EXAMINATION THEMES IN GENERAL PATHOLOGY FOR STUDENTS OF GENERAL MEDICINE
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1 EXAMINATION THEMES IN GENERAL PATHOLOGY FOR STUDENTS OF GENERAL MEDICINE 1. General mechanisms of the cell injury. 2. Cell death: necrosis, apoptosis. 3. Tissue and organ adaptation - definitions, examples. 4. Hyperplasia. 5. Hypertrophy. 6. Atrophy. 7. Metaplasia. 8. Pathology of cell organelles and cytoskeleton. 9. Metabolic disorders and intracellular metabolite accumulations. 10. Intracellular accumulation of lipids - steatosis. 11. Intracellular accumulation of proteins. 12. Amyloidosis. 13. Glycosaminoglycan accumulations (mucopolysaccharidoses), mucoviscidosis. 14. Disorders of saccharide metabolism (diabetes mellitus, glycogenoses). 15. Exogenous pigmentations, including pneumoconioses. 16. Endogenous pigmentations. 17. Pathologic calcification. 18. Disorders of water transport, hydration and cell swelling. 19. Cardial findings in circulatory failure. 20. Extracardial findings in circulatory failure. 21. Thrombosis. 22. Embolism. 23. Hyperemia. 24. Ischemia. 25. Infarction. 26. Edema. 27. Dehydration. 28. Hemorrhage. 29. Faintness, shock and circulatory collapse. 30. Definition and causes of inflammation. 31. Macroscopic findings in inflammation. 32. Basic microscopic features of inflammation. 33. Acute inflammation. 34. Phases of inflammation. 35. Cellular events in inflammation. 36. Outcomes of acute inflammation. Healing in acute inflammation. 37. Chronic inflammation. 38. Systematic in morphologic patterns of exudative inflammation. 39. Morphologic patterns of superficial inflammation and its healing. 40. Morphologic patterns of interstitial inflammation and its healing. 41. Granulomatous inflammatory disorders. 42. Tuberculosis forms and findings. 43. Primary (preimmune) tuberculosis. 44. Secondary (reactivation, postprimary) tuberculosis. 45. Sarcoidosis. 46. Acquired syphilis. 47. Congenital syphilis. 48. Leprosy. 49. Systemic effects in inflammation.
2 50. Regeneration and repair. 51. Wound healing. 52. Healing of thrombi, hematomas and fractures. 53. Immune mechanisms of tissue injury. 54. Pathology of transplantation. 55. Autoimmune diseases. 56. Immunodeficiency. 57. Definition and classification of tumors. 58. Characteristics of benign, borderline and malignant tumors. 59. Local tumor growth. Metastasis. 60. Hereditary and acquired preneoplastic conditions and lesions (precanceroses). 61. Carcinogenes. 62. Molecular basis of neoplasia. Genomic instability. 63. Tumor typing, grading and staging. 64. Tumor-like conditions (pseudotumors). 65. Epithelium tumors. 66. Mesenchymal tumors. 67. Mesothelium tumors (mesotheliomas). 68. Hematopoietic and lymphoid tissue tumors. 69. Neuroectodermal tumors. 70. Melanocytic tumors. 71. Germ cell tumors. 72. Mixed tumors. 73. Virus and host cell interactions. 74. Morphologic patterns of the most frequent viral infections of mucosae and skin. 75. Morphologic patterns of the most frequent viral infections of respiratory system. 76. Mechanisms of bacterial injury to cells and tissues. 77. Local and systemic changes in infections. 78. Morphologic patterns of the most frequent Gram-positive bacterial infections. 79. Morphologic patterns of the most frequent Gram-negative bacterial infections. 80. Acid-fast rods infections. 81. Spirochaetal infections. 82. Anaerobic infections. 83. Obligate intracellular bacterial infections. 84. Morphologic patterns of the most frequent intestinal parasitic diseases (giardiasis, amoebiasis, taeniasis, ascariasis, enterobiasis, strongyloidiasis, ancylostomiasis,...). 85. Morphologic patterns of the most frequent systemic parasitic diseases (trypanosomiasis, toxocariasis, schistosomiasis, leishmaniasis, hydatidasis, trichinosis, filariasis,...). 86. Toxoplasmosis. 87. Malaria. 88. Sexually transmitted infections. 89. Superficial mycoses. 90. Deep mycoses. 91. Chemical causes of diseases. 92. Physical causes of diseases. 93. Nutritional diseases. 94. Congenital developmental disorders types, causes, pathogenesis, consequences.
3 ORGAN PATHOLOGY RIGOROSUM QUESTIONS (GENERAL MEDICINE) THE HEART AND VESSELS 1. Vasculitis 2. Aneurysms 3. Atherosclerosis 4. Diseases of veins, varices 5. Neoplasms of blood vessels 6. Pathology of lymphatic vessels 7. Congenital heart defects 8. Ischemic heart disease 9. Hypertension, heart in hypertension 10. Pathology of pulmonary circulation 11. Diseases of endocardium 12. Rheumatic heart disease 13. Infectious endocarditis 14. Noninfectious endocarditides 15. Valvular defects 16. Diseases of myocardium 17. Diseases of pericardium 18. Age related heart diseases 19. Neoplasms of heart PATHOLOGY OF HAEMATOPOIETIC AND LYMPHOID SYSTEM 20. Anemias 21. Chronic myeloproliferative diseases 22. Myelodysplastic syndromes 23. Leukemias 24. Plasma cell neoplasms and monoclonal immunoglobulin deposition diseases 25. Hemorrhagic diseases 26. Inborn disorders of blood coagulation 27. Acquired disorders of blood coagulation THE LYMPHATIC NODULES AND THE SPLEEN 28. Lymphadenitides
4 29. Non-inflammatory lymphadenopathies 30. Neoplasms of lymph nodes and extranodal lymphatic tissue (lymphomas) 31. Non-Hodgkin lymphomas 32. Hodgkin lymphoma (Hodgkin disease) 33. Langerhans cell histiocytosis 34. Splenomegaly PATHOLOGY OF THYMUS 35. Diseases of thymus PATHOLOGY OF RESPIRATORY TRACT 36. Non-neoplastic diseases of nose, paranasal sinuses, nasopharynx 37. Tumours of nose, paranasal sinuses, nasopharynx 38. Non-neoplastic diseases of larynx and trachea 39. Tumours of larynx and trachea 40. Bronchitis, bronchostenosis and bronchiectasia. 41. Astma bronchiale 42. Disorders of lung aeration 43. Disorders of lung circulation 44. Lung edema 45. Pulmonary trombembolism 46. Diffuse alveolar damage 47. Lung inflammation - classification 48. Bronchopneumonia and lobar pneumonia 49. Interstitial pneumonias 50. Granulomatous lung inflammation 51. Pneumoconioses 52. Lung tumours 53. Pathology content of the pleural cavity 54. Pleuritis 55. Tumours of the pleural cavity PATHOLOGY OF THE GASTROINTESTINAL TRACT 56. Oral cavity regressive and metabolic changes, pigmentation 57. Acute inflammatory diseases of the oral cavity
5 58. Chronic inflammatory diseases of the oral cavity 59. Tumours and pseudotumours of the oral soft tissues 60. Orofacial epithelial neoplasms 61. Developmental disorders of dentice 62. Dental caries 63. Pulpitis. Periodontitis. Parodontopathies 64. Head and neck cysts 65. Odontogenic tumours 66. Non-neoplastic salivary gland diseases 67. Neoplasms of salivary glands 68. Diseases of pharynx and tonsils 69. Non-neoplastic diseases of esophagus 70. Tumours of esophagus 71. Gastritis 72. Peptic ulcer 73. Neoplasms of stomach 74. Diverticula 75. Malabsorption syndromes 76. Infectious inflammations of intestine 77. Idiopathic inflammations of intestine 78. Appendicitis 79. Disorders of the bowel integrity and position 80. Ileus 81. Neoplasms of intestine 82. Diseases of peritoneum 83. Hernias PATHOLOGY OF THE LIVER AND BILLIARY TRACT 84. Disorders of the liver development 85. Regressive changes of the liver (necrosis, apoptosis, storage diseases, jaundice ) 86. Metabolic liver diseases 87. Icterus and cholestasis
6 88. Viral and autoimmune hepatitides 89. Immune inflammatory diseases of the intrahepatic biliary ducts 90. Drug and chemicals related hepatopathies 91. Liver cirrhosis 92. Neoplasms and pseudotumours of the liver and intrahepatic biliary tree 93. Non-neoplastic diseases of the gall bladder and extrahepatic bile ducts 94. Neoplasms of the gallbladder and extrahepatic bile ducts 95. Non-neoplastic diseases of pancreas 96. Neoplasms of pancreas PATHOLOGY OF THE URINARY TRACT 97. Developmental renal diseases 98. Diseases of renal tubules and interstitium 99. Morphology features of benign and malignant hypertension in kidney 100. Atherosclerosis, infarction, and cortical necrosis in kidney 101. Vasculitides affecting the kidney 102. Diabetic nephropathy (glomerulosclerosis and other diabetes related kidney diseases) 103. Rapidly progressing glomerulonephritis 104. Glomerulopathies with nephrotic syndrome 105. Diseases of glomerules manifesting with hematuria 106. Systemic lupus erythematodes and its kidney manifestation 107. Kidney transplantation and rejection morphology 108. Neoplasms of kidney 109. Non-neoplastic diseases of the urinary tract 110. Neoplasms of the urinary tract PATHOLOGY OF MALE GENITAL SYSTEM 111. Non-neoplastic diseases of penis and scrotum 112. Neoplasms of penis and scrotum 113. Non-neoplastic diseases of testis 114. Neoplasms of testis 115. Non-neoplastic diseases of prostate and seminal vesicles 116. Neoplasms of prostate and seminal vesicles
7 PATHOLOGY OF FEMALE GENITAL SYSTEM AND BREAST 117. Non-neoplastic diseases of vulva 118. Neoplasms of vulva 119. Non-neoplastic diseases of vagina 120. Neoplasms of vagina 121. Non-neoplastic diseases of uterine cervix 122. Cervical precanceroses 123. Neoplasms of uterine cervix 124. Non-neoplastic diseases of uterine body 125. Neoplasms of uterine body 126. Diseases of salpinx 127. Ovarian cysts 128. Epithelial ovarian neoplasms 129. Germinal tumours of ovary 130. Gonadostromal and mixed tumours o ovary 131. Diseases of placenta 132. Pathology of pregnancy 133. Non-neoplastic diseases of breast 134. Neoplasms of breast 135. Diseases of male breast PATHOLOGY OF CENTRAL NERVOUS SYSTEM AND PERIPHERAL NERVES 136. Brain edema, hydrocephalus 137. Disorders of the CNS circulation - ischemia, hemorrhage 138. Intermeningeal bleeding 139. Fractures of the skull, brain commotion and contusion 140. Meningitis, encephalitis, myelitis 141. Degenerative diseases of CNS 142. Demyelinisation diseases 143. Prion diseases 144. Epilepsy - epileptic syndrome 145. Perinatal CNS damage
8 146. Neoplasms of brain and meninges PATHOLOGY OF MUSCULOSKELETAL SYSTEM 147. Disorders of the skeletal development 148. Rickets and osteomalacia 149. Osteitis fibrosa cystica and renal osteopathy 150. Bone atrophy: osteopenia and osteoporosis 151. Necrosis of bone 152. Fractures and their healing 153. Bone inflammation 154. Tumours and tumour-like lesions of bone 155. Non-neoplastic diseases of joints 156. Pseudotumours and tumours of joints 157. Diseases of tendons and tendon sheaths 158. Diseases of muscles PATHOLOGY OF ENDOCRINE SYSTEM 159. Non-neoplastic diseases of the pituitary gland 160. Neoplasms of the pituitary gland 161. Diseases of pineal gland 162. Non-neoplastic thyroid diseases and thyroidal syndromes 163. Neoplasms of thyroid gland 164. Non-neoplastic diseases of parathyroid glands and parathyroidal syndromes 165. Neoplasms of the parathyroid gland 166. Non-neoplastic diseases of adrenal cortex 167. Neoplasms of adrenal cortex 168. Adrenocortical syndromes 169. Diseases of adrenal medulla and related syndromes 170. Diseases of Langerhans islets and related syndromes PATHOLOGY OF THE SKIN 171. Non-infectious inflammations of the skin 172. Infectious inflammations of the skin 173. Inflammations of hair follicles 174. Benign neoplasms of the skin (epithelial and mesenchymal)
9 175. Malignant neoplasms of the skin (epithelial and mesenchymal) 176. Pigmented nevi and melanoma PERINATAL PATHOLOGY 177. Mors praenatalis and mors neonatalis 178. Perinatal injuries 179. Early and late asphyxia syndrome 180. Neonatal brain bleeding, necrotizing enterocolitis and other complications of perinatal period
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