Pathways conservation. Starch and sucrose metabolism. About Search Families Download Top Help! Blast Publications CBiB.

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1 Pathways conservation About Search Families Download Top Help! Blast Publications CBiB Starch and sucrose metabolism (link to KEGG) Synthetic pattern of the pathway : sckdy Reference Protein Genolevures gene families EC Number Phyletic pattern Profile Family name HXK1 (YFR053c) sckdy GLR.3217 HXK2 (YGL253w) sckdy GLR.3217 SUC2 (YIL162w) s-kdy GLR.1234 MAL32 (YBR299w) s-kd GLC.151 YGR287C (YGR287c) s-kd GLC.151 MAL12 (YGR292w) s-kd GLC.151 YIL172C (YIL172c) s-kd GLC.151 YJL216C (YJL216c) s-kd GLC.151 FSP2 (YJL221c) s-kd GLC.151 GSC2 (YGR032w) sckdy GLR.23 FKS1 (YLR342w) sckdy GLR.23 FKS3 (YMR306w) sckdy GLR.23 YHL012W (YHL012w) sckdy GLR.2246 UGP1 (YKL035w) sckdy GLR.2246 TPS1 (YBR126c) sckdy GLR.1979 TPS2 (YDR074w) sckdy GLR.1979 TSL1 (YML100w) sckdy GLR.1979 TPS3 (YMR261c) sckdy GLR.1979 GSY1 (YFR015c) sckdy GLR.110 GSY2 (YLR258w) sckdy GLR.110 PGM1 (YKL127w) sckdy GLR.2142 PGM2 (YMR105c) sckdy GLR.2142 GLK1 (YCL040w) sckdy GLR.3217 PGI1 (YBR196c) sckdy GLR.582 GLC3 (YEL011w) sckdy GLR.790 NTH2 (YBR001c) sckdy GLR.157 NTH1 (YDR001c) sckdy GLR.157 ATH1 (YPR026w) sckd GLR.1078 BSC1 (YDL037c) sckdy GLC.1 SGA1 (YIL099w) sckdy GLR.507 MUC1 (YIR019c) sckdy GLC.11 PGU1 (YJR153w) s none GPH1 (YPR160w) sckdy GLR.500 EXG2 (YDR261c) sckdy GLR.3219 BGL2 (YGR282c) sckdy GLR.3339 EXG1 (YLR300w) sckdy GLR.3219 SPR1 (YOR190w) sckdy GLR.3219 VPS8 (YAL002w) sckd GLR.1058 CDC15 (YAR019c) sckdy GLC.2 VPS15 (YBR097w) sckdy GLR.2300 DUN1 (YDL101c) sckdy GLC.2 KIN1 (YDR122w) sckdy GLC.2 SNF1 (YDR477w) sckdy GLC.2 SPS1 (YDR523c) sckdy GLC.52 YCK3 (YER123w) sckdy GLC.92 YCK1 (YHR135c) sckdy GLC.92 CTK2 (YJL006c) s-k-y GLR.2832 IME2 (YJL106w) sckdy GLC.8 PBS2 (YJL128c) sckdy GLC.52 Page 1 of 106

2 YAK1 (YJL141c) sckdy GLC.8 ELM1 (YKL048c) sckdy GLC.2 CTK1 (YKL139w) sckdy GLC.8 CTK3 (YML112w) sck GLR.1303 YCK2 (YNL154c) sckdy GLC.92 NPR1 (YNL183c) sckdy GLC.2 MCK1 (YNL307c) sckdy GLC.8 MKK1 (YOR231w) sckdy GLC.52 SSN3 (YPL042c) sckdy GLC.8 MKK2 (YPL140c) sckdy GLC.52 HRR25 (YPL204w) sckdy GLC.92 ENA5 (YDR038c) sckdy GLC.54 ENA1 (YDR040c) sckdy GLC.54 RAD3 (YER171w) sckdy GLR.3298 BRR2 (YER172c) sckdy GLC.40 SLH1 (YGR271w) sckdy GLC.40 HPR5 (YJL092w) sckdy GLR.3280 DDP1 (YOR163w) sckdy GLR.894 See detailed view Detailed view Reference Protein HXK1 (YFR053C) EC Number Annotation sp P04806 cerevisiae YFR053c HXK1 hexokinase I P4.22.f4.1 Systematic gene deletion Gene deletion effects (growth rate) 20 gen. in YPD 60 gen. YNB in YPD YPD + NaCl YP + Phyletic lactate pattern Profile viable NA NA NA NA NA sckdy Family name GLR.3217 Genolevures gene families Gene Name YALI0E15488g CAGL0A04829g DEHA0F26092g CAGL0M00682g CAGL0F00605g CAGL0B00726g YALI0E20207g Gene Annotation similar to sp P17709 Saccharomy cerevisiae YCL040w GLK1 aldohe specific glucokinase, hypothetical highly similar to sp P04807 cerevisiae YGL25 HXK2 or sp P04806 Saccharomyc cerevisiae YFR053c HXK1, similar to tr Q9C0M1 Candida albi CaNAG5 protein, hypothetical st similar to tr Q06204 Saccharomyc cerevisiae YLR446w, hypothetical highly similar to sp P17709 cerevisiae YCL04 GLK1 or Q04409 Saccharomyce cerevisiae YDR516c, by simil weakly similar to sp P17709 cerevisiae YCL04 GLK1 aldohexose specific glucokin by weakly similar to tr Q9C0M1 Cand albicans CaNAG5 protein, hypothe Page 2 of 106

3 HXK2 (YGL253W) SUC2 (YIL162W) P4.22.f4.1 sp P04807 cerevisiae YGL253w HXK2 hexokinase II P4.22.f4.1 sp P00724 cerevisiae YIL162w SUC2 invertase (sucrose hydrolyzing enzyme) singleton sp P38158 Exhibits growth defect on a fermentable carbon source Non 0.7 sckdy viable NA NA NA NA NA s-kdy GLR.3217 DEHA0F15169g KLLA0C01155g CAGL0H07579g KLLA0D11352g YALI0B22308g DEHA0E07007g YALI0E15488g CAGL0A04829g DEHA0F26092g CAGL0M00682g CAGL0F00605g CAGL0B00726g YALI0E20207g DEHA0F15169g KLLA0C01155g CAGL0H07579g KLLA0D11352g YALI0B22308g DEHA0E07007g YALI0E26719g GLR.1234 DEHA0F28468g KLLA0A10417g DEHA0E00627g highly similar to sp P50506 Debaryomyces occidentalis Hexoki (EC )., by similar to sp P17709 Saccharomy cerevisiae YCL040w GLK1 aldohe specific glucokinase, by simila highly similar to sp P04807 cerevisiae YGL25 HXK2 or sp P04806 Saccharomyc cerevisiae YFR053c HXK1, gi sp P33284 HXK_KLUL Kluyveromyces lactis HEXOKINA by highly similar to tr O74996 Yarrow lipolytica Hexokinase, hypothetical highly similar to CA0263 CaGLK Candida albicans aldohexose spec glucokinase, by similar to sp P17709 Saccharomy cerevisiae YCL040w GLK1 aldohe specific glucokinase, hypothetical highly similar to sp P04807 cerevisiae YGL25 HXK2 or sp P04806 Saccharomyc cerevisiae YFR053c HXK1, similar to tr Q9C0M1 Candida albi CaNAG5 protein, hypothetical st similar to tr Q06204 Saccharomyc cerevisiae YLR446w, hypothetical highly similar to sp P17709 cerevisiae YCL04 GLK1 or Q04409 Saccharomyce cerevisiae YDR516c, by simil weakly similar to sp P17709 cerevisiae YCL04 GLK1 aldohexose specific glucokin by weakly similar to tr Q9C0M1 Cand albicans CaNAG5 protein, hypothe highly similar to sp P50506 Debaryomyces occidentalis Hexoki (EC )., by similar to sp P17709 Saccharomy cerevisiae YCL040w GLK1 aldohe specific glucokinase, by simila highly similar to sp P04807 cerevisiae YGL25 HXK2 or sp P04806 Saccharomyc cerevisiae YFR053c HXK1, gi sp P33284 HXK_KLUL Kluyveromyces lactis HEXOKINA by highly similar to tr O74996 Yarrow lipolytica Hexokinase, hypothetical highly similar to CA0263 CaGLK Candida albicans aldohexose spec glucokinase, by sp Q12724 disrupted by Saccharom cerevisiae Invertase 2 precursor identified similar to sp P24133 Debaryomyc occidentalis invertase precursor (E ) (Beta-fructofuranosidas (Saccharase), by gi gb AAD AF0793 Kluyveromyces lactis invertase, sta similar to tr Q8J2T6 Aspergillus or Alpha-glucosidase, hypothetical s highly similar to CA3405 IPF864 Page 3 of 106

4 MAL32 (YBR299W) YGR287C (YGR287C) MAL12 (YGR292W) YIL172C (YIL172C) YJL216C (YJL216C) FSP2 (YJL221C) GSC2 (YGR032W) cerevisiae YBR299w MAL31 alphaglucosidase P7.4.f7.1 sp P53051 cerevisiae YGR287c strong to maltase P7.4.f7.1 sp P53341 cerevisiae YGR292w MAL12 alphaglucosidase of the MAL1 locus P7.4.f7.1 sp P40439 cerevisiae YIL172c identical to FSP2P and to other alphaglucosidases P7.4.f7.1 sp P40884 cerevisiae YJL216c strong to Mal62p P7.4.f7.1 sp P40439 cerevisiae YJL221c FSP2 strong to alpha- D-glucosidase P7.4.f7.1 sp P40989 cerevisiae YGR032w GSC2 1,3-beta-Dglucan synthase subunit P3.64.f3.1 - NA NA NA NA NA s-kdviable Non 0.6 s-kd- - Non Non Non ND Non s-kd- - NA NA NA NA NA s-kdviable NA NA NA NA NA s-kd- - NA NA NA NA NA s-kdviable sckdy GLC.151 DEHA0A14300g KLLA0D00231g DEHA0E00627g DEHA0A14300g GLC.151 KLLA0D00231g DEHA0E00627g DEHA0A14300g GLC.151 KLLA0D00231g DEHA0E00627g DEHA0A14300g GLC.151 KLLA0D00231g DEHA0E00627g DEHA0A14300g GLC.151 KLLA0D00231g DEHA0E00627g DEHA0A14300g GLC.151 KLLA0D00231g YALI0E21021g YALI0C01411g KLLA0B05841g CAGL0G01034g GLR.23 DEHA0C02112g CAGL0M13827g KLLA0C08888g KLLA0C14069g CAGL0K04037g highly similar to CA3405 IPF864 Candida albicans IPF8644 maltase homology), by gi emb CAB Kluyveromyces lactis maltase, star similar to tr Q8J2T6 Aspergillus or Alpha-glucosidase, hypothetical s highly similar to CA3405 IPF864 Candida albicans IPF8644 maltase homology), by gi emb CAB Kluyveromyces lactis maltase, star similar to tr Q8J2T6 Aspergillus or Alpha-glucosidase, hypothetical s highly similar to CA3405 IPF864 Candida albicans IPF8644 maltase homology), by gi emb CAB Kluyveromyces lactis maltase, star similar to tr Q8J2T6 Aspergillus or Alpha-glucosidase, hypothetical s highly similar to CA3405 IPF864 Candida albicans IPF8644 maltase homology), by gi emb CAB Kluyveromyces lactis maltase, star similar to tr Q8J2T6 Aspergillus or Alpha-glucosidase, hypothetical s highly similar to CA3405 IPF864 Candida albicans IPF8644 maltase homology), by gi emb CAB Kluyveromyces lactis maltase, star similar to tr Q8J2T6 Aspergillus or Alpha-glucosidase, hypothetical s highly similar to CA3405 IPF864 Candida albicans IPF8644 maltase homology), by gi emb CAB Kluyveromyces lactis maltase, star tr Q9UVK9 Yarrowia lipolytica glu synthase, identified similar to tr Q9UVK9 Yarrowia lipolytica Fks1p, hypothetical sta highly similar to sp P40989 cerevisiae GR032 GSC2 1, 3-beta-D-glucan syntha subunit, by highly similar to sp P40989 cerevisiae YGR03 GSC2 or sp P38631 Saccharomyc cerevisiae YLR342w FKS1, highly similar to tr O13428 Candi albicans Beta-1, 3-glucan syntha catalytic subunit 1, by simila similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3, similar to sp O13423 Candida albic Glucan synthase, by similari similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3, tr Q9P8N8 Candida glabrata 1, 3-b glucan synthase, identified star similar to sp Q04952 Saccharomy Page 4 of 106

5 FKS1 (YLR342W) FKS3 (YMR306W) YHL012W (YHL012W) sp P38631 cerevisiae YLR342w FKS1 1,3-beta-Dglucan synthase, catalytic subunit P3.64.f3.1 sp Q04952 cerevisiae YMR306w FKS3 to 1,3- beta-glucan synthases P3.64.f3.1 sp P38709 cerevisiae YHL012w to UDP Glucose pyrophosphorylase P2.308.f2.1 Exhibits growth defect on a fermentable carbon source. NA NA NA NA NA sckdy viable sckdy viable 0.4 Non Non sckdy DEHA0A07436g YALI0E21021g YALI0C01411g KLLA0B05841g CAGL0G01034g GLR.23 DEHA0C02112g CAGL0M13827g KLLA0C08888g KLLA0C14069g CAGL0K04037g DEHA0A07436g YALI0E21021g YALI0C01411g KLLA0B05841g CAGL0G01034g GLR.23 DEHA0C02112g CAGL0M13827g KLLA0C08888g KLLA0C14069g CAGL0K04037g DEHA0A07436g KLLA0F25652g DEHA0G24310g GLR.2246 YALI0A02310g CAGL0L01925g cerevisiae YMR306w FKS3 1,3-b glucan synthase, by similari tr Q9UVK9 Yarrowia lipolytica glu synthase, identified similar to tr Q9UVK9 Yarrowia lipolytica Fks1p, hypothetical sta highly similar to sp P40989 cerevisiae GR032 GSC2 1, 3-beta-D-glucan syntha subunit, by highly similar to sp P40989 cerevisiae YGR03 GSC2 or sp P38631 Saccharomyc cerevisiae YLR342w FKS1, highly similar to tr O13428 Candi albicans Beta-1, 3-glucan syntha catalytic subunit 1, by simila similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3, similar to sp O13423 Candida albic Glucan synthase, by similari similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3, tr Q9P8N8 Candida glabrata 1, 3-b glucan synthase, identified star similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3 1,3-b glucan synthase, by similari tr Q9UVK9 Yarrowia lipolytica glu synthase, identified similar to tr Q9UVK9 Yarrowia lipolytica Fks1p, hypothetical sta highly similar to sp P40989 cerevisiae GR032 GSC2 1, 3-beta-D-glucan syntha subunit, by highly similar to sp P40989 cerevisiae YGR03 GSC2 or sp P38631 Saccharomyc cerevisiae YLR342w FKS1, highly similar to tr O13428 Candi albicans Beta-1, 3-glucan syntha catalytic subunit 1, by simila similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3, similar to sp O13423 Candida albic Glucan synthase, by similari similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3, tr Q9P8N8 Candida glabrata 1, 3-b glucan synthase, identified star similar to sp Q04952 Saccharomy cerevisiae YMR306w FKS3 1,3-b glucan synthase, by similari highly similar to sp P32861 cerevisiae YKL03 UGP1 UTP--glucose-1-phospha uridylyltransferase, by simila highly similar to CAGL-IPF7445 Candida glabrata IPF , highly similar to sp P32861 cerevisiae YKL03 UGP1 UTP--glucose-1-phospha uridylyltransferase, by simila highly similar to sp P32861 cerevisiae YKL03 Page 5 of 106

6 UGP1 (YKL035W) TPS1 (YBR126C) sp P32861 cerevisiae YKL035w UGP1 UTP-- glucose-1-phosphate uridylyltransferase P2.308.f2.1 sp Q00764 cerevisiae YBR126c TPS1 alpha,alphatrehalose-phosphate synthase, 56 KD subunit P4.6.f4.1 inviable 0.3 Ess Ess 0.5 Ess sckdy Exhibits growth defect on a fermentable carbon source. 0.7 Ess Ess 0.4 Ess sckdy GLR.2246 CAGL0L01925g KLLA0F25652g DEHA0G24310g YALI0A02310g CAGL0L01925g KLLA0E11231g CAGL0J09812g CAGL0J06468g YALI0D14476g DEHA0E23210g CAGL0H02387g GLR.1979 CAGL0G05335g KLLA0B08822g YALI0E14685g DEHA0F07392g YALI0E31086g KLLA0E10120g DEHA0G13233g KLLA0E11231g UGP1 UTP--glucose-1-phospha uridylyltransferase, by simila highly similar to sp P32861 cerevisiae YKL03 UGP1 UTP--glucose-1-phospha uridylyltransferase, by simila highly similar to CAGL-IPF7445 Candida glabrata IPF , highly similar to sp P32861 cerevisiae YKL03 UGP1 UTP--glucose-1-phospha uridylyltransferase, by simila highly similar to sp P32861 cerevisiae YKL03 UGP1 UTP--glucose-1-phospha uridylyltransferase, by simila similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 alpha, a trehalose-phosphate synthase, 115 subunit, by highly similar to sp Q00764 cerevisiae YBR12 TPS1 alpha, alpha-trehalose-phosp synthase, similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 or sp P3 cerevisiae YML10 TSL1, similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a trehalose-phosphate synthase, 102 subunit, (trehalose 6-P phosphata activity), by highly similar to CA4084 CaTPS Candida albicans CaTPS1 TREHALOSE-6-PHOSPHATE SYNTHASE, by similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3alpha sp P38427 cerevis YML100w TSL1, by similar highly similar to sp P31688 cerevisiae YDR07 TPS2 alpha, alpha-trehalose-phosp synthase, gi sp Q07158 TPS1_KLUL Kluyveromyces lactis Alpha, alph trehalose-phosphate synthase [UD forming] 56 kda subunit (Trehalos phosphate synthase) (UDP-glucos glucosephosphate glucosyltransfera by sp O74932 Yarrowia lipolytica Alp alpha-trehalose-phosphate syntha [UDP-forming], identified similar to CA5505 CaTPS3.3 Cand albicans CaTPS3.3 alpha,alpha trehalose-phosphate synthase, regul subunit, 3-prime end (by homolog similar to tr Q9P918 Pichia angus Trehalose phosphate synthase subu similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a trehalose-phosphate synthase, 102 subunit, by similar to CA5066 CaTPS2 Candi albicans CaTPS2, hypothetical st similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 alpha, a trehalose-phosphate synthase, 115 subunit, by highly similar to sp Q00764 Page 6 of 106

7 TPS2 (YDR074W) TSL1 (YML100W) sp P31688 cerevisiae YDR074w TPS2 alpha,alphatrehalose-phosphate synthase, 102 KD subunit P4.6.f4.1 Exhibits growth defect on a fermentable carbon source. Ess Ess Ess 0.3 Ess sckdy sp P38427 cerevisiae YML100w TSL1 alpha,alpha- viable ND Non ND sckdy CAGL0J09812g CAGL0J06468g YALI0D14476g DEHA0E23210g CAGL0H02387g GLR.1979 CAGL0G05335g KLLA0B08822g YALI0E14685g DEHA0F07392g YALI0E31086g KLLA0E10120g DEHA0G13233g KLLA0E11231g CAGL0J09812g CAGL0J06468g YALI0D14476g DEHA0E23210g CAGL0H02387g GLR.1979 CAGL0G05335g cerevisiae YBR12 TPS1 alpha, alpha-trehalose-phosp synthase, similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 or sp P3 cerevisiae YML10 TSL1, similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a trehalose-phosphate synthase, 102 subunit, (trehalose 6-P phosphata activity), by highly similar to CA4084 CaTPS Candida albicans CaTPS1 TREHALOSE-6-PHOSPHATE SYNTHASE, by similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3alpha sp P38427 cerevis YML100w TSL1, by similar highly similar to sp P31688 cerevisiae YDR07 TPS2 alpha, alpha-trehalose-phosp synthase, gi sp Q07158 TPS1_KLUL Kluyveromyces lactis Alpha, alph trehalose-phosphate synthase [UD forming] 56 kda subunit (Trehalos phosphate synthase) (UDP-glucos glucosephosphate glucosyltransfera by sp O74932 Yarrowia lipolytica Alp alpha-trehalose-phosphate syntha [UDP-forming], identified similar to CA5505 CaTPS3.3 Cand albicans CaTPS3.3 alpha,alpha trehalose-phosphate synthase, regul subunit, 3-prime end (by homolog similar to tr Q9P918 Pichia angus Trehalose phosphate synthase subu similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a trehalose-phosphate synthase, 102 subunit, by similar to CA5066 CaTPS2 Candi albicans CaTPS2, hypothetical st similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 alpha, a trehalose-phosphate synthase, 115 subunit, by highly similar to sp Q00764 cerevisiae YBR12 TPS1 alpha, alpha-trehalose-phosp synthase, similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 or sp P3 cerevisiae YML10 TSL1, similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a trehalose-phosphate synthase, 102 subunit, (trehalose 6-P phosphata activity), by highly similar to CA4084 CaTPS Candida albicans CaTPS1 TREHALOSE-6-PHOSPHATE SYNTHASE, by similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3alpha sp P38427 cerevis YML100w TSL1, by similar highly similar to sp P31688 cerevisiae YDR07 Page 7 of 106

8 (YML100W) TPS3 (YMR261C) trehalose-phosphate synthase, 123 KD subunit P4.6.f4.1 sp P38426 cerevisiae YMR261c TPS3 alpha,alphatrehalose-phosphate synthase, 115 KD subunit P4.6.f4.1 viable Ess Ess 0.2 sckdy 3 CAGL0G05335g TPS2 alpha, alpha-trehalose-phosp synthase, KLLA0B08822g YALI0E14685g DEHA0F07392g YALI0E31086g KLLA0E10120g DEHA0G13233g KLLA0E11231g CAGL0J09812g CAGL0J06468g YALI0D14476g DEHA0E23210g CAGL0H02387g GLR.1979 CAGL0G05335g KLLA0B08822g YALI0E14685g DEHA0F07392g YALI0E31086g KLLA0E10120g gi sp Q07158 TPS1_KLUL Kluyveromyces lactis Alpha, alph trehalose-phosphate synthase [UD forming] 56 kda subunit (Trehalos phosphate synthase) (UDP-glucos glucosephosphate glucosyltransfera by sp O74932 Yarrowia lipolytica Alp alpha-trehalose-phosphate syntha [UDP-forming], identified similar to CA5505 CaTPS3.3 Cand albicans CaTPS3.3 alpha,alpha trehalose-phosphate synthase, regul subunit, 3-prime end (by homolog similar to tr Q9P918 Pichia angus Trehalose phosphate synthase subu similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a trehalose-phosphate synthase, 102 subunit, by similar to CA5066 CaTPS2 Candi albicans CaTPS2, hypothetical st similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 alpha, a trehalose-phosphate synthase, 115 subunit, by highly similar to sp Q00764 cerevisiae YBR12 TPS1 alpha, alpha-trehalose-phosp synthase, similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3 or sp P3 cerevisiae YML10 TSL1, similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a trehalose-phosphate synthase, 102 subunit, (trehalose 6-P phosphata activity), by highly similar to CA4084 CaTPS Candida albicans CaTPS1 TREHALOSE-6-PHOSPHATE SYNTHASE, by similar to sp P38426 Saccharomy cerevisiae YMR261c TPS3alpha sp P38427 cerevis YML100w TSL1, by similar highly similar to sp P31688 cerevisiae YDR07 TPS2 alpha, alpha-trehalose-phosp synthase, gi sp Q07158 TPS1_KLUL Kluyveromyces lactis Alpha, alph trehalose-phosphate synthase [UD forming] 56 kda subunit (Trehalos phosphate synthase) (UDP-glucos glucosephosphate glucosyltransfera by sp O74932 Yarrowia lipolytica Alp alpha-trehalose-phosphate syntha [UDP-forming], identified similar to CA5505 CaTPS3.3 Cand albicans CaTPS3.3 alpha,alpha trehalose-phosphate synthase, regul subunit, 3-prime end (by homolog similar to tr Q9P918 Pichia angus Trehalose phosphate synthase subu similar to sp P31688 Saccharomy cerevisiae YDR074w TPS2 alpha, a Page 8 of 106

9 GSY1 (YFR015C) GSY2 (YLR258W) PGM1 (YKL127W) sp P23337 cerevisiae YFR015c GSY1 UDP glucose- -starch glucosyltransferase, isoform 1 P2.249.f2.1 sp P27472 cerevisiae YLR258w GSY2 UDP-glucose- -starch glucosyltransferase, isoform 2 P2.249.f2.1 sp P33401 cerevisiae YKL127w PGM1 phosphoglucomutase, minor isoform P2.202.f2.1 viable sckdy viable NA NA NA NA NA sckdy viable 0.9 Non Non Non Non sckdy GLR.110 GLR.110 GLR.2142 KLLA0E10120g DEHA0G13233g YALI0F18502g CAGL0F04719g DEHA0B05764g KLLA0F23133g CAGL0K10626g YALI0F18502g CAGL0F04719g DEHA0B05764g KLLA0F23133g CAGL0K10626g YALI0E02090g DEHA0C05940g KLLA0B12694g CAGL0K03421g CAGL0K07480g trehalose-phosphate synthase, 102 subunit, by similar to CA5066 CaTPS2 Candi albicans CaTPS2, hypothetical st similar to sp P23337 Saccharomy cerevisiae YFR015c GSY1 UDP glucose--starch glucosyltransfera isoform 1 or sp P27472 Saccharom cerevisiae YLR258w GSY2 UDP glucose--starch glucosyltransfera isoform 2, by highly similar to sp P27472 cerevisiae YLR25 GSY2 UDP-glucose--starch glucosyltransferase, by simila highly similar to sp P23337 cerevisiae YFR01 GSY1 UDP glucose--starch glucosyltransferase, isoform 1, star highly similar to sp P23337 cerevisiae YFR01 GSY1 UDP glucose--starch glucosyltransferase, isoform 1, star highly similar to sp P23337 cerevisiae YFR01 GSY1, by similar to sp P23337 Saccharomy cerevisiae YFR015c GSY1 UDP glucose--starch glucosyltransfera isoform 1 or sp P27472 Saccharom cerevisiae YLR258w GSY2 UDP glucose--starch glucosyltransfera isoform 2, by highly similar to sp P27472 cerevisiae YLR25 GSY2 UDP-glucose--starch glucosyltransferase, by simila highly similar to sp P23337 cerevisiae YFR01 GSY1 UDP glucose--starch glucosyltransferase, isoform 1, star highly similar to sp P23337 cerevisiae YFR01 GSY1 UDP glucose--starch glucosyltransferase, isoform 1, star highly similar to sp P23337 cerevisiae YFR01 GSY1, by similar to sp P37012 Saccharomy cerevisiae YMR105c PGM2 phosphoglucomutase, major isoform sp P33401 cerevis YKL127w PGM1 phosphoglucomu minor isoform, by similarit highly similar to sp P37012 cerevisiae YMR10 PGM2 phosphoglucomutase or sp P33401 cerevis YKL127w PGM1 phosphoglucomu by highly similar to sp P37012 cerevisiae YMR10 PGM2 phosphoglucomutase, maj isoform, by highly similar to sp P37012 cerevisiae YMR10 Phosphoglucomutase 2, by highly similar to sp P37012 cerevisiae YMR10 PGM2 phosphoglucomutase, Page 9 of 106

10 PGM2 (YMR105C) GLK1 (YCL040W) PGI sp P37012 Exhibits sensitivity cerevisiae YMR105c at 15 PGM2 generations phosphoglucomutase, when grown major isoform in P2.202.f2.1 galactose. sp P17709 cerevisiae YCL040w GLK1 aldohexose specific glucokinase P4.22.f4.1 sp P12709 cerevisiae YBR196c Ess 0.7 ND sckdy viable NA NA NA NA NA sckdy inviable NA NA NA NA NA sckdy GLR.2142 GLR GLR.582 YALI0E02090g DEHA0C05940g KLLA0B12694g CAGL0K03421g CAGL0K07480g YALI0E15488g CAGL0A04829g DEHA0F26092g CAGL0M00682g CAGL0F00605g CAGL0B00726g YALI0E20207g DEHA0F15169g KLLA0C01155g CAGL0H07579g KLLA0D11352g YALI0B22308g DEHA0E07007g KLLA0E23595g CAGL0H05445g similar to sp P37012 Saccharomy cerevisiae YMR105c PGM2 phosphoglucomutase, major isoform sp P33401 cerevis YKL127w PGM1 phosphoglucomu minor isoform, by similarit highly similar to sp P37012 cerevisiae YMR10 PGM2 phosphoglucomutase or sp P33401 cerevis YKL127w PGM1 phosphoglucomu by highly similar to sp P37012 cerevisiae YMR10 PGM2 phosphoglucomutase, maj isoform, by highly similar to sp P37012 cerevisiae YMR10 Phosphoglucomutase 2, by highly similar to sp P37012 cerevisiae YMR10 PGM2 phosphoglucomutase, similar to sp P17709 Saccharomy cerevisiae YCL040w GLK1 aldohe specific glucokinase, hypothetical highly similar to sp P04807 cerevisiae YGL25 HXK2 or sp P04806 Saccharomyc cerevisiae YFR053c HXK1, similar to tr Q9C0M1 Candida albi CaNAG5 protein, hypothetical st similar to tr Q06204 Saccharomyc cerevisiae YLR446w, hypothetical highly similar to sp P17709 cerevisiae YCL04 GLK1 or Q04409 Saccharomyce cerevisiae YDR516c, by simil weakly similar to sp P17709 cerevisiae YCL04 GLK1 aldohexose specific glucokin by weakly similar to tr Q9C0M1 Cand albicans CaNAG5 protein, hypothe highly similar to sp P50506 Debaryomyces occidentalis Hexoki (EC )., by similar to sp P17709 Saccharomy cerevisiae YCL040w GLK1 aldohe specific glucokinase, by simila highly similar to sp P04807 cerevisiae YGL25 HXK2 or sp P04806 Saccharomyc cerevisiae YFR053c HXK1, gi sp P33284 HXK_KLUL Kluyveromyces lactis HEXOKINA by highly similar to tr O74996 Yarrow lipolytica Hexokinase, hypothetical highly similar to CA0263 CaGLK Candida albicans aldohexose spec glucokinase, by gi sp P12341 G6PI_KLUL Kluyveromyces lactis Glucose-6 phosphate isomerase (GPI) (Phosphoglucose isomerase) (PG (Phosphohexose isomerase) (PHI), by highly similar to sp P12709 cerevisiae YBR19 PGI1, Page 10 of 106

11 (YBR196C) GLC3 (YEL011W) NTH2 (YBR001C) NTH1 (YDR001C) ATH1 (YPR026W) PGI1 glucose-6- phosphate isomerase singleton sp P32775 cerevisiae YEL011w GLC3 1,4-glucan branching enzyme (glycogen branching enzyme) singleton sp P35172 cerevisiae YBR001c NTH2 alpha,alphatrehalase P2.445.f2.1 sp P32356 cerevisiae YDR001c NTH1 neutral trehalase (alpha,alphatrehalase) P2.445.f2.1 sp P48016 cerevisiae YPR026w ATH1 acid trehalase, vacuolar singleton inviable NA NA NA NA NA sckdy viable 0.7 Non sckdy viable sckdy viable Ess Ess Ess 0.1 Ess sckdy viable sckd GLR.582 GLR.790 GLR.157 GLR.157 DEHA0F14289g YALI0F07711g CAGL0M03377g DEHA0B01650g KLLA0A11176g YALI0C06798g DEHA0B02673g CAGL0M10439g YALI0D15598g KLLA0E17325g CAGL0C04323g DEHA0B02673g CAGL0M10439g YALI0D15598g KLLA0E17325g CAGL0C04323g KLLA0E06622g GLR.1078 CAGL0K05137g DEHA0D15774g PGI1, highly similar to sp P12709 cerevisiae YBR19 PGI1 glucose-6-phosphate isomera highly similar to sp P12709 cerevisiae YBR19 PGI1 glucose-6-phosphate isomera by highly similar to sp P32775 cerevisiae YEL01 GLC3, similar to sp P32775 Saccharomy cerevisiae YEL011w GLC3 1,4-glu branching enzyme (glycogen branc enzyme), highly similar to sp P32775 cerevisiae YEL01 GLC3 1, 4-glucan branching enzy (glycogen branching enzyme) singl by highly similar to tr Q9P5P3 Neuros crassa Probable branching enzyme ( similar to sp P52494 Candida albic Neutral trehalase (EC ), sta highly similar to sp P32356 cerevisiae YDR00 NTH1 neutral trehalase or sp P351 cerevisiae YBR00 NTH2, similar to sp P32356 Saccharomy cerevisiae YDR001c NTH1 neutr trehalase, gi sp P49381 TREA_KLU Kluyveromyces lactis NEUTRA TREHALASE (ALPHA, ALPHA TREHALASE) (ALPHA, ALPHA TREHALOSE GLUCOHYDROLA by similar to sp P32356 Saccharomy cerevisiae YDR001c NTH1 neutr trehalase, similar to sp P52494 Candida albic Neutral trehalase (EC ), sta highly similar to sp P32356 cerevisiae YDR00 NTH1 neutral trehalase or sp P351 cerevisiae YBR00 NTH2, similar to sp P32356 Saccharomy cerevisiae YDR001c NTH1 neutr trehalase, gi sp P49381 TREA_KLU Kluyveromyces lactis NEUTRA TREHALASE (ALPHA, ALPHA TREHALASE) (ALPHA, ALPHA TREHALOSE GLUCOHYDROLA by similar to sp P32356 Saccharomy cerevisiae YDR001c NTH1 neutr trehalase, similar to sp P48016 Saccharomy cerevisiae YPR026w ATH1 acid trehalase, vacuolar singleton, similar to sp P48016 Saccharomy cerevisiae YPR026w Vacuolar ac trehalase precursor, hypothetical s similar to CA2574 CaATH1 Cand albicans CaATH1 acid trehalase vacuolar, similar to CA3841 IPF16640 Cand Page 11 of 106

12 DEHA0G07777g KLLA0E24959g KLLA0C05016g DEHA0C12155g DEHA0F20570g YALI0D08140g DEHA0F27148g CAGL0C05665g KLLA0A04367g YALI0B18568g DEHA0D16907g CAGL0J11913g CAGL0L03289g YALI0D13255g KLLA0D02420g CAGL0J08910g KLLA0F04433g CAGL0G04125g YALI0A00506g YALI0C21186g CAGL0G03421g CAGL0D02530g YALI0B14795g YALI0E34463g DEHA0F22803g YALI0E08008g albicans IPF16640 unknown funct no, some similarities with sgd S00059 cerevisiae YOR38 hypothetical protein, hypothetical s some similarities with tr Q12218 cerevisiae YOR009w, frameshift weakly similar to CA4243 IPF164 Candida albicans IPF16491, hypoth similar to sp P36110 Saccharomy cerevisiae YKR013w PRY2 prote precursor (Pathogen related in Sc 2) by similar to CA1909 IPF20091 Cand albicans IPF20091, hypothetical s some similarities with sp P3617 cerevisiae YKR10 FLO10, no, frameshift some similarities with sgd S00059 cerevisiae YOR38 hypothetical protein, hypothetical s no, similar to CA0605 CaUTR2 Cand albicans CaUTR2, hypothetical st some similarities with sp P0864 cerevisiae YIR01 STA1, no, frameshift similar to sp P46955 Saccharomy cerevisiae YJL116c NCA3 or sp P3 cerevisiae YKR04 UTH1, No Similarity, Hypothetical Star some similarities with sp P3611 cerevisiae YKR01 PRY2, similar to tr Q05790 Saccharomyc cerevisiae YLR213c CRR1, hypothe similar to sp P53616 Saccharomy cerevisiae YNL066w SUN4, weakly similar to sp P20840 cerevisiae YJR00 SAG1 alpha-agglutinin, hypotheti weakly similar to sp P43633 cerevisiae YGL02 ALK1 DNA damage-responsive pro no, some similarities with sp P0864 cerevisiae YIR01 STA1, weakly similar to sp P42835 cerevisiae YNL32 EGT2 cell-cycle regulation prote some similarities with sp P4055 cerevisiae Cell w protein TIR3 precursor, hypothetical some similarities with wi NCU0669 Neurospora crassa NCU hypothetical protein ( weakly similar to CA4237 IPF63 Candida albicans IPF6375, hypothe weakly similar to tr Q08294 cerevisiae YOL15 Page 12 of 106

13 DEHA0C15092g KLLA0E24937g CAGL0H09592g YALI0E19635g YALI0A07601g YALI0F02343g KLLA0F04906g YALI0C14630g YALI0C08349g YALI0A18381g YALI0C09680g DEHA0G22066g YALI0E18700g YALI0D26257g CAGL0A00231g CAGL0G05896g CAGL0K09130g KLLA0C04928g DEHA0C05566g DEHA0B02222g YALI0E15015g CAGL0C00209g DEHA0E10109g YALI0D21230g highly similar to sp P36135 cerevisiae YKR04 UTH1, by no, highly similar to sp P10863 cerevisiae YER01 TIR1 or sp P33890 Saccharomyc cerevisiae YOR010c TIR2, no, weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase, weakly similar to tr O42970 Schizosaccharomyces pombe SPBC1E8.05 Serine rich protein, sta some similarities with sgd S00042 cerevisiae YLR21 CRR1, weakly similar to sp Q04893 cerevisiae YMR31 Weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1,4-gluc glucosidase, 5 end no, similar to sp P53301 Saccharomy cerevisiae YGR189c CRH1 family putative glycosidases might exert common role in cell wall organizat by some similarities with sp P5330 cerevisiae YGR18 CRH1 family of putative glycosida might exert a common role in cell organization, no, weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1,4-gluc glucosidase, similar to sp P43633 Saccharomy cerevisiae YGL021w ALK1 DN damage-responsive protein, hypothe similar to sp P38844 Saccharomy cerevisiae YHR143w, by simil some similarities with tr Q08673 cerevisiae YOR24 SRL1, no, similar to sp P53832 Saccharomy cerevisiae YNL283c WSC2 glucoamylase III, hypothetical sta weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1,4-gluc glucosidase, no, some similarities with sp P4717 cerevisiae YJR15 similar to sp Q04893 Saccharomy cerevisiae YMR317w mucins, glucan 1, 4-alpha-glucosid and exo-alpha-sialidase, hypothet some similarities with tr Q00658 Emericella nidulans FlbD, hypothe Page 13 of 106

14 BSC1 (YDL037C) cerevisiae YDL037c strong to glucan 1,4-alphaglucosidase P2.341.f2.1 viable NA NA NA NA NA sckdy GLC.1 YALI0F27203g YALI0D06149g DEHA0F18271g YALI0C16148g KLLA0E14982g YALI0F10175g YALI0E04532g DEHA0F04158g DEHA0G22902g DEHA0E03377g YALI0A00682g CAGL0L05434g DEHA0B02266g CAGL0C02211g YALI0F26081g DEHA0F14531g CAGL0A04081g DEHA0B10868g KLLA0E10967g CAGL0G09449g DEHA0G02618g YALI0E18722g KLLA0E04939g DEHA0F00638g KLLA0B11055g DEHA0F22242g KLLA0C17985g YALI0B15510g CAGL0F01463g DEHA0D05093g no, similar to sp P47032 Saccharomy cerevisiae YJL079c PRY1 protei precursor (Pathogen related in Sc 1) by some similarities with wi NCU0698 Neurospora crassa NCU no, similar to sp P36135 Saccharomy cerevisiae YKR042w UTH1 involve the aging process, by similar no, no, similar to CA0076 IPF8866 Cand albicans IPF8866, hypothetical st some similarities with sp P5330 cerevisiae YGR18 CRH1, similar to CA4245 IPF4303 Cand albicans IPF4303 unknown functi no, similar to sp P36135 Saccharomy cerevisiae YKR042w UTH1 or sp P46955 cerevis YJL116c NCA3, hypothetical sta similar to sp P32623 Saccharomy cerevisiae YEL040w UTR2 cell w protein, no, weakly similar to ca CA5614 IPF5 Candida albicans IPF522, hypothet weakly similar to tr Q05777 cerevisiae YLR19 some similarities with sp P4703 cerevisiae YJL07 PRY3 closely related to the plant P class of pathogen proteins, hypothe no, similar to sp P53301 Saccharomy cerevisiae YGR189c CRH1, hypothe weakly similar to tr Q9Y8F2 Cand albicans Agglutinin-like protein 6, by no, some similarities with sgd S00064 cerevisiae YLR390 Secretory Stress Response protein no, highly similar to CA0883 CaSUN Candida albicans CaSUN41 Putative wall beta-glucosidase (by homolog by some similarities with sp P3233 cerevisiae YGR01 MSB2 multicopy suppressor of a CD bud emergence defect, hypothetical similar to sp P32623 Saccharomy cerevisiae YEL040w UTR2 cell w protein P3.82.f3.1, by similar similar to sp P10863 Saccharomy cerevisiae YER011w TIR1, no, Page 14 of 106

15 CAGL0C03872g DEHA0G15543g CAGL0J02530g CAGL0J09922g DEHA0B04213g YALI0D19316g YALI0F27687g YALI0F20548g DEHA0C17644g CAGL0F05137g DEHA0B10659g CAGL0A03608g KLLA0E19657g KLLA0E02046g YALI0D02024g CAGL0J11902g CAGL0G10175g KLLA0C01496g KLLA0C04730g YALI0C20779g CAGL0G00858g DEHA0B01232g CAGL0F03003g CAGL0H06413g KLLA0C12177g similar to sp P40552 Saccharomy cerevisiae YIL011w TIR3, b similar to CA3335 IPF8682 Cand albicans IPF8682, hypothetical st some similarities with tr Q12218 cerevisiae YOR00 similar to sp P53616 Saccharomy cerevisiae YNL066w SUN4 or sp P40472 cerevis YIL123w SIM1, by similari similar to sp P32334 Saccharomy cerevisiae YGR014w MSB2 multic suppressor of a CDC24 bud emerge defect, no, no, no, weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase, similar to sp P47032 Saccharomy cerevisiae YJL079c PRY1, weakly similar to sp P54867 cerevisiae YOR00 SLG1 required for cell wall integrity for stress response, hypothetical s some similarities with tr Q08294 cerevisiae YOL15 no, some similarities with sp P4283 cerevisiae YNL32 EGT2 cell-cycle regulation prote singleton, weakly similar to KLLA-IPF5308 Kluyveromyces lactis, hypothetical some similarities with sp P0864 cerevisiae YIR01 STA1, no, frameshift some similarities with sp P4717 cerevisiae YJR15 some similarities with sp P4703 cerevisiae YJL07 PRY1, some similarities with sp P2902 cerevisiae YLR28 CTS1 endochitinase singleton, no, similar to sp P36027 Saccharomy cerevisiae YLR332w MID2 mati process protein, hypothetical sta similar to sp P36110 Saccharomy cerevisiae YKR013w PRY2 similar the plant PR-1 class of pathogen re proteins, by some similarities with sp P3233 cerevisiae YGR01 MSB2 or sp P41809 Saccharomyc cerevisiae YDR420w HKR1, similar to sp O13547 Saccharomy cerevisiae YLR390wa CW14, star some similarities with sp Q1221 cerevisiae YOL10 WSC3 cell wall integrity and stre response component 3, hypothetical Page 15 of 106

16 DEHA0A05302g CAGL0H09614g KLLA0E00704g DEHA0G19877g YALI0E33539g DEHA0C11814g KLLA0A03179g CAGL0J11176g YALI0E23969g KLLA0E24893g YALI0E35090g DEHA0B05478g YALI0E33913g KLLA0D08239g CAGL0J00253g KLLA0F02497g YALI0E20757g CAGL0G05808g YALI0F04213g YALI0D13266g CAGL0G08668g KLLA0D14377g similar to CA5213 CaSSR1 Candi albicans CaSSR1 Secretory Stres Response protein 1, by simila highly similar to sp P10863 cerevisiae YER01 TIR1 or sp P33890 Saccharomyc cerevisiae YOR010c TIR2, gi emb CAB Kluyveromyces lactis WSC4 homol by some similarities with sp P5330 cerevisiae YGR18 CRH1 family of putative glycosida might exert a common role in cell organization, similar to sp P53616 Saccharomy cerevisiae YNL066w SUN4, no, some similarities with sp P3602 cerevisiae YLR33 MID2 mating process protein, some similarities with sp P5388 cerevisiae YNL17 no, no, weakly similar to sp P32323 cerevisiae YNR04 AGA1 a-agglutinin anchor subun singleton, similar to CA0728 IPF7345 Cand albicans IPF7345 unknown functi weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1,4-gluc glucosidase P2.341.f2.1, hypotheti some similarities with sp P5388 cerevisiae YNL17 singleton, similar to sp P53214 Saccharomy cerevisiae YGR023w MTL1, weakly similar to sp P39732 cerevisiae YAL03 FUN21 hypothetical protein single some similarities with sp O1354 cerevisiae YLR390 SSR1 Secretory Stress Response pr 1, weakly similar to sp P53882 cerevisiae YNL17 by emb Z69781 Yarrowia lipolytica T gene, thermosensitive suppressor 7SRNA defect, involved in the sig recognition particle-dependent translocation pathway of secreto proteins, identified No Similarity, Hypothetical Star similar to sp P53616 Saccharomy cerevisiae YNL066w SUN4 or sp P40472 cerevis YIL123w SIM1, hypothetical sta weakly similar to sp P54867 cerevisiae YOR00 SLG1 required for cell wall integrity for stress response singleton, Page 16 of 106

17 SGA1 (YIL099W) sp P08019 cerevisiae YIL099w SGA1 sporulation specific glucan 1,4- alpha-glucosidase singleton viable Non 0.8 sckdy GLR.507 DEHA0B01804g CAGL0C03575g YALI0E05819g CAGL0F01485g CAGL0M11792g DEHA0D05423g YALI0F05720g YALI0D09185g YALI0D07854g KLLA0F22671g YALI0F05786g DEHA0E21890g YALI0A16214g KLLA0C11583g DEHA0D10780g YALI0C08140g DEHA0F26862g YALI0E24673g YALI0E05203g DEHA0A12705g KLLA0F04059g CAGL0G02717g YALI0E33715g no, some similarities with sp P4717 cerevisiae YJR15 weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase, similar to sp P10863 Saccharomy cerevisiae YER011w TIR1 or tr Q1 cerevisiae YOR00 weakly similar to sp P39732 cerevisiae YAL03 FUN21, similar to Candida albicans CaWS Cell wall integrity weakly similar to sp P53214 cerevisiae YGR02 MTL1 potential cell wall stress sen some similarities with sp P3232 cerevisiae YNR04 AGA1 a-agglutinin anchor subun no, some similarities with sp P5330 cerevisiae YGR18 CRH1 family of putative glycosida might exert a common role in cell organization, some similarities with sp P1086 cerevisiae YER01 TIR1 cold-shock, hypothetical sta no, weakly similar to sp P53832 cerevisiae Cell w integrity and stress response compo 2 precursor, weakly similar to sp P43633 cerevisiae YGL02 ALK1 DNA damage-responsive pro by similar to CA2150 IPF19940 Cand albicans IPF19940 unknown funct by no, similar to sp P47032 Saccharomy cerevisiae YJL079c PRY1, hypothe weakly similar to sp P53301 cerevisiae YGR18 CRH1, some similarities with sp P0801 cerevisiae YIL099 SGA1 sporulation specific glucan 1 alpha-glucosidase, hypothetical st similar to sp P08019 Saccharomy cerevisiae YIL099w SGA1 sporula specific glucan 1,4-alpha -glucosid weakly similar to sp P08019 cerevisiae YIL099 SGA1 sporulation specific glucan 1 alpha-glucosidase singleton, hypoth similar to sp P08019 Saccharomy cerevisiae YIL099w SGA1 sporula specific glucan 1, 4-alpha-glucosid weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1,4-gluc glucosidase P2.341.f2.1, hypotheti Page 17 of 106

18 DEHA0F13915g KLLA0B14927g KLLA0E21131g YALI0B06919g YALI0B12606g YALI0B17028g YALI0D18436g KLLA0C11517g KLLA0A04345g YALI0E16731g YALI0C05390g CAGL0E06600g DEHA0G20141g YALI0C09031g KLLA0C01276g YALI0E33737g YALI0E29425g YALI0D02299g KLLA0A11748g KLLA0D07942g YALI0D00627g KLLA0F24486g YALI0C24211g DEHA0B02244g CAGL0M14069g YALI0A01870g YALI0E16841g YALI0C13970g YALI0A09559g YALI0F15653g CAGL0M09779g KLLA0C04994g YALI0D13530g similar to ca CA2024 IPF9616 Can albicans IPF9616 unknown functi by no, no, no, no, weakly similar to tr Q8XQP2 Ralst solanacearum Putative hemagglutinin/hemolysin-related pro no, no, no, no, no, some similarities with sp P3889 cerevisiae YHR21 FLO5, weakly similar to CA2769 IPF158 Candida albicans IPF15870, hypoth no, no no, weakly similar to CA2714 CaIFF Candida albicans CaIFF2, hypothet weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1,4-gluc glucosidase, similar to sp P08640 Saccharomy cerevisiae YIR019c STA1 extracell alpha-1, 4-glucan glucosidase, no, no, weakly similar to sp P32334 cerevisiae YGR01 MSB2 multicopy suppressor of a CD bud emergence defect, hypothetical no, no, some similarities with sp P3889 cerevisiae YHR21 FLO5, similar to sp P29029 Saccharomy cerevisiae Endochitinase precursor Soluble cell wall protein 2) by no, weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase P2.341.f2.1, hypotheti no, some similarities with sp P0864 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase, similar to sp P29029 Saccharomy cerevisiae YLR286c endochitinas weakly similar to sgd S cerevisiae YDR53 by no, some similarities with sp P2084 Page 18 of 106

19 MUC1 (YIR019C) sp P08640 cerevisiae YIR019c STA1 extracellular alpha-1,4-glucan glucosidase P2.341.f2.1 viable NA NA NA NA NA sckdy GLC.11 KLLA0E09658g YALI0D22396g YALI0F10802g YALI0D13992g YALI0E22572g YALI0C16247g YALI0C08476g DEHA0A14784g YALI0C03916g KLLA0E10945g DEHA0G19096g YALI0E32395g YALI0E14993g YALI0D18249g YALI0E31273g YALI0E02442g YALI0A15796g YALI0B15422g YALI0C03894g YALI0A13079g KLLA0A01826g DEHA0G01573g YALI0D22825g YALI0F07216g YALI0D25014g YALI0C18293g cerevisiae YJR00 SAG1 alpha-agglutinin singleton weakly similar to sp P29029 cerevisiae YLR28 CTS1endochitinase singleton, weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase, no no, weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase no, weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase, similar to CA1678 IPF5185 Cand albicans IPF5185 putative cell w protein (by homology), by simi weakly similar to KLLA-IPF6186 Kluyveromyces lactis IPF some similarities with CA1898 IPF1 Candida albicans IPF11998, hypoth weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase P2.341.f2.1, hypotheti no, some similarities with tr Q8WZS Neurospora crassa Dynactin (150 k dynein-associated polypeptide) ro weakly similar to tr Q8SY55 Droso melanogaster GH09355p, hypothet no, no, no, weakly similar to DEHA-IPF8785 Debaryomyces hansenii IPF 8785 no, some similarities with sp P4180 cerevisiae YDR42 HKR1 Hansenula MrakII k9 killer t resistance protein, hypothetical st weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1, 4-glu glucosidase, by no, similar to sp P08640 Saccharomy cerevisiae YIR019c STA1 extracell alpha-1, 4-glucan glucosidase, hypothetical strart, by similar weakly similar to tr Q97P71 Streptococcus pneumoniae Cell w surface anchor family protein, weakly similar to tr Q9N4S7 Caenorhabditis elegans Y51B11A protein, weakly similar to sp P32334 cerevisiae YGR01 Page 19 of 106

20 PGU1 (YJR153W) GPH1 (YPR160W) EXG2 (YDR261C) viable 0.4 Ess Ess s sp P06738 cerevisiae YPR160w GPH1 glycogen phosphorylase singleton sp P52911 cerevisiae YDR261c EXG2 exo-beta-1,3- glucanase minor isoform P3.33.f3.1 viable NA NA NA NA NA sckdy viable NA NA NA NA NA sckdy CAGL0F08833g YALI0E22550g YALI0D02915g DEHA0G06655g YALI0B16676g DEHA0G01595g YALI0E20229g cerevisiae YGR01 MSB2 multicopy suppressor of a CD bud emergence defect, hypothetical weakly similar to sp P08640 cerevisiae YIR01 STA1 extracellular alpha-1,4-gluc glucosidase, no, similar to sp P29029 Saccharomy cerevisiae Endochitinase precursor ) (Soluble cell wall protein by no, weakly similar to sp P40442 cerevisiae YIL16 realated to glucan 1, 4-alpha-glucosi no, none - - GLR.500 KLLA0F10065g CAGL0F04895g DEHA0F23782g YALI0F04169g KLLA0F18788g CAGL0M08756g CAGL0I00484g DEHA0D09196g DEHA0F01485g KLLA0C05324g GLR.3219 DEHA0F01716g YALI0F05390g CAGL0H10120g DEHA0G07095g YALI0E34155g CAGL0G09515g DEHA0F26378g highly similar to sp P06738 cerevisiae YPR16 GPH1 glycogen phosphorylase singl by highly similar to sp P06738 cerevisiae YPR16 GPH1 glycogen phosphorylase, sta highly similar to CA5206 CaGPH Candida albicans CaGPH1 Glycog phosphorylase (by homology), similar to sp P06738 Saccharomy cerevisiae YPR160w GPH1 glyco phosphorylase, hypothetical star similar to sp P38081 Saccharomy cerevisiae YBR056w singleton, star similar to sp P52911 Saccharomy cerevisiae YDR261c exo-beta-1 glucanase, similar to sp P23776 Saccharomy cerevisiae YLR300w EXG1, similar to sp P29717 Candida albic CaEXG1 Glucan 1, 3-beta-glucosid precursor, similar to CA4180 CaEXG2 Cand albicans CaEXG2, hypothetical st gi emb CAA Kluyveromyces lactis exo-1, 3-be glucanase/1, 3-beta-D-Glucan glucanohydrolase, by similar similar to tr O93939 Hansenula ano Exo-1,3-beta-glucanase (EC sp Q12725 Yarrowia lipolytica Gluc 3-beta-glucosidase precursor (E ) (Exo-1, 3-beta- glucanas identified similar to sp P38081 Saccharomy cerevisiae YBR056w, by simil no, some similarities with KLLA-IPF6 Kluyveromyces lactis IPF similar to sp P23776 Saccharomy cerevisiae YLR300w EXG1 exo-be 3-glucanase (I/II), hypothetical st similar to ca CA5339 IPF885 Cand albicans IPF885 glucan 1,3-beta glucosidase (by homology), hypothe Page 20 of 106

21 BGL2 (YGR282C) EXG1 (YLR300W) sp P15703 cerevisiae YGR282c BGL2 endo-beta- 1,3-glucanase of the cell wall P4.19.f3.1 sp P23776 cerevisiae YLR300w EXG1 exo-beta-1,3- glucanase (I/II), major isoform P3.33.f3.1 viable NA NA NA NA NA sckdy viable 0.8 Non Non Non Non sckdy YALI0F13299g YALI0B03564g DEHA0G19943g GLR.3339 CAGL0G00220g KLLA0F03036g DEHA0E22715g KLLA0F18788g CAGL0M08756g CAGL0I00484g DEHA0D09196g DEHA0F01485g KLLA0C05324g GLR.3219 DEHA0F01716g YALI0F05390g CAGL0H10120g DEHA0G07095g YALI0E34155g CAGL0G09515g DEHA0F26378g KLLA0F18788g CAGL0M08756g CAGL0I00484g DEHA0D09196g DEHA0F01485g weakly similar to tr Q96W35 Ophiostoma novo-ulmi Glucan 1, 3 glucosidase-like protein (Fragmen similar to sp P43070 Candida albic Glucan 1,3-beta -glucosidase precu (EC ) (Exo-1, 3-betaglucanase), by similar to sp P15703 Saccharomy cerevisiae YGR282c BGL2 endo-be 3-glucanase of the cell wall, hypoth highly similar to sp P15703 cerevisiae YGR28 BGL2, by highly similar to sp P15703 cerevisiae YGR28 BGL2 endo-beta-1, 3-glucanase of cell wall, by some similarities with CA2245 IPF7 Candida albicans IPF7409 unkno function, similar to sp P38081 Saccharomy cerevisiae YBR056w singleton, star similar to sp P52911 Saccharomy cerevisiae YDR261c exo-beta-1 glucanase, similar to sp P23776 Saccharomy cerevisiae YLR300w EXG1, similar to sp P29717 Candida albic CaEXG1 Glucan 1, 3-beta-glucosid precursor, similar to CA4180 CaEXG2 Cand albicans CaEXG2, hypothetical st gi emb CAA Kluyveromyces lactis exo-1, 3-be glucanase/1, 3-beta-D-Glucan glucanohydrolase, by similar similar to tr O93939 Hansenula ano Exo-1,3-beta-glucanase (EC sp Q12725 Yarrowia lipolytica Gluc 3-beta-glucosidase precursor (E ) (Exo-1, 3-beta- glucanas identified similar to sp P38081 Saccharomy cerevisiae YBR056w, by simil no, some similarities with KLLA-IPF6 Kluyveromyces lactis IPF similar to sp P23776 Saccharomy cerevisiae YLR300w EXG1 exo-be 3-glucanase (I/II), hypothetical st similar to ca CA5339 IPF885 Cand albicans IPF885 glucan 1,3-beta glucosidase (by homology), hypothe similar to sp P38081 Saccharomy cerevisiae YBR056w singleton, star similar to sp P52911 Saccharomy cerevisiae YDR261c exo-beta-1 glucanase, similar to sp P23776 Saccharomy cerevisiae YLR300w EXG1, similar to sp P29717 Candida albic CaEXG1 Glucan 1, 3-beta-glucosid precursor, similar to CA4180 CaEXG2 Cand albicans CaEXG2, hypothetical st Page 21 of 106

22 SPR1 (YOR190W) VPS8 (YAL002W) sp P32603 cerevisiae YOR190w SPR1 exo-1,3-betaglucanase precursor P3.33.f3.1 sp P39702 cerevisiae YAL002w VPS8 vacuolar sorting protein, 134 kd singleton viable ND sckdy Exhibits sensitivity at 15 generations when grown in 10 um nystatin. NA NA NA NA NA sckd KLLA0C05324g GLR.3219 DEHA0F01716g YALI0F05390g CAGL0H10120g DEHA0G07095g YALI0E34155g CAGL0G09515g DEHA0F26378g DEHA0A09020g GLR.1058 KLLA0C18491g CAGL0A00781g KLLA0F11319g CAGL0L07810g CAGL0K11550g YALI0F11385g KLLA0A09713g KLLA0E17127g YALI0C04158g DEHA0F24676g DEHA0G14817g DEHA0C18150g CAGL0K10604g DEHA0C08591g YALI0F13629g gi emb CAA Kluyveromyces lactis exo-1, 3-be glucanase/1, 3-beta-D-Glucan glucanohydrolase, by similar similar to tr O93939 Hansenula ano Exo-1,3-beta-glucanase (EC sp Q12725 Yarrowia lipolytica Gluc 3-beta-glucosidase precursor (E ) (Exo-1, 3-beta- glucanas identified similar to sp P38081 Saccharomy cerevisiae YBR056w, by simil no, some similarities with KLLA-IPF6 Kluyveromyces lactis IPF similar to sp P23776 Saccharomy cerevisiae YLR300w EXG1 exo-be 3-glucanase (I/II), hypothetical st similar to ca CA5339 IPF885 Cand albicans IPF885 glucan 1,3-beta glucosidase (by homology), hypothe similar to sp P39702 Saccharomy cerevisiae YAL002w VPS8 vacuo sorting protein, 134 kd, by weakly similar to sp P39702 cerevisiae YAL00 VPS8 vacuolar sorting protein, 134 singleton, by similar to sp P39702 Saccharomy cerevisiae YAL002w VPS8, hypoth similar to sgd S Saccharom cerevisiae YPL150w, by simil similar to sp P25333 Saccharomy cerevisiae YCR008w SAT4 serine/threonine-specific protein kin by similar to sp P28708 Saccharomy cerevisiae YKL116c, hypothetical weakly similar to SP P38691 cerevisiae YHR08 KSP1 ser/thr protein kinase and DE IPF5974.1, by similar to sp Q03533 Saccharomy cerevisiae YMR291w, by simil similar to sp P38691 Saccharomy cerevisiae YHR082c KSP1 ser/th protein kinase, by similarit similar to sp P18961 Saccharomy cerevisiae Serine/threonine-prote kinase YPK2/YKR2, hypothetical similar to sp P24719 Saccharomy cerevisiae YOR351c MEK1 ser/t protein kinase similar to CA2643 CaHSL1 Cand albicans CaHSL1, hypothetical st similar to sp P40494 Saccharomy cerevisiae YIL095w PRK1 serine/threonine protein kinase, star similar to sp P27466 Saccharomy cerevisiae YFR014c CMK1 Ca2+/calmodulin-dependent ser/t protein kinase type I, hypothetical similar to sp P22204 Saccharomy cerevisiae YGR092w DBF2,, sequence gap some similarities with sp P2356 cerevisiae YLR36 Page 22 of 106