STANDARD COURSE SYLLABUS Pharmacology and Toxicology 4 th year Medical Faculty for academic year 2013/2014

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1 STANDARD COURSE SYLLABUS Pharmacology and Toxicology 4 th year Medical Faculty for academic year 2013/2014 Description of subject matter Instructional program Name of subject: Pharmacology and Toxicology Module code according to standards: C Director of unit conduction the course: Prof. dr hab. Adam Szeląg Faculty: Medical Course of study: Medical Level of studies Unitary MMed Form of studies full-time Year: IV Semester: VII and VIII Type of subject obligatory Language of instruction: English Name of unit conducting course Winter semester (hrs.) Summer semester (hrs.) L C S L C S Department of Pharmacology Total: Educational goals (goals for lessons set by instructor, related to the results of education, max. 6 items) C1. The aim of the course is to show the rules of rational pharmacotherapy, benefits and risks of pharmacotherapy. Students are taught how to verify the sources of knowledge about drugs and critical review of medical papers. After the pharmacology course students should know general terms from pharmacodynamics, pharmacokinetics and pharmacoeconomics, should also know basis for drugs action, and are able to characterize groups of drugs, their pharmacological effects, pharmacokinetics, indications and contraindications, adverse effects, interactions and basic dosage regiments. Student should also know how to calculate proper doses and prescribe simple prescriptions or orders to the nurses. Matrix of educational results for subjects in reference to methods for verifying intended educational results and manner of conducting lessons. Number of educational result Manner of lessons: ** provide symbol C.W34, C.W.35, C.W.36, C.W.37, C.W.38, C.W.39, C.W.40, C.W.42, C.W. 43, C.W.44, C.W.45 C.U. 13, C.U.14, C.U.15, C.U.16, C.U.17, C.U.18, C.U.19 Description of educational result (in conformance with detailed educational results defined in standards) Student defines basic pharmacokinetic terms, describes groups of drugs, explains their action, indications and contraindications as well as interactions, adverse effects and knows management with intoxicated persons. Student is able to verify the dose of drug depending on the function of main organs and prescribe it on the prescription form. Student could also asses the toxicity of various substances in regard to patient s age or health. Methods for verifying achievement of intended educational results * oral or written examinations oral answers, tests, presentations, colloquium, prescriptions *e.g.. test, presentation, oral response, essay, report, colloquium, oral examination, written examination; ** L- lecture; S- seminar; C- class; EL- e-learning; Student work input (balance of ECTS points) Lessons on-site (hrs.) 150 Own work (hrs.) 67,5 Summary of student workload 217,5 ECTS points for subject 10,5 Remarks L C

2 Content of lessons: (please provide the subject of individual lessons, keeping in mind the need to contribute to the intended educational results) Lectures winter semester Name of the lecturer Lecture 1. General pharmacology introduction. Lecture 2. General pharmacology - LADME. Lecture 3. General pharmacology pharmacokinetics. Lecture 4. General pharmacology - variation in drugs' action. Adverse and toxic reactions. Lecture 5. Autonomic nervous system physiology, drugs acting on ganglia. Lecture 6. Autonomic nervous system adrenomimetics. Lecture 7. Autonomic nervous system adrenolytics. Lecture 8. Autonomic nervous system cholinergic system. Lecture 9. Diuretics. Lecture 10. Hypolypemic drugs. Lecture 11. Heparins, oral anticoagulants. Antiplatelet drugs. Thrombolytics. Lecture 12. Therapy of chronic heart failure (RAA system - ACEI, ARB, RI, cardiac glycosides and other inotropic agents). Lecture 13. Therapy of ischemic heart disease (BB, CCB, vasodilators). Lecture 14. Therapy of arterial hypertension. Pulmonary hypertension. Lecture 15. Antiarrhythmic drugs. Lectures summer semester Name of the lecturer: Lecture 1. Respiratory tract. Lecture 2. Gastrointestinal tract, liver, pancreas. Lecture 3. Hormones of hypothalamus, pituitary gland. Hormones of thyroid gland and antithyroid drugs. Lecture 4. Insulin and other hypoglycemic drugs. Lecture 5. Hormons of adrenal gland (glucocorticoids, mineralocorticoids, adrenocortical antagonists). Lecture 6. Sex hormones. Erectile dysfunction. Lecture 7. Bone homeostasis. Mineral substances (calcium, potassium, magnesium, sodium). Iron and hematopoesis. Lecture 8. Vitamins. Lecture 9. Introduction to chemotherapy. Management of anaphylactic shock. Lecture 10. Beta-lactam antibiotics, glycopeptides and other cell-wall inhibitors (bacitracine, fosfomycin). Daptomycin. Lecture 11. Aminoglycosides and spectinomycin, tetracyclines, glycyclines, chloramphenicol. Oxazolidinines. Lecture 12. Macrolides, ketolides, streptogramines, lincosamides and oxazolidinones. Lecture 13. Toxicology. Lecture 14. Herbal preparations and dietary supplements. Therapeutic and toxic potential of OTC drugs. Lecture 15. Selected aspect of pharmacology.

3 Classes winter semester Class 1. Class 2. Class 3. Class 4. Class 5. Class 6. Class 7. Class 8. Class 9. Class 10. Class 11. Class 12. Class 13. Class 14. Class 15. Regulations of the classes and lectures in Pharmacology and Toxicology. General rules of order writing. Drug development and regulation. Eicosanoids. NSAIDS. Non-opioid analgesics. Therapy of gout and rheumatoid arthritis. Dosage forms of drugs. Drug Opioid analgetics and antagonists. Dosage forms of drugs. Drug Autakoids histamine, serotonin and ergot alkaloids. Dosage forms of drugs. Drug Spasmolytics, myorelaxants, drugs affecting neuromuscular transmission. Dosage forms of drugs. Drug Local anesthetics. Dosage forms of drugs (local anesthetics). Drug General anesthetics. Dosage forms of drugs. Drug The alcohols and drugs abuse. Dosage forms of drugs. Drug CNS Introduction. Antipsychotic drugs. Dosage forms of drugs. Drug CNS Mood disorders, antidepressants. Dosage forms of drugs. Drug CNS Hypnotic-sedative and anxiolytic drugs. Dosage forms of drugs. Drug Practical training in drug calculations and prescription writing. Made-up classes. Possibility to obtain positive degrees. Name of the teacher

4 Classes summer semester Class 1. Class 2. Class 3. Class 4. Class 5. Class 6. Class 7. Class 8. Class 9. Class 10. Class 11. Class 12. Class 13. Class 14. Class 15. CNS Neurodegenerative disorders. Dosage forms of drugs. Drug CNS Antiepileptic drugs. Dosage forms of drugs. Drug Antifungal drugs. Dosage forms of drugs. Drug Antiviral drugs. Dosage forms of drugs. Drug Antiprotozoal drugs. Dosage forms of drugs. Drug Antihelmintic drugs. Dosage forms of drugs. Drug Tuberculostatics, ryfamycines, treatment of leprosy. Dosage forms of drugs. Drug Anticancer chemotherapy. Dosage forms of drugs. Drug Immunomodulators. Biological treatment and gene therapy. Dosage forms of drugs. Drug Quinolones, sulphonamides, co-trimxazole. Polimyxines. Dosage forms of drugs. Drug calculations Nitroimidazoles (e.g. metronidazole, tinidazole), nitrofuranes and other urinary antiseptics. Disinfectants, antiseptics and sterilisants. Mupirocin, fusafungin, fusidic acid. Dosage forms of drugs. Drug Practical training in drug calculations and prescription writing. Made-up classes. Possibility to obtain positive degrees. Name of the teacher

5 Primary and secondary literature 1. Basic & Clinical Pharmacology, Katzung BG, Mc Graw Hill, 11 th Ed, 2010 or 12 th Ed, Modern Pharmacology with Clinical Application. CR Craig, RE Stitzel, Lippincott Williams and Wilkins, 6 th Ed, Brenner GM: Pharmacology 2 nd Ed, Saunders/Elsevier, Wecker L: Brody s human pharmacology. 5 th Ed, Mosby/Elsevier, Rang and Dale's Pharmacology. HP Rang, MM Dale, JM Ritter, RJ Flower, Churchill Livingstone Elsevier, 7 th Ed, Howland RD, Mycek MJ, Harvey RA, Champe PC: Lippincott's illustrated reviews: pharmacology, Lippincott Williams and Wilkins, 5 th Ed, 2012 Requirements concerning instructional aids (e.g. laboratory, multimedia projector, other ) multimedia projector, interactive board Conditions for successful completion of course: Theoretical exam: To pass the test 60% of correct answers are required. The level may be only decreased in some situations. To pass the oral exam correct answers on all of 3 chosen questions are required. Practical exam (drug calculation and order writing): To pass drug calculation test correct calculations and writing of the 2 prescriptions and 1 order for the nurse are required. Name and address of unit conducting course, contact information (tel./ ): Department of Pharmacology, Wroclaw Medical University Mikulicza-Radeckiego 2, PL Wrocław phone: secretary office: julia.panek@umed.wroc.pl Persons holding the classes and lectures: Dorota Ksiądzyna MD, PhD, Anna Merwid-Ląd MD, PhD and Monika Skrzypiec-Spring (classes) Anna Merwid-Ląd MD, PhD (lectures) Person responsible for the course for a given year Signature of head of unit conducting the course Signature of dean Date of syllabus drafting: