ASKLEPIOS Course. July 20 21, 2018 Bangkok/Thailand

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1 This ASKLEPIOS course is implemented with great support and partnership of Guerbet and RCRT Education in partnership

2 Course information This ESOR course aims to discuss the most important topics in neuroradiology. Experienced neuroradiologists will give an update on Computed tomography (CT) and magnetic resonance imaging (MRI) techniques and introduce imaging algorithms for vascular, infectious, inflammatory and demyelinating diseases of the central nervous system (CNS). Learning objectives to introduce the practical approach to image and understand traumatic brain injury to learn how to use conventional and advanced techniques in evaluation of infectious and inflammatory brain disorders to review classification and give an update on multiple sclerosis to discuss current treatment strategies in stroke

3 Programme Friday, July 20, :00 08:45 Registration 08:45 09:00 Welcome and introduction 09:00 09:30 Neuroimaging in patients with traumatic brain injury: a practical guide P.M. Parizel, Antwerp/BE 09:30 10:00 CNS infections: A roadmap from imaging to pathogen M. Thurnher, Vienna/AT 10:00 10:30 Venous ischemia, pathophysiology and diagnosis P. Vilela, Lisbon/PT 10:30 10:50 Coffee break 10:50 13:00 Workshops (P.M. Parizel, M. Thurnher, P. Vilela) 13:00 14:00 Lunch break 14:00 14:30 Presurgical and postoperative evaluation of brain tumours P.M. Parizel, Antwerp/BE 14:30 15:00 Emerging inflammatory and autoimmune CNS diseases M. Thurnher, Vienna/AT 15:00 15:30 Multiple Sclerosis: where do we stand? J.-P. Pruvo, Lille/FR 15:30 15:50 Coffee break 15:50 18:00 Workshops (P.M. Parizel, M. Thurnher, J.-P. Pruvo) Host Organiser A. Churojana Bangkok/TH Venue Anantara Riverside Bangkok Resort 257/1-3 Charoennakorn Road, Thonburi Bangkok Thailand Registration information For information about the registration, please visit Saturday, July 21, :00 09:30 Recanalization and reperfusion in acute cerebral ischemia: controlled studies and guidelines P. Vilela, Lisbon/PT 09:30 10:00 Adjunct value of vessel wall imaging in clinical practice: experience at Siriraj Hospital O. Chawalparit, Bangkok/TH 10:00 10:30 Thrombectomy in stroke J.-P. Pruvo, Lille/FR 10:30 10:50 Coffee break 10:50 13:00 Workshops (P. Vilela, O. Chawalparit, J.-P. Pruvo) 13:00 Certificate of attendance This ASKLEPIOS course is implemented with great support and partnership of Guerbet and RCRT For further information on the programme and registration please visit

4 Learning Objectives Neuroimaging in patients with traumatic brain injury: a practical guide P.M. Parizel, Antwerp/BE to present a pattern-based diagnostic approach to the patient with acute traumatic brain injury to review different types of traumatic intracranial lesions, and explain the difference between primary and secondary traumatic brain lesions to illustrate how the brain can be severely damaged in closed head injuries (deceleration trauma, diffuse axonal injuries) to demonstrate how advanced MRI techniques, such as DWI and DTI, can reveal evidence for microstructural brain damage CNS infections: A roadmap from imaging to pathogen M. Thurnher, Vienna/AT to learn how to distinguish infectious from neoplastic ring-like enhancing brain lesions to discuss the role of different MRI techniques in differentiation of bacterial, fungal and parasitic infections to introduce a roadmap for evaluation of infectious brain masses Venous ischemia, pathophysiology and diagnosis P. Vilela, Lisbon/PT to review the most common aetiologies and clinical presentation of brain and spine venous ischemia to understand the pathophysiologic mechanisms of venous ischemia to review the imaging CT and MRI findings of venous thrombosis and ischemia to become familiar with the strategies for venous thrombosis and brain malformations treatment Presurgical and postoperative evaluation of brain tumours P.M. Parizel, Antwerp/BE to review the presurgical imaging criteria for the detection and characterisation of intra- and extraaxial brain tumours to learn about the application of MR techniques including DWI, PWI, MRS for better delineation and characterisation of brain tumours to understand the crucial role of neuroimaging in the posttreatment glioma patient to differentiate normal post-operative findings from progression or pseudoprogression Emerging inflammatory and autoimmune CNS diseases M. Thurnher, Vienna/AT to learn about newly recognised classes of autoimmune encephalitides to review MR imaging findings suggestive of CNS involvement in autoimmune inflammatory diseases to understand the mechanism of antibody-mediated disorders of the nervous system This ASKLEPIOS course is implemented with great support and partnership of Guerbet and RCRT

5 Learning Objectives Multiple Sclerosis: where do we stand? J.-P. Pruvo, Lille/FR to describe new MS diagnosis criteria 2017 to discuss the next changes in MS diagnostic criteria to define a new role for neuroradiologists in MS to identify new and future imaging biomarkers in MS to harmonise our practices Recanalization and reperfusion in acute cerebral ischemia: controlled studies and guidelines P. Vilela, Lisbon/PT to review the most common aetiologies, pathophysiologic mechanisms, imaging findings and to understand the importance of multimodal CT and/or MR imaging protocols for patient selection in acute ischemic stroke to review the most recent studies on endovascular treatment of acute ischemic stroke treatment to become familiar with the most recent published guidelines for acute ischemic stroke treatment to become familiar with the interventional (endovascular) techniques used for the treatment of acute ischemic stroke to analyse some debatable issues of acute ischemic stroke: type of anaesthesia, distal occlusions treatment, acute phase arterial stenting Adjunct value of vessel wall imaging in clinical practice: experience at Siriraj Hospital O. Chawalparit, Bangkok/TH to understand the basic principle of MRI technique for vessel wall imaging to realise the Adjunct value of the VWI in stroke and common vascular disease to be aware of pitfall in interpreting the VWI to be able to give suggestion to the clinician for proper technique selection and patient management Thrombectomy in stroke J.-P. Pruvo, Lille/FR to define the global and European burden of stroke to understand the imaging criteria of stroke diagnosis, including advanced imaging to identify the indication of treatment (thrombolysis and thrombectomy) to discuss technical possibilities and devices to recognise complications and to discuss how to manage them This ASKLEPIOS course is implemented with great support and partnership of Guerbet and RCRT

6 Stability is in its DNA Upon the conception of Dotarem, Guerbet s research team, in order to minimize the release risk of gadolinium, designed the gadoterate meglumine molecule to provide high chemical stability. 1 Dotarem shows a unique profile based on its original features: Macrocyclic & ionic molecule developed by Guerbet s researchers Patented manufacturing process unconfounded cases of NSF 2-4 No visible brain hyperintensities, even in cases of repeated injections 5-8 P DOT - November Imagery : Guerbet, Shutterstock annapurna8000 COMMITTED 1. Meyer D et al. Gd-DOTA, a potential MRI contrast agent. Current status of physicochemical knowledge. Invest Radiol Sep;23 Suppl 1:S Internal data as of November Dotarem USA PI as of November de Kerviler E et al. Adverse reactions to gadoterate meglumine: review of over 25 years of clinical use and more than 50 million doses. Invest Radiol Sep;51(9): Radbruch A et al. Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology Jun;275(3): Eisele P For et further al. Lack of information increased signal intensity in the dentate nucleus after repeated administration of a macrocyclic contrast agent in multiple sclerosis: An observational study. Medicine (Baltimore) on the programme and Sep;95(39):e Radbruch A et al. No signal intensity increase in the dentate nucleus on unenhanced T1-weighted MR images after more than 20 serial injections of macrocyclic gadoliniumbased contrast agents. Radiology Mar;282(3): Radbruch A et al. Pediatric brain: no increased signal intensity in the dentate nucleus on unenhanced T1-weighted MR images after registration please visit consecutive exposure to a macrocyclic gadolinium-based contrast agent. Radiology Jun;283(3):

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8 Please note that programmes are marked with a logo to indicate their classification according to the European Training Curriculum. First three years of training Fourth and fifth year of training (general radiologist standard) Subspecialty training standard ESOR stands for education in partnership. This ASKLEPIOS course is implemented with great support and partnership of Guerbet and RCRT