Determinants of elimination and persistence of hepatitis viruses

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1 PROGRAM Symposium of the Research Unit 1202 Mechanisms of persistence of hepatotropic viruses : Determinants of elimination and persistence of hepatitis viruses May 19th May 21st 2014 German Cancer Research Center Heidelberg, Germany Sponsored by

2 Symposium of the Research Unit 1202 Symposium Chairs: Prof. Dr. Ralf Bartenschlager Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital; Research Division Virus-associated Carcinogenesis, German Cancer Research Center Heidelberg; German Centre for Infection Research (DZIF e.v.) Prof. Dr. Robert Thimme Department of Internal Medicine II, University Hospital Freiburg Prof. Dr. Ulrike Protzer Institute of Virology, TU München/ Helmholtz Zentrum München; German Centre for Infection Research (DZIF e.v.) Conference Language: The conference language will be English. Organizing Committee: Prof. Dr. Ralf Bartenschlager Prof. Dr. Robert Thimme Prof. Dr. Ulrike Protzer Dr. Sandra Bühler Dr. Antje Reuter Contact: Sandra Bühler Heidelberg University Hospital Im Neuenheimer Feld 345 D Heidelberg Tel.: Fax: sandra_buehler@med.uni-heidelberg.de

3 3 Dear Colleagues, It is a great pleasure to welcome you to the second symposium of the research unit Mechanisms of persistence of hepatotropic viruses (FOR 1202). Given the success and the very positive feed-back from the participants in the course of the last meeting, we decided to organize this symposium again in While keeping the primary thematic focus, we have expanded the scope by integrating novel aspects such as systems biology of the immune response and live cell / in vivo imaging. The symposium is intended to bring together clinicians and basic scientists that are united by their interest in the mechanisms utilized by hepatitis viruses to escape innate and adaptive immune responses and thus, to establish persistence. The topic is at the interface of virus host interactions, and therefore includes in addition to immunology a substantial amount of cell biology and molecular virology. In the light of this interdisciplinarity, a main mission of the symposium is to foster collaborations and interactions in a relaxed and rather informal atmosphere. We would like to thank all our sponsors for their generous support of the symposium, which would not be possible without their help. We are also very grateful to the German Cancer Research Center in Heidelberg for hosting this meeting. Most important is the contribution of all the speakers and chairpersons, whom we thank very much for taking their time out of busy schedules and their active participation. Finally, we thank you all for coming to Heidelberg and we wish you an exciting and productive meeting as well as a pleasant stay. Prof. Dr. Ralf Bartenschlager Prof. Dr. Ulrike Protzer Prof. Dr. Robert Thimme

4 Symposium of the Research Unit 1202 Determinants of elimination and persistence of hepatitis viruses DKFZ Heidelberg, May 19th May 21st 2014 Monday, May 19th :00-11:10 Prof. Dr. Ralf Bartenschlager Welcome address Adaptive Immune Response Chairman: PD Dr. Christoph Neumann-Haefelin 11:10 11:40 Prof. Dr. Barbara Rehermann New insights into protective immunity in HCV infection 11:40 12:05 Prof. Dr. Percy Knolle Consequences of local antigen presentation in the liver for intrahepatic immunity 12:05 12:35 Prof. Dr. Antonio Bertoletti The impact of age on HBV-specific T cell response 12:35 12:55 PD Dr. Christoph Neumann-Haefelin (FOR1202) Viral escape in HBV infection 13:00 14:00 LUNCH 14:00 14:25 Prof. Dr. Marcus Altfeld T and NK cell responses in chronic viral infection: lessons learned from HIV 14:25 14:45 Prof. Dr. Robert Thimme (FOR1202) HCV-specific CD8+ T cell restoration in patients undergoing IFN-free antiviral therapy 14:45 15:10 Dr. Bijan Raziorrouh The role of CD4+ T cells in viral hepatitis 15:10 15:35 Dr. Tobias Böttler Follicular T helper cells in viral hepatitis

5 5 15:45 16:15 COFFEE BREAK Vaccine Development and Antiviral Therapy against HCV Chairman: Prof. Dr. Ulrike Protzer 16:15 16:45 Prof. Dr. Matti Sällberg Current state of HCV vaccine development 16:45 17:15 Dr. Mirjam Zeisel Targeting host entry factors for prevention and treatment of HCV infection 17:15 17:40 Prof. Dr. Christoph Eisenbach Pathogenesis and therapy of hepatitis viral reinfection after LTx 17:40 18:10 Prof. Dr. Darius Moradpour Treatment of chronic hepatitis C - From virus discovery to oral combination therapy in 25 years 18:10 18:35 Dr. Christoph Welsch Clinical relevance of HCV-DAA resistance 18:35 21:00 GET TOGETHER (open to all participants) Foyer Conference Center DKFZ Tuesday, May 20th 2014 Innate Immunity Chairman: PD Dr. Volker Lohmann 09:00 09:25 Dr. Andreas Pichlmair The proteome under viral attack 09:25 09:50 Dr. Georg Gasteiger Help and control: Interactions of adaptive and innate lymphocytes 09:50 10:15 Prof. Dr. Jacob Nattermann Role of NK cells in the immunopathogenesis of HCV

6 Symposium of the Research Unit :15 10:45 COFFEE BREAK 10:45 11:15 Prof. Dr. Paul Klenerman CD161+/MAIT cells and the liver 11:15 11:35 PD Dr. Volker Lohmann (FOR1202) Determinants of interferon-gamma response 11:35 11:55 Prof. Dr. Ralf Bartenschlager (FOR1202) Virological and immunological mechanisms of HCV persistence 11:55 12:20 Prof. Dr. Mathias Heikenwälder Inflammation dependent and independent pathways in virally induced liver pathogenesis 12:30 13:30 LUNCH Basic and Applied Aspects of Hepatitis Virus Therapy Chairman: Prof. Dr. Robert Thimme 13:30 13:55 Prof. Dr. Michael Manns Therapy of HBV infection and HBV co-infection 13:55 14:20 Prof. Dr. Ulrike Protzer Control of HBV infection by immune mediators 14:20 14:45 Prof. Dr. Heiner Wedemeyer Immunopathogenesis and therapy of hepatitis delta 14:45 15:15 Prof. Dr. Markus Heim HCV and the IFN system: a clinical perspective 15:15 15:45 Prof. Dr. Rune Hartmann The interferon lambda 4 paradox; highly antiviral yet a disadvantage during HCV infection 15:45 16:15 COFFEE BREAK

7 7 Mouse Models for Hepatitis Viruses Chairman: Prof. Dr. Michael Nassal 16:15 16:40 Prof. Dr. Maura Dandri Chimeric mice to study determinants affecting persistence of hepatitis B and D viruses 16:40 17:10 Prof. Dr. Alexander Ploss Construction of humanized mouse models for hepatitis C Evolution and Species Barrier Chairman: Prof. Dr. Stephan Urban 17:10 17:25 PD Dr. Dieter Glebe Bat hepadnaviruses: the origin of hepatitis B virus? 17:25 17:40 Dr. Stefan Seitz A novel virus family shedding light on the long-term evolution of hepatitis B viruses 17:40 18:05 Prof. Dr. Thomas Pietschmann Control of HCV replication in mouse liver cells by innate immune signaling 19:00 SPEAKERS DINNER Wednesday, May 21st 2014 Viral Replication, Modeling and Imaging Chairman: Prof. Dr. Ralf Bartenschlager 10:15 10:35 Prof. Dr. Stephan Urban (FOR1202) Role of HBV X protein in cccdna formation 10:35 10:55 Prof. Dr. Michael Nassal (FOR1202) Role of the cellular repair machinery in HBV cccdna formation 10:55 11:20 Dr. Marco Binder A mathematical approach to understand HCV replication dynamics

8 Symposium of the Research Unit :30 12:00 COFFEE BREAK 12:00 12:25 Prof. Dr. Thomas Höfer Molecular determinants of virus-host cell population dynamics 12:25 12:45 Prof. Dr. Ursula Klingmüller (FOR1202) Addressing the multi-factorial impact on viral persistence by integrative dynamic pathway modeling 12:45 13:15 Prof. Dr. Matteo Iannacone Determinants of intrahepatic effector CD8+ T cell trafficking and antigen recognition 13:15 FAREWELL AND LUNCH

9 Conference Venue: Communication Center, DKFZ Heidelberg Im Neuenheimer Feld Heidelberg 9

10 Symposium of the Research Unit 1202 How to find the DKFZ: By Car: a) Because of the limited number of parking areas in the Neuenheimer Feld, it is recommended to arrive by public transport. b) Approaching Heidelberg on Autobahn A5 from Frankfurt or Karlsruhe, change to Autobahn A656 from direction Mannheim at the junction Heidelberger Kreuz. Continue on Autobahn A 656 to Heidelberg, which ends at the Heidelberg City limits. As you enter the city of Heidelberg, follow the signs Eberbach/HD-Wieblingen/Chirurgie : Turn left at first traffic light, then right at second. Follow the curve at the next light. Underpass the Neckar Bridge, then turn right twice heading for Chirurgie/DKFZ. Having crossed the Neckar River, take the left lane at the first intersection and head for Chirurgie/DKFZ. Follow this street to the next intersection. Do NOT turn left and drive through the gate, as indicated by DKFZ-signs (it s a checkpoint)! Drive straight ahead instead. To the right there are (charged) parking lots where you can park your car. From the car park walk back to the gate and pass it. Follow the street for about 100 meters. The German Cancer Research Center is the tall building on the right (for your orientation, you can find the house numbers on the top of each building; DKFZ has 280). Go straight ahead along the building, until you can see the main entrance on the right. In the entrance hall please contact the information desk for further help. By Tramway or bus from the main station: Tramway: Take the north exit (Kurfürstenanlage) of the central station to the tram stop. Take tram number 24 with terminus Burgstr., or tram number 21 with terminus OEG-Bahnhof. With both lines, leave at stop Jahnstraße/Chirurgie (right after the Neckar bridge). Cross the street to the left and walk into Jahnstrasse. Follow that street until you reach the gate on the left. Pass the gate and walk into Kirschnerstrasse. About 100 meters down the road you will see the DKFZ main building. Bus: Take bus number 32 with the terminus Neuenheim, Kopfklinik and leave at stop Uni Campus. Walk a few meters back and turn left. You will see the DKFZ conference center on the right. Get together (open to all) The get together will take place in the foyer of the DKFZ conference center after the last talk on Monday, May 19th. All participants are welcome to attend. Speakers Dinner: Burggasthof Strahlenburg Schriesheim Burgweg Schriesheim We have organized a bus transfer to the restaurant. Details for departure will be given during the symposium.

11 NOTES 11

12 Symposium of the Research Unit 1202 IMPRINT Publisher Department of Infectious Disease, Molecular Virology Heidelberg University Hospital Im Neuenheimer Feld Heidelberg Editorial Dr. Sandra Bühler Department of Infectious Disease, Molecular Virology Heidelberg University Hospital Im Neuenheimer Feld Heidelberg Design and Layout Print + Medien Im Zentralbereich Neuenheimer Feld Im Neuenheimer Feld Heidelberg printplusmedien@znf.uni-heidelberg.de Last revised: April

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