Validated Mouse Quantitative RT-PCR Genes Gene Gene Bank Accession Number Name

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1 5HT1a NM_ Serotonin Receptor 1a 5HT1b NM_ Serotonin Receptor 1b 5HT2a NM_ Serotonin Receptor 2a ACO-2 NM_ Aconitase 2 Adora2A NM_ Adenosine A2a Receptor Aif1 (IbaI) D Allograft Inflammatory Factor 1 ATP5b NM_ ATP Synthase BDNF I EF Brain-Derived Neurotrophic Factor, Isoform I BDNF II EF , EF , EF Brain-Derived Neurotrophic Factor, Isoform II BDNF IV EF Brain-Derived Neurotrophic Factor, Isoform IV BDNF IX EF Brain-Derived Neurotrophic Factor, Isoform IX, full length BDNF VI EF Brain-Derived Neurotrophic Factor, Isoform VI C1q, C NM_ Complement Component 1 Qc C3 ENSMUST ENSMUSG Complement Component 3 C4 ENSMUST ENSMUSG Complement Component 4 CANX NM_ , NM_ , NM_ , Calnexin CAT BC NM_ Catalase CB1 NM_ Cannabinoid Receptor 1 CD4 NM_ Cell Differentiation Antigen 4 CHAT NM_ Choline )-Acetyltransferase CHRM1 NM_ NM_ Cholinergic Recepetor 1 CHRNA4 NM_ Cholinergic Receptor a4 CHRNB2 NM_ Cholinergic Receptor b2 CTH (CSE) NM_ Cystathionine Gamma-Lyase D1A NM_ Dopamine Receptor D1 DARPP32 (PPP1R1B) NM_ Protein Phosphatase 1, Regulatory Inhibitor Subunit 1b DRD2 NM_ Dopamine Receptor D2 EEF2 NM_ Eukaryotic Translation Elongation Factor 2 EGR2 NM_ Early Growth Response 2 Eif4A2 NM_ NM_ NM_ Eukaryotic Translation Initiation Factor 4a2 FERRITIN BC BC115514:EMBL IRAMp995d1324Q Ferritin (Mitochondrial) (MITOCHONDRIAL) FTH1 (ferritin heavy chain 1) NM_ Ferritin Heavy Chain 1 FTL1 (ferritin light chain 1) NM_ Ferritin Light Chain 1

2 GABRD NM_ GABA-A Receptor delta GAD1 (GAD67) NM_ Glutamate Decarboxylase 1 GAD2 (GAD65) NM_ Glutamate Decarboxylase 2 GAPDH NM_ NM_ Glyceraldehyde-3-Phosphate Dehydrogenase GCLC NM_ Glutamate-Cystein Ligase, Catalytic Subunit GFAP NM_ NM_ Glial Fibrillary Acidic Protein HO-1 NM_ Heme Oxygenase 1 Hrh3 NM_ Histamine Receptor 3 Htt (Exon 1) NM_ Huntington Htt (knock-in) NM_ Huntington Htt (total) NM_ Huntingtin IL-10 NM_ Interleukin 10 IL-12 NM_ Interleukin 12 IL-1beta NM_ Interleukin 1 beta IL-6 NM_ Interleukin 6 inos (NOS2) NM_ Notric Oxide Synthase 2 KEAP1 NM_ , NM_ , NM_ , NM_ Kelch-Like ECH-Associated Protein 1 MAPK-1 ENSMUST Mitogen-Activated Protein Kinase 1 Matrillin1 (whole body) NM_ Matrilin 1 mglur2 (Grm2) NM_ Glutamate Receptor 2 mglur5 (Grm5) NM_ Glutamate Receptor 5 MT3 NM_ Metallothionein 3 NK1 Receptor (NK1R) NM_ Tachykinin Receptor 1 nnos (NOS1) NM_ Notric Oxide Synthase 1 NQO-1 NM_ NADPH Dehydrogenase Quinone 1 NRF-2 NM_ Nuclear Respiratory Factor 2 NT-PGC1A NR_ NM_ N-terminal isoform of PGC1a PDE10A NM_ NM_ Phosphodiesterase 10a PDE2A NM_ NM_ NM_ Phosphodiesterase 2a PDE9A NM_ NM_ Phosphodiesterase 9a PDYN (Pro-dynorphin) NM_ Prodynorphin

3 penk NM_ Proenkephalin PGC1A NR_ NM_ Peroxisome Proliferator-Activated Receptor 1 alpha Pleiotrophin (PTN) NM_ Pleiotrophin Pro-enkephalin A (PENK) NM_ Pro-enkephalin A Pvalb NM_ Parvalbumin Pvalb ENSMUST ENSMUSG Dynorphin RPL13a NM_ Ribosomal Protein L13a Serpini1 NM_ Serpin Peptidase Inhibitor 1 SLc1a2 (GLT1) NM_ NM_ NM_ Solute Carrier Family 1 (Glial High Affinity Gulatmate Transporter) SMN1 NM_ Survival of Motor Neuron 1 SOD-2 NM_ Superoxide Dismutase 2 SST NM_ Somatostatin Supt4h NM_ Suppressor of Ty 4 Homolog 1 Synaptophysin (SYP) NM_ Synaptophysin TBP NM_ TATA Binding Protein TDG NM_ Thymine-DNA Glycosylase TNF-ALPHA NM_ Tumor Necrosis Factor alpha TrkB M Tyrosine Receptor Kinase B TSPO NM_ Translocator Protein UBC NM_ Ubiquitin C

4 Validated Rat Quantitative RT-PCR Genes ATP5B NM_ ATP Synthase BDNF I EF Brain-Derived Neurotrophic Factor, Isoform I BDNF IV EF Brain-Derived Neurotrophic Factor, Isoform IV BDNF IX NM_ Brain-Derived Neurotrophic Factor, Isoform IX, full length BDNF VI EF Brain-Derived Neurotrophic Factor, Isoform VI CANX NM_ Calnexin CB1 NM_ Cannabinoid Receptor 1 CREB NM_ NM_ Camp Responsive Element Binding Protein 1 Cth NM_ Cystathionine Gamma-Lyase D1A NM_ Dopamine Receptor D1 DARPP32 NM_ Protein Phosphatase 1, Regulatory Inhibitor Subunit 1b DRD2 NM_ Dopamine Receptor D2 EIF4A2 NM_ Eukaryotic Translation Initiation Factor 4a2 GAPDH NM_ Glyceraldehyde-3-Phosphate Dehydrogenase GLT1 NM_ Solute Carrier Family 1 (Glial High Affinity Gulatmate Transporter) HTT NM_ Huntingtin NRF2 NM_ Nuclear Respiratory Factor 2 PDE10A NM_ Phosphodiesterase 10a PDE2A NM_ NM_ Phosphodiesterase 2a PGC1A NM_ Peroxisome Proliferator-Activated Receptor 1 alpha TSPO NM_ Translocator Protein

5 Validated Human Quantitative RT-PCR Genes BDNF CDS NM_ Brain-Derived Neurotrophic Factor GDNF NM_ Glial Cell Derived Neurotrophic Factor Htt NM_ Huntingtin PTN NM_ Pleiotrophin SMN2 NM_ Survival Of Motor Neuron 2

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