CURRICULUM VITAE (Last updated: October, 2018)

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1 CURRICULUM VITAE (Last updated: October, 2018) Sung Hee Baek, Ph.D. POSITION Director, Research Center for Epigenetic Code and Diseases Professor, Department of Biological Sciences Homepage URL) PROFESSIONAL EXPERIENCE 2017-present Director, Research Center for Epigenetic Code and Diseases 2013-present Professor, Dept. of Biological Sciences, Seoul National University 2012-present Distinguished Fellow, Dept. of Biological Sciences, Seoul National University 2009-present Associate Member, The Korean Academy of Science and Technology Director, Research Center for Chromatin Dynamics Associate Professor, Dept. of Biological Sciences, Seoul National University Assistant Professor, Dept. of Biological Sciences, Seoul National University Research Assistant Professor, University of California San Diego, HHMI Post-doc., University of California San Diego, HHMI (Adviser: Michael G. Rosenfeld) EDUCATION Seoul National University, Ph.D. in Molecular Biology, Adviser: Prof. Chin Ha Chung Seoul National University, M.S. in Molecular Biology, Adviser: Prof. Chin Ha Chung Seoul National University, B.S. in Molecular Biology, Nutrition (Double Major) ORGANIZED INTERNATIONAL SYMPOSIUM Mokam-Hall, SNU, 2009 Seoul Chromatin Symposium Mokam-Hall, SNU, 2010 Seoul Chromatin Symposium Mokam-Hall, SNU, 2014 Seoul Epigenetics and Chromatin Symposium Guangzhou, Chin, Cell Symposia, Functional RNAs Mokam-Hall, SNU, 2016 Seoul Symposium on Epigenetics and Chromatin Millennium Seoul Hilton, Abcam, Epigenetic regulatory pathways Seoul

2 PROFESSIONAL EXPERIENCE Presidential committee on the fourth industrial revolution, Ministry of Science and ICT 2015-present Review Board Council Member, Division of Life Sciences, National Research Foundation of Korea 2015-present Asian Advisory Committee, Keystone Symposia 2013-present Review Committee member, Human Frontier Science Program EDITORIAL BOARDS 2015-present 2010-present 2008-present 2006-present Editor, DNA and Cell Biology Guest Editor, Annual Review of Physiology Editor, BBA Molecular Basis of Disease (Elsevier) Managing Editor, Frontiers in Biosciences HONORS AND AWARDS The 24th HumanTech Paper Award Gold prize (Bio Engineering & Life Science), Samsung Electronics Co., Ltd The 2016 Official Commendation of Minister (Basic Research Project), Ministry of Science, ICT and Future Planning The 6th Dissertation of the Year Awards, S-OIL Science Prodigy and Culture Foundation The 11th Kyung-Ahm Prize in Arts & Sciences (Academic Award of Bioscience), Kyung-Ahm Education & Culture Foundation The Female Creative Award, Samsung Awards, Samsung Foundation The Women in Science and Technology Award 2012, Korea Science and Engineering Foundation The Cancer Research Award 2012 of Park Byung Kyu-Kim Byung Soo, Yonsei University The 10th Korea L OREAL-UNESCO for Women in Science Award The 12th Seoul National University, Award for the Best Scientific Research The 12th Young Scientist Award (Presidential award) The 3rd AMORE-PACIFIC New Investigator Award The 3rd Macrogen for Women in Science Award The 1st Jin-Pok Kim s Award for the Best Cancer Research The 2nd Macrogen New Investigator Award The 4th L OREAL-UNESCO for Women in Science Award (Domestic) 2

3 SELECTED PUBLICATIONS [01] Kim, D.H., Nam, H.j., Lee, W.H., Yim, H.Y., Ahn, J.-Y., Park, S.W., Shin, H.J., Yu, R., Won, K.-J., Bae, J.-S., Kim, K.I.*, and Baek, S.H.* (2018). PKCα-LSD1-NF-κB Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. Molecular Cell 69, (* co-corresponding authors) [02] Baek, S.H., and Kim, K.I. (2017) Epigenetic Control of Autophagy: Nuclear Events Gain More Attention. Molecular Cell 65(5), [03] Shin, H-J., Kim H.K., Oh, S.R., Lee, J-G., Kee, M.J., Ko, H-J., Kweon, M-N., Won, K.J., and Baek, S.H. (2016) AMPK-Skp2-CARM1 Signaling Cascade in Transcriptional Regulation of Autophagy. Nature 534(7608), [04] Hur, J., Choi, J-I., Lee, H., Nham, P., Kim, T-W., Chae, C-W., Yun, J-Y., Kang, J-A., Kang, J., Lee, S.E., Yoon, C-H., Boo, K., Ham, S., Roh, T-Y., Jun, J.K., Lee, H., Baek, S.H. *, and Kim, H-S. * (2016) KAI1 maintains dormancy of long-term hematopoietic stem cells through interaction with DARC-expressing macrophage. Cell Stem Cell 18(4), (*co-corresponding author) [05] Kim, Y., Nam, H.J., Lee, J., Park, D.Y., Kim, C., Yu, Y.S., Kim, D., Park S.W., Bhin, J., Hwang, D., Lee, H., Koh, G.Y., and Baek, S.H. (2016) Methylation-dependent Regulation of HIF-1α Stability Restricts Retinal and Tumour Angiogenesis. Nature Communications DOI: /ncomms10347 [06] Boo, K.J., Bhin, J.H., Jeon, Y., Kim, J.M., Shin, H.J., Park, J.E., Kim, K.K., Kim, C.R., Jang, H.C., Kim, I.H., Kim, V.N., Hwang, D.H.*, Lee, H.*, and Baek, S.H.* (2015) Pontin Functions As an Essential Coactivator for Oct4-Dependent LincRNA expression in Mouse Embryonic Stem Cells. Nature Communications DOI: /ncomms7810. (*co-corresponding author) [07] Nam, H.J., Boo, K.J., Kim, D.H., Han, D.H., Choe, H.K., Kim, C.R., Sun, W., Kim, H., Kim, K.J., Lee, H., Metzger, E., Schuele, R., Yoo, S.H., Takahashi, J.S., Cho, S.H., Son, G.H., and Baek, S.H. (2014) Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting. Molecular Cell 53(5), (Cover Article) [08] Baek, S.H. and Kim, K.I. (2014) Emerging Roles of Orphan Nuclear Receptors in Cancer. Annual Review of Physiol. 76(19), [09] Lee, J.M., Lee, J.S., Kim, H.K., Kim, K.K., Park, H.J., Kim, J.-Y., Lee, S.H., Kim, I.S., Kim, J.M., Lee, M.K., Chung, C.H., Seo, S.-B., Yoon, J.-B., Ko, E.Y., Noh, D.-Y., Kim, K.I., Kim, K.K., and Baek, S.H. (2012) EZH2 Generates a Methyl Degron That Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex. Molecular Cell 48, (Cover Article) [10] Kim, H., Lee, J.M., Lee, G., Bhin, J., Oh, S.K., Kim, K., Pyo, K.E., Lee, J.S., Yim, H.Y., Kim, K.I., Hwang, D., Chung, J., and Baek, S.H. (2011) DNA Damage-Induced ROR is Crucial for p53 Stabilization and Increased Apoptosis. Molecular Cell 44, (Cover Article) [11] Lee, J.S., Kim, Y., Bhin, J., Shin, H-J. R., Nam, H.J., Lee, S.H., Yoon, J.-B., Binda, O., Gozani, O., Hwang, D., and Baek, S.H. (2011) Hypoxia Induced Methylation of a Pontin Chromatin Remodeling Factor. Proc. Natl. Acad. Sci. USA 108,

4 [12] Baek, S.H. (2011) When Signaling Kinases Meet Histone and Histone Modifiers in the Nucleus. Molecular Cell 42, [13] Lee, J. S., Kim, Y., Kim, I.S., Kim, B., Choi, H.J., Lee, J.M., Shin, H-J. R., Kim, J.H., Kim, J.-Y., Seo, S.-B., Lee, H., Binda, O., Gozani, O., Semenza, G.L., Kim, M., Kim, K.I., Hwang, D.H., and Baek, S.H. (2010) Negative Regulation of Hypoxic Responses via Induced Reptin Methylation. Molecular Cell 39, (Cover Article) [14] Lee, J.M., Kim, I.S. Kim, H., Lee, J.S., Kim, K., Yim, H.Y., Jeong, J., Kim, J.H., Kim, J.-Y., Lee, H., Seo, S.-B., Kim, H., Rosenfeld, M.G., Kim, K.I., and Baek, S.H. (2010) ROR Attenuates Wnt/ - Catenin Signaling by PKC -dependent Phosphorylation in Colon Cancer. Molecular Cell 37, [15] Baek, S.H. (2008) When ATPases Pontin and Reptin Met Telomerase. Dev. Cell 14, [16] Kim, J.H., Lee, J.M., Nam, H.J., Choi, H.J., Yang, J.W., Lee, J.S., Kim, M.H., Kim, S.-I., Chung, C.H., Kim, K.I., and Baek, S.H. (2007) SUMOylation of a Pontin Chromatin-Remodeling Complex Reveals a New Signal Integration Code in Prostate Cancer Cells. Proc. Natl. Acad. Sci. USA 104, [17] Kim, K.I., and Baek, S.H. (2006) SUMOylation Code in Cancer Development and Metastasis. Mol. Cell 22, [18] Kim, J.H., Kim, K.I., and Baek, S.H. (2006) SUMOylation and DeSUMOylation Assays for a Chromatin Remodeling Complex In Vivo and In Vitro. Nature Protocols DOI: nprot [19] Kim, J.H., Choi, H.J., Kim, B., Kim, M.H., Lee, J.M., Kim, I.S., Lee, M.H., Choi, S.J., Kim, K.I., Kim, S.-I., Chung, C.H., and Baek, S.H. (2006) Roles of SUMOylation of a Reptin Chromatin Remodeling Complex in Cancer Metastasis. Nature Cell Biol. 8, [20] Baek, S.H. (2006) A Novel Link between SUMO Modification and Cancer Metastasis. Cell Cycle 5, [21] Zhu, P*, Baek, S.H.*, Bourk, E.M., Ohgi, K.A., Garcia-Bassets, I., Sanjo, H., Akira, S., Kotol, P.F., Glass, C.K., Rosenfeld, M.G., and Rose, D.W. (2006) Macrophage/Cancer Cell Interactions Mediate Hormone Resistance Through a Conserved Nuclear Receptor Derepression Pathway. Cell 124, (*: equal contribution) [22] Baek, S.H.*, Ohgi, K.A., Nelson, C.A., Welsbie, D., Chen, C., Sawyers, C.L., Rose, D.W., and Rosenfeld, M.G.* (2006) Ligand-specific Allosteric Regulation of Coactivator Functions of Androgen Receptor in Prostate Cancer Cells. Proc. Natl. Acad. Sci. USA 103, (*: co-corresponding author) 4

5 [23] Kim, J.H., Kim, B., Ling, C., Choi, H.J., Ohgi, K.A., Tran, C, Chen, C., Chung, C.H., Huber, O., Rose, D.W., Sawyers, C.L., Rosenfeld, M.G., and Baek, S.H. (2005) Transcriptional Regulation of a Metastasis Suppressor Gene by Tip60 and -Catenin Complexes. Nature 434, [24] Baek, S.H., Kioussi, C., Briata, P., Wang, D., Nguyen, H.D., Ohgi, K.A., Glass, C.K., Wynshaw- Boris, A., Rose, D.W., and Rosenfeld, M.G. (2003) Regulated Subset of G1 Growth-Control Genes in Response to Derepression by the Wnt Pathway. Proc. Natl. Acad. Sci. USA 100, [25] Kioussi, C*., Briata, P*., Baek, S.H. *, Rose, D.W. *, Hamblet, N S., Herman, T., Ohgi, K.A., Lin, C., Gleiberman, A., Wang, J., Brault, V., Ruiz-Lozano, P., Nguyen, H.D., Kemler, R., Glass, C.K., Wynshaw-Boris, A., and Rosenfeld, M.G. (2002) Identification of a Wnt/Dvl/ -Catenin to Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development. Cell 111, (*: Equal contribution) [26] Baek, S.H., Ohgi, K.A., Rose, D.W., Koo, E.H., Glass, C.K., and Rosenfeld, M.G. (2002) Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF- B and -Amyloid Precursor Protein. Cell