UNIVERSITY OF ZAGREB SCHOOL OF MEDICINE. Plan of the course. Pharmacology. Academic year 2017/2018. prof. dr. sc. Melita Šalković-Petrišić

Transcription

1 UNIVERSITY OF ZAGREB SCHOOL OF MEDICINE Plan of the course Pharmacology Academic year 2017/2018

2 I. COURSE AIMS To give the students the understanding of pharmacokinetics and pharmacodynamics principles regulating the action of drugs in general, as well as of the particular drug classes and their prototype To give the students the necessary knowledge to the rational use of drugs, i.e. to select and prescribe appropriate medications in such a way as to maximize the desirable and minimize the undesirable effects The course should prepare students to incorporate new information and the use of new drugs into their practice in the on-coming clinical courses, as well as afterwards in their independent work In line with these aims, necessary knowledge to deal with the course should be: anatomy, biochemistry, physiology and pathophysiology, pathology and microbiology V./I. LIST OF LECTURERS AND DEPARTMENTAL TEACHING STAFF (Alphabetically) 1. Associate Professor Alenka Boban-Blagaić, Vet. Med., PhD 2. Associate Professor Nada Božina, MD, PhD 3. Research Assistant Ivan Domagoj Drmić, MD, PhD 4. Professor Marijan Klarica, MD, PhD 5. Research Assistant Ana Knezović, dipl. Ing. Mol. Biol., PhD 7. Research Assistant Ivica Matak, dipl. Ing. Mol. Biol., PhD 8. Assistant Professor Jelena Osmanović-Barilar, MD, PhD 09. Professor Predrag, MD, PhD 10. Professor Melita, MD, PhD 11. Professor Vladimir, MD, PhD 12. Associate Professor Tvrdeić Ante, MD, PhD Course co-ordinator: Professor Melita Head of Department: Professor Marijan Klarica V./II EXTERNAL ASSOCIATES: (Alphabetically) 01. Professor Zdravko, MD, PhD 02. Professor Martina Lovrić-Benčić, MD, PhD 03. Professor Antonio Juretić, MD, PhD 04. Assistant Branko Miše, MD

3 05. Professor Ivana Pavlić Renar, MD, PhD 06. Professor Mihael Skerlev, MD, PhD II. COURSE STRUCTURE Course hours: : 59 : 66 : 22 Total hours: 147 LECTURES (L) (60 hours) L1 - Introduction to Pharmacology (1) L2 - General principles of pharmacokinetics I: absorption, distribution and drug elimination (2) L3 - General principles of pharmacokinetics II: pharmacokinetics (1) L4 - Mechanism of drug action, receptors, signal transduction (2) L5 - Growth factors (1) L6 - Drug discovery and development, and regulatory issues (1) L7 - General principles of autonomic pharmacology I: drugs affecting cholinergic transmission (2) L8 - General principles of autonomic pharmacology II: drugs affecting adrenergic transmission (2) L9 - Drugs and blood brain barrier (1) L10 - Pharmacogentics (1) L11 - Antiepileptic drugs (2) L12 - Antipsychotic and antiparkinsonian drugs (2) L13 - Drugs used to treat neurodegenerative diseases (1) L14 - Drug addiction, dependence and abuse (2) L15 - Opioid drugs and analgesics (2) L16 - Drugs used to treat ishaemic heart disease (2) L17 - Antiarrhytmic drugs (2)

4 L18 - Drugs used to treat chronic heart failure (2) L19 - Antihypertensive drugs (2) L20 - Basic toxicology and principles of poisoning therapy (2) L21 - Drugs used to treat anaemia and coagulation disorders (2) L22 - General principles of diuretic drug action (1) L23 - Nonsteroidal anti-inflammatory drugs (1) L24 - Immunopharmacology (2) L25 - Drugs used to treat diabetes mellitus (2) L26 - Glucocorticoides (2) L27 - Drugs used to treat asthma and respiratory system disorders (1) L28 - Drugs used to treat peptic ulcer disease (1) L29 - Basic principles of chemotherapy (1) L30 - Sulphonamides, macrolides, fluoroquinolones (2) L31 - Penicillins and aminoglycosides (2) L32 - Principles of skin disorder pharmacology and antifungal drugs (2) L33 - Anticancer drugs (2) L34 - Antiviral agents (2) L35 - Excipients related drug adverse effects (1) L36 - Introduction to prescription writing (1) L37 - Prescription writing for tablets, injections, solutions and powders for oral and topical administration, ointments (2) SEMINARS (S) 62 hours S1 - The movement of drug molecules across cell barriers, routs of drug administration, body fluid compartments, drug metabolism, renal and biliary excretion (3) S2 - Single and two-compartment kinetic models (2) S3 - Protein targets for drug action, ion channels, G-protein coupled receptors, nuclear receptors, control of receptor expression (2) S4 - Quantitative aspects of drug-receptor interactions, types of agonists and antagonists (2) S5 - Chemical mediators (acetylcholine, biogene amines and peptides) and the autonomic nervous system (2) S6 - Muscarinic and nicotinic actions of cholinergic and anticholinergic drugs (2) S7 - Neuromuscular blocking agents, botulinum toxin (1)

5 S8 - Adrenergic agonists and antagonists, drugs that affect noradrenergic neurons (3) S9 - Anaesthetics, local anaesthetics (2) S10 - Hypnotics, anxiolytics (2) S11 - CNS stimulants, amphetamines, cocaine, cannabis, ethanol, psychotomimetic drugs (2) S12 - Antidepresents (2) S13 - Antipsychotic agents and lithium (2) S14 - Histamine and serotonine pharmacology (2) S15 - Blood and blood products (1) S16 - Inhibitors of renin-angiotensin system (2) S17 - Calcium channel antagonists and vasodilatators (2) S18 - Strategy of antihypertnesive therapy (1) S19 - Inotropic drugs (1) S20 - Statins and drugs affecting cholesterol and lipid metabolism (2) S21 - Antithrombotic drugs (2) S22 - Diuretic drugs, drugs used to treat volume, electrolyte, and acid-base disorders (2) S23 - NSAIDs, antirheumatic drugs, antigout therapy (2) S24 - Insulin, oral hypoglycaemic drugs and antiobesity agents (2) S25 - Oral contraceptives, estrogen and progesterone replacement, estrogen and progesterone antagonists, androgen replacement and antagonists (2) S26 - Thyroid hormones and drugs used in thyroid disease (1) S27 - Drugs used to treat osteoporosis and bone diseases (1) S28 - Antidiarrheal drugs, prokinetic drugs, antiemetic drugs (2) S29 - Drugs used to treat inflammatory bowel diseases (1) S30 - Tetracyclins, Macrolides, Cloramphenicol, Clindamycin (2) S31 - Cefalosporins, Monobactams, Carbapenemes, Vancomycin (2) S32 - Repetition of antibiotic therapy (2) S33 - Pharmacovigilance (1) S34 - Herbal drugs, alternative medicine (1) S35 - Vitamin deficiencies and/or toxicities (1) PRACTICALS (P) 22 hours P1 - Pharmacokinetic practicum (2) P2 - Principles of agonist-antagonist effects in the smooth muscle in vitro (3)

6 P3 - Antinociceptive effects of opiod analgesics in experimental models (2) P4 - Effects of psychopharmacologic agents in experimental models (2) P5 - NO pharmacology (2) P6 - Cardiovascular practicum (3) P7 - Pharmacology in specific populations; paediatric and geriatric pharmacology, pregnancy and lactation (2) P8 - Prescription writing (3) P9 - Drug interactions (integrated pharmacology) (3) Short Qiuzes (Q): 4 hours Q1 - General pharmacology Q2 - Autonomic and central nervous system pharmacology, opioid analgesics Prescription writing test (T1): 1 hour 60 s 62 Practicals 22 Quiz 2 Prescription Writing Test 1 TOTAL 147 will take place in: Lecture hall (Department of Pharmacology) s will take place in: Lecture hall/ room (Department of Pharmacology) Practicals will take place in: room (Department of Pharmacology) Students will be informed in advance for any change in room/department location.. Introductory imicrobiology classes will be held by the teaching stuff of the Department of Microbiology at the location of the Department of Pharmacology. III. PLAN OF THE COURSE AND COURSE SCHEDULE BLOCKS OF THE COURSE Number of blocks: 1 Block number Start End

7 BLOCKS OF THE COURSE Number of blocks: 1 Block number Start End BLOCKS OF THE COURSE SHEME Block 1 Date Time Group Course hours type Theme 08:30-09:15; Introduction to Pharmacology :30-13:45; 11:30-13:45; 08:30-09:15; 11:15-12:45; 11:15-12:45; 12:00-12:45; General principles of pharmacokinetics I: absorption, distribution and drug elimination The movement of drug molecules across cell barriers, routs of drug administration, body fluid compartments, drug metabolism, renal and biliary The movement of drug molecules across cell barriers, routs of drug administration, body fluid compartments, drug metabolism, renal and biliary General principles of pharmacokinetics II: pharmacokinetics Single and two-compartment kinetic models Single and two-compartment kinetic models Pharmacokinetic practicum Pharmacokinetic practicum Mechanism of drug action, receptors, signal transduction Protein targets for drug action, ion channels, G-protein coupled receptors, nuclear receptors Protein targets for drug action, ion channels, G-protein coupled receptors, nuclear receptors Growth factors Quantitative aspects of drugreceptor interactions, types of agonists and antagonists Quantitative aspects of drugreceptor interactions, types of agonists and antagonists Teaching staff dr. sc. Ana Knezović dr. sc. Ivica Matak

8 Date Time Group Course hours type Theme :15-12:30; 13:00-15:15; 08:30-09:15; 09:30-10:15; 10:45-12:15; :15-11:00; 10:15-11:00; 11:15-13:30; 11:15-13:30; :30-09:15; 11:15-12:00; 12:15-13:45; , Principles of agonist-antagonist effects in the smooth muscle in vitro (GROUP 1) Principles of agonist-antagonist effects in the smooth muscle in vitro (GROUP 2) Drug discovery and development, preclinical trials GENERAL PHARMAC OLOGY-Q1 General principles of autonomic pharmacology I: drugs affecting cholinergic transmission C hemical mediators (acetylcholine, biogene amines ands peptides) and the autonomic nervous system C hemical mediators (acetylcholine, biogene amines ands peptides) and the autonomic nervous system Muscarinic and nicotinic actions of cholinergic and anticholinergic drugs, antiglaucoma drugs Muscarinic and nicotinic actions of cholinergic and anticholinergic drugs, antiglaucoma drugs General principles of autonomic pharmacology II: drugs affecting adrenergic transmission Neuromuscular blocking agents, botulinum toxin Neuromuscular blocking agents, botulinum toxin Adrenergic agonists and antagonists, drugs acting on adrenergic neurones Adrenergic agonists and antagonists, drugs acting on adrenergic neurones Drugs and blood barrier Anaesthetics, local anaesthetics Anaesthetics, local anaesthetics Pharmacogenetics Antiepileptic drugs Antipsychotic and antiparkinsonian drugs Teaching staff dr. sc. Ivica Matak, dr. sc. Ana Knezović, prof. dr. sc. Melita Šalković- Petrišić, dr. sc. Ivica Matak, dr. sc. Ana Knezović dr. sc. Ivica Matak dr. sc. Ivica Matak prof. dr. sc. Marijan Klarica Nada Božina Nada Božina

9 Date Time Group Course hours type Theme 12:15-13:00; :30-12:00; 10:30-12:00; 12:15-13:45; 12:15-13:45; :00-13:30; :30-12:00; 12:15-13:45; :30-09:15; 11:30-13:00; Hypnotics, anxiolytics Hypnotics, anxiolytics Antidepressants Antidepressants Drugs used to treat neurodegenerative diseases Drug addiction, dependence and abuse C NS stimulants, amphetamines, cocaine, cannabis, ethanol, psychotomimetic drugs C NS stimulants, amphetamines, cocaine, cannabis, ethanol, psychotomimetic drugs Opioid drugs and analgesics Antinociceptive effects of opioid analgesics in experimental models (GROUP 2) Antinociceptive effects of opioid analgesics in experimental models (GROUP 3) Antipsychotic agents and lithium Antipsychotic agents and lithium, Effects of psychopharmacologic agents in experimental models (GROUP 2) Effects of psychopharmacologic agents in experimental models (GROUP 1) AUTONOMIC AND C ENTRAL NERVOUS SYSTEM PHARMAC OLOGY, OPIOID ANALGESIC S-Q2 Histamine and serotonin pharmacology Nada Božina Nada Božina, dr. sc. Ivica Matak, dr. sc. Ana Knezović dr. sc. Ivica Matak, dr. sc. Ana Knezović, prof. dr. sc. Vladimir Nada Božina prof. dr. sc. Marijan Klarica, dr. sc. Ivan Domagoj Drmić dr. sc. Ivan Domagoj Drmić, prof. dr. sc. Marijan Klarica Histamine and serotonin pharmacology dr. sc. Ana Knezović Drugs used to treat chronic heart failure Drugs used to treat ishaemic heart disease Teaching staff

10 Date Time Group Course hours type Theme 12:00-13:30; :15-11:00; 10:15-11:00; 11:30-13:00; :15-13:00; 12:15-13:00; :15-09:00; 08:30-10:45; 09:15-10:45; 11:15-12:00; 11:15-13:30; 12:15-13:00; :30-09:15; NO pharmacology NO pharmacology Antiarrhytmic drugs Blood and blood products Blood and blood products Antihypertensive drugs Inhibitors of renin-angiotensin system Inhibitors of renin-angiotensin system C alcium channel antagonists, vasodilatators C alcium channel antagonists, vasodilatators Strategy of antihypertensive therapy Strategy of antihypertensive therapy Inotropic drugs C ardiovascular practicum Inotropic drugs Statins and other drugs affecting cholesterol and lipid metabolism C ardiovascular practicum Statins and other drugs affecting cholesterol and lipid metabolism Drugs used to treat anaemia and coagulation disorders Antithrombotic drugs Teaching staff, dr. sc. Ana Knezović, dr. sc. Ivica Matak Martina Lovrić- Benčić dr. sc. Ivan Domagoj Drmić, dr. sc. Ivan Domagoj Drmić, Nada Božina

11 Date Time Group Course hours type Theme :30-09:15; 11:15-12:00; 12:15-13:45; 12:15-13:45; :15-11:00; :00-13:30; 12:00-13:30; :30-09:15; 08:30-09:15; 09:30-10:15; 09:30-10:15; Antithrombotic drugs General principles of diuretic drug action Diuretic drugs, drugs used to treat volume, electrolyte, and acid-base disorders Diuretic drugs, drugs used to treat volume, electrolyte, and acid-base disorders Nonsteroidal antiinflammatory drugs NSAIDs, antirheumatic drugs, antigout drugs NSAIDs, antirheumatic drugs, antigout drugs Basic toxicology and principles of poisoning therapy Pharmacology in specific populations: paediatric and geriatric pharmacology, pregnancy and lactation Pharmacology in specific populations: paediatric and geriatric pharmacology, pregnancy and lactation Immunopharmacology Drugs used to treat diabetes mellitus Insulin and oral hypoglycaemic drugs Ivana Pavlić-Renar Insulin and oral hypoglycaemic drugs dr. sc. Ana Knezović Glucocorticoides Oral contraceptives, estrogen, progesterone and androgen replacement/antagonizing drugs Oral contraceptives, estrogen, progesterone and androgen replacement/antagonizing drugs Thyroid hormones and drugs used in thyroid disease Thyroid hormones and drugs used in thyroid disease Drugs used to treat osteoporosis and bone metabolism diseases Drugs used to treat osteoporosis and bone metabolism diseases Teaching staff Alenka Boban Blagaić Alenka Boban Blagaić dr. sc. Ana Knezović Alenka Boban Blagaić

12 Date Time Group Course hours type Theme 10:30-11:15; :30-09:15; 11:15-12:00; 11:15-12:00; :30-09:15; 11:30-13:00; 11:30-13:00; MEF Mašek MEF Mašek 12:15-13:45; MEF Mašek MEF Mašek MEF (C) - Šercer 10:15-11:00; MEF (C) - Šercer 08:30-09:15; MEF Mašek 08:30-09:15; MEF Nova vijećnica 09:30-10:15; MEF Mašek 10:30-12:00; MEF Mašek Drugs used to treat asthma and respiratory system disorders Drugs used to treat peptic ulcer disease Antidiarrheal drugs, prokinetic drugs, antiemetic drugs Antidiarrheal drugs, prokinetic drugs, antiemetic drugs Drugs used to treat inflammatory bowel diseases Drugs used to treat inflammatory bowel diseases Basic principles of chemotherapy Sulphonamides, macrolides, fluoroquinolones Tetracyclines, Macrolides, C loramphenicol, C linamycin Tetracyclines, Macrolides, C loramphenicol, C linamycin Penicillins and aminoglycosides C ephalosporins, Monobactams, C arbapenemes, Vancomycin (GROUP 1) C ephalosporins, Monobactams, C arbapenemes, Vancomycin (GROUP 2) Principles of skin disorder pharmacology and antifungal drugs Anticancer drugs Alenka Boban Blagaić Alenka Boban Blagaić dr. sc. Ivica Matak prof. dr. sc. Mihael Skerlev prof. dr. sc. Antonio Juretić Antiviral drugs mr. sc. Branko Miše Repetition of antibiotic therapy Repetition of antibiotic therapy Pharmacovigilance Pharmacovigilance Excipient-related drug adverse effects Introduction to prescription writing Prescription writing for tablets, injections, solutions and powders for oral and topical administrations, ointments Teaching staff

13 Date Time Group Course hours type Theme Thursday Wednesday Wednesday Wednesday :30-09:15; MEF Kompjutorska učionica 08:30-10:45; MEF (C) - Šercer 09:30-10:15; MEF Kompjutorska učionica 08:30-09:15; MEF Kompjutorska učionica 08:30-10:45; MEF Mašek 09:30-10:15; MEF Kompjutorska učionica 08:30-10:45; MEF Mašek 08:30-10:45; MEF (C) - Šercer 11:00-11:45; MEF Č ačković 09:45-12:45; MEF (C) - Šercer MEF Č ačković MEF Biološka MEF Nova vijećnica MEF Nova vijećnica MEF Č ačković MEF Biološka MEF Biološka MEF Č ačković MEF Nova vijećnica 11:00-13:15; MEF Nova vijećnica 11:00-13:15; MEF Biološka 11:00-13:15; MEF Č ačković MEF Č ačković MEF Biološka Herbal drugs, alternative medicine Prescription writing Vitamin deficiencies and/or toxicities Herbal drugs, alternative medicine 1 Prescription writing Vitamin deficiencies and/or toxicities Drug interactions (integrated pharmacology) Drug interactions (integrated pharmacology) Prescription writing test Prescription writing test Teaching staff

14 Date Time Group Course hours type Theme Friday MEF Nova vijećnica MEF Nova vijećnica MEF Biološka MEF Č ačković Teaching staff BLOCKS OF THE COURSE Number of blocks: 1 Start End LOCATION A1 Department of Pharmacology, Medical School, Salata 11, Zagreb will take place in: Lecture hall (Department of Pharmacology) s will take place in: Lecture hall/ room (Department of Pharmacology) Practicals will take place in: room (Department of Pharmacology) Students will be informed in advance for any change in room/department location.. Introductory imicrobiology classes will be held by the teaching stuff of the Department of Microbiology at the location of the Department of Pharmacology. IV. EXAMINATIONS B. Types of examination and examination dates 1) Obligatory short quizzes (30 questions each): Quiz I: October 9, 2017 Quiz II: November 6, 2017 Passing is not a requirement for continuing the course attendance or for the final exam but students can earn credits (maximum 2 per Quiz) which are added to the results of the final test.

15 Quiz score 20 = 0 points Quiz score 21-25= 1point Quiz score 26-30= 2 points 2) Obligatory Prescription Writing Test Passing is required for signing up for the final exam. First term of the Prescription Writing Test is scheduled at the end of Pharmacology Course (February 15, 2018) and the other terms will be determined if needed. 2 ) Final exam: a) Prerequisites: completed course and Prescription Writing Test passed Students must have recorded attendance of ALL seminars and practicums and of 30 lecture units (7 out of 37 are allowed to be missed). All missed seminars/practicums must be compensated by colloquium while lectures must be compensated only if more than 7 are missed. b) Final Test (110 multiple choice questions) + oral Final test: passing threshold score is 66 points provided requested minimum points per topic for all 8 topics have been achieved ( 3 points in total are tolerated to be missed from the threshold minimums if the total score is 66). The topics and requested threshold minimums are presented in the table below. Credits earned in Quizzes are added to the final test score ONLY if the requested minimum points per topic have been achieved for all topics ( 3 missing points are not tolerated here) AND the final test score is 66. c) Topics: Topic Maximal points (number of questions) Minimal threshold General pharmacology 12 6 Pharmacology of the autonomic nervous system 15 8 Pharmacology of the central nervous system 14 7 Cardiovascular pharmacology 15 8 Chemotherapeutic drugs 16 8 Antiinflammatory drugs; Immunosuppressant drugs; Drugs used to treat diseases of the blood 14 7

16 Drugs used to treat diseases of the gastrointestinal 12 6 and urogenital tract Endocrine drugs; Drugs used to treat respiratory system disorders 12 6 total 110 d) Terms: Regular terms Date Winter February 15, 2018 Summer July 4, 2018 July 18, 2018 Autumn September 3, 2018 September 12,, 2018 September 21, 2018 Additional term ONLY for generation 2016/2017 and below December 18, 2017 VI. LIST OF EXAMINERS 01. Associate Professor Alenka Boban-Blagaić, Vet. Med., PhD 02. Professor Marijan Klarica, MD, PHD 03. Senior Assistant Jelena Osmanovic-Barilar, MD, PhD 04. Professor Predrag, MD, PhD 05. Professor Melita, MD, PhD 06. Associate Professor Vladimir, MD, PhD 07. Associate Professor Tvrdeić Ante, MD, PhD

17 V./I. LIST OF LECTURERS AND TEACHING STAFF Alenka Boban Blagaić 3. Nada Božina 4. dr. sc. Ivan Domagoj Drmić 5. prof. dr. sc. Marijan Klarica 6. dr. sc. Ana Knezović dr. sc. Ivica Matak Martina Lovrić-Benčić 14. prof. dr. sc. Antonio Juretić 15. prof. dr. sc. Mihael Skerlev 16. mr. sc. Branko Miše 17. Ivana Pavlić-Renar V./II EXTERNAL ASSOCIATES: V./III UNTENURED LECTURERS:

18 VI. LITERATURE VII. LITERATURE A. Obligatory 1. Basic & Clinical Pharmacology, BG Katzung, A Trevor (eds). 13st McGraw Hill Companies, New York, Pharmacology Mannual, 1st edition, V. Bradamante, M. Klarica, M. Salkovic-Petrisic (eds), Medicinska naklada, Zagreb, 2010.