rcbf-mr rcbf-pet ATT

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2 Arterial spin labeling (ASL) MR S/N ASL 0 ASLCBF ATT CBF ATT OEF (acbv) ASL 4 DWIb=0 b=50 mm3/sacbv acbv N=3 acbv rcbf-mr rcbf-pet S/N MR ATT PET-OEF (N=11: y=1.68x+2.6, p<0.05, r2=0.68 ) 3.0T MR GESigna HD 3D-FSE TR/TE /10-20(ms) Matrix = 128x128x36Nex=3 pcasl PET-CBF, PET-OEF pseudocontinuous, ATT ASL-CBF, ATT spiralfse PLD0.7 3 T1 T1 T msbrain/blood 0.9 ml/min/100g pixel rcbf map Kimura H, et. al. ICS, Vol.1265, 2004, Pp transit time IC rcbf MR PET rcbf pixel ATT PET-OEF ATT PET-OEF asymmetric index 2. ASL-CBF PET-CBF 2D.

3 Micro-vascular DWI 2 compartment ASL ASL ROI DWI(b=50) Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients Masamichi Ikawa, Makoto Yoneda, Tomoko Muramatsu, Akiko Matsunaga, Tetsuya Tsujikawa, Tatsuya Yamamoto, Nobuyuki Kosaka, Kazuyuki Kinoshita, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Hirohiko Kimura. Mitochondrion. 13(6), Imaging the early response to chemotherapy in advanced lung cancer with diffusion-weighted magnetic resonance imaging compared to fluorine-18 fluorodeoxyglucose positron emission tomography and computed tomographyt.tsuchida, M. Morikawa, Y. Demura, Y. Umeda, H. Okazawa, H. Kimura. Journal of Magnetic Resonance Imaging. 38(1), ASL ROI ROI ASL CBF,ATT,CBV ROI67ml/min/100g,1.77s,1.5ml/100g, ROI39ml/min/100g,1.98s,0.4ml/100g 9 Arterial spin labeling perfusion-weighted MRI for long-term follow-up of a cerebral arteriovenous malformation after stereotactic radiosurgerykazuhiro Shimizu, Nobuyuki Kosaka, Tatsuya Yamamoto, Hiroki Shioura, Toshiaki Kodera, Ken-ichiro Kikuta, Hirohiko Kimura. Acta Radiologica Short Reports. 3(1), Monitoring of extra-axial brain tumor response to radiotherapy using pseudo-continuous arterial spin labeling images: Preliminary results Yamamoto T, Kinoshita K, Kosaka N, Sato Y, Shioura H, Takeuchi H, Kimura H. Magn Reson Imaging. 31(8), Hashimoto s encephalopathy with hippocampus involvement detected on continuous arterial spin labeling M.Ishitobi, M.Yoneda, M.Ikawa, A.Matsunaga, K.Ueno, H.Kimura, Y.Wada. Psychiatry and Clinical Neurosciences. 67(2), MRS/CSI. INNERVISION. 27(9), D-ASL(3D-Arterial Spin Labeling),,,,. The 30th Meeting of The Mt. Fuji Workshop on CVD. 30, perfusion imaging,.. 326, MR perfusion imaging by alternate slab width inversion recovery arterial spin labeling(airasl) : a technique with higher signal-to-noise ratio at 3.0T Yasuhiro Fujiwara, Hirohiko

4 Kimura, Toshiaki Miyati, Hiroyuki Kabasawa, Tsuyoshi Matsuda, Yoshiyuki Ishimori, Isao Yamaguchi, Toshiki Adachi. Magn Reson Mater phy. 25(2), ,,, MR 37 CI 2014, 2.28,,,,,,,,,, 3T-MRI ASL(Arterial Spin Labeling)CEA , 10.16,,,,,,,,,, 3T-MRI Arterial spin labeling(asl) , Arterial Spin Labeling , 9.21,,, Pseudo continuous ASL , 9.20,,, Transit Time mapping 3D ASL , 9.19 Reevaluation of ASL signal and ASL beyond CBF , 9.19 S.Yamada, M.Isozaki, A.Tada, H.Arai, H.Takeuchi, H.Okazawa, H.Kimura, K.Kikuta Quantitative Evaluation of Cerebral Blood Flow Using Pulsed Continuous Arterial Spin Labeling Technique Compared with Imp-spectXV WFNS World Congress of Neurosurgery 2013, Seoul(Korea) Hirohiko Kimura Arterial Spin Labeling(ASL)MR perfusion:pro and con for the clinical application to cerebrovascular disorders AIMS Neuro Imaging , 7.14,,,,,,,,, MRI_CASL , 6 M.Isozaki, H.Okazawa, A.Tada, H.Takeuchi, H.Kimura, K.Kikuta Feasibility of using pulsed continuous arterial spin labeling technique for quantitative evaluation of cerebral blood flow. Brain2013: XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function 2013, 5.22Shanghai (China) T.Yamamoto, H.Takeuchi, Y.Fujiwara, H.KimuraAssessment of Tumor Blood Flow in Skull Base Meningiomas and Schwannomas by using Pulsed-Continuous Arterial Spin Labeling Images and its Correlation with Histopathologic Features21st Annual Meeting and Exhibition of International Society for Magnetic Resonance in Medicine (ISMRM) 2013, 4.23Salt Lake City (USA),,,, Pulsed-Continuous ASL , 4.13,,,,,,,, MRI-CASL , 3,,,,,,,,, CEA 3T-MRI ASL , 3.22,,,,,,,,,

5 Pulsed continuous ASL(PCASL) , 3.21,,, 3D ASL 25 MR M.Ikawa, H.Kimura, T.Muramatsu, A.Matsunaga, T.Tsujikawa, T.Yamamoto, N.Kosaka, K.Kinoshita, O.Yamamura, T.Hamano, Y.Nakamoto, M.Yoneda Detection of presymptomatically latent lesions developing into stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patientsthe 65th Annual Meeting of American Academy of Neurology 2013, San Diego(USA),,,,,,,,,,, SPECT MRI-ASL , 3.8,,,,,,,, MELAS MRI-ASL MRS ,,,,,,,,, , H.Neishi, R.Kitai, A.Tada, H.Arai, S.Yamada, M.Isozaki, K.Tsunetoshi, H.Arishima, T.Kodera, H.Takeuchi, H.Kimura, K.KikutaCerebral blood flow measured by Continuous Arterial Spin Labeling in INPH patientsthe 4th Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders Kyoto 23,,,,,,,,,,, CEA ASL ,,,,,,,,,,, MRI-CASL ,,,,,,,,,,, 24 MRI-CASL ,,,, 3D ASL What we can understand using 3D-ASL MR perfusion : Basic concepts of ASL and Clinical Applieation to Cerebro-vascular aisorders H.KimuraThe Application of 3D ASL in Intracranial Tumor 3T Advanced Applications Seminar China 29,,,,,,, MELAS MRI-ASL T.Yamamoto, H.Takeuchi, H.KimuraUsefulness of continuous arterial spin labeling images for MR monitoring of radiotherapy for non-glial brain tumors American Society of Neuroradiology (ASNR) 50th annual meeting New York(USA) 31,,,,,,

6 CASL MR ,,,,,, 3D-CASL 1 24 MR ,,,,,,,,,,,, CASL continuous arterial spin labeling ,,,,,, MRI-ASL MELAS MRI Arterial Spin Labeling (ASL) MR 21 SPECT