Positive Airway Pressure Therapy for Sleep Breathing. Disorder 陽壓呼吸器於睡眠呼吸疾病

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1 Positive Airway Pressure Therapy for Sleep Breathing Disorder 陽壓呼吸器於睡眠呼吸疾病 辦理時間 : 民國 104 年 04 月 18 日 ( 星期六 )13:20~17:40 地點 : 基隆長庚醫院五樓國際會議廳 Time Topic Speaker Moderator 13:20-13:30 報到 13:30-13:40 Opening Remark 簡榮南副院長 13:40-14:30 The role of Humidifier in CPAP 于鍾傑主任 蘇茂昌主任 14:30-15:20 Application of Positive Airway Pressure for Central Sleep Apnea 15:20-15:40 Coffee Break 15:40-16:30 Nasal surgery and CPAP treatment on daytime sleepiness relief 16:30-17:20 The Why, Who and How - A Realistic look at CPAP Therapy 17:20-17:30 Panel Discussion 邱國樑主任 Prof. Nakata Seiichi Prof. Ron Grunstein 林嘉謨理事長李學禹部長陳濘宏主任 17:30-17:40 Close Remark 林嘉謨理事長

2 Curriculum Vitae 1. Name: Chung-Chieh Yu 2. Institution:Chang Gung Memorial Hospital, Keelung / Chang Gung University 3. Position:Physician / Director/Assistant professor 4. Department:Department of Internal Medicine/ Department of Pulmonary, Critical Care, and Sleep medicine 5. Address:No.200, Ln. 208, Jijin 1st Rd., Anle Dist., Keelung City, 204, Taiwan (R.O.C.) 6. Tel/Fax: ext 2568 / ycc@adm.cgmh.org.tw; terminatorchieh@yahoo.com.tw 8. Personal Website: nil 9.Focus of Interest:( 4 3 ) Others (Pulmonary and Sleep medicine) 10.Fulltime Employment: A. From AUG-1999 to JUL-2002/ Resident / Department of Internal Medicine / Chang Gung Memorial Hospital, Linkuo B. From JUN-2002 to FEB-2004/ Fellow / Division of Chest medicine / Chang Gung Memorial Hospital, Keelung

3 C. From Aug-2004 to now/ Attending/ Division Pulmonary, Critical care, and Sleep medicine / Chang Gung Memorial Hospital, Keelung 11.Education:From OCT-1993 to JUN-1999/ Yang-Ming University/ Medical School 12.Honors and Awards: Best paper awards from Taiwan society of sleep medicine in SelectedMain Publications(up to 5 ): 1. Chung-Chieh Yu, Chung-Ching Hua, Jo-Chi Tseng, Yu-Chi Liu. Comparison optimal pressure between automatic titrating and predicting continuous positive airway pressure. Chang Gung Med J 2006;29: Chung-Chieh Yu, Cheng-Ming Luo, Yu-Chih Liu, Huang-Pin Wu. The effects of heated humidifier in continuous positive airway pressure titration. Sleep Breath 2013;17: Patents:nil 15.Board Certification: A. NOV, / Internal Medicine of Taiwan B. OCT, / Pulmonary Medicine of Taiwan C. DEC, / Critical Care Medicine of Taiwan D. MAR, / Sleep Medicine of Taiwan 16.Ongoing projects:the efficacy of CPAP on nocturia, systemic reaction, depression, and CPAP compliance in post stroke OSA 17.Publications: (1).Chung-Chieh Yu, Chung-Ching Hua, Jo-Chi Tseng, Yu-Chi Liu. Comparison optimal pressure between automatic titrating and predicting continuous positive airway pressure. Chang Gung Med J 2006;29:583-9.

4 (2).Chung-Ching Hua, Chung-Chieh Yu. Smoothed periodogram of oxyhemoglobin saturation by pulse oximetry in sleep apnea syndrome. Chest 2007;131: (3). Huang-Pin Wu, Chia-Ling Wu, Chung-Chieh Yu, Yu-Chih Liu, Duen-Yan Chuang. Efficiency of interleukin-4 expression in patients with tuberculosis and nontubercular pneumonia. Human Immunolgy 2007;68: (4).Chung-Chieh Yu, Yu-Chih Liu, Chien-Ming Chu,Duen-Yau Chuang, Wen-Chen Wu, Huang-Pin Wu. In Vitro Interferon-gamma Production Correlated with Tuberculosis and Interleukin-12. Journal of the Formosan Medical Association ;110(4): (5).Chungyao Chen, Chih-Chin Hsu, Yu-Cheng Pei, Chung-Chieh Yu, Ying-Syuan Chen, Chia-Ling Chen. Nocturia is an Independent Predictor of Severe Obstructive Sleep Apnea in Patients with Ischemic Stroke. Journal of Neurology, 2011;258(2): (6). Jen-Hao Cheng, Chung-Ching Hua, Ning-Hung Chen, Yu-Chih Liu, Chung-Chieh Yu. Autonomic activity difference during continuous positive airway pressure titration in patients with obstructive sleep apnea/hypopnea syndrome with or without hypertension. Chang Gung Med J. 2011;34(4): (7). Chien-Ming Chu, Chung-Chieh Yu, Huang-Ping Wu, Bor-Yiing Jiang, Jo-Chi Tseng, Chung-Chinh Hua, Teng-Jen Yu, Yu-Chih Liu, Wen-Pin Shieh. Anti-inflammatory Activity and Mucolytic Effect of Ambroxol in Patients with Stable Chronic Bronchitis- A preliminary Report. Thorac Med 2012;27:13-20 (8). Chung-Chieh Yu, Cheng-Ming Luo, Yu-Chih Liu, Huang-Pin Wu. The effects of heated humidifier in continuous positive airway pressure titration. Sleep Breath 2013;17: (9). Shan-Jie Huang, Chien-Ming Chu, Yu-Chih Liu, Chung-Chieh Yu, The Difference of Morning and Evening Blood Pressure in Obstructive Sleep Apnea. Thorac Med 2014

5 Introduction of Dr.Kuo-Liang Chiu 姓名 : 邱國樑 (Kuo-Liang Chiu), MD, MSc 學歷及訓練資歷中國醫藥大學臨床醫學研究所博士班 ( 進修中 ) 中國醫藥學院醫學研究所碩士中國醫藥學院中醫學系醫學士 University of Toronto, Toronto, Ontario, Canada, Sleep Medicine, Division of Respirology, Department of Medicine, 研究員 (Research Fellowship) 工作經歷現任 2014 Aug ~ 迄今 : 台中慈濟醫院醫務部部長 2012 Aug ~ 迄今 : 台中慈濟醫院內科部主任兼胸腔內科主任 2012 Aug ~ 迄今 : 慈濟大學醫學院專任助理教授 2012 Aug ~ 迄今 : 中國醫藥大學呼吸治療學系兼任助理教授 2010 Mar ~ 迄今 : 台灣睡眠醫學學會理事 2014 Apr ~ 迄今 : 大台中市醫師公會理事 經歷 台中慈濟醫院內科部胸腔內科主任兼教學部副主任 台灣睡眠醫學學會秘書長 中國醫藥大學附設醫院內科部胸腔暨重症系主治醫師 朝陽科技大學兼任助理教授 Research Interest: Sleep related breathing disordered, Sleep apnea and Cardiovascular disease Publication: 1. Chen, H.-J., et al. (2008)."Sonographic Appearances in Transudative Pleural Effusions: Not Always an Anechoic Pattern." Ultrasound in Medicine and Biology 34(3): Chen, W., et al. (2008). "Clinical outcome and prognostic factors of patients with pyogenic liver abscess requiring intensive care." Critical Care Medicine 36(4):

6 3. Chiu, K.-L., et al. (2010). Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart. 4. Chiu, K.-l., et al. Fluid Shift by Lower Body Positive Pressure Increases Pharyngeal Resistance in Healthy. 5. Chiu, K.-L., et al. (2006). Fluid Shift by Lower Body Positive Pressure Increases Pharyngeal Resistance in Healthy Subjects. 6. Hsu, W.-H., et al. (2008). "Dynamic Flow US, Color Doppler US, and Power Doppler US in the Assessment of Vessel Signals of Thoracic Lesions Abutting Pulsatile Organs." Academic Radiology 15(3): Su, M.-C., et al. (2008). Lower body positive pressure increases upper airway collapsibility in healthy subjects. 8. Su, M.-C., et al. (2008). "Lower body positive pressure increases upper airway collapsibility in healthy subjects." Respiratory Physiology & Neurobiology 161(3): Su, M.-C., et al. (2009). "Difference in upper airway collapsibility during wakefulness between men and women in response to lower-body positive pressure." Clinical Science 116(9). 10. Tu, C.-Y., et al. (2006). "The changing pathogens of complicated parapneumonic effusions or empyemas in a medical intensive care unit." Intensive Care Medicine 32(4): Wang, H., et al. (2007). "Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure." Journal of The American College of Cardiology 49(15): Yu, Y.-H., et al. (2008). "Computer-aided diagnosis in two-phase 201Tl-SPECT of thoracic lesions." Nuklearmedizin-nuclear Medicine.

7 Profile Seiichi Nakata M.D., Ph.D. Associate Professor Department of Otorhinolaryngology Second Hospital, Fujita Health University School of Medicine Address3-6-10Otobashi, Nakagawa-Ku, Nagoya , Japan Tel Fax Representative Publication:

8 1. Pathogenetic role of increased nasal resistance in obese patients with obstructive sleep apnea syndrome. MitsuhikoTagaya, Seiichi Nakata, FumihikoYasuma, Akiko Noda, Mami Morinaga, Hidehito Yagi, Makoto Sugiura, Masaaki Teranishi, Tsutomu Nakashima. American Journal of Rhinology & Allergy - AM J RHINOL ALLERGY, vol. 24, no. 1, pp , Pharyngeal morphology: A determinant of successful nasal surgery for sleep apnea Mami Morinaga, Seiichi Nakata, FumihikoYasuma, Akiko Noda, Hidehito Yagi, MitsuhikoTagaya, Makoto Sugiura, Masaaki Teranishi, Tsutomu Nakashima. Laryngoscope, vol. 119, no. 5, pp , Effects of nasal surgery on sleep quality in obstructive sleep apnea syndrome with nasal obstruction. Seiichi Nakata, Akiko Noda, FumihikoYasuma, Mami Morinaga, Makoto Sugiura, Naomi Katayama, Mine Sawaki, Masaaki Teranishi, Tsutomu Nakashima. American Journal of Rhinology - AMER J RHINOL, vol. 22, no. 1, pp , Influence of Nasal Resistance on Initial Acceptance of Continuous Positive Airway Pressure in Treatment for Obstructive Sleep Apnea Syndrome. TatsukiSugiura, Akiko Noda, Seiichi Nakata, Yoshinari Yasuda, Taro Soga, Seiko Miyata, SigeruNakai, Yasuo Koike. Respiration, vol. 74, no. 1, pp , Continuous Positive Airway Pressure Improves Daytime Baroreflex Sensitivity and Nitric Oxide Production in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome. Akiko Noda, Seiichi Nakata, Yasuo Koike, Seiko Miyata, KiyoyukiKitaichi, Takao Nishizawa, Kohzo Nagata, FumihikoYasuma, ToyoakiMurohara, Mitsuhiro Yokota. Hypertension Research - HYPERTENS RES, vol. 30, no. 8, pp , Reduced nasal resistance after simple tonsillectomy in patients with obstructive sleep apnea (Citations: 5)Seiichi Nakata, Soichiro Miyazaki, Motofumi Ohki, Mami Morinaga, Akiko Noda, TatsukiSugiura, Makoto Sugiura, Masaaki Teranishi, Naomi Katayama, Tsutomu Nakashima. American Journal of Rhinology & Allergy - AM J RHINOL ALLERGY, vol. 21,

9 no. 2, pp , Tonsil size and body mass index are important factors for efficacy of simple tonsillectomy in obstructive sleep apnoea syndrome. S. Nakata, A. Noda, E. Yanagi, K. Suzuki, H. Yamamoto, T. Nakashima. Clinical Otolaryngology and Allied Sciences, vol. 31, no. 1, pp , Quantification of Facial Motion for Objective Evaluation Using a High-Speed Three-Dimensional Face Measurement SystemA Pilot Study. Seiichi Nakata, Yukio Sato, PujithaGunaratne, Yoshiro Suzuki, SaikoSugiura, Tsutomu Nakashima. Otology &Neurotology - OTOL NEUROTOL, vol. 27, no. 7, pp , Obstructive sleep apnoea associated with congenital choanal atresia. Seiichi Nakata, Akiko Noda, Hayato Misawa, Eriko Yanagi, Hidehito Yagi, Tsutomu Nakashima. Journal of Laryngology and Otology - J LARYNGOL OTOL, vol. 119, no. 03, Effects of nasal obstruction on continuous positive airway pressure treatments in obstructive sleep apnea syndrome. Seiichi NAKATA, Akiko NODA, Hidehito YAGI, Eriko YANAGI, Keisuke SUZUKI, Hayato MISAWA, Yasuo KOIKE, Tsutomu NAKASHIMA. Sleep and Biological Rhythms - SLEEP BIOL RHYTHMS, vol. 2, no. 1, pp , 2004

10 Prof. Ron Grunstein ProfessorSleep Medicine, Central Clinical SchoolWoolcock Institute of Medical Research Biographical details Ron Grunstein is currently Professor of Sleep Medicine and head of the NHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS) and the NHMRC Australasian Sleep Trials Network. He has been a Practitioner Fellow of the NHMRC since Professor Grunstein is a staff specialist physician in Respiratory and Sleep Medicine at Royal Prince Alfred Hospital, has an honorary appointment in respiratory and sleep medicine at St Vincent s Hospital, Sydney and heads the Sleep and Circadian Research Group, Woolcock Institute of Medical Research. Prof. Grunstein has a strong interest in translational clinical research in sleep health and was involved in the early development of nasal CPAP and non-invasive ventilatory support for sleep-breathing disorders. His current main interests involve in metabolic and neurobiological effects of sleep loss. As well he leads research in the simplification of sleep apnea diagnosis and new treatment interventions in sleep disorders. Dr Grunstein has been a visiting scientist at the University of Gothenburg, Sweden and other overseas universities. He was awarded the Nathaniel Kleitman Award of the American Academy of Sleep Medicine in 2011 and the Distinguished Achievement Award of the Australasian Sleep Association in In 2012, he was awarded the RPA Foundation research medal. He has a long standing interest in health communication through the media and in 2008 was appointed a Public Member of the Australian Press Council. Dr Grunstein also serves as chief medical advisor to Sleep Disorders Australia, an advocacy body for patients with sleep disorders. He has

11 also advised Australian, British and EU road regulatory bodies on sleep disorders and has served as Associate Editor of Sleep and a member of the editorial board of the Journal of Sleep Research, Sleep Medicine Reviews, Sleep Medicine and Respiratory Research. He has Bachelor of Medicine and Surgery degrees and a Doctor of Medicine from the University of Sydney and a PhD from the University of Gothenburg, Sweden. Professor Grunstein was the President of the World Sleep Federation ( ) that represents over 12,000 researchers and sleep clinicians globally and was President of the Australasian Sleep Association Research interests Professor Grunstein has diverse interests in clinical research in sleep disorders and sleep health. Research includes diagnosis, effects and management of sleep apnea, epidemiology of sleep disorders, impact of sleep loss on human health, interaction of work and sleep and evaluating and developing new treatment approaches in sleep disorders. Representative Publication: 1. Marshall, N., Wong, K., Cullen, S., Knuiman, M., Grunstein, R. (2014). Sleep apnea and 20-year follow-up for all-cause mortality, stoke, and cancer incidence and mortality in the busselton health study cohort. The Journal of Clinical Sleep Medicine, 10(4), Phillips, C., Grunstein, R., Darendeliler, M., Mihailidou, A., Srinivasan, V., Yee, B., Marks, G., Cistulli, P. (2013). Health Outcomes of Continuous Positive Airway Pressure versus Oral Appliance Treatment for Obstructive Sleep Apnea: A Randomised Controlled Trial. American Journal of Respiratory and Critical Care Medicine, 187(8), Bartlett, D., Wong, K., Richards, D., Moy, E., Espie, C., Cistulli, P., Grunstein, R. (2013). Increasing adherence to obstructive sleep apnea treatment with a group social cognitive therapy treatment intervention: A randomized trial. Sleep, 36(11), Hoyos, C., Killick, R., Yee, B., Phillips, C., Grunstein, R., Liu, P. (2012). Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study. Thorax, 67(12),

12 Sivam, S., Phillips, C., Trenell, M., Yee, B., Liu, P., Wong, K., Grunstein, R. (2012). Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea. The European Respiratory Journal, 40(4), Phillips, C., McEwen, B., Morel-Kopp, M., Yee, B., Sullivan, D., Ward, C., Tofler, G., Grunstein, R. (2012). Effects of continuous positive airway pressure on coagulability in obstructive sleep apnoea: a randomised, placebo-controlled crossover study. Thorax, 67(7), D'Rozario, A., Wong, K., Dungan, G., Gilholme, J., Marshall, N., Grunstein, R. (2012). Residual sleep-disordered breathing during autotitrating continuous positive airway pressure therapy. European Respiratory Journal, 39(6), Dungan, G., Marshall, N., Hoyos, C., Yee, B., Grunstein, R. (2011). A Randomized Crossover Trial of the Effect of a Novel Method of Pressure Control (SensAwake) in Automatic Continuous Positive Airway Pressure Therapy to Treat Sleep Disordered Breathing. The Journal of Clinical Sleep Medicine, 7(3), Phillips, C., Yee, B., Marshall, N., Liu, P., Sullivan, D., Grunstein, R. (2011). Continuous Positive Airway Pressure Reduces Postprandial Lipidemia in Obstructive Sleep Apnea. A Randomised, Placebo Controlled Crossover Trial. American Journal of Respiratory and Critical Care Medicine, 184(3), Piper, A., Grunstein, R. (2011). Obesity Hypoventilation Syndrome - Mechanisms and Management. American Journal of Respiratory and Critical Care Medicine, 183(3), Williams, S., Marshall, N., Kennerson, M., Rogers, N., Liu, P., Grunstein, R. (2010). Modafinil Effects during Acute Continuous Positive Airway Withdrawal: A Randomized Crossover Double-Blind Placebo-controlled Trial. American Journal of Respiratory and Critical Care Medicine, 181(8), Marshall, N., Grunstein, R. (2009). Losing weight in moderate to severe obstructive sleep apnoea. BMJ: British Medical Journal, 339(7734),

13 13. McEvoy, R., Pierce, R., Hillman, D., Esterman, A., Ellis, E., Catcheside, P., O'Donoghue, F., Barnes, D., Grunstein, R. (2009). Nocturnal non-invasive nasal ventilation in stable hypercapnic COPD: a randomised controlled trial. Thorax, 64(7), Weaver, T., Grunstein, R. (2008). Adherence to Continuous Positive Airway Pressure Therapy. The Challenge to Effective Treatment. Proceedings of the American Thoracic Society, 5(2), Phillips, C., Yee, B., Yang, Q., Villaneuva, A., Hedner, J., Berend, N., Grunstein, R. (2008). Effects of Continuous Positive Airway Pressure Treatment and withdrawal in patients with obstructive sleep apnea on arterial stiffness and central BP. Chest, 134(1), Piper, A., Wang, D., Yee, B., Grunstein, R., Barnes, D. (2008). Randomised trial of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation. Thorax, 63(5), Marshall, N., Wong, K., Liu, P., Cullen, S., Knuiman, M., Grunstein, R. (2008). Sleep Apnea as an Independent Risk Factor for All-Cause Mortality: The Busselton Health Study. Sleep, 31(8), Williams, S., Rogers, N., Marshall, N., Leung, S., Starmer, G., Grunstein, R. (2008). The effect of modafinil following acute CPAP withdrawal: a preliminary study. Sleep and Breathing, 12(4), Piper, A., Grunstein, R. (2007). Current perspectives on the obesity hypoventilation syndrome. Current Opinion in Pulmonary Medicine, 13(6), Richards, D., Bartlett, D., Wong, K., Malouff, J., Grunstein, R. (2007). Increased adherence to CPAP with a group cognitive behavioral treatment intervention: a randomized trial. Sleep, 30(5), Banerjee, D., Yee, B., Piper, A., Zwillich, C., Grunstein, R. (2007). Obesity hypoventilation syndrome: Hypoxemia During Continuous Positive Airway Pressure. Chest, 131(6),

14 22. Phillips, C., Yang, Q., Williams, A., Roth, M., Yee, B., Hedner, J., Berend, N., Grunstein, R. (2007). The effect of short-term withdrawal from continuous positive airway pressure therapy on sympathetic activity and markers of vascular inflammation in subjects with obstructive sleep apnoea. Journal of Sleep Research, 16(2), Grunstein, R., Stenlof, K., Hedner, J., Peltonen, M., Karason, K., Sjostrom, L. (2007). Two year reduction in sleep apnea symptoms and associated diabetes incidence after weight loss in severe obesity. Sleep, 30(6), Bartlett, D., Richards, D., Wong, K., Malouff, J., Grunstein, R. (2006). Increased adherence to continuous positive airway pressure with a group cognitive behavioural treatment intervention: a randomised trial. Journal of Sleep Research, 15(Suppl. 1), Yee, B., Cheung, J., Phipps, P., Banerjee, D., Piper, A., Grunstein, R. (2006). Treatment of obesity hypoventilation syndrome and serum leptin. Respiration, 73(2), Cistulli, P., Grunstein, R. (2005). Medical devices for the diagnosis and treatment of obstructive sleep apnea. Expert Review of Medical Devices, 2(6), ] 27. Willson, G., Piper, A., Norman, M., Chaseling, W., Milross, M., Collins, E., Grunstein, R. (2004). Nasal Versus Full Face Mask For Noninvasive Ventilation In Chronic Respiratory Failure. European Respiratory Journal, 23(4), Yee, B., Liu, P., Phillips, C., Grunstein, R. (2004). Neuroendocrine Changes in Sleep Apnea. Current Opinion in Pulmonary Medicine, 10(6), Howard, M., Desai, A., Grunstein, R., Hukins, C., Armstrong, J., Joffe, D., Swann, P., Campbell, D., Pierce, R. (2004). Sleepiness, sleep-disordered breathing, and accident risk factors in commercial vehicle driversrs. American Journal of Respiratory and Critical Care Medicine, 170(9),