A resource for doctors. An opportunity for patients.

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1 A resource for doctors. An opportunity for patients. A way for experts to work together to provide the best treatment for patients around the world.

2 Our understanding of cancer is constantly growing, making many cancers more treatable than they once were. This also means that options for treatment are constantly changing and becoming more complicated. What hasn t changed is the goal, of everyone involved, to provide the best possible treatment for a patient diagnosed with cancer. This is why second opinions have become so important to treating cancer: they give patients a wider perspective of their condition and they enable doctors to work together to find solutions. Arbuda makes those second opinions easier and more impactful.

3 What is Arbuda? Arbuda USA is a platform for physicians and patients to securely share health information with top cancer experts. Through an easy-to-use website, doctors around the world can upload patient information which is then shared with oncologists at world-class hospitals in the United States. The local oncologist then receives a report to implement the best treatment for the patient. The gateway s partnerships mean patients and doctors everywhere can now get input from the best researchers in the field. The gateway s partnerships mean patients and doctors everywhere can now get input from the best researchers in the field. Importance of a Second Opinion ESSENTIAL COLLABORATIVE LIFE-CHANGING A second opinion is essential to a complete understanding of a patient s situation. It compliments the diagnosis of a primary physician by adding input from other oncologists and specialists. With the intricacies of modern medicine, second opinions are necessary. With a second opinion, there is nothing to lose and everything to gain. And with a second opinion through Arbuda, doctors and patients gain insights from some of the top researchers and oncology professionals in the United States and the world.

4 Value of United States Laboratories and Pathologists WORLD-RENOWNED ACCREDITED SPECIALIZED Certified accreditation. U.S. labs adhere to the highest quality standards through accreditation and licensure. Strict accreditation requirements ensure that U.S. laboratories are providing the safest and highest quality care for patients. Superb training and diverse specializations. Training in the U.S. encourages doctors to specialize in unique and specific fields of oncology, including: hematopathology, gastrointestinal and liver pathology, dermatopathology, breast pathology, gynecologic pathology, cytopathology, and more. Comprehensive in-house testing. Specialized testing in Arbuda s partner hospitals enables doctors to process and render patient diagnoses faster and with more specificity. Tests include: diverse immunohistochemical markers, breast cancer prognostic markers, flow cytometry, FISH analysis, and molecular or cytogenetic testing. Access to world-renowned experts. For particularly challenging cases, Arbuda enables rapid access to experts in the field within the U.S. **Arbuda is proud to partner with South Central Pathology Lab as its U.S.-based pathology laboratory, making your connection to pathology consultation in the US easy and seamless.

5 Resources for Patients and Doctors In addition to access to some of the best oncologists in the world, Arbuda provides resources for patients and doctors to stay up-to-date on the latest in cancers research, including: Access to clinical trials. C atalogue of various types of cancers and information about them. Drug dictionary to help explain and understand what is involved in different treatments. Membership to an international community of doctors and oncologists Updates on conferences and webinars on cancer treatment breakthroughs. News updates on the latest research happening in the world s premier hospitals.

6 How Arbuda Works 1. The patient discusses the need for a second opinion with their primary physician. The physician s role is essential, not only to ensure accurate transmission of information but also to work with Arbuda s service to ultimately decide and administer the best treatment for the patient. 2. Medical history, patient information and any tests or tissue samples are submitted to the Arbuda platform, along with a medical questionnaire to understand more about the patient s condition. 3. Oncologists and pathologists from top hospitals and research centers work together to evaluate the information. Advanced techniques, such as next-generation sequencing, are also used to uncover insights. 4. The result is a comprehensive treatment plan tailored to the patient. The process is simple and secure, and the potential could be life-changing. Patient Information Patients Experts at Top Hospitals Expert Report

7 Arbuda s Philosophy The Arbuda platform builds a collaborative, supportive network. One doctor alone can do wonders, but a network of doctors can assess a patient s condition from multiple angles. And, more importantly, that group of doctors can develop an all-encompassing treatment with the best odds for success. Our mission is to build ways for doctors to work together to provide the best treatment possible for more patients around the world.

8 Frequently Asked Questions 1. Once submitted, how long does it take to get results? The turnaround for results can vary from one to four weeks depending on the complexity of the diagnosis and the number of specialists that need to be involved to provide the most accurate assessment possible 2. How does Arbuda choose it s doctors? We have partnered with leading hospitals in the U.S. to ensure access to the top experts in cancer research. 3. Do I need to request a specific doctor through Arbuda? No. Arbuda focuses on connecting you with the best-suited oncologist so you don t have to. 4. Is my information secure on Arbuda? Information security and privacy is of the utmost importance for Arbuda. All information on the platform is encrypted and processed in a way that ensures only the necessary parties can access your information. Arbuda also promises never to sell your information or use it in any other way without your permission.

9 Frequently Asked Questions 5. Could Arbuda replace a personal physician? Absolutely not, Arbuda cannot match the important role of in-person visits with a local physician. Rather, Arbuda is an extension of that doctor to help them tap into more resources. Arbuda works in partnership with a personal physician and cannot succeed without them. 6. What is involved in the medical questionnaire? The questionnaire is a form to gather information on the patient s medical history and current condition. It is formatted to surface the as much useful information as possible. 7. Where is Arbuda based? Based in Madison, Wisconsin, and partners with hospitals across the U.S. and the world.

10 What to do Next? Whether you re a patient interested in a second opinion through Arbuda or a doctor looking to provide Arbuda s services as a benefit to patients, visit today to learn more.