Virus-host interactions
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1 Virus-host interactions - Strategies viruses use to replicate their genomes in susceptible host cells replication - Strategies viruses use to move their genomes throughout susceptible host plants cell-to-cell movement - Strategies viruses use to suppress host defenses
2 Little Cherry Plant viruses cause many different symptoms Vein-banding Tissue Deformation Necrosis Flower Breaking
3 Virions of plant viruses Rigid rod Icosahedral/ spherical Flexuous rod
4 Plant virus classes
5 Genes encoded by Tobacco mosaic virus
6 Viral Pathogenesis Within the plant, viruses must complete three major steps in order to infect a susceptible plant host. Infection of single cells Cell-to-cell movement Long-distance movement Replication Replication Movement to adjacent cells Replication Movement to adjacent cells Movement to cells throughout the plant
7 Early steps in plant virus infection Huang et al Curr. Opin. Virol.
8 Roles of host factors in (+) RNA virus replication Huang et al Curr. Opin. Virol.
9 Assembly of viral replication complexes Mine and Okuno Curr. Opin. Virol.
10 Virus movement After the virus replicates it has to be able to move to new cells and new tissues/organs in order to systemically infect Infection of single cells Cell-to-cell movement Long-distance movement Replication Replication Movement to adjacent cells Replication Movement to adjacent cells Movement to cells throughout the plant
11 General view of virus cell-to-cell and long-distance movement Hipper et al Front. Plant Sci.
12 Steps in cell-to-cell movement Cell-to-cell movement 1) Viruses need to leave sites of replication 2) Viruses need to locate the plasmodesmata 3) Viruses need to pass through plasmodesmata Viral encoded movement proteins (MPs) facilitate these steps. Most MPs are Multifunctional. Replication Movement to adjacent cells 1) MPs are required for movement 2) MPs bind to virus genomes 3) MPs interact with plant cytoskeleton 4) MPs localize to plasmodesmata 5) MPs gate plasmodesmata
13 Genes encoded by Tobacco mosaic virus
14 Replication and early steps in movement Hyodo et al Front. Plant Sci.
15 Plasmodesmata Lucas Virology. 344:
16 Structure of plasmodesmata and comparison to viral particles
17 Model for trafficking through plasmodesmata Lucas Virology. 344:
18 Model for TMV movement Lucas Virology. 344:
19 Proposed accumulation and movement pathway for TMV Liu and Nelson Front. Plant Sci.
20 Suppression of host defenses Successful pathogens overcome innate host defense responses by targeting signaling, defense gene expression, or defense gene function. - Suppression of RNA silencing - Breaking through or breaking down physical or biochemical barriers - Suppression (or modulation) of basal defense - Suppression (or modulation) of (HR cell death)
21 The RNA silencing pathways innate resistance to viruses RNA silencing is logically an antiviral defense mechanism Small RNAs corresponding to viruses can be found in infected tissues Mutation of RNA silencing components can lead to increased virus infection Viruses must protect themselves against this degradation pathway
22 Plant antiviral RNA silencing Waterhouse (2006) Science 313:54-55
23 Anti-viral RNA silencing and its suppression by plant viruses Incarbone and Dunoyer Trends Plant Sci.
24 Tombusvirus P19 is a silencing suppressor Scholthof (2006) Nat. Rev. Microbiol.
25 Antiviral RNA silencing: defense and counter defense Incarbone and Dunoyer Trends Plant Sci.
26 Perturbation of mirna pathways to enhance resistance or viral pathogenesis Incarbone and Dunoyer Trends Plant Sci.
27 Can virus infection be beneficial? Roossinck PLoS Pathog.
28 New overlapping viral ORFs Chung et al PNAS. 105:5897 Ling et al Virology 446:397
29 Summary - Plant viruses encode proteins that direct the replication and movement of their genomes - Viral replication occurs in association with host membranes and host factors - Viral movement is directed by movement proteins that serve many functions: binding the viral genome transporting the viral genome to plasmodesmata gating plasmodesmata trafficking through plasmodesmata - RNA silencing an antiviral defense plant viruses encode suppressors of RNA silencing RNA silencing suppressors function by a variety of mechanisms
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