CURRICULUM VITAE. P.O Box , Yaya Centre, Nairobi-Kenya Ext (Office) (Cell).

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1 CURRICULUM VITAE PERSONAL DETAILS. Name Nationality Contact Address Joshua A. Nyagol. Kenyan. P.O Box , Yaya Centre, Nairobi-Kenya. Tel Ext (Office) (Cell). FORMAL EDUCATION. Oct Oct PhD, Medical Biotechnology (Quantitative & Molecular Diagnostic Pathology) - University of Siena- Italy. Apr Advanced Immunology for Oncologists-European School of Oncology (ESO), Ascona-Switzerland. Oct Jan Molecular and Cell Biology - Witwatersrand University/ South African Institute of Medical Research (SAIMR)/NHLS BSc. - Egerton University, Kenya. 1

2 Other courses: Dec Human Research Curriculum for Human Subjects Research. Ohio State University. Ref No (CITI Collaborative Institutional Training Initiative) SYSTAT statistical program for data analysis- University of Siena Computer literacy - Dataease Softwares and Computer Training College, Nairobi- Kenya. WORK EXPERIENCE To date- Lecturer, Dept. Human Pathology, University of Nairobi Honorary lecturer, The Aga Khan University Hospital, Nairobi-Kenya 2006-To date-coordinates Collaborative and linkage Research programs in Molecular Diagnostic Pathology at the department of Human Pathology, University of Nairobi Ass. Lecturer, Dept. Pathology and Human Oncology, University of Siena, Siena-Italy Laboratory based experimental research on the Carcinogenic and angiogenic roles of HIV-1 Tat protein; at the department of Anatomical Pathology and Human Oncology, University of Siena Research on prevalence of Her-2/neu in breast cancers, at The Nairobi Hospital, Nairobi- Kenya; supported by The Roche Products Ltd research grants, Nairobi. 2

3 Other responsibilities: 2006/2008: Organizing Committee member for the organization of the International conference on Burkitt s lymphoma and related lymphoproliferative disorders ( Participated in update of both scientific program as well as financial support requests for the participants from Africa from the sponsors of the conference. WORKSHOPS AND CONFERENCES ATTENDED: 2 nd -4 th June, Tropical and infectious Diseases Control, workshop on curriculum review for MSc program. Naivasha, Kenya. 25th-27 th February, International conference on Burkitt lymphoma and related lymphoproliferative disorders. Kampala, Uganda. 13 th -15 th May, International workshop on soft tissue tumor genetics. University of Siena 16 th -18 th April, International workshop on monoclonal-antibody based cancer therapy; ESO, Ascona, Switzerland. 13 th -15 th June, International workshop on cancer vaccines. University of Siena. Achievements Establishment and strengthening of collaboration for the research on HIV positive and AIDS associated malignancies between: -the department of Human Pathology, University of Siena-Italy leoncinil@unisi.it -Institute of Pathology, Campus Benjamin Franlin, Charitè University of Medicine, Berlin, Germany (herald.stein@charite.de). -Dept. Human Pathology, University of Nairobi Research based proof (with publication), for the inclusion of Her-2/neu gene assessment as a routine diagnostic test alongside estrogen and progesterone receptors in breast cancer patients presenting at The Nairobi hospital pathology/laboratory department; Nairobi-Kenya. The project was supported by Roche Products Research Grants in Nairobi-Kenya. 3

4 PUBLICATIONS. 1. Leucci E, Onnis A, Cocco M, Costanzo V, Cerino G, Mannuci S, Castisani R, Nyagol J, Mwanda W, Iriso R, Schurfeld K, Bellan C, Leoncini L. B cell differentiation in EBVpositive Burkitt Lymphoma is impaired at post-transvriptional level by mirna altered expression. Int J. Cancer [PMID : ] 2. Leucci E, Cocco M, Onnis A, van Cleef P, Bellan C, van Rijk A, De Falco G, Nyagol J, Byakika B, Lazzi S, Tosi P, van Krieken J, Leoncini L. MYC-negative classical Burkitt s Lymphoma cases: an alternative pathogenetic mechanism involving mirna deregulation. [J Pathol. PMID : ] 3. Nyagol J, DeFalco G, Shahin S, Bellan C, Spina D, Lazzi S, Leoncini L. HIV-1 Tat mimetic of VEGF correlates with increased micro vessel density in diffuse large B-cell and Burkitt s lymphomas. (J.Hematopath, DOI /s z). 4. De Falco G, Leucci E, Lenze D, Piccaluga PP, Claudio PP, Onnis A, Cerino G, Nyagol J, Mwanda W, Bellan C, Hummel M, Pileri S, Tosi P, Stein H, Giordano A, Leoncini L. Gene expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt's lymphoma cell lines and primary tumors. (Blood. 2007; 110(4):1301-7). 5. Nyagol J, Leucci E, DeFalco G. et al. The Effects of HIV-1 Tat Protein on Cell Cycle during Cervical Carcinogenesis [Cancer Biol Ther. 2006,5 (6):684-90] 6. Nyagol J, Nyong o A, Byakika B, et al. Routine assessment of hormonal receptor and Her- 2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancer. [J.of AQCH 2006, 28(2):97-103]. 7. Bellan C, Lazzi S, Hummel M, Palummo N, de Santi M, Amato T, Nyagol J, Sabattini E, Lazure T, Pileri SA, Raphael M, Stein H, Tosi P, Leoncini L. Immunoglobulin gene analysis reveals two distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas. (Blood. 2005; 106(3):1031-6). 4

5 ABSTRACT PRESENTATIONS; PUBLISHED. 1. Giulia De Falco, Cerino G, Leucci E, Nyagol J, et al. Role of chromatin remodelling mediated by the HIV-1 TAT protein in the genesis of HIV-associated malignancies. J. Haematopathology, 2008; Vol.1: Nyagol J, De Falco G, Palummo N, et al. HIV-1 TAT mimetic of VEGF correlates with increased micro vessels density in AIDS-related diffuse large B-cell and Burkitt s lymphomas. J. Haematopathology, 2008; Vol.1: Leucci E, Cocco M, Onnis A, van Cleef P, Bellan C, van Rijk A, De Falco G, Nyagol J, Byakika B, et al. C-MYC negative classical Burkitt lymphoma: alternative pathogenetic mechanisms. J. Haematopathology, 2008; Vol.1: Carugi, A. Onnis, M. Cocco, J. Nyagol, G. Cerino, S. Shaheen, et al. Chlamydia infection and the development of the ocular adnexal lymphomas. J. Haematopathology, 2008; Vol.1: Nyagol J, Leucci E, DeFalco G, et al. New Insight into the effect of HIV-1 on HPV infected cells [Sept. 10 th, Paris, France] 6. De Falco G, Leucci E, P.P. Claudio, J Nyagol, A. Giordano, et al. Re- introduction of prb2/p130 reduces the proliferation rate in Burkitt s lymphoma. XII Meeting of European Society of Heamatopathology. Sept Int. Conference of Cancer: University of Thessalonika- Greece. 5

6 REFEREES. Prof. Leoncini Lorenzo, University of Siena, Department of Anatomical Pathology and Human Oncology, Via Delle Scotte 6, Siena-Italy. Tel Fax: Dr. Byakika Bessie Dept. of Pathology The Nairobi Hospital Argwings Kodhek Road P.O Box GPO Nairobi, Kenya Tel Fax: Prof. Harald Stein, Institute of Pathology Campus Benjamin Franklin Charité University Medicine Berlin-Germany 6