Research Article Antitumor Ability of Berberine Accompanied by Modulation of Gut Microbiome in Sarcoma-180 Tumor-bearing Mice
|
|
|
- Laurence Harrell
- 5 years ago
- Views:
Transcription
1
2 OPEN ACCESS International Journal of Pharmacology ISSN DOI: /ijp Research Article Antitumor Ability of Berberine Accompanied by Modulation of Gut Microbiome in Sarcoma-18 Tumor-bearing Mice 1 Yanhong Yang, 2 Zili Lei, 2 Li Huang, 2 Fei Yang, 3 Na Zhang, 4 Jian Yuan, 3 Kundong Li, 3 Juan Chen and 3 Jufeng Zhang 1 The First Affiliated Hospital (School of Clinical Medicine), Guangdong Pharmaceutical University, Nong-Lin-Xia Road #19, Yue-Xiu District, 518 Guangzhou, People's Republic of China 2 Guangdong Research Center of Metabolic Diseases of Integrated Western and Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, 516 Guangzhou, People's Republic of China 3 School of Life Science and Biopharmacology, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, 516 Guangzhou, People's Republic of China 4 Department of Pathology and Guangdong Key Laboratory for Bioactive Drugs Research, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, 516 Guangzhou, People's Republic of China 1st and 2nd author contributed equally to this paper
3 E E G G
4 E E E E E E
5 12 (a) G/G1 G2M S-phase G/G1: 2.66% S: 68.26% 12 (b) G/G1: 19.16% S: 72.3% 9 9 Number 6 Number Channels (PL2APBS) Channels (PL2APBS) (c) G/G1: 17.99% S: 75.34% 12 (d) G/G1: 13.75% S: 76.6% Number 6 Number Channels (PL2APBS) Channels (PL2APBS) 1 (e) Cell production (%) Control 5 µmol LG 1 1 µmol LG 1 2 µmol LG 1 * * G1 Phase S G G G
6 1 7 (a) 1 7 (b) (c) 1 7 (d) Proportion of apoptic cells (%) (e) ** Control 5 µmol LG 1 ** ** 1 µmol LG 1 2 µmol LG 1 G G G
7 2 (a) 1.5 (b) Tumor indux * Spleen index 1..5 Control BBR. Control BBR 1.5 (c) Thymus index Control BBR (a) (b) (c) (d) Cell numbers of Ki-67 positive (e) BBR * Control
8 Relative abundance Taxonomy stack distribution of phylum Bacteriodetes Firmicutes Proteobacteria Tenericutes Cyanobacteria Deferribacteres Others Unclassified 25 BBR-1 BBR-2 BBR-3 BBR-4 BBR-5 BBR-6 Tumor-1 Tumor-2 Tumor-3 Tumor-4 Tumor-5 Tumor-6 Sample names Normal-1 Normal-2 Normal-3 Normal-4 Normal-5 Normal-6 Relative abundance Taxonomy stack distribution of family Bacteriodetes_S24-7_group Prevotellaceae Lachnospiraceae Ruminoco ccaceae Bacteroidaceae Rikenellaceae Porphyromonadacea Helicobacteraceae Alcaligenaceae Lactobacilaceae Others Unclassified 25 BBR-1 BBR-2 BBR-3 BBR-4 BBR-5 BBR-6 Tumor-1 Tumor-2 Tumor-3 Tumor-4 Tumor-5 Tumor-6 Normal-1 Normal-2 Normal-3 Normal-4 Normal-5 Normal-6 Sample names
9 PCO1 (18.16%) Normal-3 Normal-2 Normal-6 Normal-4 Normal-1 Normal-5 Tumor-4 BBR-4 BBR-6 BBR-3 BBR-1 BBR-5 BBR-2 Tumor-5 BBR Normal Tumor Tumor-1 Tumor-3 Tumor-2 Tumor-6 PCO2 (11.5%) Bacteriodaceae Acidaminococcaceae Rikenellaceae Anaeroplasmataceae Rhodospirillaceae Ruminococcaceae Spirochaetaceae Porphyromonadaceae Clostridiales_vadinBB6_group Streptococcaceae Bacteroidales_S24-7_group Alcaligenaceae Lactobacillaceae Coriobacteriaceae Erysipelotrichaceae Bifidobacteriaceae Helicobacteraceae Deferribacteraceae Lachnosporaceae Desulfovibrionaceae Peptococcaceae Verrucomicrobiaceae Clostridiaceae_1 Prevotellaceae Peptostreptococcaceae Normal-1 Normal-2 Normal-3 Normal-4 Normal-5 Normal-6 Tumor-1 Tumor-2 Tumor-3 Tumor-4 Tumor-5 Tumor-6 BBR-1 BBR-2 BBR-3 RRB-4 BBR-5 BBR-6 Sample names
10 ABC transporters Two-component system Purine metabolism Aminoacyl-tRNA biosynthesis Pyrimidine metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Ribosome Peptidoglycan biosynthesis Porphyrin and chlorophyll metabolism Arginine and proline metabolism Homologous recombination Fructose and mannose metabolism Cell cycle-caulobacter Mismatch repair Nucleotide excision repair Oxidative phosphorylation RNA degradation Alanine, aspartate and glutamate metabolism Methane metabolism BBR-1 BBR-2 BBR-3 RRB-4 BBR-5 BBR-6 Tumor-1 Tumor-2 Tumor-3 Tumor-4 Tumor-5 Sample names Tumor-6 Normal-1 Normal-2 Normal-3 Normal-4 Normal-5 Normal-6
11
12 $
Supplementary Figures and Tables
Supplementary Figures and Tables Supplementary Figure 1. Intestinal epithelial MyD88 deletion decreases fat mass under HFD. (a) Final fat mass expressed as a percentage of final body weight (n=25). (b)
Benakis et al. Supplementary Figure 1
Benakis et al. Supplementary Figure a flora Naive C7BL/ d AC weeks d S rrna sequencing Antibiotic in drinking water Stool pellet collection riginal seeder flora flora Naive C7BL/ d AC weeks d S rrna sequencing
traits and fasdng TMAO concentradons..6
FIGURE S1: Variability of gut microbiota composidon in Metsim samples 2 FIGURE S2: AssociaDon of bacterial diversity and richness measures with traits.3 FIGURE S3: AssociaDons of OTUs with fasdng blood
Fig S2 Efficiencies of primers used in the taxon-specific qpcr assay. CT: threshold value (A) Universal: 907F R efficiency: 99.
Fig S2 Efficiencies of primers used in the taxon-specific qpcr assay. CT: threshold value (A) Universal: 907F + 1062R efficiency: 99.1% (B) Bacteroidetes: Bac960F+Bac1100R efficiency: 98.5% (C) Firmicutes:
SUPPLEMENTARY INFORMATION
In the format provided by the authors and unedited. SUPPLEMENTARY INFORMATION ARTICLE NUMBER: 16220 DOI: 10.1038/NMICROBIOL.2016.220 Dual-specificity phosphatase 6 deficiency regulates gut microbiome and
Dynamics of the human gut microbiome in inflammatory bowel disease
In the format provided by the authors and unedited. SUPPLEMENTARY INFORMATION VOLUME: 2 ARTICLE NUMBER: 174 Dynamics of the human gut microbiome in inflammatory bowel disease Jonas Halfvarson, Colin J.
Figure S1, SDC Additional measures of microbial diversity during perioperative period In addition to the Shannon diversity index of Figure 1,
Figure S1, SDC Additional measures of microbial diversity during perioperative period In addition to the Shannon diversity index of Figure 1, additional measures of diversity are shown: Figure S2, SDC
Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment
Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment Lin Wang, Peicheng Li, Zhaosheng Tang, Xinfeng Yan, Bo Feng
PREBIOTIC MECHANISMS OF ACTION
PREBIOTIC MECHANISMS OF ACTION Seema Hooda, Kelly S. Swanson, George C. Fahey, Jr. Department t of Animal Sciences Division of Nutritional Sciences University of Illinois at Urbana-Champaign Institute
SUPPLEMENTARY DATA Supplementary Figure 1. Body weight and fat mass of AdicerKO mice.
SUPPLEMENTARY DATA Supplementary Figure 1. Body weight and fat mass of AdicerKO mice. Twelve week old mice were subjected to ad libitum (AL) or dietary restriction (DR) regimens for three months. (A) Body
Development of OTU Analysis in NutriGen
Development of OTU Analysis in NutriGen Integrating OTU data with other NutriGen Data Mateen Shaikh and Joseph Beyene McMaster University December 19 2014 Mateen and Joseph (McMaster) Development of OTU
Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented
Supplemental information Title. Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core. Authors. Giuseppe D'Auria, Francesc Peris-Bondia, Mária
Supplemental Information. Colonic Pro-inflammatory Macrophages. Cause Insulin Resistance in an Intestinal. Ccl2/Ccr2-Dependent Manner
Cell Metabolism, Volume Supplemental Information Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl/Ccr-Dependent Manner Yoshinaga Kawano, Jun Nakae, Nobuyuki Watanabe,
Diet, microbiota and the immune system: A gut feeling about type 1 diabetes. Dr. Eliana Mariño Monash University Melbourne, Australia
Diet, microbiota and the immune system: A gut feeling about type 1 diabetes Dr. Eliana Mariño Monash University Melbourne, Australia Diet, gut microbiota and Western lifestyle diseases Asthma Fatty liver
Research Article Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis
BioMed Research International Volume 216, Article ID 9462571, 11 pages http://dx.doi.org/1.1155/216/9462571 Research Article Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced
Prevention and treatment of acute exacerbations of COPD
Prevention and treatment of acute exacerbations of COPD Prof. Laurent P Nicod Service de pneumologie CHUV-Lausanne-CH SSP-SSC: 15.06.2016 COPD EXACERBATION is an event in the natural course of the disease
The Cystic Fibrosis Airway Microbiome: Cultivability, Diversity and Contribution to Disease
The Cystic Fibrosis Airway Microbiome: Cultivability, Diversity and Contribution to Disease Michael G Surette Canada Research Chair in Interdisciplinary Microbiome Research Farncombe Family Digestive Health
EFFECTS OF ANTIBIOTIC PROPHYLAXIS ON THE PERFORMANCE AND GUT MICROBIOTA OF GROWING BROILER CHICKS
EFFECTS OF ANTIBIOTIC PROPHYLAXIS ON THE PERFORMANCE AND GUT MICROBIOTA OF GROWING BROILER CHICKS Alexandra Tonks Supervisors: Dr Caroline Rymer, Prof Martin Woodward School of Agriculture, University
Asthma and the Airway Microbiome: New Insights and Hypotheses
Asthma and the Airway Microbiome: New Insights and Hypotheses Yvonne J. Huang, MD Division of Pulmonary and Critical Care Medicine Department of Internal Medicine University of Michigan, Ann Arbor 3 rd
Paul Cotter Teagasc Food Research Centre & APC
http://apc.ucc.ie Research into the relationship between digestive bacteria, nutrition and health Paul Cotter Teagasc Food Research Centre & APC paul.cotter@teagasc.ie Our microbes - Some impressive facts
SUPPLEMENTARY FIGURES
SUPPLEMENTARY FIGURES Supplementary Figure 1. Experimental design of Pulsed Antibiotic Treatment (PAT) study and effect on growth rate. a, In the PAT experiment, female C57/BL6J mice were bred and divided
OncoLog. Breast Cancer Treatment without Surgery. Many oncologists have long suspected
OncoLog MD ANDERSON S REPORT TO PHYSICIANS n May/June 2018 Vol. 63, No. 4 5 Breast Cancer Treatment without Surgery New approach may let certain breast cancer patients who respond to systemic therapy forgo
Microbiome and liver diseases
Klinik und Poliklinik für Innere Medizin I Microbiome and liver diseases Bernd Schnabl, M.D. Department of Medicine I have no financial relationship relevant to my presentation AND my presentation does
Impaired gut health: the root of systemic disorders in cattle
Impaired gut health: the root of systemic disorders in cattle Qendrim Zebeli An inside outside approach to dairy cow health University of Veterinary Medicine, Vienna Gut and disease 2 12.2.219 1 Diet for
AMINO ACIDS NON-ESSENTIAL ESSENTIAL
Edith Frederika Introduction A major component of food is PROTEIN The protein ingested as part of our diet are not the same protein required by the body Only 40 to 50 gr of protein is required by a normal
Modulation of Gut Microbiota during Probiotics-Mediated. Attenuation of Metabolic Syndrome in High Fat Diet-Fed Mice
Modulation of Gut Microbiota during Probiotics-Mediated Attenuation of Metabolic Syndrome in High Fat Diet-Fed Mice 1 2 3 Jingjing Wang 1,2, Huang Tang 2, Chenhong Zhang 2, Yufeng Zhao 1, Muriel Derrien
University of Groningen
University of Groningen Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups Steegenga, Wilma T.; Mischke, Mona;
Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressantlike Effects and Reverse the Impact of Chronic Stress in Mice
Archival Report Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressantlike Effects and Reverse the Impact of Chronic Stress in Mice Aurelijus Burokas, Silvia Arboleya, Rachel
Hannah D Holscher, J Gregory Caporaso, Seema Hooda, Jennifer M Brulc, George C Fahey Jr., and Kelly S Swanson
See corresponding editorial on page 1. Fiber supplementation influences phylogenetic structure and functional capacity of the human intestinal microbiome: follow-up of a randomized controlled trial 1 4
CHAPTER 5 MICROBIAL METABOLISM
CHAPTER 5 MICROBIAL METABOLISM I. Catabolic and Anabolic Reactions A. Metabolism - The sum of all chemical reactions within a living cell either releasing or requiring energy. (Overhead) Fig 5.1 1. Catabolism
Research Article Microflora Disturbance during Progression of Glucose Intolerance and Effect of Sitagliptin: An Animal Study
Journal of Diabetes Research Volume 2016, Article ID 2093171, 10 pages http://dx.doi.org/10.1155/2016/2093171 Research Article Microflora Disturbance during Progression of Glucose Intolerance and Effect
MICROBIAL PATTERNS IN PATIENTS WITH HISTAMINE INTOLERANCE
journal OF PHYSIOLOGY AND PHARMACOLOGY 2018, 69, 4, 579-593 www.jpp.krakow.pl DOI: 10.26402/jpp.2018.4.09 M. SCHINK 1, P.C. KONTUREK 2, E. TIETZ 1, W. DIETERICH 1, T.C. PINZER 3, S. WIRTZ 3, M.F. NEURATH
Structural changes of gut microbiota in mice with chronic constipation and intestinal tumor.
Biomedical Research 017; 8 (): 1006-10067 ISSN 0970-938X www.biomedres.info Structural changes of gut microbiota in mice with chronic constipation and intestinal tumor. Yunpeng Luan 1,*, Dechang Mao, Min
INTRODUCTION. Ireland
Microbiology (215), 161, 182 193 DOI 1.199/mic..8261- Streptozotocin-induced type-1-diabetes disease onset in Sprague Dawley rats is associated with an altered intestinal microbiota composition and decreased
If you ate a clown, would it taste funny? Oh, wait, that s cannibalism . Anabolism
If you ate a clown, would it taste funny? Oh, wait, that s cannibalism. Anabolism is about putting things together. Anabolism: The Use of Energy in Biosynthesis Anabolism energy from catabolism is used
Supplementary files. Tissue metabolomics study to reveal the toxicity of a Traditional Tibetan. medicines Renqing Changjue in rat
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2018 Supplementary files Tissue metabolomics study to reveal the toxicity of a Traditional Tibetan
Individual Apostichopus japonicus fecal microbiome reveals a link with polyhydroxybutyrate producers in host growth gaps
Individual Apostichopus japonicus fecal microbiome reveals a link with polyhydroxybutyrate producers in host growth gaps Yohei Yamazaki 1#, Pedro Milet Meirelles 2#, Sayaka Mino 1, Wataru Suda 3,4, Kenshiro
Inflammatory bowel diseases (IBDs) including Crohn s
Imaging and Advanced Technology A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes BEN P. WILLING,* JOHAN DICKSVED,* JONAS HALFVARSON,
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
GASTROENTEROLOGY 2009;137:1716 1724 BASIC High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity MARIE A. HILDEBRANDT,* CHRISTIAN HOFFMANN, SCOTT A. SHERRILL MIX,
K-means Clustering of a subset of five datasets that were identified as. TNBC by IHC. Since TNBCs are not identified by GE in the clinical setting, we
Supplemental Results K-means Clustering of a subset of five datasets that were identified as TNBC by IHC. Since TNBCs are not identified by GE in the clinical setting, we performed a similar GE analysis
Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups
1600141 (1 of 17) Mol. Nutr. Food Res. 61, 1, 2017, 1600141 DOI 10.1002/mnfr.201600141 RESEARCH ARTICLE Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition
Carnelian uncovers hidden functional patterns across diverse study populations from whole metagenome sequencing reads
Carnelian uncovers hidden functional patterns across diverse study populations from whole metagenome sequencing reads Sumaiya Nazeen 1 and Bonnie Berger 1,2* 1 Computer Science and Artificial Intelligence
ISSN: (Print) (Online) Journal homepage:
Gut Microbes ISSN: 1949-0976 (Print) 1949-0984 (Online) Journal homepage: http://www.tandfonline.com/loi/kgmi20 The structures of the colonic mucosa-associated and luminal microbial communities are distinct
Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life McKee, Trudy ISBN-13: 9780195305753 Table of Contents * New to this edition Preface 1. WHAT IS LIFE? 1.1 The Living World Bacteria Archaea Eukarya 1.3 Biomolecules
Physiology of the Weaner Pig
Physiology of the Weaner Pig Microbiota,, Gut Immunity and Performance Denise Kelly, Rowett Institute of Nutrition & Health, University of Aberdeen, Scotland Gut surfaces and Epithelial cells Gut Bacteria
Metabolomic Data Analysis with MetaboAnalystR
Metabolomic Data Analysis with MetaboAnalystR Name: guest623839008349489450 February 7, 2018 1 Background Understanding the functional importance of metabolites in untargeted metabolomics is limited due
microorganisms ISSN Review
Microorganisms 2015, 3, 759-791; doi:10.3390/microorganisms3040759 OPEN ACCESS microorganisms ISSN 2076-2607 www.mdpi.com/journal/microorganisms Review Gut Microbiota and Host Reaction in Liver Diseases
Infant Immune Responses and the Microbiome
Infant Immune Responses and the Microbiome Kei E. Fujimura, Ph.D. Division of Gastroenterology, Department of Medicine, University of California San Francisco, USA. IMPAACT Network Laboratory Science Retreat
Fecal bacterial microbiome diversity in chronic HIV-infected patients in China
OPEN (2016) 5, e31; doi:10.1038/emi.2016.25 www.nature.com/emi ORIGINAL ARTICLE Fecal bacterial microbiome diversity in chronic HIV-infected patients in China Yang Sun 1,2,3, *, Yingfei Ma 4, *, Ping Lin
Carbohydrates. Building a carbohydrate:
Carbohydrates Monomer: Monosaccharide (simple s) Example: glucose, fructose Disaccharide: 2 monosaccharides joined together Example: sucrose (glucose + fructose) olymer: olysaccharide (starch) Example:
(51) Int Cl.: A61K 35/37 ( ) A61P 1/00 ( )
(19) TEPZZ 68 9ZB_T (11) EP 2 683 390 B1 (12) EUROPEAN PATENT SPECIFICATION (4) Date of publication and mention of the grant of the patent: 03.0.17 Bulletin 17/18 (21) Application number: 127616.9 (22)
Personal Genomics: Using Big Data and Genomics to Manage Health and Disease
Personal Genomics: Using Big Data and Genomics to Manage Health and Disease Michael Snyder June 8, 2015 Conflicts: Personalis, Genapsys, AxioMx, Novartis Precision Medicine is of High Interest Health Is
Four Classes of Biological Macromolecules. Biological Macromolecules. Lipids
Biological Macromolecules Much larger than other par4cles found in cells Made up of smaller subunits Found in all cells Great diversity of func4ons Four Classes of Biological Macromolecules Lipids Polysaccharides
E.coli Core Model: Metabolic Core
1 E.coli Core Model: Metabolic Core 2 LEARNING OBJECTIVES Each student should be able to: Describe the glycolysis pathway in the core model. Describe the TCA cycle in the core model. Explain gluconeogenesis.
Short polymer. Dehydration removes a water molecule, forming a new bond. Longer polymer (a) Dehydration reaction in the synthesis of a polymer
HO 1 2 3 H HO H Short polymer Dehydration removes a water molecule, forming a new bond Unlinked monomer H 2 O HO 1 2 3 4 H Longer polymer (a) Dehydration reaction in the synthesis of a polymer HO 1 2 3
Characterisation of Gut Microbiota in Ossabaw and Göttingen Minipigs as Models of Obesity and Metabolic Syndrome
Downloaded from orbit.dtu.dk on: Dec 12, 2018 Characterisation of Gut Microbiota in Ossabaw and Göttingen Minipigs as Models of Obesity and Metabolic Syndrome Pedersen, Rebecca; Ingerslev, Hans-Christian;
Lipid hydrolysis products affect the composition of infant gut microbial communities in vitro
, page 1 of 1 q The Authors 15 doi:1.117/s711515811 Lipid hydrolysis products affect the composition of infant gut microbial communities in vitro Rikke G. Nejrup 1,, Martin I. Bahl, Louise K. Vigsnæs,
What really is a prebiotic and why? ISAPP Cork 2012 Discussion Group 1
What really is a prebiotic and why? ISAPP Cork 2012 Discussion Group 1 Juliet Ansell Paul Blatchford George Fahey Glenn Gibson Yong Jun Goh Arland Hotchkiss Bob Hutkins Christophe Lacroix Jose Garcia Mazcorro
Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea
ORIGINAL ARTICLE SLEEP alters gut microbiota diversity in a mouse model of sleep apnoea Isabel Moreno-Indias 1,2,9, Marta Torres 3,4,9, Josep M. Montserrat 3,4,, Lidia Sanchez-Alcoholado 1,2, Fernando
Amino Acid Metabolism
Amino Acid Metabolism Last Week Most of the Animal Kingdom = Lazy - Most higher organisms in the animal kindom don t bother to make all of the amino acids. - Instead, we eat things that make the essential
Shifts on gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer s disease during lifespan
Shifts on gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer s disease during lifespan Journal: Applied Microbiology Manuscript ID Draft Journal Name: Letters in Applied Microbiology
Fatty acids and phospholipids
PYS 4xx Intro 2 1 PYS 4xx Intro 2 - Molecular building blocks We now describe in more detail the nomenclature and composition of several classes of compounds of relevance to the cell, including: membrane
Identification of Tissue-Specific Protein-Coding and Noncoding. Transcripts across 14 Human Tissues Using RNA-seq
Identification of Tissue-Specific Protein-Coding and Noncoding Transcripts across 14 Human Tissues Using RNA-seq Jinhang Zhu 1, Geng Chen 1, Sibo Zhu 1,2, Suqing Li 3, Zhuo Wen 3, Bin Li 1, Yuanting Zheng
Mary D. Boudreau,*,1 Greg R. Olson, Volodymyr P. Tryndyak,* Matthew S. Bryant,* Robert P. Felton, and Frederick A.
TOXICOLOGICAL SCIENCES, 158(2), 2017, 302 318 doi: 10.1093/toxsci/kfx105 Advance Access Publication Date: May 19, 2017 Research Article Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological
Protein Class/Name KEGG Pathways
Electronic Supplementary Material (ESI) for Analyst. This journal is The Royal Society of Chemistry 2017 Supplemental Table 4. Proteins Increased in Either Soil medium at 37 o C and 25 o C Table 4A. Proteins
NBCE Mock Board Questions Biochemistry
1. Fluid mosaic describes. A. Tertiary structure of proteins B. Ribosomal subunits C. DNA structure D. Plasma membrane structure NBCE Mock Board Questions Biochemistry 2. Where in the cell does beta oxidation
Gut microbiome in Hadza huntergatherers, adaptation to a Paleolithic lifestyle
Gut microbiome in Hadza huntergatherers, adaptation to a Paleolithic lifestyle Patrizia Brigidi Dept. Pharmacy and Biotechnology University of Bologna patrizia.brigidi@unibo.it THE HUMAN MICROBIOTA: PHYLOGENETIC
A diet based on cured acorn ham with oleic acid content promotes anti-inflammatory gut
1 2 3 Article A diet based on cured acorn ham with oleic acid content promotes anti-inflammatory gut microbiota shifts and prevents ulcerative colitis in an animal model 4 5 6 J. Fernández, 1 V. García
Signal transduction camp signaling pathway ko Signal transduction MAPK signaling pathway ko
Table S2 - Summary of the KEGG pathway annotation results for the P transcriptome. Pathway Hierarchy1 Pathway Hierarchy2 KEGG Pathway Pathway ID Gene Metabolism Amino acid metabolism Lysine degradation
Investigation of bacterial diversity in the feces of cattle fed different diets
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Faculty Publications in Food Science and Technology Food Science and Technology Department 2014 Investigation of bacterial
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
Received Mar Accepted 7 Apr Published Jun DOI:.8/ncomms8 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites Alison N. Thorburn, Craig I. McKenzie,
Biology. Lectures winter term st year of Pharmacy study
Biology Lectures winter term 2008 1 st year of Pharmacy study 3 rd Lecture Chemical composition of living matter chemical basis of life. Atoms, molecules, organic compounds carbohydrates, lipids, proteins,
Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine
Xiong et al. Microbiome () : DOI./s---x RESEARCH Perilipin- modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine Open Access Xuejian Xiong, Elise S. Bales, Diana
Cells. Variation and Function of Cells
Cells Variation and Function of Cells Plasma Membrane= the skin of a cell, it protects and nourishes the cell while communicating with other cells at the same time. Lipid means fat and they are hydrophobic
Li et al. Journal of Experimental & Clinical Cancer Research (2018) 37:108
Li et al. Journal of Experimental & Clinical Cancer Research (2018) 37:108 https://doi.org/10.1186/s13046-018-0774-7 CORRECTION Correction to: Novel smac mimetic APG- 1387 elicits ovarian cancer cell killing
The gut microbiota in conventional and serrated precursors of colorectal cancer
Peters et al. Microbiome (2016) 4:69 DOI 10.1186/s40168-016-0218-6 RESEARCH The gut microbiota in conventional and serrated precursors of colorectal cancer Open Access Brandilyn A. Peters 1, Christine
Diet shapes the gut microbiota of the omnivorous cockroach Blatella germanica
FEMS Microbiology Ecology Advance Access published February 26, 2015 1 2 3 Diet shapes the gut microbiota of the omnivorous cockroach Blatella germanica Ana Elena Pérez-Cobas 1,2,3, Elisa Maiques 1, Alexandra
Chapter 2. Chemical Composition of the Body
Chapter 2 Chemical Composition of the Body Carbohydrates Organic molecules that contain carbon, hydrogen and oxygen General formula C n H 2n O n -ose denotes a sugar molecule Supply energy Glucose Complex
HUMAN GUT MICROBIOTA
HUMAN GUT MICROBIOTA Patrizia Brigidi Department of Pharmaceutical Sciences, University of Bologna, Italy patrizia.brigididi@unibo.it The Gut-Liver axis: a bidirectional relation in health and disease
Lecture 11 - Biosynthesis of Amino Acids
Lecture 11 - Biosynthesis of Amino Acids Chem 454: Regulatory Mechanisms in Biochemistry University of Wisconsin-Eau Claire 1 Introduction Biosynthetic pathways for amino acids, nucleotides and lipids
Course Title Form Hours subject
Course Title Form Hours subject Types, and structure of chromosomes L 1 Histology Karyotyping and staining of human chromosomes L 2 Histology Chromosomal anomalies L 2 Histology Sex chromosomes L 1 Histology
PhyloChip microarray analysis reveals altered gastrointestinal microbial communities in a rat model of colonic hypersensitivity
Neurogastroenterol Motil (2011) 23, 169 e42 doi: 10.1111/j.1365-2982.2010.01637.x PhyloChip microarray analysis reveals altered gastrointestinal microbial communities in a rat model of colonic hypersensitivity
Role of the Gut Microbiota in Autoimmunity
Role of the Gut Microbiota in Autoimmunity Pavan Bhargava, MD - Neuroimmunology Fellow Division of Neuroimmunology and Neurological Infections Johns Hopkins University, Baltimore, MD. May, 2015 None Disclosures
and the cells removed by centrifugation. These were resuspended in sterile 1949a), growth was measured in terms of acid production while dextran was
THE NUTRITIONAL REQUIREMENTS OF LEUCONOSTOC DEXTRANICUM FOR GROWTH AND DEXTRAN SYNTHESIS1 VIRGINIA WHITESIDE-CARLSON AND CARMEN L. ROSANO Biochemistry Department, Medical College of Alabama, Birmingham,
AP BIOLOGY: READING ASSIGNMENT FOR CHAPTER 5
1) Complete the following table: Class Monomer Functions Carbohydrates 1. 3. Lipids 1. 3. Proteins 1. 3. 4. 5. 6. Nucleic Acids 1. 2) Circle the atoms of these two glucose molecules that will be removed
Expression of programmed death ligand-1 on tumor cells varies pre and post
Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer Jin Sheng 1,2,3,*, Wenfeng Fang 1,2,3,*, Juan Yu 3, Yunpeng Yang 1,2,3, Yuxiang Ma
Different Flavonoids Can Shape Unique Gut Microbiota Profile In Vitro
Different Flavonoids Can Shape Unique Gut Microbiota Profile In Vitro Jiacheng Huang, Long Chen, Bin Xue, Qianyue Liu, Shiyi Ou, Yong Wang, and Xichun Peng Abstract: The impact of flavonoids has been discussed
NUCLEOLUS CELL MEMBRANE MITOCHONDRIA CELL WALL CHLOROPLAST NUCLEAR MEMBRANE VACOULE NUCLEUS ORGANELLE CARD ORGANELLE CARD ORGANELLE CARD
CELL MEMBRANE NUCLEOLUS CELL WALL MITOCHONDRIA NUCLEAR MEMBRANE CHLOROPLAST NUCLEUS VACOULE CENTRAL VACOULE LEUCOPLAST CHROMOPLAST LYSOSOME CYTOPLASM CYTOSKELETON CENTRIOLE RIBOSOME CHROMATIN ROUGH ENDOPLASMIC
A look at macromolecules (Text pages 38-54) What is the typical chemical composition of a cell? (Source of figures to right: Madigan et al.
A look at macromolecules (Text pages 38-54) What is the typical chemical composition of a cell? (Source of figures to right: Madigan et al. 2002 Chemical Bonds Ionic Electron-negativity differences cause
Diet-induced extinction in the gut microbiota compounds over generations
Diet-induced extinction in the gut microbiota compounds over generations The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation
Joint Department of Biomedical Engineering
Electronic Supplementary Material (ESI) for Biomaterials Science. This journal is The Royal Society of Chemistry 2018 Supplementary Data Systemic Delivery of CRISPR/Cas9 with PEG-PLGA Nanoparticles for
Thermal processing of food reduces gut microbiota diversity of the host and triggers adaptation of the microbiota: evidence from two vertebrates
Zhang and Li Microbiome (2018) 6:99 https://doi.org/10.1186/s40168-018-0471-y RESEARCH Thermal processing of food reduces gut microbiota diversity of the host and triggers adaptation of the microbiota:
Amino acids-incorporated nanoflowers with an
Amino acids-incorporated nanoflowers with an intrinsic peroxidase-like activity Zhuo-Fu Wu 1,2,+, Zhi Wang 1,+, Ye Zhang 3, Ya-Li Ma 3, Cheng-Yan He 4, Heng Li 1, Lei Chen 1, Qi-Sheng Huo 3, Lei Wang 1,*
Canqiu Yu 1, Jinwei Chen 2, Li Huang 3*
A STUDY ON THE ANTITUMOUR EFFECT OF TOTAL FLAVONOIDS FROM PTERIS MULTIFIDA POIR IN H22 TUMOUR-BEARING MICE 459 Canqiu Yu 1, Jinwei Chen 2, Li Huang 3* 1 Department of General Surgery, The Second Xiangya
Chapter 5: Structure and Function of Macromolecules AP Biology 2011
Chapter 5: Structure and Function of Macromolecules AP Biology 2011 1 Macromolecules Fig. 5.1 Carbohydrates Lipids Proteins Nucleic Acids Polymer - large molecule consisting of many similar building blocks
M1 - Renal, Fall 2007
University of Michigan Deep Blue deepblue.lib.umich.edu 2007-09 M1 - Renal, Fall 2007 Lyons, R.; Burney, R. Lyons, R., Burney, R. (2008, August 07). Renal. Retrieved from Open.Michigan - Educational Resources
Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery
Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.3748/wjg.v21.i14.4150 World J Gastroenterol 2015 April 14; 21(14): 4150-4158 ISSN 1007-9327
Structural Changes of Gut Microbiota during Berberine- Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats
Structural Changes of Gut Microbiota during Berberine- Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats Xu Zhang 1, Yufeng Zhao 2, Menghui Zhang 1, Xiaoyan Pang 1, Jia Xu
Microbiota-gut-brain-axis and Autism Spectrum disorders
Review Microbiota-gut-brain-axis and Autism Spectrum disorders Piranavie Srikantha, M. Hasan Mohajeri * Department of medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.