Lab 3: Excitability & Response of Skeletal Muscle
|
|
- Nelson Buddy Bates
- 5 years ago
- Views:
Transcription
1 Lab 3: Excitability & Response of Skeletal Muscle รศ.ดร.นพ. ช ยเล ศ ชยเลศ พ ช ตพรช ย พชตพรชย ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล Objectives 1. Threshold, submaximal, maximal, supramaximal stimulus of 1.1 Nerve & 1.2 Muscle 2. Length-Tension Relationship - Physiological length or Resting length 3. Repetitive stimuli Summation of m. contraction 4. Fatigue mechanism Muscle Physiology Chailerd Pichitpornchai 2 Materials Tissue: Gastrocnemius-sciatic preparation Electronics: PowerLab, Dual Bio Amp., Quad Bridge Amp., Force Transducer Muscle tension adjuster, Selecting switch box Electrodes :- Sleeve, Needles Surgical instrument t Frog board, Femur clamp Force transducer Selecting switch box PowerLab Set Muscle Physiology Chailerd Pichitpornchai 3 Muscle Physiology Chailerd Pichitpornchai 4 Experimental Design 1. Threshold & Maximal stimuli of Nerve & Muscle 2. Length-Tension Relationship 3. Effect of Double Stimulation 4. Effect of Repetitive Stimulation 5. Muscular Fatigue 1. Threshold & Maximal stimuli of Nerve & Muscle Stimulate Sciatic Nerve Gastrocnemius Muscle Record Muscle Contraction Channel 1 Compound muscle action potential Channel 2 Electromyograph (EMG) Muscle Physiology Chailerd Pichitpornchai 5 Muscle Physiology Chailerd Pichitpornchai 6
2 Conceptual Design (1): Stimulate Nerve Duration Delay Force transducer 1. Muscle contraction Rate of rise (slope) Channel 1 Bridge Amp Channel 2 + Bio Amp Channel 3 Marker Stimulator 2. EMG Muscle Physiology Chailerd Pichitpornchai 7 Muscle Physiology Chailerd Pichitpornchai 8 Channel settings Channel 1 Bridge Amp Muscle Contraction Muscle Physiology Chailerd Pichitpornchai 9 Muscle Physiology Chailerd Pichitpornchai 10 Channel 2 Bio Amp EMG or CAP Stimulator setting Muscle Physiology Chailerd Pichitpornchai 11 Muscle Physiology Chailerd Pichitpornchai 12
3 Calibration & Unit Conversion 0.5 s Put 50 g weight on the 3 blades of force transducer Click Start to record the 50 g force in Channel 1 From the Channel function pop-up menu Select Unit Conversion... Select 2 point calibration Muscle Physiology Chailerd Pichitpornchai 13 Muscle Physiology Chailerd Pichitpornchai 14 Calibration & Unit Conversion 1.1 Stimulate Sciatic Nerve Stimulate via SLEEVE electrodes Voltage 200 mv + increment 50 mv Record Mechanical response Muscle contraction Electrical response EMG or Compound M. AP Observe Threshold, submaximal, maximal, supramaximal stimuli Muscle Physiology Chailerd Pichitpornchai 15 Muscle Physiology Chailerd Pichitpornchai 16 Conceptual Design (2): Stimulate Muscle Force transducer 1. Muscle contraction Channel 1 Bridge Amp + Channel 2 Channel 3 Marker Bio Amp Stimulator Muscle Physiology Chailerd Pichitpornchai 17 Muscle Physiology Chailerd Pichitpornchai 18
4 1.2 Stimulate Gastrocnemius Muscle Stimulate muscle via NEEDLE electrodes Voltage 200 mv + increment 100 mv threshold + increment 500 mv maximal stimulus Record mechanical response Muscle contraction Channel 2 Turn Input Off Selecting switch box Needle Stimulator / Off Recording Observe Threshold, submaximal, maximal, supramaximal stimuli Activity 1 1. Compare the threshold of nerve stimulation & muscle stimulation 2. Compare the maximal stimulus of nerve stimulation & muscle stimulation 3. Why? Muscle Physiology Chailerd Pichitpornchai 19 Muscle Physiology Chailerd Pichitpornchai Length-Tension Relationship Muscle tension adjuster Stimulate N. Single pulse, Maximal Stimulus Record Muscle Contraction & EMG Change Muscle tension adjuster anti-clockwise Muscle tension adjuster clockwise Muscle Physiology Chailerd Pichitpornchai 21 Muscle Physiology Chailerd Pichitpornchai 22 Activity 2 1. Observe changes of amplitude of m. contraction at different initial length 2. What is resting length or physiological length? 3. Explain why does the amplitude of m. contraction change in relation to muscle initial length Muscle Physiology Chailerd Pichitpornchai 23 Muscle Physiology Chailerd Pichitpornchai 24
5 3. Effect of Double Stimulation Stimulator setting for Double stimuli Adjust Muscle tension adjuster to get the highest response Stimulate N. 2 pulses, Maximal stimulus Change Interval: 500 ms, decrement 50 ms at a time until a single complete summation of muscle contraction is observed Muscle Physiology Chailerd Pichitpornchai 25 Muscle Physiology Chailerd Pichitpornchai 26 Activity 3 1. Observe Summation of contraction 2. Observe EMG 4. Effect of Repetitive Stimulation Adjust Muscle tension adjuster to get the highest response Stimulate N. with maximal stimulus Stimulate 3s + Rest 20s Change Frequency: Hz Number of pulses: pulses Muscle Physiology Chailerd Pichitpornchai 27 Muscle Physiology Chailerd Pichitpornchai 28 Stimulator setting for Repetitive stimuli (10 Hz) Stimulator setting for Repetitive stimuli (20 Hz) Muscle Physiology Chailerd Pichitpornchai 29 Muscle Physiology Chailerd Pichitpornchai 30
6 Stimulator setting for Repetitive stimuli (30 Hz) Stimulator setting for Repetitive stimuli (40 Hz) Muscle Physiology Chailerd Pichitpornchai 31 Muscle Physiology Chailerd Pichitpornchai 32 Activity 4 1. Observe Incomplete & Complete Tetanus 2. Compare Amplitude of m. contraction between Complete & Incomplete Tetanus 3. EMG during Complete & Incomplete Tetanus Muscle Physiology Chailerd Pichitpornchai Muscular Fatigue Adjust Muscle tension adjuster Stimulate N. Maximal stimulus Frequency 40 Hz and wait until the amplitude is 1/3 left Click Off in the Stimulator Channel 2 Turn Input Off Selecting switch box Needle Stimulator / Off Recording Stimulate Muscle directly with 5 V Click On in the Stimulator Muscle Physiology Chailerd Pichitpornchai 34 Stimulator setting for fatigue : stimulating N. Stimulator setting for fatigue: stimulating M. Muscle Physiology Chailerd Pichitpornchai 35 Muscle Physiology Chailerd Pichitpornchai 36
7 Activity 5 1. Observe amplitude of muscle contraction 2. What's happened to the Action Potential of the muscle during fatigue? 3. What is the difference between Neuromuscular fatigue and Muscle fatigue? More Questions 1. Why doesn't the amplitude of muscle contraction increase when we stimulate with supramaximal stimulus? 2. Why does the tetanic contraction have a higher amplitude than single muscle twitch? Muscle Physiology Chailerd Pichitpornchai 37 Muscle Physiology Chailerd Pichitpornchai 38
Biology 325 Fall 2003 Human anatomy and physiology
SKELETAL MUSCLE PROPERTIES Background : In this experiment, you will investigate the physiological properties of skeletal muscle from the isolated amphibian gastrocnemius. You will examine skeletal muscle
More informationLabs #7 and #8: Vertebrate Skeletal Muscle
Labs #7 and #8: Vertebrate Skeletal Muscle In this experiment, you will investigate the physiological properties of skeletal muscle from the isolated toad gastrocnemius. Concepts to understand include
More information1724 Lab: Frog Skeletal Muscle Physiology (Marieb Exercise 16A) Marieb/iWorx / Ziser, 2002
1724 Lab: Frog Skeletal Muscle Physiology (Marieb Exercise 16A) Marieb/iWorx / Ziser, 2002 I. Introduction. Read the introductory material in your lab manual Marieb Ex 16A: Skeletal Muscle Physiology Frog
More informationExercise 2: Skeletal Muscle Physiology: Activity 3: The Effect of Stimulus Frequency on Skeletal Muscle Contraction Lab Report
Name: Courtney.Sims Exercise 2: Skeletal Muscle Physiology: Activity 3: The Effect of Stimulus Frequency on Skeletal Muscle Contraction Lab Report Pre-lab Quiz Results You scored 100% by answering 4 out
More informationExercise 6: Muscle Physiology II Twitch & Summation
Exercise 6: Muscle Physiology II Twitch & Summation Text Reading: Silverthorn, 5 th ed. 412 419, 425 427; 6 th ed. pg. 410 420 In this exercise, we will investigate the physiology of contraction in the
More informationLab #9: Muscle Physiology
Background Overview of Skeletal Muscle Contraction Sarcomere Thick Filaments Skeletal muscle fibers are very large, elongated cells (Fig 9.1). Roughly 80% of the content of each muscle fiber consists of
More informationMuscles & Physiology
Collin County Community College BIOL 2401 Muscles & Physiology 1 Tension Development The force exerted by a contracting muscle cell or muscle group on an object is called muscle tension, and the opposing
More informationHumans make voluntary decisions to talk, walk, stand up, or sit down. The
2 E X E R C I S E Skeletal Muscle Physiology O B J E C T I V E S 1. To define motor unit, twitch, latent period, contraction phase, relaxation phase, threshold, summation, tetanus, fatigue, isometric contraction,
More informationNeuromuscular Mechanics
Schematic Representation of Motor Units in Skeletal Muscle Neuromuscular Mechanics Hamill & Knutzen (Ch 4) Whatever text you read do not focus on motorneuron structure and sensory receptors Muscle Fibres
More informationVersion A. AP* Biology: Nervous System. Questions 1 and 2. Name: Period
Name: Period Version A AP* Biology: Nervous System Directions: Each of the questions or incomplete statements below is followed by four suggested answers or completions. Select the one that is best in
More informationEffects of adrenaline on nerve terminals in the superior cervical ganglion of the rabbit
Br. J. Pharmac. (1971), 41, 331-338. Effects of adrenaline on nerve terminals in the superior cervical ganglion of the rabbit D. D. CHRIST AND S. NISHI Neurophysiology Laboratory, Department of Pharmacology,
More informationEFFECT OF THE BLACK SNAKE TOXIN ON THE GASTROCNEMIUS-SCIATIC PREPARATION
[20] EFFECT OF THE BLACK SNAKE TOXIN ON THE GASTROCNEMIUS-SCIATIC PREPARATION BY A. H. MOHAMED AND O. ZAKI Physiology Department, Faculty of Medicine, Abbassia, Cairo (Received 3 June 1957) When the toxin
More informationQuestion and answers related to the first seven lectures:
Recitations and Labs # 01, # 02, #3 06 The goal of this recitations / labs is to review material for the first test of this course. Info on osmosis, diffusion, metaboism, transport across biological membranes,
More informationBSL PRO Lesson H03: Nerve Conduction Velocity: Along the Ulnar Nerve of a Human Subject
Updated 12-22-03 BSL PRO Lesson H03: Nerve Conduction Velocity: Along the Ulnar Nerve of a Human Subject This PRO lesson describes hardware and software setup of the BSL PRO System to record and measure
More informationFT-302 Force Transducer
Technical Note FT-302 LabScribe is a trademark of 2015 Overview The FT-302 is a high-sensitivity dual-range research grade force transducer designed to measure forces in the 0.005 to 10 gram and 0 to 100
More informationiworx Sample Lab Experiment AN-5: Cockroach Leg Mechanoreceptors
Experiment AN-5: Cockroach Leg Mechanoreceptors Exercise 1: Chordotonal Organs Aim: To explore the basic characteristics of the chordotonal organs, their response to direction and intensity of leg movement,
More informationChapter 9 Muscle. Types of muscle Skeletal muscle Cardiac muscle Smooth muscle. Striated muscle
Chapter 9 Muscle Types of muscle Skeletal muscle Cardiac muscle Smooth muscle Striated muscle Chapter 9 Muscle (cont.) The sliding filament mechanism, in which myosin filaments bind to and move actin
More informationSkeletal Muscle Qiang XIA (
Skeletal Muscle Qiang XIA ( 夏强 ), PhD Department of Physiology Rm C518, Block C, Research Building, School of Medicine Tel: 88208252 Email: xiaqiang@zju.edu.cn Course website: http://10.71.121.151/physiology
More informationEE 4BD4 Lecture 20. Therapeutic Stimulation
EE 4BD4 Lecture 20 Therapeutic Stimulation 1 2 Extracellular Stimulation (at cathode) 3 4 Design of FES (cont.): Example stimulus waveform shapes: monophasic, biphasic, chopped, triphasic, and asymmetric,
More informationTechniques to Evaluate Elderly Human Muscle Function: A Physiological Basis
Journal of Gerontology: BIOLOGICAL SCIENCES 1998, Vol. 53A. No. 3, B2O4-B2I6 Copyright 1998 by The Gerontological Society of America Techniques to Evaluate Elderly Human Muscle Function: A Physiological
More informationPSK4U THE NEUROMUSCULAR SYSTEM
PSK4U THE NEUROMUSCULAR SYSTEM REVIEW Review of muscle so we can see how the neuromuscular system works This is not on today's note Skeletal Muscle Cell: Cellular System A) Excitation System Electrical
More informationPhysiology sheet #2. The heart composed of 3 layers that line its lumen and cover it from out side, these layers are :
Physiology sheet #2 * We will talk in this lecture about cardiac muscle physiology, the mechanism and the energy sources of their contraction and intracellular calcium homeostasis. # Slide 4 : The heart
More informationExercise 5: Muscle Physiology I - Electromyography
Exercise 5: Muscle Physiology I - Electromyography Readings: Silverthorn, 6 th ed. pg. 410 420 Your brain communicates with your muscles through action potentials on the motor neurons, which are then transmitted
More information10 - Muscular Contraction. Taft College Human Physiology
10 - Muscular Contraction Taft College Human Physiology Muscular Contraction Sliding filament theory (Hanson and Huxley, 1954) These 2 investigators proposed that skeletal muscle shortens during contraction
More informationLab #3: Electrocardiogram (ECG / EKG)
Lab #3: Electrocardiogram (ECG / EKG) An introduction to the recording and analysis of cardiac activity Introduction The beating of the heart is triggered by an electrical signal from the pacemaker. The
More informationNEUROMUSCULAR PHYSIOLOGY OF THE LONGITUDINAL MUSCLE OF THE EARTHWORM, LUMBRICUS TERRESTRIS
J. Exp. Biol. (1974), 60, 453-467 453 With 7 text-figures Printed in Great Britain NEUROMUSCULAR PHYSIOLOGY OF THE LONGITUDINAL MUSCLE OF THE EARTHWORM, LUMBRICUS TERRESTRIS II. PATTERNS OF INNERVATION
More informationDevelopment of Ultrasound Based Techniques for Measuring Skeletal Muscle Motion
Development of Ultrasound Based Techniques for Measuring Skeletal Muscle Motion Jason Silver August 26, 2009 Presentation Outline Introduction Thesis Objectives Mathematical Model and Principles Methods
More information2/19/2018. Learn and Understand:
Muscular System with Special Emphasis on Skeletal Muscle Anatomy and Physiology Learn and Understand: The definition of cell changes again The contractile unit of muscle is the sarcomere. ATP and Ca 2+
More informationCentral and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle
Clinical Science and Molecular Medicine (1978) 54,609-614 Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle B. BIGLAND-RITCHIE*, D. A. JONES, G. P. HOSKING
More informationEQA DISCUSSION QUESTIONS: INFLUENCE OF MUSCLE FIBER TYPE ON MUSCLE CONTRACTION. Influence of Muscle Fiber Type on Muscle Contraction
0907T_c13_205-218.qxd 1/25/05 11:05 Page 209 EXERCISE 13 CONTRACTION OF SKELETAL MUSCLE 209 Aerobic cellular respiration produces ATP slowly, but can produce large amounts of ATP over time if there is
More informationNeurophysiology of Nerve Impulses
M52_MARI0000_00_SE_EX03.qxd 8/22/11 2:47 PM Page 358 3 E X E R C I S E Neurophysiology of Nerve Impulses Advance Preparation/Comments Consider doing a short introductory presentation with the following
More informationNATIONAL COMPETENCY SKILL STANDARDS FOR PERFORMING NERVE CONDUCTION STUDIES
NATIONAL COMPETENCY SKILL STANDARDS FOR PERFORMING NERVE CONDUCTION STUDIES Nerve Conduction Study (NCS) providers practice in accordance with the facility policy and procedure manual which details every
More informationStructure of the striated muscle general properties
Structure of the striated muscle general properties Structure of the striated muscle membrane systems 1. Myofibrillum (contractile proteins) 2. Sarcoplasmic reticulum (SR) longitudinal tubule 3. SR terminal
More informationElectromyography Segmented Assessment for Lower Limb Muscle Transition to Fatigue During Isometric Contraction
Electromyography Segmented Assessment for Lower Limb Muscle Transition to Fatigue During Isometric Contraction By Jorge Garza-Ulloa, Pablo Rangel, Olatunde Adeoye Department of Electrical and Computer
More informationCardiovascular Effects of Exercise. Background Cardiac function
Cardiovascular Effects of Exercise In this experiment, you will record an electrocardiogram, or ECG, and finger pulse from a healthy volunteer. You will then compare the ECG and pulse recordings when the
More informationDynamic Muscle Recorder
Dynamic Muscle Recorder Team 17 By: Michael Petrowicz Farrukh Rahman James Porteus Client: Biomedical Engineering Department Dr. Enderle Executive Summary The biomedical department requires a lab setup
More informationEffects of high-frequency initial pulses and posttetanic potentiation on power output of skeletal muscle
J. Appl. Physiol. 88: 35 40, 2000. Effects of high-frequency initial pulses and posttetanic potentiation on power output of skeletal muscle F. ABBATE, 1 A. J. SARGEANT, 1,2 P. W. L. VERDIJK, 1 AND A. DE
More informationLab #3: Electrocardiogram (ECG / EKG)
Lab #3: Electrocardiogram (ECG / EKG) An introduction to the recording and analysis of cardiac activity Introduction The beating of the heart is triggered by an electrical signal from the pacemaker. The
More informationCardiac muscle is different from other types of muscle in that cardiac muscle
6 E X E R C I S E Cardiovascular Physiology O B J E C T I V E S 1. To define autorhythmicity, sinoatrial node, pacemaker cells, and vagus nerves 2. To understand the effects of the sympathetic and parasympathetic
More informationElectromyography II Laboratory (Hand Dynamometer Transducer)
(Hand Dynamometer Transducer) Introduction As described in the Electromyography I laboratory session, electromyography (EMG) is an electrical signal that can be recorded with electrodes placed on the surface
More informationfacial nerve behind the angle of the jaw (Fig. 1). The cathode was positioned near the nerve by finding a RECORDING OF ELECTRICAL RESPONSES
Journal of Neurology, Neurosurgery, and Psychiatry, 1977, 40, 234-240 Electrical and mechanical responses in the platysma and in the adductor pollicis muscle: in normal subjects C. KRARUP From the Laboratory
More informationMotor and sensory nerve conduction studies
3 rd Congress of the European Academy of Neurology Amsterdam, The Netherlands, June 24 27, 2017 Hands-on Course 2 Assessment of peripheral nerves function and structure in suspected peripheral neuropathies
More informationPostgraduate Medical School, Du Cane Road, London W12 OHS, complete in a few minutes, but is not wholly so for many hours.
J. Physiol. (1977), 272, pp. 769-778 769 With 7 text-fg'ure8 Printed in Great Britain FATIGUE OF LONG DURATION IN HUMAN SKELETAL MUSCLE AFTER EXERCISE BY R. H. T. EDWARDS,* D. K. HILL, D. A. JONES* AND
More informationMUSCULAR SYSTEM CHAPTER 09 BIO 211: ANATOMY & PHYSIOLOGY I
1 BIO 211: ANATOMY & PHYSIOLOGY I 1 CHAPTER 09 MUSCULAR SYSTEM Part 2 of 2 Dr. Dr. Lawrence G. G. Altman www.lawrencegaltman.com Some illustrations are courtesy of McGraw-Hill. Some illustrations are courtesy
More informationNerve Conduction Studies NCS
Nerve Conduction Studies NCS Nerve conduction studies are an essential part of an EMG examination. The clinical usefulness of NCS in the diagnosis of diffuse and local neuropathies has been thoroughly
More informationCell Physiolgy By: Dr. Foadoddini Department of Physiology & Pharmacology Birjand University of Medical Sciences
Chapt. 6,7,8 Cell Physiolgy By: Department of Physiology & Pharmacology Birjand University of Medical Sciences ١ Contraction of Skeletal Muscle ٢ ٣ ٤ T tubule ٥ Sliding Filament Mechanism ٦ ٧ ٨ ٩ ١٠ ١١
More informationNerve Conduction Studies NCS
Nerve Conduction Studies NCS Nerve conduction studies are an essential part of an EMG examination. The clinical usefulness of NCS in the diagnosis of diffuse and local neuropathies has been thoroughly
More informationLab 5: Electromyograms (EMGs)
Lab 5: Electromyograms (EMGs) Overview A motorneuron and all the muscle fibers that it innervates is known as a motor unit. Under normal circumstances, a neuronal action potential activates all of the
More informationBIONB/BME/ECE 4910 Neuronal Simulation Assignments 1, Spring 2013
BIONB/BME/ECE 4910 Neuronal Simulation Assignments 1, Spring 2013 Tutorial Assignment Page Due Date Week 1/Assignment 1: Introduction to NIA 1 January 28 The Membrane Tutorial 9 Week 2/Assignment 2: Passive
More informationControl of Ventilation [2]
Control of Ventilation [2] สรช ย ศร ส มะ พบ., Ph.D. ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล มหาว ทยาล ยมห ดล Describe the effects of alterations in chemical stimuli, their mechanisms and response to
More informationLesson 2 ELECTROMYOGRAPHY II Motor unit recruitment Fatigue
Physiology Lessons for use with the PC running Windows 98SE, Me, 2000 Pro, XP Pro/Home/Media Lesson 2 ELECTROMYOGRAPHY II Motor unit recruitment Fatigue Manual Revision PL3.7.0 M3.0.6 080706 Richard Pflanzer,
More informationLesson 2 EMG 2 Electromyography: Mechanical Work
Physiology Lessons for use with the Biopac Science Lab MP40 Lesson 2 EMG 2 Electromyography: Mechanical Work PC running Windows XP or Mac OS X 10.3-10.4 Lesson Revision 5.23.2006 BIOPAC Systems, Inc. 42
More informationMechanisms of the inhibition by neostigmine of tetanic contraction in the mouse diaphragm
Br. J. Pharmac. (1986), 87, 757-762 Mechanisms of the inhibition by neostigmine of tetanic contraction in the mouse diaphragm C.C. Chang, S.J. Hong & Jane-Ling Ko Department of Pharmacology, College of
More informationCardiovascular system progress chart
Neural muscular system Topic 3A: Characteristics and functions of different muscle fibre types for a variety of sporting activities Term Muscle fibre Slow twitch (type I) Fast oxidative glycolytic (type
More informationSUPPLEMENTARY INFORMATION. Supplementary Figure 1
SUPPLEMENTARY INFORMATION Supplementary Figure 1 The supralinear events evoked in CA3 pyramidal cells fulfill the criteria for NMDA spikes, exhibiting a threshold, sensitivity to NMDAR blockade, and all-or-none
More information*.bbbb *. * *,,sn. instrumentally and the results to be read as the ballistic deflection. University College, London.)
THE SUPERNORMAL PHASE IN MUSCULAR CONTRACTION. BY TAKEO KAMADA. (From the Department of Physiology and Biochemistry, University College, London.) 6I2.7414 THE isometric response of a muscle to a single
More informationBiomedical Instrumentation
University of Zagreb Faculty of Electrical Engineering and Computing Biomedical Instrumentation Electrical stimulation prof.dr.sc. Ratko Magjarević December 2015 Electrical stimulation The effect of electric
More informationLecture Overview. Muscular System. Marieb s Human Anatomy and Physiology. Chapter 9 Muscles and Muscle Tissue Lecture 16
Marieb s Human Anatomy and Physiology Marieb Hoehn Chapter 9 Muscles and Muscle Tissue Lecture 16 1 Lecture Overview Types, characteristics, functions of muscle Structure of skeletal muscle Mechanism of
More informationCompound Action Potential, CAP
Stimulus Strength UNIVERSITY OF JORDAN FACULTY OF MEDICINE DEPARTMENT OF PHYSIOLOGY & BIOCHEMISTRY INTRODUCTION TO NEUROPHYSIOLOGY Spring, 2013 Textbook of Medical Physiology by: Guyton & Hall, 12 th edition
More informationForce enhancement in single skeletal muscle fibres on the ascending limb of the force length relationship
The Journal of Experimental Biology 207, 2787-2791 Published by The Company of Biologists 2004 doi:10.1242/jeb.01095 2787 Force enhancement in single skeletal muscle fibres on the ascending limb of the
More informationIntro. Comp. NeuroSci. Ch. 9 October 4, The threshold and channel memory
9.7.4 The threshold and channel memory The action potential has a threshold. In figure the area around threshold is expanded (rectangle). A current injection that does not reach the threshold does not
More informationCh 12: Muscles sarcolemma, t-tubules, sarcoplasmic reticulum, myofibrils, myofilaments, sarcomere...
Ch 12: Muscles Review micro-anatomy of muscle tissue Terminology examples: sarcolemma, t-tubules, sarcoplasmic reticulum, myofibrils, myofilaments, sarcomere... SLOs Differentiate levels of muscle structure:
More informationSkeletal Muscle. Connective tissue: Binding, support and insulation. Blood vessels
Chapter 12 Muscle Physiology Outline o Skeletal Muscle Structure o The mechanism of Force Generation in Muscle o The mechanics of Skeletal Muscle Contraction o Skeletal Muscle Metabolism o Control of Skeletal
More informationBME 701 Examples of Biomedical Instrumentation. Hubert de Bruin Ph D, P Eng
BME 701 Examples of Biomedical Instrumentation Hubert de Bruin Ph D, P Eng 1 Instrumentation in Cardiology The major cellular components of the heart are: working muscle of the atria & ventricles specialized
More informationGENERAL PHYSIOLO GY, NERVE & MUSCLE. 1. How many % of the body weight is the total blood volume? A. 5% B. 8% C. 15% D. 40% E. 60%
GENERAL PHYSIOLO GY, NERVE & MUSCLE 1. How many % of the body weight is the total blood volume? A. 5% B. 8% C. 15% D. 40% E. 60% 2. Which of the following statements is INCORRECT? A. Osmole is the molecular
More informationSkeletal muscles are composed of hundreds to thousands of individual cells,
2 E X E R C I S E Skeletal Muscle Physiology O B J E C T I V E S 1. To define these terms used in describing muscle physiology: multiple motor unit summation, maximal stimulus, treppe, wave summation,
More informationNeuromuscular Stimulation (NMS)
Neuromuscular Stimulation (NMS) Electrode Placement Manual Visit our website: www.veritymedical.co.uk for detailed application protocols 1 Contents Contents Page Introduction 4 Muscle profile 4 Classification
More informationPhysiology of the skeletal muscle
Physiology of the skeletal muscle Objectives Mechanical properties of the skeletal muscle Physiological properties of the skeletal muscle Organization of the skeletal muscle Mechanism of muscle contraction
More informationPrinciples of Electrical Currents. HuP 272
Principles of Electrical Currents HuP 272 Electricity is an element of PT modalities most frightening and least understood. Understanding the basis principles will later aid you in establishing treatment
More informationMuscles and Muscle Tissue
1 Muscles and Muscle Tissue Chapter 9 2 Overview of Muscle Tissues Compare and Contrast the three basic types of muscle tissue List four important functions of muscle tissue 3 Muscle Terminology Muscle
More informationNerve. (2) Duration of the stimulus A certain period can give response. The Strength - Duration Curve
Nerve Neuron (nerve cell) is the structural unit of nervous system. Nerve is formed of large numbers of nerve fibers. Types of nerve fibers Myelinated nerve fibers Covered by myelin sheath interrupted
More informationSession 3-Part 2: Skeletal Muscle
Session 3-Part 2: Skeletal Muscle Course: Introduction to Exercise Science-Level 2 (Exercise Physiology) Presentation Created by Ken Baldwin, M.ED, ACSM-H/FI Copyright EFS Inc. All Rights Reserved. Skeletal
More informationWarning: Avoid putting the tip of the syringe needle too deeply into the hole to avoid damage to the heart tissue.
Experiment AM-12: Crayfish Electrocardiogram (ECG) Exercise 1: The Crayfish ECG and Heart Rate Aim: To record the electrical trace (ECG) produced by the contraction of a resting heart, and to determine
More informationElectromyography Lab
Electromyography Lab By: Chelsea L. Giles Instructor: Professor Delon Washo-Krupps Experiment Conducted On: February 15, 2015 Lab Report Submitted: February 23, 2015 Title: Electromyography Lab Introduction:
More informationGENERAL MUSCLE CHARASTARISTIC AND FIBER TYPES
GENERAL MUSCLE CHARASTARISTIC AND FIBER TYPES UNITARY CONTRACTION OF SMOOTH MUSCLE Smooth muscles are present in hollow/visceral organs, like the Gastrointestinal tract (GIT), Urinary Bladder, and Blood
More informationEvaluation copy. EMG and Muscle Fatigue. Computer
EMG and Muscle Fatigue Computer 18 Voluntary muscle contraction is the result of communication between the brain and individual muscle fibers of the musculoskeletal system. A thought is transformed into
More informationGuidelines for Repetitive Nerve Stimulation recording (decrement study)
Guidelines for Repetitive Nerve Stimulation recording (decrement study) RNS recordings are performed in patients with muscular fatigue symptoms such as Myastenia Gravis (MG) or Myastenic syndrome (MyS
More informationThe nervous system is responsible for most of the functions that characterize
3 E X E R C I S E Neurophysiology of Nerve Impulses O B J E C T I V E S 1. To define the following: irritability, conductivity, resting membrane potential, polarized, sodium-potassium pump, threshold stimulus,
More informationPD233: Design of Biomedical Devices and Systems
PD233: Design of Biomedical Devices and Systems (Lecture-7 Biopotentials- 2) Dr. Manish Arora CPDM, IISc Course Website: http://cpdm.iisc.ac.in/utsaah/courses/ Electromyogram (EMG) Skeletal muscles are
More informationAction potentials in nerve and muscle. Erik Stålberg Uppsala University Hospital Sweden. Kimura, Intracellular recording
Action potentials in nerve and muscle Erik Stålberg Uppsala University Hospital Sweden Kimura, 2001 Intracellular recording 1 Electrical field around the dipole Muscle fibre and unmyelinated axon (continous
More informationInvestigation of human cardiovascular physiology is very interesting, but many
6 E X E R C I S E Frog Cardiovascular Physiology O B J E C T I V E S 1. To list the properties of cardiac muscle as automaticity and rhythmicity, and to define each. 2. To explain the statement, Cardiac
More informationof Pennsylvania, Philadelphia, Pa.) forearm flexor, interosseus and palmaris brevis contract.
ALTERATIONS IN MUSCLE TENSION WITHOUT SIMILAR CHANGES IN ELECTRICAL ACTIVITY IN PATIENTS WITH MYASTHENIA GRAVIS' By STELLA Y. BOTELHO (rom the Department of Physiology and Pharmacology, Graduate School
More informationSample Lab Report 1 from 1. Measuring and Manipulating Passive Membrane Properties
Sample Lab Report 1 from http://www.bio365l.net 1 Abstract Measuring and Manipulating Passive Membrane Properties Biological membranes exhibit the properties of capacitance and resistance, which allow
More informationFellow of King's College, Cambridge.
ON AN APPARENT MUSCULAR INHIBITION PRO- DUCED BY EXCITATION OF THE NINTH SPINAL NERVE OF THE FROG, WITH A NOTE ON THE WEDENSKY INHIBITION. BY V. J. WOOLLEY, Fellow of King's College, Cambridge. (From the
More information238. Picrotoxin: A Potentiator of Muscle Contraction
No. 101 Proc. Japan Acad., 46 (1970) 1051 238. Picrotoxin: A Potentiator of Muscle Contraction By Kimihisa TAKEDA and Yutaka OOMURA Department of Physiology, Faculty of Medicine Kanazawa University, Kanazawa
More informationAnimal Physiology Study Guide
Animal Physiology Study Guide 1. Which of the following are an example of passive transport? 2. Which active transport? 3. How can you tell? 1. Which of the following are an example of passive transport?
More informationWarm Up! Test review (already! ;))
Warm Up! Test review (already! ;)) Write a question you might find on the Unit 5 test next week! (Multiple choice, matching, fill in, or short answer!) - challenge yourself and be ready to share!!! PowerPoint
More informationSkeletal Muscle and the Molecular Basis of Contraction. Lanny Shulman, O.D., Ph.D. University of Houston College of Optometry
Skeletal Muscle and the Molecular Basis of Contraction Lanny Shulman, O.D., Ph.D. University of Houston College of Optometry Like neurons, all muscle cells can be excited chemically, electrically, and
More informationMonitoring of neuromuscular block Conor D McGrath BSc(Hons) MB ChB FRCA
Conor D McGrath BSc(Hons) MB ChB FRCA Jennifer M Hunter MB ChB PHD FRCA There is increasing evidence that residual neuromuscular block is common, and also that it may adversely affect patient outcome.
More informationPhysiology of the nerve
Physiology of the nerve Objectives Transmembrane potential Action potential Relative and absolute refractory period The all-or-none law Hoorweg Weiss curve Du Bois Reymond principle Types of nerve fibres
More informationLearning Goals and Outcomes for LabScribe Physiology Exercises
Learning Goals and Outcomes for LabScribe Physiology Exercises The iworx 214 and LabScribe V2.0 Tutorial Chapter Experiment T-1: LabScribe Tutorial 1. Students will be able to successfully operate both
More informationFig Copyright McGraw-Hill Education. Permission required for reproduction or display. Nucleus. Muscle fiber. Endomysium. Striations.
Fig. 11.1 Nucleus Muscle fiber Endomysium Striations Ed Reschke 1 Fig. 11.2 Muscle fiber Nucleus I band A band Z disc Mitochondria Openings into transverse tubules Sarcoplasmic reticulum Triad: Terminal
More information- Lab. - Rama Nada. - Aya Alomoush. - Mohammad khatatbeh. 1 P a g e
- Lab - Rama Nada - Aya Alomoush - Mohammad khatatbeh 1 P a g e In this sheet well discuss four main topics which are measuring the: 1- Simple muscle twitch 2- Treppe phenomena 3- Summation 4- Muscle fatigue
More informationQuantal Analysis Problems
Quantal Analysis Problems 1. Imagine you had performed an experiment on a muscle preparation from a Drosophila larva. In this experiment, intracellular recordings were made from an identified muscle fibre,
More informationA and P CH 8 Lecture Notes.notebook. February 10, Table of Contents # Date Title Page # /30/17 Ch 8: Muscular System
Table of Contents # Date Title Page # 1. 01/30/17 Ch 8: Muscular System 2. 1 3. 4. 5. 6. 7. i 1 Turnitin.com Class #: 13551662 Password: GoViks 2 01/30/17 Ch 8: Muscular System Objective: Students will
More informationEffects of muscle perfusion pressure on fatigue and systemic arterial pressure in human subjects
Effects of muscle perfusion pressure on fatigue and systemic arterial pressure in human subjects JULIE R. WRIGHT, D. I. MCCLOSKEY, AND RICHARD C. FITZPATRICK Prince of Wales Medical Research Institute,
More informationThe Muscular System 6PART B. PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College
PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College The Muscular System 6PART B Contraction of Skeletal Muscle Muscle fiber contraction is all or none
More informationSITES OF FAILURE IN MUSCLE FATIGUE
of 4 SITES OF FAILURE IN MUSCLE FATIGUE Li-Qun Zhang -4 and William Z. Rymer,2,4 Sensory Motor Performance Program, Rehabilitation Institute of Chicago Departments of 2 Physical Medicine and Rehabilitation,
More informationMusculoskeletal Systems. Anatomy: Arrangement of Cells Physiology: Contractions
Musculoskeletal Systems Anatomy: Arrangement of Cells Physiology: Contractions Characteristics of all muscle Contractile: it shortens Excitable: receives & responds to electrical signals Extensible: stretches
More informationNeurobiology: The nerve cell. Principle and task To use a nerve function model to study the following aspects of a nerve cell:
Principle and task To use a nerve function model to study the following aspects of a nerve cell: INTRACELLULAR POTENTIAL AND ACTION POTENTIAL Comparison between low and high threshold levels Comparison
More information