Ultra Antioxidants (Pack #1) Superfruits Hyaluronic acid Lipoic acid Co-Q10 Multivitamin

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1 Ultra Antioxidants (Pack #1) Superfruits Hyaluronic acid Lipoic acid Co-Q10 Multivitamin DESCRIPTION Ultra Antioxidants pack (# 1) of Functionalab, offers a comprehensive antioxidant blend including antioxidant-rich superfruits designed to protect cells against free radical attacks. This comprehensive pack includes Key ingredients combined together for optimal results; Superfruit blend: apple, pomegranate and grapes act together as a strong antioxidant blend to fight free radical damage to cells Polyphenols from the superfruit blend also exert strong antioxidant effects Hyaluronic acid and Lipoic acid, two additional antioxidants, protect cells against free radical damage CONTENT Functionalab s line of Advanced Nutraceuticals offers potent nutrient blends of vitamins, minerals and other natural extracts to achieve optimal health. Our health scientists have selected only the purest and highest quality natural ingredients to maximize effectiveness. Our Personalized Packs propose complete supplement solutions in daily packets that combine the perfect assortment of vitamins, nutrients and natural extracts tailored to individual profiles or objectives. Ultra Antioxidant pack main objective is to complement healthy food intake and regular exercise. This program also addresses general health and appearance. It offers the highest quality bioactive blend of nutrients with antioxidant benefits, including antioxidant-rich superfruits to complement healthy food intake and regular exercise. This comprehensive pack includes: 2 Ultra Health multivitamin with over 50 nutritional ingredients to support optimal health and vitality 1 Superfruit capsule providing superfruit antioxidants 1 Hyaluronic acid tablet, a bioactive antioxidant 1 Co-Q10 tablet, an antioxidant that helps support cardiovascular and immune health 1 Lipoic acid capsule, a water and fat soluble antioxidant FUNCTIONS Studies show that a high percentage of adults eat less than the minimum daily recommendation of 10 or more essential nutrients. Adequate amounts and proper balance of these nutrients are needed not only for maintaining good health, but also for the dietary management of the body s structure as well as the optimal functioning of the body, such as the immune and gastrointestinal systems. Ultra Health has been carefully developed to contain the right proportions of

2 vitamins, minerals, trace elements, and other nutrients without danger of toxic build-up or other side effects. In Scientific parlance, Free radicals are any chemicals that have an unpaired electron or a free electron. Excessive production of free radicals can damage useful cells and compromise your health essentially by trying to steal electrons from other cells. Fats, proteins, carbohydrates, and DNA are all subject to free radical damage. Once damaged, a tissue may no longer function properly. Indeed, it is widely accepted in the scientific community that free radical may be one of the causal factor driving the aging process. Fortunately our body has developed effective strategies to detect and limit free radical damages. Aging is an inevitable process of life. However, cutting-edge research has shown that it is possible to do something about it, and the notion of healthy aging was born. Free radicals have been coined by scientists. They can cause damage to proteins, lipids and DNA. In the skin, the deleterious action free radicals will negatively affect cell membranes, the fibrillar structure of collagen and elastin and the integrity of lipids involved in the epidermal barrier function. Ultimately, damage caused by free radicals become irreversible and may lead to functional and structural alterations. Indeed, it is widely accepted in the scientific community that free radical may be one of the causal factors driving the aging process. The outcome is obviously readily visible at the skin level. Fortunately, our body has developed effective strategies to detect and detoxify free radicals limiting collateral damage. Antioxidants help to buffer the damage induced by free-radicals. The Superfruit formula included in this pack is a potent blend of botanical extracts that supplies powerful antioxidant activity to fight free radicals. ORAC value is measured on every lot of Superfruit, and is typically around 7,000 µmole TE per serving which is the ORAC equivalent of 8 11 servings of fruits and vegetables. Superfruit antioxidant blend includes health benefits of white tea extract (standardized to 90% polyphenols and 70% catechins), Apple and Pomegranate fruits extract, and Blueberry extracts. it functions much like vitamin E in that it participates in certain antioxidant and free radical reactions. According to some experts, coenzyme Q10 should be considered an essential nutrient, as it is well established that coenzyme Q10 is essential for the health of every cell in the human body. Numerous studies indicate coenzyme Q10 also plays an important role in the maintenance of the entire cardiovascular system. Supplementation with coenzyme Q10 in patients has shown to be useful for the maintenance of already healthy blood pressure. Coenzyme Q10 is also important for the maintenance of blood vessels and heart muscle function. Lipoic acid is unique among biological antioxidants, because it is soluble in both water and lipids. This allows it to neutralize free radicals just about everywhere in the body, inside and outside the cells. Because alpha-lipoic acid is involved in so many different antioxidant functions in virtually all body tissues, it has been called the universal antioxidant. Besides being a universal free radical scavenger, alpha-lipoic acid can also recharge other antioxidant systems throughout the body. Also, it can extend the activity of vitamins C and E and regenerate glutathione. Hyaluronic acid is found in varying levels in the dermis. Variations in levels account for natural skin alterations associated with aging, such as altered elasticity, decreased hydration and appearance of fine lines and wrinkles. Hyaluronic acid is also a well known antioxidant helping to protect against free radicals attacks.. Ultra Antioxidant pack (#1) is specially formulated to offer a comprehensive antioxidant blend including antioxidant-rich superfruits designed to protect cells against free radical attacks.. CoQ10 is a well known antioxidant that helps support the immune system and promote cardiovascular health by impeding the formation of free radicals. Coenzyme Q10 is a naturally-occurring antioxidant nutrient which retards free radical formation in biological systems. Coenzyme Q10 resembles vitamin E and vitamin K in chemical structure. Biochemically,

3 SUGGESTED USE Take 1 pack per day with meals for a period of 3 months for optimal results. Do not exceed the recommended dose. SIDE EFFECTS No adverse effects have been reported. STORAGE Store in a cool, dry place, away from direct light. Keep out of reach of children. REFERENCES Cao G, Alessio HM, Cutler RG. Oxygen radical absorbance capacity assay for antioxidants. Free Radical Bio Medicine : Cao GH, Soffic E, Prior RL. Antioxidant capacity of tea and common vegetables. Journal of Agricultural and Food Chemistry : Dashwood WM, Orner GA, Dashwood RH. Inhibition of betacatenin/tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochem Biophys Res Commun Aug 23;296(3): Gio MI, Tomas-Barberan FA, Hess-Pierce B, et al. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural and Food Chemistry (10): Giovannucci E, Stampfer MJ, Colditz GA, et al. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study [see comments]. Ann Intern Med 1998;129: Hughes DA. Effects of dietary antioxidants on the immune function of middle-aged adults. Proc Nutr Soc 1999;58: Johnson K, Kligman EW. Preventive nutrition: an 'optimal' diet for older adults. Geriatrics 1992;47: Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern Med Rev 1999;4: Miranda MS, Cintra RG, Barros SB, et al. Antioxidant activity of the microalga Spirulina maxima. Braz J Med Biol Res 1998;31: Mukhtar H, Ahmad N. Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr 2000;71:1698S- 1702S. Orner GA, Dashwood WM, Blum CA, Diaz GD, Li Q, Dashwood RH. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis Feb;24(2): Ou B, Hampsch-Woodill M, Prior RL. Development and validation of oxygen radical absorbance activity using fluorescein as the fluorescent probe. Journal of Agricultural and Food Chemistry : Prior RL, Cao G. Antioxidant capacity and polyphenolic components of teas: implications for altering in vivo antioxidant status. Proc Soc Exp Biol Med 1999;220: Santana-Rios G, Orner GA, Xu M, Izquierdo-Pulido M, Dashwood RH. Inhibition by white tea of 2-amino-1-methyl- 6-phenylimidazo [4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat. Nutr Cancer. 2001;41(1-2): Shobana S, Naidu KA. Antioxidant activity of selected Indian spices. Prostaglandins Leukot Essent Fatty Acids 2000;62: van Poppel G, Verhoeven DT, Verhagen H, et al. Brassica vegetables and cancer prevention. Epidemiology and mechanisms. Adv Exp Med Biol 1999;472: Weisburger JH. Approaches for chronic disease prevention based on current understanding of underlying mechanisms. Am J Clin Nutr 2000;71:1710S-1714S. Folkers K. Relevance of the biosynthesis of coenzyme Q10 and of the four bases of DNA as a rationale for the molecular causes of cancer and a therapy. Biochem Biophys Res Commun 1996;224: Folkers K, Osterborg A, Nylander M, Morita M, Mellstedt H. Activities of vitamin Q10 in animal models and a serious

4 deficiency in patients with cancer. Biochem Biophys Res Commun 1997;234: Folkers K, Simonsen R. Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochim Biophys Acta 1995;1271: Hofman-Bang C, Rehnqvist N, Swedberg K, Wiklund I, Astrom H. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group. J Card Fail 1995;1: Hofman-Bang C, Rehnquist N, Swedberg K, et al. Coenzyme Q10 as an adjunctive treatment of congestive heart failure. J Am Coll Cardiol. 1992;19:216A. Koroshetz WJ, Jenkins BG, Rosen BR, Beal MF. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann Neurol 1997;41: Langsjoen PH, Langsjoen A, Willis R, Folkers K. Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med 1997;18:S Langsjoen PH, Langsjoen JO, Langsjoen AM, Lucas LA. Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation. Biofactors. 2005;25(1-4): Langsjoen H, Langsjoen P, Langsjoen P, et al. Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med. 1994;15(suppl):S165 S175 Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18 Suppl:S Sander S, Coleman CI, Patel AA, Kluger J, White CM. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail Aug;12(6): Altman, R. D. Status of hyaluronan supplementation therapy in osteoarthritis. (2003) Curr Rheumatol Rep 5(1), Moskowitz, R. W. Hyaluronic acid supplementation. (2000) Curr Rheumatol Rep 2(6), Lebel, L., Gabrielsson, J., Laurent, T. C., and Gerdin, B. Kinetics of circulating hyaluronan in humans. 4. (1994) Eur J Clin Invest 24(9), Roth, S. H. A controlled clinical investigation of 3% diclofenac/2.5% sodium hyaluronate topical gel in the treatment of uncontrolled pain in chronic oral NSAID users with osteoarthritis. (1995) Int J Tissue React 17(4), Ames BN. Micronutrients prevent cancer and delay aging. Toxicol Lett 1998; :5-18 Anuradha B, Varalakshmi P. Activities of glucosemetabolizing enzymes in experimental neurotoxic models with lipoate as an alleviator. J Appl Toxicol 1999;19: Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories [In Process Citation]. Med Klin 1999;94 Suppl 3:84-9. Borcea V, Nourooz-Zadeh J, Wolff SP, Klevesath M, Hofmann M, Urich H, Wahl P, Ziegler R, Tritschler H, Halliwell B, Nawroth PP. alpha-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic Biol Med 1999;26: Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med 1998;24: Cameron NE, Cotter MA, Horrobin DH, Tritschler HJ. Effects of alphalipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia 1998;41: Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. Faseb J 1999;13: Henriksen EJ, Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ.Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats. Life Sci 1997;61: Hong YS, Jacobia SJ, Packer L, Patel MS. The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components. Free Radic Biol Med 1999;26: Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo- controlled pilot trial [In Process Citation]. Free Radic Biol Med 1999;27: Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ, Dietze GJ,Henriksen EJ. The antioxidant alpha-lipoic acid enhances insulinstimulated glucose metabolism in insulinresistant rat skeletal muscle. Diabetes 1996;45: Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern Med Rev 1999;4: Khanna S, Roy S, Packer L, Sen CK. Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of alpha-lipoic acid. Am J Physiol 1999;276:R Konrad T, Vicini P, Kusterer K, Hoflich A, Assadkhani A, Bohles HJ, Sewell A, Tritschler HJ, Cobelli C, Usadel KH. alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 1999;22: Lodge JK, Traber MG, Packer L. Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation. Free Radic Biol Med 1998;25: Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Ageassociated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alphalipoic acid supplementation. Faseb J 1998;12: Mitsui Y, Schmelzer JD, Zollman PJ, Mitsui M, Tritschler HJ, Low PA. Alpha-lipoic acid provides neuroprotection from ischemiareperfusion injury of peripheral nerve. J Neurol Sci 1999;163:11-6. Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA,Tritschler H, Low PA. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 1995;18: Ou P, Nourooz-Zadeh J, Tritschler HJ, Wolff S. Activation of aldose reductase in rat lens and metal-ion chelation by aldose reductase inhibitors and lipoic acid. Free Radic Res 1996;25: Packer L. alpha-lipoic acid: a metabolic antioxidant which regulates NFkappa B signal transduction and protects against oxidative injury. Drug Metab Rev 1998;30: Sen CK, Tirosh O, Roy S, Kobayashi MS, Packer L. A positively charged alpha-lipoic acid analogue with increased cellular uptake and more potent immunomodulatory activity. Biochem Biophys Res Commun 1998;247:223-8.

5 Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 1997;273:E Strokov IA, Kozlova NA, Mozolevskii Iu V, Miasoedov SP, Iakhno NN. [The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy]. Zh Nevrol Psikhiatr Im S S Korsakova 1999;99: Thurich T, Bereiter-Hahn J, Schneider M, Zimmer G. Cardioprotective effects of dihydrolipoic acid and tocopherol in right heart hypertrophy during oxidative stress. Arzneimittelforschung 1998;48: Tirosh O, Sen CK, Roy S, Kobayashi MS, Packer L. Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue. Free Radic Biol Med 1999;26: Tomlinson DR. Future prevention and treatment of diabetic neuropathy. Diabetes Metab 1998;24 Suppl 3: Wiznitzer A, Ayalon N, Hershkovitz R, Khamaisi M, Reece EA, Trischler H, Bashan N. Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes. Am J Obstet Gynecol 1999;180: Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schutte K, Kerum G, Malessa R. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy [In Process Citation]. Diabetes Care1999;22: This product is not intended to diagnose, treat, cure, or prevent any disease.