors, Libraries, Natural ) 25

26 Cat.No. L9000 Apoptosis Compound Library The apoptosis compound library contains 78 compounds related to apoptotic signaling pathways; most are involved in carcinogenesis and are also used in anti-cancer drug screening. A unique collection of 78 bioactive compounds associated with apoptosis for HTS and HCS. Targets include Bcl-2, caspases, p53, TNF-α, Survivin, etc. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Some compounds have FDA approval. Detailed compound information, including structure, target, activity, IC50 value, and description. Targeted Pathways of Apoptosis NMR and HPLC validated to ensure high purity 1% Apoptosis and quality. 3%2%2% 4% Immunology/Inflammation 4% MAPK Signaling 5% 40% Tyrosine Kinase/Adaptors Cell Cycle/Checkpoint 5% GPCR/G Protein Metabolism Neuroscience 6% Proteases/Proteasome Angiogensis 78 7% 9% 12% JAK/STAT Signaling Ubiquitination DNA Damage/DNA Repair Apoptosis Compound Library Composition Mar Bcl-2 Apoptosis inducer TNF-alpha Adrenergic Receptor Mdm2 p53 PKD ERK NF-κB PERK VEGFR Caspaseactivator AuroraKinase E3 Ligase activator JAK MEK CysLTRantagonist Egr IAP MAO PDE PDGFR Plasminogen Raf Survivin Thrombomodulin CDK c-met c-myc 26 Tel: (857) info@targetmol.com

27 Cat.No. L2600 CNS Library The CNS library contains 600 compounds that target the central nervous system; they are used for drug screening for neurological diseases. A unique collection of 600 compounds associated with the CNS for HTS and HCS. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Targets include 5-HT receptor, AChR, histamine receptor, opioid receptor, etc Adrenergic Receptor COX AChR antagonist 5-Lipoxygenase Histamine Receptor antag... Dopamine uptake 60 CNS Library Composition Mar GABAR potentiator ChE GluR Opioid Receptor AChE Serotonin uptake LRRK2 P2 Receptor antagonist Calcium Channel NF-κB Potassium Channel AMPAR modulator NMDAR Noradrenaline uptake OX Receptor antagonist Antibiotic CaMK Dopa decarboxylase Gamma-secretase Substance P antagonist TXA2 Receptor antagonist TNF-alpha Topoisomerase Drug Screening Expert (Inhibitors, Libraries, Natural ) 27

28 Cat.No. L2700 Adrenergic Library The adrenergic library contains 129 varieties of compound that specifically target the adrenergic receptor, and are used for drug screening. A unique collection of 129 bioactive compounds that target the adrenergic receptor. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. 129 Adrenergic Library Composition Mar Adrenergic Receptor Calcium Channel 5-HT Receptor Histamine Receptor anta... Potassium Channel AChR antagonist Serotonin uptake Dopamine Receptor Noradrenaline uptake CAMP PDE activator E-selectin GABAR antagonist 28 Tel: (857) info@targetmol.com

29 Cat.No. L2800 Serotonin Library The serotonin library contains 114 varieties of compound that target the 5-HT receptor, and are for use in the screening of drugs targeting neurologic diseases. A unique collection of 114 compounds for HTS and HCS. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Target the 5-HT receptor specifically Serotonin Library Composition Mar HT Receptor Dopamine Receptor Serotonin uptake Histamine Receptor AChR antagonist Adrenergic Receptor Noradrenaline uptake AMPAR modulators Antibiotic ATPase GABAR antagonist GluR antagonist MRP Drug Screening Expert (Inhibitors, Libraries, Natural ) 29

30 Cat.No. L2900 Oxidation-Reduction Library The oxidation-reduction library contains 71 bioactive compounds aliquoted to 96-well plates that are ideal for drug screening and mechanisms research. A unique collection of 71 compounds for HTS and HCS. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Library includes ROS scavengers, inos/enos, and natural antioxidant compounds. 71 Oxidation-Reduction Library Composition Mar ROS Others Annexin A NF-κB NOS PDE s Adenosine receptor antag... IL receptor MAO NO agonist TGF-beta/Smad TNF-alpha IL AKR Antibiotic Topoisomerase Tyrosinase 30 Tel: (857) info@targetmol.com

31 Cat.No. L3000 CADD Target Library The target library consists of collections according to the directions of researches following computerized virtual screening. Antibacterial GSK3β library c-met kinase library Antiviral HDAC library CB1/2 library GPCRs HSP90 library Cl- channels library Ion channels IGF-1R library CNS library Kinases K+ channels library CXCR1/2 library Peptidomimetics Purinergic library EphB4 inhibitors library AcetylCo library mglur ligands RAR library AGRO library MK2 inhibitors library Secretase library Akt kinase library Na+ channels library Steroids/steroid-like library Antiapoptotic library nachr library Transporter inhibitors library PI3 kinase library p2x7 focused library YES kinase library Arginine kinase library PDZ library BCL2/MCL1 library Aurora A/B kinase library Phosphatases library A collection of over 1.5 million compounds, used to select specific target compounds for HTS and HCS with computer-aided screening. An effective tool for research and drug screening. Covers numerous signal transduction areas, including GPCR/G protein, neuroscience, membrane transporter/ion channel, microbiology & virology, immunology/inflammation, tyrosine kinase/adaptors, etc. Detailed compound information, including structure, target, activity, IC50 value, and brief introduction. 10,000* 1.5 million Drug Screening Expert (Inhibitors, Libraries, Natural ) 31

32 Cat.No. L3100 The Hematopoietic Toxicity Library The hematopoietic toxicity library is a collection of 104 compounds with a range of defined hematopoietic toxicities, such as myelosuppression, neutropenia, leucopenia, anemia, etc. Included are a variety of structurally and mechanistically diverse compound classes, in addition to non-toxic controls; compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. This library is an essential tool for predictive toxicology screening and assay development. A unique collection of 104 compounds for HTS and HCS. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Targets include HDAC, PPAR, DNA alkylating agents, EGFR, etc. 104 The Hematopoietic Toxicity Library Composition Mar DNA Synthesis Antibiotic Adrenergic Receptor ant... DNA Alkylating Sodium Channel Microtubule Associated Potassium Channel AChR antagonist MRP 5-HT receptor antagonist Histamine Receptor Topoisomerase c-kit COX EGFR antagonist HDAC PDGFR Antifungal PPAR agonist Reverse Transcriptase Thyroid Hormone Abl ACE Amino Acids and Derivat... Antibacterial TRP/TRPV VEGFR 32 Tel: (857) info@targetmol.com

33 Cat.No. L3200 Autophagy Library A unique collection of 254 compounds related to cell autophagy, for use in the research of autophagy, and for HTS and HCS. A unique collection of 254 compounds associated with autophagy. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. An effective tool in the study of cell autophagy mechanisms and drug target research. Activity includes autophagy induction and autophagy inhibition, proteasome, HIF, E3 ligase, mtor, etc Autophagy Library Composition Mar PI3K HDAC mtor Bcl-2 Calcium channel NF-κB Adrenergic Recepto... Apoptosis inducer Aurora Kinase Autophagy DUB HIF LRRK2 TNF-alpha ATM/ATR Mdm2 p53 activator Pim PKD Proteasome Sirtuin Sodium Channel BET bromodomain Caspase activator DPP-4 MMP PDE ROCK VEGFR IGF-1R p97 PDGFR NO agonist Drug Screening Expert (Inhibitors, Libraries, Natural ) 33

34 Cat.No. L3300 Histamine & Melatonin Library The histamine & melatonin library contains 93 bioactive compounds, ideal for drug screening, and for research into the mechanisms of neurodegenerative diseases. A unique collection of 93 compounds for HTS and HCS. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. specifically target the histamine receptor and melatonin receptor. 93 Histamine & Melatonin Library Composition Mar Histamine Receptor 5-HT receptor AChR antagonist Serotonin uptake Adrenergic Receptor Calcium Channel Dopamine uptake Melatonin receptor Noradrenaline uptake Antifungal ChE Cholinergic DNA interaction EGFR TGF-beta/Smad 34 Tel: (857) info@targetmol.com

35 Cat.No. L3400 Clinical Compound Library The clinical compound library is a collection of 432 compounds, all of which have been permitted into the clinical phase. Every compound contains comprehensive information on pharmacological activities, as well as sources and references etc. A unique collection of 432 drugs for HTS and HCS. All compounds have been permitted into clinical phases and have known biological activities. An effective tool for drug screening and new drug discovery. Detailed compound information, including structure, target, activity, IC50 value, and biological introduction. All compounds are in stock. 432 Clinical Compound Library Composition Mar Cancer Cardiovascular System Endocrine system Immunology Metabolism system Nervous system Others Respiratory system Drug Screening Expert (Inhibitors, Libraries, Natural ) 35

36 Cat.No. L4700 Anti-inflammation Library A unique collection of 247 bioactive anti-inflammation compounds for drug screening, drug target identification, and other pharmaceutical-related applications. A unique collection of 247 bioactive Anti-infection compounds for high throughput screening (HTS) and high content screening (HCS); Bioactivity and safety confirmed by preclinical research and clinical trials, some have been approved by the FDA; A useful tool to research infectious disease for academic institutions, medical research organizations, and the pharmaceutical industry Anti-infammation library Composition Mar Antibiotic Antibacterial DNA/RNA Synthesis Topoisomerase Antifungal Antiviral Reverse Transcriptase Antiparasitic HIV Protease Antiprotozoal DHPS DHFR Influenza Virus Nucleoside Antimetabolite/Ana... Integrase HCV Histamine Receptor Others Potassium Channel AChR antagonist AntiVirus ATM/ATR Biliation activator Carbonic anhydrase, beta Catenin Caspase activator CCR Chelator Dehydrogenase DNA damage Fe(II)-protoporphyrin IX HCMV IL antagonist MAO Microtubule Associated Purine nucleoside phosphorylase Rac1 Rhinovirus Thymidylate synthase UMP-CMP kinase 36 Tel: (857) info@targetmol.com

37 Cat.No. L5000 HTS Library Advantages of this library are its large capacity, diversity, range of new compounds, and higher cost performance. In addition, compounds are more easily selected for HTS and HCS. As many as 5 million small molecular compound collections, wide selection scope is easier to screen out the desired result; All compounds meet strict criteria screening to avoid adverse groups; different skeleton structure, comprehensive coverage; More than is updated into the library every year; An effective tool for scientific research and drug screening; Detailed specifications, chemical structure, activity description, etc.; Structurally diverse, medicinally active, and cell permeable NMR and HPLC validated to ensure high purity and quality; 10,000* 5 million Drug Screening Expert (Inhibitors, Libraries, Natural ) 37

38 Cat.No. L7000 Bioactive Lipid Library The bioactive lipid library contains 112 bioactive lipids aliquoted to 96-well plates. A unique collection of 112 bioactive lipid compounds for HTS and HCS. Compound biological activity and safety have been verified through preliminary clinical studies and clinical trials. Targets include GPCR, HDAC, PPAR, DNA alkylating agents, EGFR, etc. 112 Bioactive Lipid Library Composition Mar MAO Lipid RXR/RAR Cannabinoid Receptor Factor Xa Others Dehydrogenase Farnesoid X recept.. Plasminogen Phospholipase PLK VA CETP LPL LXR agonist PLA Adrenergic Recepto PRPP Amidotransferase TpoR agonist 38 Tel: (857) info@targetmol.com

39 Cat.No. L8000 Stem Cell Library The stem cell library consists of 150 small molecular compounds for use in research of the stem cell signaling pathway, and for new drug screening. A unique collection of 150 compounds associated with stem cell signaling pathways for HTS and HCS. An effective means of studying the mechanisms of stem cell regeneration, regeneration therapy, and drug screening based on stem cells. Targets include Wnt, GSK-3, Hedgehog, JAK, ROCK, γ-secretase, etc. 150 Stem Cell Library Composition Mar TGF-beta/Smad JAK GSK-3 Wnt/beta-catenin Hedgehog/Smoothened ROCK Rho STAT JNK PKC Akt CK EGFR Gamma-secretase ipscs MEK Casein Kinase CDK Antibiotic Aurora Kinase Carbonic anhydrase IGF-1R MEK Sirtuin Drug Screening Expert (Inhibitors, Libraries, Natural ) 39

40 Cat.No. L2500 The Human Endogenous Ligand Library The human endogenous ligand library consists of 200 biologically active compounds related to endogenous metabolism; they are used for the study of endogenous metabolic diseases, and for new drug screening. A unique collection of 200 human endogenous biologically active compounds for HTS and HCS. An effective means of studying human metabolic diseases and identifying new drug targets. All compounds can be selected according to molecular structure Tel: (857) info@targetmol.com

41 Drug Screening Expert (Inhibitors, Libraries, Natural ) 41

42 Headquarters North America United States Order & Inquiry Tel: Fax: Add: One Boston Place Suite 2600 Boston, MA Technical Support Europe Asia Pacific region Germany China Order & Inquiry Tel: Add: Willi-Graf-Str. 25/ /Munich Order & Inquiry Tel: Fax: Add: NO 228 Jiangchang San Road,Shanghai,China Target Molecule Corp. ---Drug Screening Expert(Inhibitors, Libraries, Natural )