PROGRAM RNA VIRUS PERSISTENCE MEETING: MECHANISMS AND CONSEQUENCES. AUGUST 23-25, 2018 Institute of Virology, Medical Center - University of Freiburg

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1 PROGRAM RNA VIRUS PERSISTENCE MEETING: MECHANISMS AND CONSEQUENCES AUGUST 23-25, 2018 Institute of Virology, Medical Center - University of Freiburg

2 WELCOME Mechanisms and consequences of RNA virus persistent infections: It is generally assumed that following acute infection RNA viruses are effectively cleared by the immune system. However, an increasing number of observations indicate that the majority of acute infections can result in the establishment of persistent infection. Many of these infections undergo undetected and the consequences for their animal and human hosts are not well understood. Furthermore, the emergence and re-emergence of infectious diseases may be determined by persistent infections in the human community as well as in wild and domestic animal populations, potentially increasing the zoonotic potential of some viruses. Establishing persistent infection likely involves a number of molecular, cellular and immunological determinants, including the genetics of the viruses, the genetics of their hosts and potential new host species, and many environmental factors, such as other microorganisms. The purpose of this two-day conference is bringing together scientists working on many different viruses to address and extensively discuss underlying general and specific questions concerning the mechanisms and consequences of persistent RNA virus infections with an emphasis on zoonotic aspects. Organizing committee: Prof. Dr. Martin Schwemmle Institute of Virology Medical Center - University of Freiburg Dr. Dennis Rubbenstroth, PhD Friedrich-Loeffler-Institut Federal Research Institute for Animal Health Prof. Raul Andino Microbiology and Immunology University Clinic San Francisc

3 DAY 1 - THURSDAY, AUGUST 23, :00 Registration & snacks 13:00 Schwemmle/ Andino Opening remarks Session I - Chairs: Conzelmann/Griffin 13:20 Bergmann CNS viral persistence: When T cells retire, B cells move in 13:55 Pinschewer Humoral immune defense and evasion in persistent viral infection 14:30 Snijder Arteriviruses: new names, old tricks 15:05 Reuther Visualization and characterization of non-cytolytic clearance of LCMV-infected cells during persistent viral infection 15:20 Coffee break Session II - Chairs: Kochs/Weber 16:05 Becker Regulation of filovirus transcription/replication 16:40 Lee Emerging paramyxoviruses: diversity and danger? 17:15 Randall Phosphorylation of the P protein of PIV5 facilitates establishment of persistent infections 17:30 Rima Nucleotide sequence stability of measles virus in persistent infection and undiluted passage 17:45 Poster session (Snacks and drinks) 19:45 Freiburg tour by foot (optional) 3

4 DAY 2 - FRIDAY, AUGUST 24, 2018 Session III - Chairs: Pietschmann/Stäheli 08:30 Cadwell Virust-Host Interactions and the Gut Microbiota 09:05 Baldridge Regulation of persistent enteric norovirus infection by the commensal microbiota 09:40 Lohmann Contribution innate immune responses to persistence versus clearance of hepatitis C virus and hepatitis A virus infections 09:55 Coffee break Session IV - Chairs: Haller/Stertz 10:40 Carpentier Improved HCV infection of stem cell-derived hepatocytes allows analysis and modulation of the cellular antiviral innate immune response 10:55 Tautz Alternative protein interactions as switch between RNA replication and virion morphogenesis lessons learned from a persisting RNA virus 11:30 Thiel Illuminating the coronavirus replicase: a platform for virus-host interactions 12:05 Lunch break (Networking with PIs) 4

5 DAY 2 - FRIDAY, AUGUST 24, 2018 Session V - Chairs: Briese/Rubbenstroth 14:05 Tomonaga Roles of non-coding RNAs from endogenous bornavirus-like elements in Borna disease virus infection 14:40 Beer Zoonotic Bornaviruses: From Persistence to Lethal Infection 15:15 Ensser Severe encephalitis caused by Borna disease virus 1 (BoDV-1) 15:30 Bourgade Molecular and cellular mechanisms underlying the neuroprotective properties of Bornavirus X protein 15:45 Coffee break Session VI - Chairs: Bergmann/Randall 16:30 Griffin Characterization of alpha virus persistence in the CNS 17:05 Conzelmann Protein kinase R is the key player in rabies virus cytotoxicity 17:40 Valarcher Gene signatures associated with foot-and-mouth disease virus infection and persistence. Part I: Model of Persistent FMDV infection in a three-dimensional model of the bovine soft palate 17:55 Eschbaumer Gene signatures associated with foot-and-mouth disease virus infection and persistence. Part II: Transcriptomic analysis 18:10 Poster session 20:00 Dinner (Barbeque at the Institute) 5

6 DAY 3 - SATURDAY, AUGUST 25, 2018 Session VII - Chairs: Beer/Hengel 09:00 Andino Chronic infection as an evolutionary driving force determining lifespan setpoints 09:35 Schmidt- Chanasit The role of viral persistance in human arbovirus infections 10:10 Kemming Characterization of the HEV-specific CD8+ T-cell response in acute and chronic Hepatitis E virus infection 10:25 Coffee break 10:55 Müller Exploring the role of viral persistence in context of reservoir host species 11:30 Palacios The Egyptian rousette genome reveals unexpected features of the bat innate and adaptive immune response 12:05 Schwemmle/ Andino Final Discussion 12:45 Schwemmle/ Andino Closing remarks End of Meeting 6

7 WITH THE KIND SUPPORT OF: THANKS TO OUR SPONSORS: GOLD SPONSOR: SILVER SPONSORS: All payments of our sponsors are disclosed on the following web: CONGRESS INFORMATION Martin Schwemmle Institute of Virology Medical CenterUniversity Freiburg CONTACT CONVENER Melanie Springmann Stabsstelle Unternehmenskommunikation Medical CenterUniversity Freiburg fon Stand nach Drucklegung: Redaktion: Universitätsklinikum Freiburg CCI Layout: Universitätsklinikum Freiburg Medienzentrum 7

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