25 Things To Know. Neurons

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1 25 Things To Know Neurons

2 Neurons receive & transmit to other cells

3 Neurons Many last your whole life

4 Neurons Many last your whole life Other cells die and are replaced Most aren t replaced

5 Neurons Hippocampus neurons CAN re-grow

6 Neurons In General have less neurons as get older

7 Neuron Development

8 Neurons Development create twice as many as need

9 Winnowing just before and after birth

10 Neurons 50,000 cells each second for most of intrauterine life

11 Neural Anatomy

12 Neural Anatomy Soma

13 Neural Anatomy maintains cell life contains nucleus support structures Soma

14 Neural Anatomy only one per neuron cell body Soma

15 Neural Anatomy Looks spotty (Nissl substance) Soma

16 Neural Anatomy Looks spotty (Nissl substance) Chromophil granules Soma

17 Neural Anatomy Chromophil granules In soma & dendrites Not in axons Soma

18 Neural Anatomy Synthesize proteins & regulate metabolism Soma

19 Neural Anatomy Thicker than axon 1 or many Dendrites Soma

20 Neurons Dendrite look like tree roots or ginger attached to the soma

21 Neurons Dendrite receives info from other neurons

22 Branched Bumpy Bulbous

23 Dendritic Spines Stubby

24 Dendritic Spines Stubby Mushroom

25 Dendritic Spines Stubby Mushroom Thin

26 Dendritic Spines Spine head Long skinny neck

27 Dendritic Spines spiny outgrowths adults have fewer children more

28 Dendritic Spines Synapse plasticity Involved how?

29 Dendritic Spines Not in most brain neurons

30 Control which gates open Control how quickly gates open Control how long stay open Control rate thru gate

31 Dendrites Ribosomes Rough texture

32 Dendrites Ribosomes an organelle specialized function

33 Dendrites Ribosomes Protein factory Local use

34 Neural Anatomy In larger neurons Axon Dendrites Hillock Axon Soma

35 Axon Hillock expanded region at initial end of axon connects cell body to the axon

36 Axon Hillock site of summation collection of incoming information Electric charge adds up

37 Axon Hillock site of summation More than threshold causes discharge ACTION POTENTIAL

38 Neural Anatomy Impulse travels down axon Axon Dendrites Hillock Axon Soma Initial Segment

39

40

41 Soma

42

43 Axon Vary in length.1 mm to 1 meter

44 Axon Vary in width Thin About 1 micrometer

45 Axon Can branch at end

46

47 COMPARE Axon Thinner than dendrite Longer than dendrite

48 COMPARE Axon Usually only 1 Output

49 COMPARE Axon Branch at end (not near cell) Smooth surface

50 COMPARE Axon No ribosomones Can have myelin

51 Myelin Insulation

52 Myelin fatty layers coats some axons Myelin sheath

53 Myelin wraps axon type of glial cell

54 Myelin prevents activation of adjacent axons 14 th week of fetal development

55 Myelin Two Types 1. In Brain & Spinal Cord Oligodendrocyte 80% lipid 20% protein

56 Myelin Oligodendrocyte Can cover 50 axons

57 Myelin Two Types 2. Peripheral System Schwann Cells myelinating & nonmyelinating

58 Myelin Schwann Cells 1 axon only Help keep neurons alive Insulate 100 micrometres of axon

59 Myelin Schwann Cells Insulation 100 micrometers long

60 Myelin Schwann Cells 10k per meter Regularly spaced Gaps = Nodes of Ranvier

61 Schwann Cells Spiral around axon 100+ revolutions Looks like log or rolled-up paper

62 Schwann Cells Inner layers are myelin Mostly lipid Outer layers = neurolemma Plasma membrane

63 Conduction Saltatory Conduction Repropagation Node to node 10x faster

64 Nodes of Ranvier Exposes neuron to extracell. fluid

65 Nodes of Ranvier ION FLOW

66 Nodes of Ranvier naked section of myelinated axon

67 Axon Terminals branches at end of axons presynaptic

68 Terminal Buttons Secrete neurotransmitter

69 Neurons Organelles = specialty units Mitochondrion Cellular power plants Generate ATP Power chemical changes

70 Neurons Organelles = specialty units Nucleus contains chromosomes covered by membrane

71 Organelles Nissl Bodies groups of ribosomes protein synthesis

72 Organelles Endoplasmic reticulum (ER) system of tubes

73 Organelles Endoplasmic reticulum (ER) transport materials within cytoplasm

74 Organelles Endoplasmic reticulum (ER) smooth (no ribosomes) rough (ribosomes)

75 Organelles Golgi Apparatus stuff peptides & proteins into vesicles (sack-like cavities)

76 Organelles Microfilaments/Neurotubules transport system within a neuron also used for structural support

77 dendrites soma Golgi apparatus nucleus axon

78 TYPES OF NEURONS

79 Location Peripheral nervous system Sensory neuron detects changes in world detects internal changes sends info to CNS

80 Location Central nervous system Motor neuron controls contraction of a muscle controls secretion of a gland

81 Location Central nervous system Interneuron connects other neurons

82 # of extensions Bipolar Pseudounipolar Multiploar

83 # of extensions Bipolar 1 dendrite, 1 axon Retina and smell

84 Bipolar 2 processes (extensions) Axon Soma Dendrite

85 Pseudounipolar Biploar who lose 1 process Axon Soma

86 Pseudounipolar (transitional name) No dedrites Split Axon Soma Cell to skin PNS Cell to spinal cord CNS

87 Unipolar Sensory Neuron Soma is in spinal cord Touch Receptor To Brain

88 Types of Neurons # of extensions Bipolar Pseudounipolar & Unipolar Multipolar

89 Multipolar 99% of neurons many processes (extensions) only one axon

90 Multipolar spinal motor neurons pyramidal neurons Purkinje cells Soma

91 Purkinje cells can have over 1000 dendrites connect to 10-20k cells in cortex

92 Purkinje cells some of largest neurons in brain stacked one in front of the other look like dominos

93 Types of Neurons Direction they send info Sensory neurons (afferent) from sensory receptors skin, eyes, nose, tongue, ears to central nervous system

94 Direction of info Direction they send info Motor neurons (efferent) from central nervous system to muscles or glands

95 Direction of info Direction they send info Motor neurons (efferent) get info from interneurons directly from sensory neurons in some reflexes

96 Direction of info Interneurons between sensory & motor neurons

97 Interneurons No other neurons around them Don t need dendrites

98 Interneurons Connect to each other Called: intrinsic, association, relay, or local circuit neurons

99 Glial Cells Supporting cells called neuroglia or neural glue supporting cells of CNS

100 6 Types of Glial Cells 1. radial glial Help generate neurons & astrocytes Cables neurons use to find home

101 6 Types of Glial Cells 2. astrocytes surround synapses provide nutrients & raw material

102 6 Types of Glial Cells 2. astrocytes limit neurotransmitters engulf dead cells & form scar tissue = phagocytosis

103 6 Types of Glial Cells 2. astrocytes Regulate chemical composition of extracellular fluid

104 6 Types of Glial Cells 2. astrocytes Star cells

105 6 Types of Glial Cells 2. astrocytes Help neurons: 1) transport nutrients to neurons 2) regulates extracellular space

106 6 Types of Glial Cells 2. astrocytes Help neurons: 3) digest parts of dead neurons 4) clean up brain "debris 5) hold neurons in place

107 6 Types of Glial Cells 1. radial 2. astrocytes 3. oligodendrocytes produce mylein sheath in CNS

108 6 Types of Glial Cells 4. Schwann cells produce myelin sheath in PNS

109 6 Types of Glial Cells 5. microglia smallest glial cells act as if they were phagocytes (Bacterial eating white blood cells)

110 6 Types of Glial Cells 5. microglia protect brain from invading microorganisms

111 6 Types of Glial Cells 6. satellite cells physical support to PNS neurons

112 Biological Psych.com

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