Case Presentation. Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD. Department of Pathology Jordan University Hospital Amman, Jordan
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1 Case Presentation Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD Department of Pathology Jordan University Hospital Amman, Jordan The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
2 Clinical Background 39 year old smoker lady, presented with a 6 month history of toothache and headache Medical history: hypertension The 25 th Annual Congress of the ADIAP 8/11/2013 The 5 th 2 International Conference of JSP
3 Clinical Background Multiple visits to dental clinics, received pain killers but without relief Visited an ENT clinic, physical exam revealed a nasal cavity mass CT scan was performed The 25 th Annual Congress of the ADIAP 8/11/2013 The 5 th International Conference of JSP 3
4 CT scan
5 Radiologic findings Large, lobulated, destructive solid tumor measuring 5 cm in maximum dimension, involving the roof of the mouth, the right nasal cavity, maxillary sinus, orbit The tumor also extends to the right infratemporal fossa, ptregopalatine fossa and parapharyngeal space, sparing the oropharynx The patient underwent endoscopic biopsy from the nasal mass The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
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13 Differential Diagnosis Sarcoamtoid carcinoma(ck??) Extracranial meningeoma (EMA, vimentin??) Leiomyosarcoma ( Desmin, SMA??) Solitary fibrous tumor (Bcl2, EMA??) Anaplastic large cell lymphoma(cd30,cd45??) Melanoma (HMB45??) The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
14 cytokeratin 14
15 vimentin 15
16 CD45 16
17 SMA 17
18 Desmin 18
19 S100 19
20 EMA 20
21 Bcl2 21
22 CD30 22
23 CD21 23
24 CD23 24
25 CD68 25
26 Immunoprofile Positive vimentin CD21 CD23 CD68 (focal) Negative S100 CD45 CK EMA SMA Desmin HMB45 CD99 Bcl2 CD20 CD30 ALK CD1a The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
27 Diagnosis Extranodal follicular dendritic cell sarcoma The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
28 FDC sarcoma A rare neoplastic proliferation of FDCs (antigen-presenting immune accessory cells that are widely distributed in tissues) First reported by Monda et al, in 1986 Almost all patients are adults, with a median age of 40 years and with no sex predilection Some association with Castleman disease (hyaline vascular variant) The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
29 Etiology Most cases: unknown Hyaline-vascular Castleman disease (10-20%) of cases A pathway for tumor evolution: FDC hyperplasia, dysplasia then transformation Overexpression of p53 protein is noted in FDC sarcoma, and is weakly positive in spindle cells in Castleman disease Epidermal growth factor receptor expression The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
30 Clinical symptoms Patients often present with a slow-growing, painless mass Constitutional symptoms and paraneoplastic syndromes are rare, unless associated with Castleman disease, or in inflammatory pseudotumor variant of FDC sarcoma Abdominal tumors present with pain and compression symptoms The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
31 Nodal vs Extranodal sites Nodal FDC sarcoma accounts for more than two thirds of cases, with cervical lymph nodes being the most commonly affected Extranodal FDC sarcoma is very rare (37 cases by 2010)* Most of the prototype: oropharynx IPT-variant: spleen or liver Other reported sites: GIT, soft tissue, skin, lung and breast * Duan GJ, Wu F, Zhu J, Guo DY, Zhang R, Shen LL, Wang SH, Li Q, Xiao HL, Mou JH, Yan XC, Extranodal follicular dendritic cell sarcoma of the pharyngeal region: a potential diagnostic pitfall, with literature review, Am j clin pathol, 2010 jan. 8/11/
32 Gross features Size range from 1 to 20 cm maximum diameter, with a median size of 6 cm Round to ovoid, well-circumscribed, fleshy masses that on cut section are solid and tan Interspersed areas of hemorrhage and yellowish necrotic areas might be present particularly in larger tumors The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
33 Microscopic features The tumor is characterized by a proliferation of spindle to ovoid cells that form fascicles, storiform patterns and whorls (360 o ) Cells tend to be plump, with slightly eosinophilic, fibrillary cytoplasm and indistinct cell borders The nuclei are elongated, unevenly spaced, small distinct nucleoli Occasional nuclear pseudoinclusions The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
34 Microscopic features Small lymphocytes are scattered throughout the tumor and perivascular cuffing Occasional binucleated and multinucleated tumor cells may be present Although highly cellular, atypia is only mild to moderate Mitotic figures: 0-10/ 10HPF Necrosis can be seen in higher grade tumors The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
35 IPT variant Spleen or liver Prominent lymphoplasmacytic infiltrate, masking neoplastic cells Atypia is more variable within the tumor Necrosis and hemorrhage are more common EBV positive (EBER-ISH) More aggressive The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
36 Immunophenotype Normal FDC antigens: CD21, CD35, CD23, D2-40, CXCL-13 Common positivity: vimentin, fascin, desmoplakin, HLA-DR, EGFR, CD4 Variable positivity: CD68, S100, EMA, CD15 Negative: CD45, CD20, CD1a, lysozyme, MPO, CD34, CD3, CD79a, CD30, HMB-45, CK Clusterin: sensitive and specific Ki-67 index: 1-25% The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
37 Treatment The current approach is to apply therapeutic guidelines similar to those used for soft tissue sarcomas of high grade Complete surgical resection is the therapy of choice Adjuvant radiation or chemotherapy decreases the rate of recurrence The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
38 Biologic behavior and Prognosis The behavior of these tumors is more akin to that of a low-grade soft tissue sarcoma than a malignant lymphoma Local recurrences rate: 36%, metastasis: 28%, mostly to LN and liver Poor prognostic factors: intra-abdominal location size 6 cm mitotic count 5 /10 HPFs coagulative necrosis significant nuclear pleomorphism The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
39 Message? As spindle cell tumors within lymph nodes are rare, the diagnosis of FDCS within a node is not that difficult. However, extranodal FDCS cases are much more challenging in diagnosis because sarcomatoid carcinoma and sarcoma are by far much more common Clue: morphologic features The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
40 Our patient Patient still alive with disease Receiving radiotherapy... No surgery yet. The 25th Annual Congress of the ADIAP The 8/11/ th International Conference of JSP
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