GC-MS analysis of e-liquids taken. from e-cigarettes and e-liquids (e-juice) before use in e-cigarettes
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1 GC-MS analysis of e-liquids taken from e-cigarettes and e-liquids (e-juice) before use in e-cigarettes John H. Lauterbach, Ph.D., DABT Lauterbach & Associates, LLC, Macon, GA USA Deborah A. Grimm, Ph.D. Coordinated Instrumentation Facility Tulane University, New Orleans, LA USA
2 Objectives for this presentation Identify major and minor species in e-liquids using traditional GC-MS analytical techniques Main aerosol-forming species (PG, VG) Flavorful components Unexpected components Determine if published ingredient information was consistent with analytical findings Attempt to identify compounds present that might account for the cytotoxicity reported in some e-liquids (Bahl et al., Reproductive Toxicology :529-37) ST05_CORESTA_2013 L&ALLC 2
3 Analytical approach Capillary column gas chromatography mass spectrometry (GC-MS) has been main tool for analyses of flavors for more than three decades Ability to separate and identify volatiles and semivolatile components of complex mixtures Long history of use in tobacco industry for analyses of flavor concentrates, finished flavors, and flavors applied to tobacco products Tobacco flavors and flavor concentrates often formulated in propylene glycol (PG) These factors make GC-MS the ideal tool for the analyses of e-liquids and their components ST05_CORESTA_2013 L&ALLC 3
4 Example chromatogram 1a Monoacetin Peppermint flavor 1.2% DB-5 MS column Lab 1 Diacetin Triacetin Caryophyllene ST05_CORESTA_2013 L&ALLC 4
5 Example chromatogram 1b PG Peppermint flavor TMS 1.2% DB-5 MS column Lab 1 Carvone Menthol ST05_CORESTA_2013 L&ALLC 5
6 Example chromatogram 1c PG Menthol Peppermint flavor 1.2% SolGel-Wax column Lab 2 Carvone Monoacetin Triacetin Diacetin ST05_CORESTA_2013 L&ALLC 6
7 Peppermint e-liquid Vendor s web page Found by analysis Compound Amount Compound Relative amount Propylene glycol Very Large Propylene glycol Very large Malic acid Medium Large Vanillin Medium Monoacetins Large Acetyl pyrazine Small Diacetins Medium Menthol Small Triacetin Medium Ethyl acetate Small Menthol Small Aliphatic acid Very small Menthone Small Common flavors Very small Carvone Small Pulegone Very small Anethol Very small Caryophyllene Very small ST05_CORESTA_2013 L&ALLC 7
8 Example chromatogram 2a Chocolate flavor 1.2% DB-5 MS column Lab 1 ST05_CORESTA_2013 L&ALLC 8
9 Example chromatogram 2b PG Chocolate flavor TMS 1.2% DB-5 MS column Lab 1 Hexitol Di-PG ST05_CORESTA_2013 L&ALLC 9
10 Example chromatogram 2c Chocolate flavor 1.2% SolGel-Wax DB-Wax column column Lab 2 PG ISTD Di-PG ST05_CORESTA_2013 L&ALLC 10
11 Chocolate e-liquid Vendor s web page Found by analysis Compound Amount Compound Relative amount Propylene glycol Very Large Propylene glycol Very large Vanilla extract Large Medium Terpene alcohol Medium C-6 sugar alcohol Very small Acetyl pyrazine Small Dipropylene glycol Very small Alkyl pyrazine Small C-5 aliphatic acid Small Common flavors Small ST05_CORESTA_2013 L&ALLC 11
12 Example chromatogram 3 Syringol Tobacco flavor PG Free 1.8% SolGel-Wax column Lab 2 PG EtMaltol Acetic acid Menthol Cyclotene Maltol EtVanillin Vanillin ST05_CORESTA_2013 L&ALLC 12
13 Lagniappe Most information reported to date on the mainstream e-cigarette aerosol (MECA) has focused on nicotine content and/or known smoke toxicants However, the same techniques that are used for analyses of e-liquids should be useful for analyses of major components of MECA Collect MECA on Cambridge pad Health Canada Intensive smoking 100 puffs ( 90 mg) Extract pad with 2-propanol containing heptadecane as the internal standard (ISTD) ST05_CORESTA_2013 L&ALLC 13
14 Example chromatogram 4 ISTD Chocolate flavor MECA 1.2% SolGel-Wax column Lab 2 PG Di-PG C-14 HC ST05_CORESTA_2013 L&ALLC 14
15 Example chromatogram 5 ISTD Tobacco flavor MECA 1.8% SolGel-Wax column Lab 2 Syringol EtMaltol? ST05_CORESTA_2013 L&ALLC 15
16 Concluding remarks Traditional GC-MS techniques for analyses of flavors and smoke can be applied to e-liquids and mainstream e-cigarette aerosols (MECA) There were differences in e-liquid composition between what was expected and what was found Are users getting the hedonic properties expected by the manufacturers of the e-liquids? Do e-liquid vendors have accurate information on the composition of the products they are selling? However, nothing to support report of cytotoxicity Is there sufficient flavor transfer for superior consumer satisfaction? ST05_CORESTA_2013 L&ALLC 16
17 Acknowledgement Some of the GC-MS analyses reported in this presentation were performed by Dr. Andrae Spencer of Global Laboratory Services of Wilson, NC. The author would like to thank Dr. Spencer very much for his excellent scientific work on the GC-MS analyses. The lead author of this presentation and Lauterbach & Associates, LLC, are totally responsible for the content of this presentation. ST05_CORESTA_2013 L&ALLC 17
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