Symposium in Immunology IV

Transcription

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2 M. M. Eibl C. Huber H. H. Peter U. Wahn (Eds.) Symposium in Immunology IV Allergic Diseases With 34 Figures and 14 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest

3 Prof. Dr. MARTHA M. EmL Institut fur Immunologie der UniversiHit Wien Borschkegasse 8a 1090 Wien, Austria Prof. Dr. CHRISTOPH HUBER Department of Hematology Johannes Gutenberg Universitat Langenbeckstr Mainz, Germany Prof. Dr. HANS H. PETER Abteilung fur Rheumatologie und Klinische Immunologie Medizinische Universitatsklinik Hugstetter Str Freiburg, Germany Prof. Dr. ULRICH WAHN Padiatrische Pneumologie und Immunologie Universitats-Klinikum Rudolf Virchow Standort Charlottenburg Heubnerweg Berlin, Germany ISBN-13: Library of Congress Cataloging-in-Publication Data. Symposium in Immunology (4th: 1994: Heidelberg, Germany) Symposium in Immunology IV: allergic diseaseslm.m. Eibl... let al.1 (eds). p. em. Includes bibliographical references and index. ISBN-13 :97& e-isbn-13 :97& DOl: /97& Allergy - Congresses. I. Eibl, Martha M. II. Title. III. Title: Symposium in Immunology 4. IV. Title: Symposium in Immunology four. [DNLM: 1. Immunity - congresses. 2. Hypersensitivity - congresses. 3. Immunotherapy - congresses. QW 504 S9891s 1995) RC583.2.S dc20 DNLMIDLC for Library of Congress This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting. reproduction on microfilm or in any other ways, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag Berlin Heidelberg 1995 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Best-set Typesetter Ltd., Hong Kong SPIN: /3130/SPS Printed on acid-free paper

4 Contents Basic Mechanisms Cytokines and Neuroendocrine Hormones as Mediators of Cutaneous Immunity and Inflammation T.A. LUGER and T. SCHWARZ Human Thl and Th2 Responses: Mechanisms of Polarization and Practical Implications S. ROMAGNANI The Central Role of T Cells in IgE Regulation and Bronchial Hyperreactivity - A Target for Specific Immunomodulation H. RENZ and E.W. GELFAND Regulation of B Cell Switching to IgE D. VERCELLI FceRI: Structure, Cellular Distribution, and Function D. MAURER, E. FIEBIGER, B. REININGER, and G. STINGL Molecular Genetic Studies of Atopic Allergy D.G. MARSH Allergic Inflammation Predictors and Determinants of Atopy in Childhood U. WAHN, R.L. BERGMANN, C.P. BAUER, W. DORSCH, J. FORSTER, and E. SCHMIDT Atopic Dermatitis - The Skin Manifestation of Atopy A. KAPP Inflammation in Chronic Asthma P. CHANEZ, A.M. CAMPBELL, A.M. VIGNOLA, F.-B. MICHEL, and J. BOUSQUET Allergies of the Gastrointestinal Tract S. STROBEL

5 VI Contents Immunotherapy: Possibilities and Perspectives Strategies for Indoor Allergen Elimination S. LAU-SCHADENDORF and U. WARN Effect of Immunotherapy on Humoral and Cellular Markers in Allergic Patients S. RAK, L. HAKANSON, and P. VENGE Recombinant Allergens: Basic Aspects and New Therapeutic Concepts R. VALENTA, 8. VRTALA, T. BALL, S. LAFFER, P. STEINBERGER, W.R. SPERR, P. VALENT, and D. KRAFT Perspectives of Immunological Prevention and Therapy of IgE-Mediated Allergic Diseases A.L. DE WECK Subject Index

6 List of Contributors T. BALL AKH, University of Vienna, Wahringer Giirtel 18-20, 1090 Vienna, Austria c.p. BAUER University Children's Hospital, Technical University, Miinchen, Germany R.L. BERGMANN University Children's Hospital, University Clinic Rudolf Virchow, Heubnerweg 6, Berlin, Germany J. BOUSQUET Clinic for Respiratory Diseases, Hopital Arnaud de Villeneuve, Montpellier, A.M. CAMPBELL Clinic for Respiratory Diseases, Hopital Arnaud de Villeneuve, Montpellier, P. CHANEZ Clinic for Respiratory Diseases, Hopital Arnaud de Villeneuve, Montpellier, A.L. DE WECK Allergy Research Laboratory, Gerimmun Foundation, 16, Grands Places, 1700 Fribourg, Switzerland W. DORSCH University Children's Hospital, Langenbeckstr. 1, Mainz, Germany E. FIEBIGER Division of Immunology, Allergy, and Infectious Diseases (DIAID), Department of Dermatology, University of Vienna Medical School, 1090 Vienna, Austria J. FORSTER University Children's Hospital, Mathildenstr. 1, Freiburg, Germany E.W. GELFAND National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA L. HAKANSON Asthma Research Center, Department of Clinical Chemistry, University Hospital, Uppsala, Sweden

7 VIII List of Contributors A. KAPp Department of Dermatology, University of Freiburg, Hauptstr. 7, Freiburg, Germany D.KRAFr AKH, University of Vienna, Wiihringer Gurtel 18-20, 1090 Vienna, Austria S. LAFFER AKH, University of Vienna, Wiihringer Gurtel 18-20, 1090 Vienna, Austria S. LAU-SCHADENDORF University Children's Hospital, University Clinic Rudolf Virchow, Heubnerweg 6, Berlin, Germany T.A. LUGER Department of Dermatology and Ludwig Boltzmann Institute of Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 56, Munster, Germany D.G. MARSH Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Boulevard, Baltimore, MD 21224, USA D. MAURER Division of Immunology, Allergy, and Infectious Diseases (DIAID), Department of Dermatology, University of Vienna Medical School, 1090 Vienna, Austria F.-B. MICHEL Clinic for Respiratory Diseases, H6pital Arnaud de Villeneuve, Montpellier, S.RAK Asthma Research Center, Department of Clinical Chemistry, University Hospital, Uppsala, Sweden B. REININGER Division of Immunology, Allergy, and Infectious Diseases (DIAID), Department of Dermatology, University of Vienna Medical School, 1090 Vienna, Austria H. RENZ Institut for Clinical Chemistry and Biochemistry, University Clinic Rudolf Virchow, Spandauer Damm 130, Berlin, Germany S. ROMAGNANI Division of Clinical Immunology and Allergy, University of Florence, Istituto di Clinica Medica 3, Viale Morgagni 85, Florence 50134, Italy E. SCHMIDT University Children's Hospital, Moorenstr. 5,40225 Dusseldorf, Germany

8 List of Contributors IX T. SCHWARZ Department of Dermatology and Ludwig Boltzmann Institute of Cell Biology and Immunobiology of the Skin, University of Miinster, Von Esmarch Strasse 56, Miinster, Germany W.R. SPERR Department of Hematology, AKH, University of Vienna, Wiihringer Giirtel 18-20, 1090 Vienna, Austria P. STEINBERGER AKH, University of Vienna, Wiihringer Giirtel 18-20, 1090 Vienna, Austria G. STINGL Division of Immunology, Allergy, and Infectious Diseases (DIAID), Department of Dermatology, University of Vienna Medical School, 1090 Vienna, Austria S. STROBEL Division of Clinical Sciences, Host Defence Unit, Great Ormond Street Hospital for Children NHS Trust, Institute of Child Health, 30 Guilford Street, London WC1N leh, UK P. VALENT Department of Hematology, AKH, University of Vienna, Wiihringer Giirtel 18-20, 1090 Vienna, Austria R. VALENTA AKH, University of Vienna, Wiihringer GiirteI18-20, 1090 Vienna, Austria P. VENGE Asthma Research Center, Department of Clinical Chemistry, University Hospital, Uppsala, Sweden D. VERCELU Molecular Immunoregulation Unit, DIBIT, San Raffaele Scientific Institute, Milan, Italy, and Division of Immunology, Children's Hospital/Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA A.M. VIGNOLA Clinic for Respiratory Diseases, H6pital Arnaud de Villeneuve, Montpellier, S. VRTALA AKH, University of Vienna, Wiihringer Giirtel 18-20, 1090 Vienna, Austria U. WAHN University Children's Hospital, University Clinic Rudolf Virchow, Heubnerweg'6, Berlin, Germany