ubiquitinylation succinylation butyrylation hydroxylation crotonylation
|
|
|
- Leo Thompson
- 5 years ago
- Views:
Transcription
1 Supplementary Information S1 (table) Overview of histone core-modifications histone, residue/modification H1 H2A methylation acetylation phosphorylation formylation oxidation crotonylation hydroxylation ubiquitinylation succinylation butyrylation citrullination propionylation proposed function K46 1 K48 oxidative damage (formyl) 1,2 R54 chromatin compaction, transcription 3 K65 oxidative damage (formyl) 2,4 K66 oxidative damage (formyl) 2,4 Y73 4 K83 oxidative damage (formyl) 4 K87 oxidative damage (formyl) 4 K92 oxidative damage (formyl) 1,4 K99 1 K36 4,5 Y39 4 R42 4 K74 6 K75 6 R77 6 R88 4 K95 6 Q105 rdna transcription 7 Ref. 1
2 H2B H3 K20 transcription 4 K23 4 K30 S33 K34 oxidative damage (formyl) 2,4,8 Y37 4 K43 5 K46 oxidative damage (formyl) 2,5 K57 4 R79 4 Y83 4 K85 4 R99 4 Y41 transcription 9 R42 transcription 10 T45 apoptosis 11 transcription, replication, DNA and oxidative damage (formyl) 4, K56 S57 16 R63 4 K64 transcription 4,6,17 transcription, oxidative damage K79 (formyl) 2,18-20 T80 mitosis 16 K122 R128 transcription, oxidative damage (formyl) 2,4,21 4 2
3 H4 K20 4 K31 oxidative damage (formyl) 2,4,22 R35 4 K44 22 S47 nucleosome assembly 23 Y51 4 R55 4 K59 oxidative damage (formyl) 2,4 R67 4 K77 4 K79 oxidative damage (formyl) 2,4 Y88 4 K91 replication, DNA damage 4 R92 4,6 References 1. Wisniewski, J. R., Zougman, A., Krüger, S. & Mann, M. Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue. Mol. Cell Proteomics 6, (2007). 2. Jiang, T., Zhou, X., Taghizadeh, K., Dong, M. & Dedon, P. C. N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proc Natl Acad Sci USA 104, (2007). 3. Christophorou, M. A. et al. Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature 507, (2014). 4. Tan, M. et al. Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification. Cell 146, (2011). 5. Zhang, L., Eugeni, E. E., Parthun, M. R. & Freitas, M. A. Identification of novel histone post-translational modifications by peptide mass fingerprinting. Chromosoma 112, (2003). 6. Freitas, M. A., Sklenar, A. R. & Parthun, M. R. Application of mass spectrometry to the identification and quantification of histone posttranslational modifications. J Cell Biochem 92, (2004). 3
4 7. Tessarz, P. et al. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature 505, (2014). 8. Xie, Z. et al. Lysine Succinylation and Lysine Malonylation in Histones. Mol. Cell Proteomics 11, (2012). 9. Dawson, M. A. et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, (2009). 10. Casadio, F., Lu, X., Pollock, S. B. & LeRoy, G. H3R42me2a is a histone modification with positive transcriptional effects. Proc. Natl Acad. Sci. USA 110, (2013) 11. Hurd, P. J. et al. Phosphorylation of Histone H3 Thr-45 Is Linked to Apoptosis. Journal of Biological Chemistry 284, (2009). 12. Xu, F., Zhang, K. & Grunstein, M. Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast. Cell 121, (2005). 13. Ozdemir, A. Characterization of Lysine 56 of Histone H3 as an Acetylation Site in Saccharomyces cerevisiae. Journal of Biological Chemistry 280, (2005). 14. Masumoto, H., Hawke, D., Kobayashi, R. & Verreault, A. A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature 436, (2005). 15. Yu, Y. et al. Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA. Mol. Cell 46, 7-17 (2012) 16. Vermeulen, M. et al. Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers. Cell 142, (2010). 17. Di Cerbo, V. et al. Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription. elife 3, e01632 e01632 (2014). 18. Schübeler, D. et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes & Development 18, (2004). 19. Vakoc, C. R., Sachdeva, M. M., Wang, H. & Blobel, G. A. Profile of Histone Lysine Methylation across Transcribed Mammalian Chromatin. Molecular and Cellular Biology 26, (2006). 20. Steger, D. J. et al. DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells. Molecular and Cellular Biology 28, (2008). 21. Tropberger, P. et al. Regulation of Transcription through Acetylation of H3K122 on the Lateral Surface of the Histone Octamer. Cell 152, (2013). 22. Chen, Y. et al. Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in Histones. Molecular & Cellular Proteomics 6, (2007). 4
5 23. Kang, B. et al. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. Genes & Development 25, (2011). 5
Supplemental Figure 1: Asymmetric chromatin maturation leads to epigenetic asymmetries on sister chromatids.
Supplemental Material: Annu. Rev. Cell Dev. Biol. 2017. 33:291 318 https://doi.org/10.1146/annurev-cellbio-100616-060447 The Inherent Asymmetry of DNA Replication Snedeker, Wooten, and Chen Supplemental
Histones modifications and variants
Histones modifications and variants Dr. Institute of Molecular Biology, Johannes Gutenberg University, Mainz www.imb.de Lecture Objectives 1. Chromatin structure and function Chromatin and cell state Nucleosome
Lecture 10. Eukaryotic gene regulation: chromatin remodelling
Lecture 10 Eukaryotic gene regulation: chromatin remodelling Recap.. Eukaryotic RNA polymerases Core promoter elements General transcription factors Enhancers and upstream activation sequences Transcriptional
Transcriptional control in Eukaryotes: (chapter 13 pp276) Chromatin structure affects gene expression. Chromatin Array of nuc
Transcriptional control in Eukaryotes: (chapter 13 pp276) Chromatin structure affects gene expression Chromatin Array of nuc 1 Transcriptional control in Eukaryotes: Chromatin undergoes structural changes
Biochemical Determinants Governing Redox Regulated Changes in Gene Expression and Chromatin Structure
Biochemical Determinants Governing Redox Regulated Changes in Gene Expression and Chromatin Structure Frederick E. Domann, Ph.D. Associate Professor of Radiation Oncology The University of Iowa Iowa City,
Epigenetics. Lyle Armstrong. UJ Taylor & Francis Group. f'ci Garland Science NEW YORK AND LONDON
... Epigenetics Lyle Armstrong f'ci Garland Science UJ Taylor & Francis Group NEW YORK AND LONDON Contents CHAPTER 1 INTRODUCTION TO 3.2 CHROMATIN ARCHITECTURE 21 THE STUDY OF EPIGENETICS 1.1 THE CORE
Eukaryotic Gene Regulation
Eukaryotic Gene Regulation Chapter 19: Control of Eukaryotic Genome The BIG Questions How are genes turned on & off in eukaryotes? How do cells with the same genes differentiate to perform completely different,
Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest
Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest Adam F. Kebede, Robert Schneider and Sylvain Daujat Institut de Genetique et de Biologie Moleculaire
Minjia Tan, Ph.D Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5 Minjia Tan, Ph.D Shanghai Institute of Materia Medica, Chinese Academy of Sciences Lysine: the most frequently modified
Epigenetics: The Future of Psychology & Neuroscience. Richard E. Brown Psychology Department Dalhousie University Halifax, NS, B3H 4J1
Epigenetics: The Future of Psychology & Neuroscience Richard E. Brown Psychology Department Dalhousie University Halifax, NS, B3H 4J1 Nature versus Nurture Despite the belief that the Nature vs. Nurture
Lecture 8. Eukaryotic gene regulation: post translational modifications of histones
Lecture 8 Eukaryotic gene regulation: post translational modifications of histones Recap.. Eukaryotic RNA polymerases Core promoter elements General transcription factors Enhancers and upstream activation
Transcription and chromatin. General Transcription Factors + Promoter-specific factors + Co-activators
Transcription and chromatin General Transcription Factors + Promoter-specific factors + Co-activators Cofactor or Coactivator 1. work with DNA specific transcription factors to make them more effective
Epigenetics Armstrong_Prelims.indd 1 04/11/2013 3:28 pm
Epigenetics Epigenetics Lyle Armstrong vi Online resources Accessible from www.garlandscience.com, the Student and Instructor Resource Websites provide learning and teaching tools created for Epigenetics.
Prokaryotes and eukaryotes alter gene expression in response to their changing environment
Chapter 18 Prokaryotes and eukaryotes alter gene expression in response to their changing environment In multicellular eukaryotes, gene expression regulates development and is responsible for differences
SUPPLEMENTARY INFORMATION
doi:10.1038/nature23267 Discussion Our findings reveal unique roles for the methylation states of histone H3K9 in RNAi-dependent and - independent heterochromatin formation. Clr4 is the sole S. pombe enzyme
Where Splicing Joins Chromatin And Transcription. 9/11/2012 Dario Balestra
Where Splicing Joins Chromatin And Transcription 9/11/2012 Dario Balestra Splicing process overview Splicing process overview Sequence context RNA secondary structure Tissue-specific Proteins Development
Regulation of Gene Expression in Eukaryotes
Ch. 19 Regulation of Gene Expression in Eukaryotes BIOL 222 Differential Gene Expression in Eukaryotes Signal Cells in a multicellular eukaryotic organism genetically identical differential gene expression
PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
AD Award Number: W81XWH-12-1-0248 TITLE: Targeted Inhibition of Tyrosine Kinase-Mediated Epigenetic Alterations to Prevent Resurgence of Castration-Resistant Prostate Cancer PRINCIPAL INVESTIGATOR: Dr.
Eukaryotic transcription (III)
Eukaryotic transcription (III) 1. Chromosome and chromatin structure Chromatin, chromatid, and chromosome chromatin Genomes exist as chromatins before or after cell division (interphase) but as chromatids
Computational Analysis of UHT Sequences Histone modifications, CAGE, RNA-Seq
Computational Analysis of UHT Sequences Histone modifications, CAGE, RNA-Seq Philipp Bucher Wednesday January 21, 2009 SIB graduate school course EPFL, Lausanne ChIP-seq against histone variants: Biological
Genetics and Genomics in Medicine Chapter 6 Questions
Genetics and Genomics in Medicine Chapter 6 Questions Multiple Choice Questions Question 6.1 With respect to the interconversion between open and condensed chromatin shown below: Which of the directions
Session 2: Biomarkers of epigenetic changes and their applicability to genetic toxicology
Session 2: Biomarkers of epigenetic changes and their applicability to genetic toxicology Bhaskar Gollapudi, Ph.D The Dow Chemical Company Workshop: Genetic Toxicology: Opportunities to Integrate New Approaches
EPIGENTEK. EpiQuik Total Histone Extraction Kit. Base Catalog # OP-0006 PLEASE READ THIS ENTIRE USER GUIDE BEFORE USE
EpiQuik Total Histone Extraction Kit Base Catalog # PLEASE READ THIS ENTIRE USER GUIDE BEFORE USE Uses: The EpiQuik Total Histone Extraction Kit is suitable for a quick preparation of total histone extracts
Gene Expression DNA RNA. Protein. Metabolites, stress, environment
Gene Expression DNA RNA Protein Metabolites, stress, environment 1 EPIGENETICS The study of alterations in gene function that cannot be explained by changes in DNA sequence. Epigenetic gene regulatory
Gene Regulation Part 2
Michael Cummings Chapter 9 Gene Regulation Part 2 David Reisman University of South Carolina Other topics in Chp 9 Part 2 Protein folding diseases Most diseases are caused by mutations in the DNA that
An epigenetic approach to understanding (and predicting?) environmental effects on gene expression
www.collaslab.com An epigenetic approach to understanding (and predicting?) environmental effects on gene expression Philippe Collas University of Oslo Institute of Basic Medical Sciences Stem Cell Epigenetics
Stem Cell Epigenetics
Stem Cell Epigenetics Philippe Collas University of Oslo Institute of Basic Medical Sciences Norwegian Center for Stem Cell Research www.collaslab.com Source of stem cells in the body Somatic ( adult )
9/3/2009 DNA i DNA n euk euk yotes Organizatio Organ izatio n of o f gen ge e n tic Locati t on: In n ucleu e s material mater in e ial
DNA in eukaryotes Organization of genetic material in eukaryotes Location: In nucleus In mitochondria DNA in eukaryotes Nuclear DNA: Long, linear molecules; Chromatin chromosomes; 10% of DNA in genes,
Einführung in die Genetik
Einführung in die Genetik Prof. Dr. Kay Schneitz (EBio Pflanzen) http://plantdev.bio.wzw.tum.de schneitz@wzw.tum.de Prof. Dr. Claus Schwechheimer (PlaSysBiol) http://wzw.tum.de/sysbiol claus.schwechheimer@wzw.tum.de
RESEARCHER S NAME: Làszlò Tora RESEARCHER S ORGANISATION: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
Thursday 5 November EU-India PARTNERING EVENT Theme: Health RESEARCHER S NAME: Làszlò Tora RESEARCHER S ORGANISATION: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM,
Organization of genetic material in eukaryotes
Organization of genetic material in eukaryotes biologiemoleculara.usmf.md pass.: bmgu e.usmf.md 1 DNA in eukaryotes Location: In nucleus In mitochondria biologiemoleculara.usmf.md e.usmf.md pass.: bmgu
RNA-seq Introduction
RNA-seq Introduction DNA is the same in all cells but which RNAs that is present is different in all cells There is a wide variety of different functional RNAs Which RNAs (and sometimes then translated
9 th TRR81 PhD Minisymposium Kinases as regulators of chromatin structure and transcription
9 th TRR81 PhD Minisymposium Kinases as regulators of chromatin structure and transcription Friday, 20 th of November 2015, 13:00h Institute of Molecular Biology and Tumor Research (IMT) Philipps-University
Epigenetics and Environmental Health A Step-by-Step Tutorial
Powerful ideas for a healthier world Epigenetics and Environmental Health A Step-by-Step Tutorial Andrea Baccarelli, MD, PhD, MPH Laboratory of Environmental Epigenetics Objective of my presentation To
DNA and Histone Methylation in Learning and Memory
EXPERIMENTAL BIOLOGY ANNUAL MEETING April 2010 DNA and Histone Methylation in Learning and Memory J. David Sweatt Dept of Neurobiology McKnight Brain Institute UAB School of Medicine The Molecular Basis
Histones, histone chaperones and nucleosome assembly
Protein Cell 2010, 1(7): 607 612 DOI 10.1007/s13238-010-0086-y Protein & Cell PERSPECTIVE Histones, histone chaperones and nucleosome assembly Rebecca J. Burgess, Zhiguo Zhang Department of Biochemistry
Repressive Transcription
Repressive Transcription The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation As Published Publisher Guenther, M. G., and R. A.
Nature Genetics: doi: /ng Supplementary Figure 1. Assessment of sample purity and quality.
Supplementary Figure 1 Assessment of sample purity and quality. (a) Hematoxylin and eosin staining of formaldehyde-fixed, paraffin-embedded sections from a human testis biopsy collected concurrently with
Epigenetics q&more 01.11
Laurie. Knight, istockphoto.com Epigenetics 6 Bookmarks About the reading of genes in the Book of Life Prof. Dr. Manfred Jung, Julia M. Wagner, Institute for Pharmaceutical Sciences, Albert-Ludwig-University
DSB. Double-Strand Breaks causate da radiazioni stress ossidativo farmaci
DSB Double-Strand Breaks causate da radiazioni stress ossidativo farmaci METODI DDR foci formation in irradiated (2 Gy) cells fixed 2 h later IRIF IRradiation Induced Focus Laser micro-irradiation DDR
H2B Monoubiquitylation and H3 Methylation Levels
Pittard 1 H2B Monoubiquitylation and H3 Methylation Levels Throughout Drosophila Development By Holly Pittard Senior Honors Thesis Biology University of North Carolina at Chapel Hill April16, 2016 This
EPIGENOMICS PROFILING SERVICES
EPIGENOMICS PROFILING SERVICES Chromatin analysis DNA methylation analysis RNA-seq analysis Diagenode helps you uncover the mysteries of epigenetics PAGE 3 Integrative epigenomics analysis DNA methylation
R. Piazza (MD, PhD), Dept. of Medicine and Surgery, University of Milano-Bicocca EPIGENETICS
R. Piazza (MD, PhD), Dept. of Medicine and Surgery, University of Milano-Bicocca EPIGENETICS EPIGENETICS THE STUDY OF CHANGES IN GENE EXPRESSION THAT ARE POTENTIALLY HERITABLE AND THAT DO NOT ENTAIL A
Nature Structural & Molecular Biology: doi: /nsmb.2419
Supplementary Figure 1 Mapped sequence reads and nucleosome occupancies. (a) Distribution of sequencing reads on the mouse reference genome for chromosome 14 as an example. The number of reads in a 1 Mb
Fragile X Syndrome. Genetics, Epigenetics & the Role of Unprogrammed Events in the expression of a Phenotype
Fragile X Syndrome Genetics, Epigenetics & the Role of Unprogrammed Events in the expression of a Phenotype A loss of function of the FMR-1 gene results in severe learning problems, intellectual disability
Alternative splicing. Biosciences 741: Genomics Fall, 2013 Week 6
Alternative splicing Biosciences 741: Genomics Fall, 2013 Week 6 Function(s) of RNA splicing Splicing of introns must be completed before nuclear RNAs can be exported to the cytoplasm. This led to early
Ch. 18 Regulation of Gene Expression
Ch. 18 Regulation of Gene Expression 1 Human genome has around 23,688 genes (Scientific American 2/2006) Essential Questions: How is transcription regulated? How are genes expressed? 2 Bacteria regulate
Epigenetic Mechanisms
RCPA Lecture Epigenetic chanisms Jeff Craig Early Life Epigenetics Group, MCRI Dept. of Paediatrics Overview What is epigenetics? Chromatin The epigenetic code What is epigenetics? the interactions of
Stacie Bulfer Proteins Research Proposal April 27, Background
Background Stacie Bulfer Proteins Research Proposal April 27, 2003 DNA Packaging in Eukaryotes Eukaryotes have five histones: H1, H2A, H2B, H3 and H4 which form repeating units that compact DNA. Histones
Identifying the Combinatorial Effects of Histone Modifications by Association Rule Mining in Yeast
Evolutionary Bioinformatics Original Research Open Access Full open access to this and thousands of other papers at http://www.la-press.com. Identifying the Combinatorial Effects of Histone Modifications
Complexity DNA. Genome RNA. Transcriptome. Protein. Proteome. Metabolites. Metabolome
DNA Genome Complexity RNA Transcriptome Systems Biology Linking all the components of a cell in a quantitative and temporal manner Protein Proteome Metabolites Metabolome Where are the functional elements?
HHS Public Access Author manuscript Nat Genet. Author manuscript; available in PMC 2012 September 01.
Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas Gang Wu 1,*, Alberto Broniscer 2,*, Troy A McEachron 3,*, Charles Lu 4, Barbara S Paugh 3,
Morphogens: What are they and why should we care?
Morphogens: What are they and why should we care? Historic, Theoretical Mechanism of Action Nucleoprotein: the specific trophic cellular material extracted from the cell nucleus. DNA and RNA which regulates
Kenneth B. Storey, Carleton University, Ottawa
Kenneth B. Storey, Carleton University, Ottawa www.carleton.ca/~kbstorey Nature s BioPreservation [Organs-OFF] Nature s [NEW!] Mechanisms In Vitro Preservation Technology TEMP ANIMAL OUTCOME High Lemur
DSB. Double-Strand Breaks causate da radiazioni stress ossidativo farmaci
DSB Double-Strand Breaks causate da radiazioni stress ossidativo farmaci DSB e CROMATINA Higher-order chromatin packaging is a barrier to the detection and repair of DNA damage DSBs induce a local decrease
Transcription Regulation And Gene Expression in Eukaryotes Cycle G2 (lecture 13709) FS 2014 P Matthias & RG Clerc
Transcription Regulation And Gene Expression in Eukaryotes Cycle G2 (lecture 13709) FS 2014 P Matthias & RG Clerc P. Matthias, 16 April 2014 DNA methylation basics Acetylation Acetyltransferases/Deacetylases
Removal of Shelterin Reveals the Telomere End-Protection Problem
Removal of Shelterin Reveals the Telomere End-Protection Problem DSB Double-Strand Breaks causate da radiazioni stress ossidativo farmaci DSB e CROMATINA Higher-order chromatin packaging is a barrier to
Course Title Form Hours subject
Course Title Form Hours subject Types, and structure of chromosomes L 1 Histology Karyotyping and staining of human chromosomes L 2 Histology Chromosomal anomalies L 2 Histology Sex chromosomes L 1 Histology
Introduction to Cancer Biology
Introduction to Cancer Biology Robin Hesketh Multiple choice questions (choose the one correct answer from the five choices) Which ONE of the following is a tumour suppressor? a. AKT b. APC c. BCL2 d.
The Epigenome Tools 2: ChIP-Seq and Data Analysis
The Epigenome Tools 2: ChIP-Seq and Data Analysis Chongzhi Zang zang@virginia.edu http://zanglab.com PHS5705: Public Health Genomics March 20, 2017 1 Outline Epigenome: basics review ChIP-seq overview
Are you the way you are because of the
EPIGENETICS Are you the way you are because of the It s my fault!! Nurture Genes you inherited from your parents? Nature Experiences during your life? Similar DNA Asthma, Autism, TWINS Bipolar Disorders
Additional Data File 1
Additional Data File 1 Detailed text profiles for clusters {B, C, D, E, F, G, H, J, and K} in Eisen M, Spellman P, Brown P, Botstein D: Cluster analysis and display of genome-wide expression patterns.
Overview: Conducting the Genetic Orchestra Prokaryotes and eukaryotes alter gene expression in response to their changing environment
Overview: Conducting the Genetic Orchestra Prokaryotes and eukaryotes alter gene expression in response to their changing environment In multicellular eukaryotes, gene expression regulates development
HDAC1 Inhibitor Screening Assay Kit
HDAC1 Inhibitor Screening Assay Kit Catalog Number KA1320 96 assays Version: 03 Intended for research use only www.abnova.com Table of Contents Introduction... 3 Background... 3 Principle of the Assay...
Jayanti Tokas 1, Puneet Tokas 2, Shailini Jain 3 and Hariom Yadav 3
Jayanti Tokas 1, Puneet Tokas 2, Shailini Jain 3 and Hariom Yadav 3 1 Department of Biotechnology, JMIT, Radaur, Haryana, India 2 KITM, Kurukshetra, Haryana, India 3 NIDDK, National Institute of Health,
Epigenetics & cancer. Present by : Sanaz Zebardast Under supervision : Dr. Gheibi. 31 December 2016
Epigenetics & cancer Present by : Sanaz Zebardast Under supervision : Dr. Gheibi 31 December 2016 1 contents Introduction Epigenetic & signaling pathways Epigenetic & integral protein Epigenetic & apoptosis
Patterns of Histone Methylation and Chromatin Organization in Grapevine Leaf. Rachel Schwope EPIGEN May 24-27, 2016
Patterns of Histone Methylation and Chromatin Organization in Grapevine Leaf Rachel Schwope EPIGEN May 24-27, 2016 What does H3K4 methylation do? Plant of interest: Vitis vinifera Culturally important
Host cell activation
Dept. of Internal Medicine/Infectious and Respiratory Diseases Stefan Hippenstiel Epigenetics as regulator of inflammation Host cell activation LPS TLR NOD2 MDP TRAF IKK NF-κB IL-x, TNFα,... Chromatin
Removal of Shelterin Reveals the Telomere End-Protection Problem
Removal of Shelterin Reveals the Telomere End-Protection Problem DSB Double-Strand Breaks causate da radiazioni stress ossidativo farmaci DSB e CROMATINA Higher-order chromatin packaging is a barrier to
Mechanisms of alternative splicing regulation
Mechanisms of alternative splicing regulation The number of mechanisms that are known to be involved in splicing regulation approximates the number of splicing decisions that have been analyzed in detail.
BCHM3972 Human Molecular Cell Biology (Advanced) 2013 Course University of Sydney
BCHM3972 Human Molecular Cell Biology (Advanced) 2013 Course University of Sydney Page 2: Immune Mechanisms & Molecular Biology of Host Defence (Prof Campbell) Page 45: Infection and Implications for Cell
Proteins are sometimes only produced in one cell type or cell compartment (brain has 15,000 expressed proteins, gut has 2,000).
Lecture 2: Principles of Protein Structure: Amino Acids Why study proteins? Proteins underpin every aspect of biological activity and therefore are targets for drug design and medicinal therapy, and in
Regulation of cell cycle. Dr. SARRAY Sameh, Ph.D
Regulation of cell cycle Dr. SARRAY Sameh, Ph.D Control of cell cycle: Checkpoints Are the cell cycle controls mechanisms in eukaryotic cells. These checkpoints verify whether the processes at each phase
Epigenetic Principles and Mechanisms Underlying Nervous System Function in Health and Disease Mark F. Mehler MD, FAAN
Epigenetic Principles and Mechanisms Underlying Nervous System Function in Health and Disease Mark F. Mehler MD, FAAN Institute for Brain Disorders and Neural Regeneration F.M. Kirby Program in Neural
Chapter 11 How Genes Are Controlled
Chapter 11 How Genes Are Controlled PowerPoint Lectures Campbell Biology: Concepts & Connections, Eighth Edition REECE TAYLOR SIMON DICKEY HOGAN Lecture by Edward J. Zalisko Introduction Well-preserved
Supplementary Figure S1. Appearacne of new acetyl groups in acetylated lysines using 2,3-13 C 6 pyruvate as a tracer instead of labeled glucose.
Supplementary Figure S1. Appearacne of new acetyl groups in acetylated lysines using 2,3-13 C 6 pyruvate as a tracer instead of labeled glucose. (a) Relative levels of both new acetylation and all acetylation
Epigenetics: Basic Principals and role in health and disease
Epigenetics: Basic Principals and role in health and disease Cambridge Masterclass Workshop on Epigenetics in GI Health and Disease 3 rd September 2013 Matt Zilbauer Overview Basic principals of Epigenetics
Biol115 The Thread of Life"
Biol115 The Thread of Life" Lecture 9" Gene expression and the Central Dogma"... once (sequential) information has passed into protein it cannot get out again. " ~Francis Crick, 1958! Principles of Biology
The Role of Protein Domains in Cell Signaling
The Role of Protein Domains in Cell Signaling Growth Factors RTK Ras Shc PLCPLC-γ P P P P P P GDP Ras GTP PTB CH P Sos Raf SH2 SH2 PI(3)K SH3 SH3 MEK Grb2 MAPK Phosphotyrosine binding domains: PTB and
The role of G9a gene in various cancers
Health Biotechnology and Biopharma (2017), 1(3): 5-11 Minireview Article The role of G9a gene in various cancers Hassan Taghizadeh 1, Eskandar Taghizadeh 2 * 1 Cellular and Molecular Research Center, Yasuj
Biotransformation-induced toxicity. Challenges in drug design M. Matilde Marques
Biotransformation-induced toxicity. Challenges in drug design M. Matilde Marques Drug Discovery Session July 4, 2016 Drug Discovery Toxicology The Road to Safe Drugs Attrition in drug development remains
ACK1 Tyrosine Kinases: A Critical Regulator of Prostate Cancer
ACK1 Tyrosine Kinases: A Critical Regulator of Prostate Cancer Nupam Mahajan Moffitt Cancer Center Learners Objectives How Androgen Receptor (AR) signaling is accomplished in absence of androgen What are
Biology. Lectures winter term st year of Pharmacy study
Biology Lectures winter term 2008 1 st year of Pharmacy study 3 rd Lecture Chemical composition of living matter chemical basis of life. Atoms, molecules, organic compounds carbohydrates, lipids, proteins,
Not IN Our Genes - A Different Kind of Inheritance.! Christopher Phiel, Ph.D. University of Colorado Denver Mini-STEM School February 4, 2014
Not IN Our Genes - A Different Kind of Inheritance! Christopher Phiel, Ph.D. University of Colorado Denver Mini-STEM School February 4, 2014 Epigenetics in Mainstream Media Epigenetics *Current definition:
Epigenetics and Autism Prevention
Epigenetics and Autism Prevention Autism One Conference Chicago, Illinois May 25, 2016 William J. Walsh, PhD Walsh Research Institute Walsh Research Institute Public Charity Expertise in Brain Disorders
Session 6: Integration of epigenetic data. Peter J Park Department of Biomedical Informatics Harvard Medical School July 18-19, 2016
Session 6: Integration of epigenetic data Peter J Park Department of Biomedical Informatics Harvard Medical School July 18-19, 2016 Utilizing complimentary datasets Frequent mutations in chromatin regulators
PhD THESIS Epigenetic mechanisms involved in stem cell differentiation
Romanian Academy Institute of Cellular Biology and Pathology "Nicolae Simionescu" PhD THESIS Epigenetic mechanisms involved in stem cell differentiation Coordinator: Acad. Maya Simionescu PhD Student:
U3.2.3: Eukaryotic chromosomes are linear DNA molecules associated with histone proteins. (Oxford Biology Course Companion page 151).
Cell Division Study Guide U3.2.3: Eukaryotic chromosomes are linear DNA molecules associated with histone proteins. (Oxford Biology Course Companion page 151). 1. Describe the structure of eukaryotic DNA
Protein Modification Overview DEFINITION The modification of selected residues in a protein and not as a component of synthesis
Lecture Four: Protein Modification & Cleavage [Based on Chapters 2, 9, 10 & 11 Berg, Tymoczko & Stryer] (Figures in red are for the 7th Edition) (Figures in Blue are for the 8th Edition) Protein Modification
'''''''''''''''''Fundamental'Biology' BI'1101' ' an'interdisciplinary'approach'to'introductory'biology' Five'Levels'of'Organiza-on' Molecular'
'''''''''''''''''Fundamental'Biology' BI'1101' ' an'interdisciplinary'approach'to'introductory'biology' Anggraini'Barlian,' Iriawa-' Tjandra'Anggraeni' SITH4ITB' Five'Levels'of'Organiza-on' Molecular'
EpiQuik Circulating Acetyl Histone H3K18 ELISA Kit (Colorimetric)
EpiQuik Circulating Acetyl Histone H3K18 ELISA Kit (Colorimetric) Base Catalog # PLEASE READ THIS ENTIRE USER GUIDE BEFORE USE Uses: The EpiQuik Circulating Acetyl Histone H3K18 ELISA Kit (Colorimetric)
Epigenetic Effects of Iron and Zinc Deficiency in Saccharomyces cerevisiae
Epigenetic Effects of Iron and Zinc Deficiency in Saccharomyces cerevisiae Investigation of heat and oxidative stress resistance for discovering phenotypic alterations induced by iron and zinc deficiency
Epigenetics and Chromatin
Progress in Molecular and Subcellular Biology 38 Epigenetics and Chromatin Bearbeitet von Philippe Jeanteur 1. Auflage 2008. Taschenbuch. xiii, 266 S. Paperback ISBN 978 3 540 85236 0 Format (B x L): 15,5
Protein Post Translational Modification (PTM) & Profiling Core Erol E. Gulcicek
Protein Post Translational Modification (PTM) & Profiling Core Erol E. Gulcicek Determine sites of Post Translational Modifications and changes in their Levels - Phosphorylation*** - Ubiquitination - Palmitoylation
Comprehensive analysis of histone post translational modifications in mouse and human male germ cells
DOI 10.1186/s13072-016-0072-6 Epigenetics & Chromatin RESEARCH Comprehensive analysis of histone post translational modifications in mouse and human male germ cells Lacey J. Luense 1,4, Xiaoshi Wang 2,4,
PG16: Epigenetics of Lung Disease Designing Studies of DNA Methylation
Andrea Baccarelli, MD, PhD, MPH Laboratory of Environmental Epigenetics Harvard School of Public Health PG16: Epigenetics of Lung Disease Designing Studies of DNA Methylation Presentation Outline Intro
Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III
For reprint orders, please contact: reprints@futuremedicine.com Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III RNA polymerase III (Pol III) synthesizes a range of
Hox Gene Expression in mouse Embryonic Stem Cells
MRes Biomedical Research Thesis UNIVERSITY OF BIRMINGHAM Hox Gene Expression in mouse Embryonic Stem Cells By Nicholas Drinkall Neurogenic Differentiation of Mesenchymal Stem Cells By Nicholas Drinkall
Introduction to Proteomics 1.0
Introduction to Proteomics 1.0 CMSP Workshop Pratik Jagtap Managing Director, CMSP Objectives Why are we here? For participants: Learn basics of MS-based proteomics Learn what s necessary for success using
Chromatin Remodeling: A Novel Mechanism. of Psychotropic Drug Action
Molecular Pharmacology This article has Fast not been Forward. copyedited Published and formatted. The on final May version 25, 2006 may differ as doi:10.1124/mol.106.027078 from this version. Chromatin