Medical Advisory Council. 1 - dipg symposium schedule (2) Foundational Leadership Partners. Foundational Partners. Symposium Sponsors

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1 Foundational Leadership Partners Foundational Partners Symposium The Goal of the Symposium To increase collaboration within research and foundational partners, thus ensuring an efficient, productive and transparent search for a cure to DIPG and the global lessons this research may offer in a homerun cure for all cancers. DIPG Symposium Planning Committee Jonathan Agin (DIPG Collaborative Steering Committee member; Co-Director Washing DC Chapter The Cure Starts Now Foundation) Dr. Gavin Baumgardner (The Cure Starts Now Medical Advisory Council Chairman) Keith Desserich (DIPG Collaborative Steering Committee member; Co-Founder and Chairman of The Cure Starts Now Foundation) Dr. Maryam Fouladi (Medical Director of Neuro-Oncology, Cincinnati Children s Research ) Dr. Stewart Goldman (Medical Director of Neuro-Oncology, Lurie Children s Hospital of Chicago) Tim Hayden (DIPG Collaborative Steering Committee member; Founder of The Jeffrey Thomas Hayden Foundation) Dr. Trent Hummel (Assistant Professor, Cincinnati Children s Research ) Dr. John Perentesis (Director of Oncology, Cincinnati Children s Research ) Medical Advisory Council Dr. Gavin Baumgardner (The Cure Starts Now Medical Advisory Council Chairman) Pat Adams (The Cure Starts Now Alabama Chapter Director) Dr. Alberto Bronsicer (Associate Professor, St. Jude Children s Research Hospital) Dr. Shana Coley (Chief Resident of Anatomic Pathology, Columbia University Medical ) Dr. James Geller (Associate Professor of Clinical Pediatrics, Cincinnati Children's ) Dr. Stewart Goldman (Medical Director of Neuro-Oncology, Gus Foundation Chair Neuro-Oncology, Lurie Children s Hospital of Chicago) Dr. Nicholas Joseph Gottardo (Consultant Pediatric Oncologist & Senior Research Fellow, Princess Margaret Hospital for Children and Telethon Institute for Child Health Research, Perth, Australia) Dr. Daniel McPherson (Organic Chemistry and Biochemistry, Section Head of Radiochemistry, Private Drug Company) Dr. Roger J. Packer (Senior Vice President, for Neuroscience and Behavioral Medicine; Director, Brain Tumor Institute; Director, Daniel and Jennifer Gilbert Neurofibromatosis Institute, Children's National Medical ) 1 - dipg symposium schedule (2)

2 Thursday - May 2, 2013 Time Subject Location Attendees 5:00-8:30 pm PLANNING COMMITTEE AND SPONSOR DINNER Dinner at restaurant ending with dessert/welcoming TBD and CSN Offices By Invitation Only Cost: orientation at The Cure Starts Now offices Covered by sponsor SHUTTLE TRANSPORTATION PROVIDED FROM LOBBY AT PROMPTLY 4:30PM Friday - May 3, 2013 Time Subject Location Attendees 7:15-7:45 am MEET FOR TRAVEL SERVICE IS ONLY PROVIDED Marriott Kingsgate All PROMPTLY DURING TIMES AS LISTED (hotel is located within 5 blocks of meeting location for those that wish to walk) Hotel Lobby 7:15-8:00 am Continental Breakfast Cincinnati Children s All S1.203 and S :00-8:20 am Welcome and Introductions Dr. Maryam Fouladi (Medical Director of Neuro- Oncology, Cincinnati Children s Research Hospital Medical ) Keith Desserich (DIPG Collaborative Steering Committee member; Co-Founder and Chairman of The Cure Starts Now Foundation) Dr. John Perentesis (Director of Oncology, Cincinnati Children s Research ) Dr. Stewart Goldman (Medical Director of Neuro- Oncology, Gus Foundation Chair Neuro-Oncology Lurie Children s Hospital of Chicago) Dr. Gavin Baumgardner (The Cure Starts Now Medical Advisory Council Chairman) Dr. Trent Hummel (Assistant Professor, Cincinnati Children s Research ) 8:20-8:50 am Keynote Dr. Nada Jabado (Associate Professor, McGill University Health, Montreal, Canada) S1.203 and S1.204 Sponsored by All 8:50-9:20 am Review of current funded research Preclinical and Translational Moderated by Dr. Gavin Baumgardner Eliminating Therapy Resistant Diffuse Intrinsic Pontine Gliomas with Oncolytic Picorna Virus SVV- 001: an in vivo Study in Intra-brain Stem Xenograft Mouse Models Dr. Xiao-Nan Li (Associate Professor, Baylor College of Medicine) 2 - dipg symposium schedule (2)

3 9:20-9:50 am Preclinical Evaluation of Systemic and Direct Delivery of a PDGFR-Alpha Antibody Dr. Oren Becher (Assistant Professor, Duke University) 9:50-10:20 am Rapid Preclinical Development of a Targeted Therapy Combination for DIPG Dr. Michelle Monje-Deisseroth (Assistant Professor, Neurology and Neurological Sciences, Stanford School of Medicine) 10:20-10:35 am BREAK 10:35-11:05 am Review of current funded research Preclinical and Translational Moderated by Dr. Gavin Baumgardner Establishment and Characterization of Renewable S1.203 All Tissue Resources for Diffuse Intrinsic Pontine Glioma Research Dr. Suzanne Baker (Co-Leader, Neurobiology and Brain Tumor Program, St. Jude Children s Research Hospital) 11:05-11:35 pm Preclinical Evaluation of Novel BMI---1 Inhibitors in S1.203 All vivo in Intra-Brainstem Orthotopic Xenograft Mouse Models Dr. Patricia Baxter (Instructor of Pediatrics, Baylor College of Medicine) 11:35-12:05 pm A Combinatorial Approach to Target Cellular S1.203 All Subpopulations in Diffuse Intrinsic Pontine Glioma Dr. Michelle Monje-Deisseroth (Assistant Professor, Neurology and Neurological Sciences, Stanford School of Medicine) 12:05-1:00 pm LUNCH 1:00-1:30 pm Review of current funded research Clinical Moderated by Dr. Gavin Baumgardner Phase I Study of Tumor-Targeting Convection- Enhanced Delivery (CED) of Radio Immunotherapy for Diffuse Pontine Glioma in Children Dr. Mark Souweidane (Vice Chair Department of Neurological Surgery, Weill Cornell Medical College) 1:30-3:00 pm DIPG Registry Application and Results Dr. Maryam Fouladi (Medical Director of Neuro-Oncology, Cincinnati Children s Research ) Dr. Dannis G. van Vuurden (Consultant Pediatric Oncologist, VU Cancer Amsterdam) Dr. Chris Jones (Leader, Glioma Team, The Institute of Cancer Research, Sutton, England) Dr. Lili Miles (Associate Professor, Cincinnati Children s ) Dr. Timothy Hassall (Senior Staff Specialist, Royal Children s Hospital, Brisbane, Australia) Dr. Ute Bartels (Associate Professor, Sick Kids Hospital, Canada) 3:00-3:15 pm BREAK 3:15-3:45 pm Biological Update for DIPG Dr. Cynthia Hawkins (Associate Professor, Department of Laboratory Medicine and Pathobiology, The Hospital for Sick Children) 3 - dipg symposium schedule (2)

4 3:45-4:45 pm Optional Tour and Introduction to Cincinnati Children s Hospital This is for families, foundations and chapters to see the exciting research and facilities of CCHMC. Cincinnati Children s Meeting outside of S1.203 Families / 3:45-4:05 pm Support for Existing DIPG Diagnoses Moderated by Dr. Stewart Goldman Quality of Life S1.203 and S1.204 Oncology Dr. Jin-Shei Lai (Professor, Feinberg School of Medicine at Northwestern University) 4:05-4:25 pm Palliative Care Dr. Norbert Weidner (Medical Director, Pediatric Palliative Care, Cincinnati Children s ) 4:25-4:45 pm Xerecept Dr. Stewart Goldman (Medical Director of Neuro-Oncology, Gus Foundation Chair Neuro- Oncology, Lurie Children s Hospital of Chicago) 5:45-9:30 pm NETWORKING DINNER Reservation only, space limited S1.203 and S1.204 Oncology S1.203 and S1.204 Oncology Moerlein Lager All House Cost: Doctors and Researchers - $0 Sponsoring - $0 Others - $70 per person SHUTTLE TRANSPORTATION PROVIDED FROM LOBBY AT PROMPTLY 5:45 PM 4 - dipg symposium schedule (2)

5 Saturday - May 4, 2013 Time Subject Location Attendees 7:15-8:30 am MEET FOR TRAVEL SERVICE IS ONLY PROVIDED Marriott Kingsgate All PROMPTLY DURING TIMES AS LISTED (hotel is located within 5 blocks of meeting location for those that wish to walk) Hotel Lobby 7:15-8:30 am Continental Breakfast Cincinnati Children s S1.203 and S1.204 All 8:00-8:45 am The Next Step: DIPG Registry Discussion and Planning Dr. Maryam Fouladi (Medical Director of Neuro- Oncology, Cincinnati Children s Research Hospital Medical ) Keith Desserich (DIPG Collaborative Steering Committee member; Co-Founder and Chairman of The Cure Starts Now Foundation) CLOSED SESSION THIS SESSION ONLY OPEN TO REGISTRY PARTICIPANTS 8:45-9:15 am European DIPG Modeling Dr. Dannis G. van Vuurden (Consultant Pediatric Oncologist, VU Cancer Amsterdam) 8:00-8:15 am DIPG Collaborative Objectives The Next 2 Years Keith Desserich (DIPG Collaborative Steering Committee member; Co-Founder and Chairman of The Cure Starts Now Foundation) 8:15-8:30 am Overview of DIPG Collaborative Dr. Trent Hummel (Assistant Professor, Cincinnati Children s Research ) 8:30-9:15 am Structure of DIPG Collaborative Jonathan Agin (DIPG Collaborative Steering Committee member; Co-Director Washington DC Chapter The Cure Starts Now Foundation) Tim Hayden (DIPG Collaborative Steering Committee member; Founder of The Jeffrey Thomas Hayden Foundation) 9:15-9:30 am BREAK S1.203 DIPG Registry Participants 9:30-10:00 am Existing Research Clinical Moderated by Dr. Stewart Goldman Overview of Current Trends Dr. Darren Hargrave (Consultant Pediatric Oncologist, Great Ormond Street Hospital for Children, London, England) 10:00-10:30 am Biopsy Study Dr. Mark Kieran (Director of Pediatric Neuro- Oncology, Dana-Farber Cancer Institute) 10:30-11:00 am Vaccine Study Dr. Ian Pollack (Chief, Pediatric Neurosurgery, Children s Hospital of Pittsburgh) 5 - dipg symposium schedule (2)

6 11:00-11:10 am Q&A SESSION 9:30-11:10 am Collaborative Efforts and Successful Research Moderated by Jonathan Agin and Tim Hayden Dr. Oren Becher (Assistant Professor, Duke University) Dr. Katherine Warren (Head, Pediatric Neuro- Oncology Section, National Cancer Institute) 11:10-11:40 am Perspectives on Biopsy Moderated by Dr. Maryam Fouladi European Biopsy Perspective Dr. Darren Hargrave (Consultant Pediatric Oncologist, Great Ormond Street Hospital for Children, London, England) 11:40-12:10 pm North American Perspective Dr. Mark Kieran (Director of Pediatric Neuro- Oncology, Dana-Farber Cancer Institute) 11:10-12:10 pm Private Foundational Role in Collaboratives Moderated by Jonathan Agin and Tim Hayden 12:10-12:40 pm Optional Tour of CCHMC Gene and Viral Vector Therapy This is for families, foundations and chapters to see the exciting research and facilities of CCHMC. Cincinnati Children s All Meeting outside of S1.203 and returning for shortened lunch. 12:10-1:15 pm LUNCH All 1:15-2:15 pm Planned Unstructured Discussion and Unresolved Questions Moderated by Dr. Stewart Goldman and Dr. John Perentesis 1:15-1:30 pm How We Find a Cure Moderated by Jonathan Agin and Tim Hayden John Mackintosh (Co-Director Massachusetts Chapter, The Cure Starts Now Foundation) 1:30-2:15 pm Planned Unstructured Discussion and Unresolved Questions Moderated by Jonathan Agin and Tim Hayden 2:15-2:30 pm BREAK 2:30-3:00 pm DIPG Collaborative and Consortium International Development Dr. Katherine Warren (Head, Pediatric Neuro- Oncology Section, National Cancer Institute) 6 - dipg symposium schedule (2)

7 5:00 10:30pm The Cure Starts Now Foundation Once in a Lifetime Gala Duke Energy Convention and Grand Ballroom Semi-formal attire / VIP Cocktail and Dinner Join over 1,000 other foundations, res supporters at one of the most innovative and fastest growing charity galas in the area. In the gala s sixth year, we welcome a circus theme, complete with a three ring circus of incredible auctions, decadent food and extraordinary entertainment by the Cincinnati Circus and special guest, "King of the Highwire" Nik Wallenda, most famous for his walk over Niagara Falls last summer. This is not a year to be missed! Cost: Doctors, Res Symposium provided by private donation Others - $120 per person, space limited to 1,200 attendees SHUTTLE TRANSPORTATION PROVIDED FROM LOBBY AT 5:00 PM. RETURNS TO HOTEL AT 11:00 PM. Additional breakout rooms at discretion of facilitators may be used. They are located at S Questions? jennifer.gault@thecurestartsnow.org ** Schedule is subject to change. 7 - dipg symposium schedule (2)