Bone Regeneration Summit 2018 Program March 23 24, 2018, Hamburg, GER

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1 Bone Regeneration Summit 2018 Program March 23 24, 2018, Hamburg, GER in interdisciplinary collaboration with Universitätsklinikum Hamburg-Eppendorf

2 Dear participant, We are delighted to welcoming you to the 1 st Bone Regeneration Summit in Hamburg, Germany. Under the patronage of the UKE 1, the IOBM 2, and the ESTROT Society 3 this two day scientific event will give you the opportunity to gain deep knowledge about the fundamentals of bone regeneration, cartilage repair and regeneration. We have gained international speakers who will present their latest scientific results, paired with clinical case reports, pit-fall analysis and practical solutions for your daily surgical work. The symposium will be accompanied by dry hands-on workshops, led by experienced orthopedic, trauma and spine surgeons. We wish you an exciting educational event within an international atmosphere where science meets practice! Prof. Dr. Gerald Zimmermann Theresienkrankenhaus Mannheim, DE Prof. Dr. Michael Amling IOBM Hamburg-Eppendorf, DE 1 UKE: Universitätsklinikum Hamburg-Eppendorf 2 IOBM: Institut für Osteologie und Biomechanik 3 ESTROT: European Society of Tissue Regeneration in Orthopaedics and Traumatology

3 Thursday, March 22, 2018 All day Arrival of participants All participants 5:00 6:30 pm Speakers reunion (IOBM Institute) All speakers 7:30 10:00 pm Welcome Dinner (Dorint Hotel Hamburg-Eppendorf) All participants Friday, March 23, 2018 Start of Scientific Program at UKE Hamburg 7:30 8:45 am On-site registration All participants 8:45 9:00 am Welcome & Introduction Prof. Dr. G. Zimmer mann/ 9:00 9:20 am 9:20 9:40 am 9:40 10:00 am Fundamentals of Bone Regeneration History, chronology and rationale behind the development of bone regeneration materials The principals of bone regeneration The Pentagon model Bone remodeling Cellular basis for unlimited regeneration Dr. F. Peters Prof. Dr. G. Zimmermann 10:00 10:20 am A biomechanical perspective on bone quality Prof. Dr. B. Busse 10:20 10:45 am Coffee Break All participants 10:45 11:05 am Histological evaluation of bone scaffolds An in-vivo reflection of material science Prof. Dr. C. Knabe-Ducheyne 11:05 11:25 am Release kinetics of drugs from bioceramic scaffolds Prof. Dr. A. Bernstein 11:25 11:45 am 11:45 12:05 pm 12:05 12:25 pm Biokinetic release of Antibiotics from biomimetic, pure-phase β-tcp s an in-vitro analysis The role of combining growth factors with bioceramic scaffolds for bone regeneration Advantages of synthetic vs. autologous bone graft materials in spine surgery PD Dr. K. Roth Prof. Dr. P. Giannoudis Dr. A. Reinhardt 12:25 12:45 pm Local hemostasis in trauma surgery Dr. W.-D. Hübner 12:45 1:05 pm Q&A Session All participants 1:05 2:05 pm Lunch Break All participants Case Discussions Part I Orthopedics 2:05 2:20 pm Case Dr. A. Reinhardt 2:20 2:35 pm Case Dr. H. Röhl

4 Part II Trauma 2:35 2:50 pm Case Prof. Dr. G. Schmidmaier 2:50 3:05 pm Case Prof. Dr. P. Giannoudis Part III Spine 3:05 3:20 pm Case Prof. Dr. D. Daentzer 3:20 3:45 pm Case PD Dr. G. Maestretti 3:45 4:00 pm Case Dr. I. Dominguez 4:00 4:20 pm Q&A Session All participants 4:20 4:40 pm Coffee Break All participants Industry Exhibition & Networking from 4:20 5:30 pm 6:45 7:00 pm Meeting in the hotel lobby / Departure for Dinner All participants 7:30 10:00 pm Dinner (AuQuai) All participants 10:00 10:30 pm Transfer to the hotel All participants Saturday, March 24, 2018 Cartilage Repair & Regeneration 9:00 9:15 am Recap of day 1 / Open questions Prof. Dr. G. Zimmermann/ 9:15 9:30 am Cell therapies in musculoskeletal regeneration Prof. Dr. G. Zimmermann 9:30 9:45 am 9:45 10:00 am Autologous conditioned plasma in Orthopedics and Sports Medicine Minimally-invasive bone grafting techniques in spine surgery Dr. F. Gellweiler Dr. I. Dominguez 10:00 10:15 am Cell therapy for the treatment of cartilage defects Prof. Dr. S. Nehrer 10:15 10:30 am Scientific study updates Dr. G. Thomas 10:30 10:45 am The future concept of regenerative medicine challenges and opportunities Prof. Dr. H.-J. Meisel 10:45 11:15 am Q&A Session All participants 11:15 12:00 am Farewell remarks of the chairmen & handout of certificates Prof. Dr. G. Zimmermann/ 12:00 1:00 pm Lunch Break & Individual departure All participants

5 Speakers Chairman: Prof. Dr. Gerald Zimmermann Theresienkrankenhaus Mannheim, DE Co-Chairman: Prof. Dr. Michael Amling IOBM Hamburg-Eppendorf, DE Prof. Dr. Anke Bernstein Universitätsklinikum Freiburg, DE Prof. Dr. Björn Busse IOBM Hamburg-Eppendorf, DE Prof. Dr. Dorothea Daentzer DIAKOVERE Annastift Hannover, DE Dr. Ignacio Dominguez Hospital Clinico San Carlos de Madrid, ES Prof. Dr. Peter Giannoudis University of Leeds, UK Dr. Wolf-Dietrich Hübner curasan AG, DE Prof. Dr. Christine Knabe-Ducheyne Philipps-Universität Marburg, DE PD Dr. Gianluca Maestretti HFR Kantonspital Freiburg, CH Dr. Frank Gellweiler Promedi Orthopädie Frankenthal, DE Prof. Dr. Hans-Jörg Meisel Berufsgenossenschaftliche Kliniken Bergmannstrost Halle-Saale, DE Prof. Dr. Stefan Nehrer Donau Universität Krems, AT Dr. Fabian Peters curasan AG, DE Dr. Axel Reinhardt Oberlinklinik Postdam, DE Dr. Henning Röhl Diakonissenkrankenhaus Mannheim, DE PD Dr. Klaus Edgar Roth Universitätsklinikum Mainz, DE Prof. Dr. Gerhard Schmidmaier Universitätsklinikum Heidelberg, DE Dr. Gregor Thomas curasan AG, DE

6 European Society of Tissue Regeneration in Orthopaedics and Traumatology The conference is CME accredited by the Landesärztekammer Hamburg, Germany (Medical Association of the State of Hamburg). Registration fee: 800,00 *1 *1 (includes accommodation March 22 24, 2018, catering during the event and training sessions) Spine Trauma Orthopedics Orthopedics Orthopedics Spine Trauma Trauma supported by E.S.T.R.O.T. curasan AG Lindigstrasse Kleinostheim T + 49 (0) F + 49 (0) ESTORT Keep International Via Giuseppe Vigoni, Milan (Italy) T (+39) F (+39) Silony Medical Eurpoe GmbH Bahnhofstraße Bremen T +49 (0) F +49 (0) implantcast GmbH Lüneburger Schanze Buxtehude T +49 (0) F +49 (0) For detailed information please contact Ms. Lisa Plappert (brs@curasan.com).