Recording ac0vity in intact human brain. Recording ac0vity in intact human brain
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1 Recording ac0vity in intact human brain Recording ac0vity in intact human brain BIONB 4910 April 8, 2014 BIONB 4910 April 8, 2014 Objec0ves: - - review available recording methods EEG and MEG single unit recording PET fmri - - discuss strengths and limita0ons of fmri in par0cular Recording ac0vity in intact human brain EEG and MEG Electroencephalogram (EEG) and magnetoencephalogram (MEG) are safe and simple, but can only iden0fy mass ac0on of many neurons and have low spa0al resolu0on. EEG also clinically useful for iden0fying stages of sleep, diagnosing brain death, etc. BIONB 4910 April 8, 2014 Animal studies can yield informa0on on sensory and motor systems, and even simple memory tasks, but to learn about more complex mental states we must study the human brain. Above all techniques must be safe. 1
2 Electrodes for single unit recordings in intact human brain Positron emission tomography: PET Tradi0onal physiology is possible using pa0ents in mid- brain surgery, and has yielded exci0ng results, but it is difficult to recruit subjects and they will all have disease states. - - tracks gamma rays from a radionucelo0de tracer - - different tracers can scan for glucose metabolism, neurotransmiver binding, etc. - - poor spa0al and temporal resolu0on, requires exposing subject to tracers, tracers difficult to work with Func0onal magne0c resonance imaging: fmri Nuclear magne0c resonance (NMR) When nuclei are immersed in a stable magne0c field, those nuclei with a non- zero spin have a magne0c moment and tend to align themselves with the sta0c field. As the nuclei are exposed to a second, oscilla0ng field (RF), when the oscilla0ng field changes the nuclei are perturbed and then relax back into alignment. During relaxa0on, they emit RF radia0on characteris0c of the nuclei and their environment. 2
3 Sta0c magne0c resonance imaging (MRI) BOLD fmri MR at the resonance frequency for 1 H in water to take sta0c 3- D pictures of living organism. Different so_ 0ssues have sufficiently large differences in relaxa0on rates that the algorithm can dis0nguish between them. Blood flows rapidly to brain areas with increased energy use. The blood oxygena0on level dependent (BOLD) contrast measures the oxygena0on level of hemoglobin and acts as a surrogate signal for neuronal ac0vity. Seiji Ogawa First fmri without exogenous contrast agents BOLD fmri So where do the colored blobs come from? Blood flows rapidly to brain areas with increased energy use. The blood oxygena0on level dependent (BOLD) contrast measures the oxygena0on level of hemoglobin and acts as a surrogate signal for neuronal ac0vity. From hvp:// 3
4 Six painful problems for fmri: 1. Indirect measurement of neuronal ac0vity 2. Low temporal resolu0on Problem 1: fmri is an indirect measurement of neuronal ac0vity All fmri operates on the assump0on that the brain is organized in func0onal modules that map onto brain regions. 3. Low spa0al resolu0on 4. Comparisons between individuals 5. Comparisons over 0me 6. Sta0s0cs and analysis Logothe0s 2008 One voxel typically contains millions of neurons, billions of synapses, and kilometers of axons and dendrites. Increased neuronal ac0vity does not necessarily represent increased net excitatory ac0vity in that brain area. Problem 2: fmri has low temporal resolu0on Problem 3: fmri has low spa0al resolu0on It depends on the strength on the magne0c field, with a minimum of about 1 mm for most applica0ons (~0.5 mm has been claimed). Lowest magne0c field strength for fmri ~ 1.5 T, which yields about 5 mm resolu0on. Human study maximum is 4 T. Smoothing further reduces resolu0on. Logothe0s et all 2001 fmri is only as fast as blood flow- - hemodynamic delay of seconds. 4
5 Problem 4: Comparisons between individuals are challenging fmri data must be transformed to map onto an ideal brain to compensate for differences in anatomy. Individual differences in anatomy and fmri ac0vity do not necessarily translate into differences in func0on individual varia0on is high, and even gross abnormali0es can actually be compensatory. Problem 5: Comparisons over 0me are very challenging The test- retest reliability of fmri is fairly low the average overlap between single tests of the same subject 1 hour apart is about 33%, and gets lower the longer the interval. Why? - - minimal number of scans, low field strength, poorly op0mized equipment lead to high SNR (fixable) - - neuromodula0on and aven0on have strong BOLD signal (not so fixable) Reliability depends greatly on the experimental design; motor and sensory tasks are the most repeatable, cogni0ve and emo0onal least Aging and illness can effect numerous func0onal and anatomical changes Real brain Corrected brain Damaged but func0onal brain Normal brain Problem 6: Sta0s0cal models are challenging The sta0s0cs involved in large data sets can become prohibi0vely complex, and spurious correla0ons can crop up in studies even from experienced inves0gators. Solving problem 1 (proxy signal): Decoding- - a bever way to use fmri for mind reading Earlier fmri strategy: simple subtrac0on method Generally, results are presented as a voxelwise level of significance Univariate: compare a par0cular voxel between trials or individuals Mul0variate: compare voxels recorded at many loca0ons simultaneously BenneV et al These problems are NOT specific to fmri studies they arise in many data- heavy fields. 5
6 Solving problem 1 (proxy signal): Decoding- - a bever way to use fmri for mind reading Earlier fmri strategy: simple subtrac0on method Solving problem 1 (proxy signal): Decoding- - a bever way to use fmri for mind reading Most recent decoding strategies can par0ally reconstruct images shown to subjects, predict decision making, and predict whether a subject will believe a statement with above- chance accuracy. Newer strategy: analyze many more voxels, try to iden0fy widely distributed representa0ons of s0muli Gallant lab, UC Berkeley Basic problem for all neuroscience: it s difficult to study any neural ac0vity without either a clear input (sensory) our output (motor). Background ac0vity is extremely variable for all types of tasks, but is par0cular problem for more complex and abstract tasks. Is there any way to help control for background variability? Basic problem for all neuroscience: it s difficult to study any neural ac0vity without either a clear input (sensory) our output (motor). Background ac0vity is extremely variable for all types of tasks, but is par0cular problem for more complex and abstract tasks. Is there any way to help control for background variability? Simultaneous compe0ng tasks Sleep imagery Use the physiological state of sleep to create a control background ac0vity in the brain Can t perform tasks while you re asleep, but you can dream. 6
7 Words in red extracted as significant visual aspects of the scene Polysom- nography fmri Take Awaken three subject for scans of verbal selected descrip0on of brain hallucina0on regions (~ 9 seconds) Horikawa et al Horikawa et al Apply mul0variate decoder to same sleep fmri scans, give a yes/no answer as to whether a par0cular synset is present. Six painful problems for fmri: Are we any closer to solving them? 1. Indirect measurement of neuronal ac0vity Some progress 2. Low temporal resolu0on NO 3. Low spa0al resolu0on Some progress, may be nearing the wall 4. Comparisons between individuals NO 5. Comparisons over 0me Some progress Horikawa et al Apply mul0variate decoder to same sleep fmri scans, give a yes/no answer as to whether a par0cular synset is present. 6. Sta0s0cs and analysis Considerable progress It s a very impressive leap for fmri, but as a mind- reading technique it s not very effec0ve. 7
8 Summary - - there are mul0ple techniques for studying ac0vity in the human brain, all of which have significant limita0ons - - applying the right technique is cri0cal for success - - fmri studies require the best experimental design to maximize reliability and reproducibility 8
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