INDEX. surgpath.theclinics.com. Note: Page numbers of article titles are in boldface type. diffuse pleural fibrosis, pleural plaques,

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1 INDEX Note: Page numbers of article titles are in boldface type. A Adenocarcinoma, minimally invasive. See Minimally invasive adenocarcinoma (MIA). Airway-centered interstitial fibrosis, ALK (anaplastic large-cell lymphoma kinase) gene, in adenocarcinomas, in non-small cell lung carcinoma, 77 translocaton partners in, 76 Allergic angiitis and granulomatosis. See Churg-Strauss syndrome (allergic angiitis and granulomatosis). Asbestosis, asbestos bodies in, counting by light microscopy, ferruginous, 115, 119, 120 formation of, morphology of, clinical perspective on, 114 differential diagnosis of, vs. interstitial penumonias, 121 vs. mixed-dust pneumoconiosis, 123 vs. silicosis, fibrosis in, , 125 grade 4, 114, 117 gross features of, honeycomb changes in, , 117 pleural plaques, 114 traction bronchiectasis, 114 histologic grading of, fibrozing process in, 115, 117 microscopic features of, alveolar duct fibrosis, asbestos bodies, , 125 fibroblastic foci, 116, 118 in bronchioles, 115, 117 interstitial pneumonia vs., 116, 118 morphologic, peribronchiolar fibrosis, mineral analysis in, electron microscopic, 120 light microscopic, 120 role of, in asbestosis-induced pathology, pitfals in, 125 Asbestos-related lung disease, mineralogy of asbestos and, amosites in, chrysotile, crocidolite in, neoplastic, lung cancer, malignant mesothelioma, nonneoplastic, asbestosis, benign pleural effusion, Surgical Pathology 3 (2010) doi: /s (10) /10/$ see front matter ª 2010 Elsevier Inc. All rights reserved. B diffuse pleural fibrosis, pleural plaques, Benign mesothelial cell proliferation, diagnosis of, 103 malignant melaoma vs., Bevacizumab (Avastin), contraindication to, in small cell carcinoma, in nonsquamous cell lung cancer, 75 Bronchiolitis, acute, 174 acute and chronic, causes of, 175 chronic, causes of, 176 histologic pattern in, constrictive, follicular, Bronchiolitis obliterans. See Constrictive bronchiolitis. Bronchiolitis obliterans organizing pneumonia (BOOP). See Organizing pneumonia with intraluminal polyps. Bronchioloalveolar carcinoma and minimally invasive adenocarcinoma, 1 26 Bronchioloalveolar carcinoma (BAC) diagnosis of, prognosis in, with multifocal GGO lung nodules, mucinous, aspiration biopsy of, 18 20, differential diagnosis of, 22 microscopic features of, 16 17, 22 vs. colloiod adenocarcinoma, 18, 22 vs. mucinous-producing mixed subtype adenocarcinoma, 11, 17 nonmucinous, See also Nonmucinous bronchioloalveolar carcinoma (BAC). vs. minimally invasive adenocarcinoma, C Carcinoid pulmonary tumor(s), atypical, differential diagnosis of, gross features of, necrosis in, 32, 38 vs. metastatic breast carcinoma, 36, WHO definition of, 32, typical, bone formation in, 30, 34 differential diagnosis of, fibrovascular stroma in, 30, 33 surgpath.theclinics.com

2 202 Index Carcinoid (continued) gross features, 29 microscopic features of, 30, nests and trabeculae in, 30, 33 neuroendocrine cell hyperplasia in, nuclear chromatin in, 30, 32, 34 35, 36, 40 spindle cell features in, 35 stroma in, 30, 34 tumorlets in, 34, 39 vs. medullary carcinoma of thyroid, vs. metastatic breast carcinoma, vs. thyroid primary, 43 WHO criteria for, 32 with spindle cell features, 30, 35 Churg-Strauss syndrome (allergic angiitis and granulomatosis), 155, characterization of, differential diagnosis of, key points in, 161 microscopic features of, 161 allergic granuloma, 161, 163 eosinophilic pneumonia, 162 prognosis in, Constrictive bronchiolitis, D Diffuse alveolar hemorrhage with capillaritis, differential diagnosis of, disorders associated with, 156, key points in, 164 pigmented macrophages in, smoking-associated, 168 pitfal in, 168 siderophages associated with hemorrhage and, Diffuse panbronchiolitis, Diffuse pleural thickening, gross appearance of, G Gefitinib, for bronchioalveolar carcinoma, 75 targeted therapy for lung cancer with EGFR mutations, 75 H Hypersensitivity pneumonitis, air trapping in, airway-centered chronic interstitial inflammation in, 192, 195 antigens in, 187, 189 biopsy diagnosis of, causes and examples of, 189 centrilobular nodules in, 190 classification of, criteria for, 188 differential diagnosis of, vs. lymphoid interstitial pneumonitis, 194 vs. nonspecific interstitial pneumonitis, 194 vs. sarcoidosis, 194, 197 vs. usual interstitial pneumonitis, 194 high-resolution computed tomography in, 188, histologic evaluation of, 197 honeycombing in, 190, 191 interstitial fibrosis in, 193 interstitial non-necroizing granulomas in, 192, 196 key features of, 188 microscopic features of, multifocal ground glass opacities in, organizing pneumonia in, 192, 196 pathogenesis, prognosis, and treatment of, predictors of, 188 radiologic and pathologic findings in, traction bronchiectasis in, 190, 192 E EGFR, assessment of, 72 genetic mutations in, 72 FISH amplification and, targeted agents against, 75 immunohistochemistry of, in lung adenocarcinomas, Erlotinib, for bronchioalveolar carcinoma, 75 targeted therapy for lung cancer with EGFR mutations, 75 Extrinsic allergic alveolitis. See Hypersensitivity F Follicular bronchiolitis, peribronchiolar lymphoid hyperplasia in, 176 I Idiopathic bronchiolocentric idiopathic pneumonia, Interstitial lung disease, airway-centered fibrosis, 183 hypersensitivity See Hypersensitivity peribronchiolar metaplasia-related, 183 L Large cell neuroendocrine carcinoma (LCNEC), combined small cell and large cell, differential diagnosis of, gross features of, 48 groups of, 47 microscopic features of, 48

3 Index 203 nests of cells, 49 on neuroendocrine immunohistochemical stain, WHO diagnostic criteria for, Lung cancer, asbestos-related, 124 cumulative exposure or dose correlates in, mineral analysis in, 125 fibrosis-cancer hypothesis in, 124 incidence of, 71 targeted therapies for. See Targeted therapies. tobacco asbestos synergy and, year survival rate in, 71 Lung carcinoma, staging problems in. See Staging problems. Lymphoid and plasma cell infiltrates, evaluation of, histologic features of, 131 inflammatory pseudotumor minicking marginal zone lymphoma, larger B-lymphoid cells in, vs. Burkitt lymphoma, vs. diffuse B-cell lymphoma, larger T-lymphoid cells in, lymphoid follicles in, FISH for, 132 follicular lymphoma vs., , immunohistochemical staining for, in marginal zone B-cell lymphoma, 130 molecular diagnostic studies of, 133 reactive, nodular reactive, 129 plasmacytic differentiation of cytoplasmic immunoglobulin light chain restriction in, 136 for distinction between reactive and neoplastic infiltrates, , identification and evaluation of, , immunohistochemistry for, , 143 in situ hydridization in, reactive, 129 small B-lymphoid cells in, neoplasms of, vs. chronic lymphocytic leukemia/small lymphocytic lymphoma, vs. follicular lymphoma, 139, vs. mantle cell lymphoma, vs. marginal zone lymphoma, 139, 141, small T-lymphoid cells in, vs. lymphomatoid granulomatosis, vs. T-cell non-hodgkin lymphoma, M Malignant mesothelioma (MM), asbestos-related, causes of, characterization of, 83 cytologic features of, 101 diagnosis of, , 123 antibody panels in, calretinin positivity in, epithelial mesenchymal transition in, 104 histopathologic patterns in, 101 homozygous deletions in, keratin positivity in, pitfalls in, 104 pleural biopsies in, 101 differential diagnosis of, 89, adenocarcinoma and, 97 histopathologic feature of, 101 immunohistochemical markers in, 101, GLUT-1, 94, in biphasic mesothelioma, lymphohistiocytic variant, 101 morphologic features in, 95, 98 pleural biopsy and cytomorphologic assessment, 94 95, 97 sarcomatous mesothelioma, synovial carcinoma, biphasic and monophasic, vs. adenocarcinoma, vs. benign mesothelial proliferation, vs. epitheilioid hemangioendothelioma, vs. metastatic adenocarcinoma, 95, 97 98, 101 gross features of, local spread in, 84 mesothelial cells and, 85 pleural thickening in, tumor nodules in, histopathologic features in, incidence of, key features of, 84 link with asbestos, 121 microscopic features of, adenomatoid pattern in, 87 bland looking mesothelial cells, 85, 87 cuboidal morphology, deciduoid cells in, 86, 90 desmoplastic, 87, 92 histologic types of, in biphasic, 87, 90 in sarcomatous, 84, 87, myxoid stroma in, 90 osteoid metaplasia, 92 small cell variant, 86, 88 tubulopapillary/adenoid pattern in, 86, 89 tubulopapillary pattern, well-differentiated pleural mesothelioma, 84, 87, 93 pleural, histologic patterns and differential diagnosis of, 90 prognosis in, 105 vascular endothelial growth factor in, 105 Mesothelioma, well-differentiated pleural. See Well-differentiated pleural mesothelioma (WDPM).

4 204 Index Mesothelioma proliferation, benign and malignant, See Benign mesothelial cell proliferation; Malignant myeloma (MM). Microscopic polyantiitis (MPA), characterization of, 163 clinical features of, 164, 166 diffuse alveolar hemorrhage with capillaritis and, 166 Minimally invasive adenocarcinoma (MIA), 20, as diagnosis of exclusion, 20 22, 24 as new concept, 23 lepidic growth pattern in, 8, 20 microscopic features of, papillary adenocarcinoma and, 21, 24 vs. bronchioalveolar carcinoma, 24 N Necrotizing sarcoid granulomatosis (NSG), characterization of, 163 areas of necrosis in, 165 vasculitic component, 165 vs. infection, 163 Nonmucinous bronchioloalveolar carcinoma (BAC) cell types in, 3 diagnosis of, aspiration biopsy in, adenocarcinoma with BAC features, of pulmonary nodule, sclerosing hemangioma, 14, 16 core biopsy in, adenocarcinoma with BAC features in, 9 13 atypical pneumocyte proliferation in, 10 11, 15 sclerosing hemangioma and, cytologic, frozen section in, histologic examination in, 8 18 differential diagnosis of, 4 8 gross features of, 1 2 histologic appearance, columnar, 3 4 cuboidal, 3, 5 hobnail, 4 5 key features of, 2 lepidic growth pattern in, 2, 5 microscopic features of, 2 4 vs. atypical adenomatous hyperplasia, 5 8 vs. papillary adenocarcinoma, 5 7 vs. peribronchiolar metaplasia, 7 9 vs. pulmonary adenocarcinoma, 5, 7 vs. well-differentiated pulmonary adenocarcinoma, 4 5 Nonsquamous small cell lung cancer (NSCLC), bevacizumab (Avastin) for, O Obliterative bronchiolitis. See Constrictive bronchiolitis. Organizing pneumonia with intraluminal polyps, causes of, 180 differential diagnosis of, microscopic features of, polypoid granulation tissue in, 179 P Panbronchiolitis, diffuse, Peribronchiolar metaplasia, 172 differential diagnosis of, microscopic features of, vs. atypical adenomatous hyperplasia, 173 Peribronchiolar metaplasia-related interstitial lung disease, 183 Pleural effusion, benign, asbestos-related, Pleural fibrosis. See Diffuse pleural thickening. Pleural plaques, asbestos exposure and, 112, 114 characterization of, Pleural thickening, diffuse, Pneumonitis, hypersensitivity. See Hypersensitivity Pulmonary neuroendocrine tumor(s), carcinoid, atypical, 28 29, 32, typical, frozen section diagnosis of, artifacts in, pitfalls in, large cell neuroendocrine carcinoma, small biopsy diagnosis of, application of criteria for small cell lung carcinoma, crush artifact and, 52, 56 Ki-67 labeling in, 52 pitfalls in, 27, 50 54, 56 small cell carcinoma, WHO classification of, R Respiratory bronchiolitis-associated interstitial lung disease (RBILD), microscopic features of, mild lymphocytic bronchiolar infiltrate in, 181 pigmented macrophages, S Small airways disease, airway-centered interstitial fibrosis/peribronchiolar metaplasia, 183 bronchiolitis, acute, 174 acute and chronic, chronic, constrictive, follicular, conditions primary to, 172 definition of, pathological, 172 diffuse panbronchiolitis, fibrosis/idiopathic bronchiolocentric interstitial pneumonia, 183

5 Index 205 key features of, 171 organizing pneumonia with intraluminal polyps, causes of, 180 peribronchiolar metaplasia, pitfalls in, 184 secondary involvement of, 172 smoking-related, Small cell lung carcinoma (SCLC) criteria for cell size in, differential diagnosis of, gross appearance of, on surgical resection, microscopic appearance of, crush artifact in, 43, 46 extensive necrosis in, 43, microscopic features of, 41 43, 46 overview of, paraneoplastic syndromes in, 40 WHO classification of, Smoking, lung fibrosis and, Smoking related bronchiolar disease(s), diagnosis of, differential diagnosis of, microscopic features of, respiratory bronchiolitis, respiratory bronchiolitis-associated insterstitial lung disease, vs. chronic bronchiolitis, 180 vs. hypersensitivity pneumonitis, 180 Staging problems, differential diagnosis and, lymphovascular spread and, 66, 68 multiple tumor nodules and, 63, 65 66, 68 visceral pleural invasion in, gross features and, adequate sampling, 62 determination of tumor size, 62 specific measurements and, 62 surgical margins and, 62 microscopic features and, TNM pathologic descriptors, 67 TNN stage groups, tumor-node-metastasis system, changes to, 61 62, 67 visceral pleural invasion and, absent, assessment of, present, 63, T Targeted therapies, ALK abnormalities and, EGFR abnormalities and, genetic mutations in, genotype-phenotype correlations and, 75 for EGFR signaling pathway, genetic basis of, 71 in nonsquamous cell lung cancer, bevacizumab (Avastin), molecular abnormalities and, ALK, EGFR, HER-2, molecular alterations and, receptor tyrosine kinases targets, with angiogenesis inhibitors in nonsquamous small cel lung cancer, Trastuzumab (Herceptin), against HER-2 NSCLC, 78 Tumor-node-metastasis system (TNM) staging system, 61 changes to, 61 62, 67 Tumor-node-metastasis (TNM) pathologic descriptors, 67 V Vasculitis, See also named, e.g. Wegener granulomatosis. Churg-Strauss syndrome, diffuse alveolar hemorrhage syndromes, microscopic polyangiitis, necrotizing sarcoid granulomatosis, 163, 165 vasculitic syndromes of lung, 155 Wegener granulomatosis, W Wegener granulomatosis associated with diffuse alveolar hemorrhage with capillaritis, 156 clinical features of, in pulmonary disease, 156 nodules in, diagnosis of, antineutrophilic cytoplasmic antibodies in, 156 differential diagnosis of, vs. Churg-Strauss syndrome, 158 vs. granulomatosis infections, , 161 vs. lymphomatoid granulomatosis, , 162 vs. rheumatoid nodule, 158, 160 vs. vasculitic syndromes, 158 key points, 155 microscopic features of, capillaritis in, 157 geographic necrosis, 156, 158 microgranuloma in, 157, 159 necrosis with histiocytes and giant cells, 157, 159 organizing pneumonia in, 157 peribronchiolar involvement, small arteries and veins, 157, 160 pitfalls in, 160 Well-differentiated pleural mesothelioma (WDPM), microscopic features of, 84, 87, 93