Bern (CH), September 6 9, 2008

Size: px

Start display at page:

Download "Bern (CH), September 6 9, 2008"

Oswald Anderson
6 years ago
Views:

1 Program of the 16 th EUROCONFERENCE ON APOPTOSIS and 5 th SWISS APOPTOSIS MEETING (including 5 th TRAINING COURSE on CONCEPTS AND METHODS IN PROGRAMMED CELL DEATH ) Bern (CH), September 6 9, 2008 MEETING ORGANIZERS: Thomas Brunner (Bern) Hans-Uwe Simon (Bern) CONGRESS VENUE: University Hospital Bern, Lecture room: Ettore Rossi

2 Saturday, September 6, :00 Registrations Opens 5 th Training course on Concepts and Methods in Programmed Cell Death Chair Seamus Martin (Dublin, Ireland) 14:00 14:45 Adi Kimchi (Rehovot, Israel) Many ways to die the different forms of programmed cell death and their analysis 14:45 15:30 Andreas Villunger (Innsbruck, Austria) Death signaling pathways leading to apoptosis and their analysis 15:30 16:00 Coffee break 16:00 16:45 Peter Vandenabeele (Ghent, Belgium) Mechanisms of dead cell removal 16:45 17:30 Klaus Schulze-Osthoff (Tübingen, Germany) Cell death and disease 17:30 18:15 Peter Krammer (Heidelberg, Germany) Milestones and future perspectives in cell death research 18:15 18:30 Discussion 19:30 19:40 19:40 19:50 Welcome and ECDO Honorary Lecture Chairs: Hans-Uwe Simon (Bern, Switzerland) & Boris Zhivotovsky (Stockholm, Sweden) Alexander Tschäppät (President of the city, Bern, CH): Welcome Peter Eggli (Dean of the Medical Faculty, Bern, CH): Welcome 19:50 20:00 Hans-Uwe Simon (Bern, CH): Welcome 20:00 20:05 Harald Reuter (Bern, CH): Israeli-Palestinian Science Organization background and goals 20:05 20:15 Boris Zhivotovsky (Stockholm, Sweden): Laudatio 20:15 21:00 ECDO honorary lecture Pierre Golstein (Marseille, France) Cell deaths from mouse to Dictyostelium 21:00 Reception House of the University

3 Sunday, September 7, 2008 Session 1: System biology approaches in cell death research Chair Boris Zhivotovsky (Stockholm, Sweden) 09:00 9:30 Inna Lavrik (Heidelberg, Germany) Promises and challenges of systems biology: Life/Death decisions in the CD95 signaling pathway 09:30 9:45 Aswin Pyakurel (Geneva, CH) The role of Mek1 in controlling mitochondrial morphology 09:45 10:00 Syam Prakash Somasekharan (Geneva, CH) The large dynamin GTPase Drp1 stimulates Bax activation 10:00 10:30 Jochen Prehn (Dublin, Ireland) Real-time imaging and mathematical systems analysis of mitochondrial outer membrane permeabilisation and caspase activation during apoptosis: Is very little already too much? 10:30 11:00 Coffee break (with exhibition viewing) Session 2: Cell death signalling Chair Simone Fulda (Ulm, Germany) 11:00 11:30 Douglas R. Green (Memphis, TN, USA) Mitochondria, ER, and the greasy path to apoptosis 11:30 11:45 Christoph Borner (Freiburg, Germany) Lysosomal proteases: Triggers or amplifiers of apoptosis? 11:45 12:00 Margaret E. Harley (Dundee, UK) The regulation of Mcl-1 during mitosis 12:00 12:15 Dagmar Kulms (Stuttgart, Germany) Sensitization of melanoma cells to TRAIL by UVBinduced and NK-κB-mediated downregulation of XIAP 12:15 12:30 Leobaldo Solorzano (Philadelphia, PA, USA) XIAP regulation by asparagine deamidation and PIMT 12:30 13:00 Seamus Martin (Dublin, Ireland): A role for the Bcl-2 family in mitochondrial fission-fusion dynamics unrelated to apoptosis 13:00 14:30 Lunch (with exhibition viewing)

4 Session 3: Cell death and inflammation Chair Hans-Uwe Simon (Bern, Switzerland) 14:30 15:00 Jürg Tschopp (Lausanne, Switzerland) Inflammasomes: danger sensing complexes involved in inflammatory diseases 15:00 15:15 Clemens A. Dahinden (Bern, CH) IL-3 induces a Pim1-dependent anti-apoptotic pathway in primary human basophils 15:15 15:30 Alexander U. Lüthi (Dublin, Ireland) Suppression of IL-33 bioactivity through proteolysis by apoptotic caspases 15:30 15:45 Sara Y. Demiroglu (Göttingen, Germany) Analysis of the role of heat shock protein 70 in granzyme B induced apoptosis 15:45 16:00 Claudia Manzl (Innsbruck, Austria) Is the PIDDosome required for caspase-2 processing? 16:00 16:30 Shigekazu Nagata (Kyoto, Japan) Engulfment of apoptotic cells 16:30 18:00 Poster Viewing Session #1, posters 1-93 (with refreshments) 20:00 23:00 Dinner (Kornhauskeller)

5 Monday, September 8, 2008 Session 4: Cell death in model organisms Chair Pierre Golstein (Marseille, France) 09:00 09:30 Michael Hengartner (Zurich, Switzerland) Death, destruction and mayhem: regulation of apoptosis in the nematode C. elegans 09:30 09:45 Daniele Bano (Leicester/Zurich, UK/CH) Alteration of nucleocytoplasmic transport occurs during calcium-mediated cell death 09:45 10:00 Brigitte Galliot (Geneva, CH) Apoptosis, a driving force for head regeneration in hydra 10:00 10:30 Shai Shaham (New York, NY, USA) A new C. elegans cell death program 10:30 11:00 Coffee break (with exhibition viewing) Session 5: Cell death in experimental mouse systems Chair Gerry Melino (Rome/Leicester, Italy/UK) 11:00 11:30 Philippe Bouillet (Melbourne, Australia) BH3 mutations to study the mechanism of action of Bim 11:30 11:45 Wim Declercq (Ghent, Belgium) Caspase-14 is a crucial protease in proper stratum corneum formation 11:45 12:00 Silke F. Fischer (Melbourne/Ulm, Australia/Germany) Proapoptotic BH3-only proteins Bim and Puma are essential for apoptosis of germinal center-derived memory B cells and antibody-forming cells 12:00 12:15 Lars Joeckel (Freiburg, Germany) Biological role of orphan granzymes in LCMV-WE infection 12:15 12:30 Oksana Voloshanenko (Heidelberg, Germany) Detachment-induced sensitization to TRAIL explains the metastasis-specific role of the TRAIL/TRAIL-R system in epithelial tumorigenesis 12:30 13:00 Thomas Brunner (Bern, Switzerland) Interactions between death receptor and mitochondrial apoptosis pathway in hepatocyte cell death 13:00 14:30 Lunch (with exhibition viewing)

6 Session 6: Autophagic cell death Chair Laszlo Fesus (Debrecen, Hungary) 14:30 15:00 Guido Kroemer (Villejuif, France) Autophagy control by transcription factors 15:00 15:30 Eric Baehrecke (Worcester, MA, USA) Genetic regulation of autophagic programmed cell death 15:30 15:45 Laura Bonapace (Zurich, CH) The BH3 mimetic obatoclax overcomes glucocorticoidresistance by activating autophagic cell death 15:45 16:00 Patricia Boya (Madrid, Spain) The autophagic machinery is necessary for removal of cell corpses during the development of the nervous system 16:00 16:30 Mauro Piacentini (Rome, Italy) Regulation of autophagy in mammals by AMBRA1 and its partners 16:30 18:00 Poster Viewing Session #2, posters (with refreshments) 18:00-20:00 ECDO Board meeting (seminar room, Institute of Pharmacology) Free evening

7 Tuesday, September 9, 2008 Session 7: Cell death and cancer Chair Guido Kroemer (Villejuif, France) 09:00 09:30 Gerard Evan (San Francisco, CA, USA) The ins and outs of oncogene-induced tumor suppression 09:30 09:45 Arun Dharmarajan (Perth, Australia) Pro-apoptotic, anti-proliferative, and anti-angiogenic therapeutics in cancer 09:45 10:00 Nina Gebhardt (Berlin, Germany) Bax/Bak independent induction of apoptosis by BH3- mimetic small molecule compounds 10:00 10:30 Gerry Melino (Rome/Leicester, Italy/UK) mir, "stemness" & skin 10:30 11:00 Coffee break (with exhibition viewing) Session 8: Cell death biomarkers Chair Marie-Lise Gougeon (Paris, France) 11:00 11:30 Klaus-Michael Debatin (Ulm, Germany) Cell death and cancer therapy in the clinic 11:30 11:45 Sharon Leong (Sydney, Australia) Proteomic profiling for apoptotic biomarkers of breast cancer response to chemotherapy 11:45 12:00 Dieter Demon (Ghent, Belgium) Proteome analysis reveals different cleavage site preferences for caspase-3 and -7 12:00 12:15 Bonafsheh Mirnikjoo (Houston, TX, USA) The redistribution of lysosomal phosphatidylserine to the plasma membrane outer membrane leaflet during apoptosis 12:15 12:30 Gabriela Brumatti (Parkville, Australia) Regulated Hox gene expression reveals a novel role for Hox genes in myeloid cell proliferation and survival 12:30 13:00 Heike Bantel (Hannover, Germany) Apoptosis biomarkers in liver diseases 13:00 14:30 Lunch (with exhibition viewing)

8 Session 9: ECDO Keynote Lecture Chair Thomas Brunner (Bern, Switzerland) 14:30 15:30 Josef Penninger (Vienna, Austria) Title to be announced 15:30 16:00 Coffee break Session 10: Cutting Edge Young Investigator Session Chair Boris Turk (Ljubljana, Slovenia) 16:00 16:20 16:20 16:40 Thomas Kaufmann (Melbourne, Australia/Bern, CH) Fatal hepatitis mediated by secreted TNFα requires caspase-8 and the two BH3-only proteins Bid and Bim Guillermo Velasco (Madrid, Spain) Cannabinoid antitumoral action: inducing ER stress and autophagy to promote cell death 16:45 17:00 Concluding remarks 17:00 17:45 ECDO General Assembly 19:30 24:00 Apéro, Gala dinner and Disco (Dählhölzli, Tierpark) Dinners and coffee breaks are sponsored by pharmaceutical companies.

1:10 1:30 Opening Lecture: Vice Rector Research and Innovation: Prof. Eugene Cloete, Stellenbosch University. (South Africa)

1:10 1:30 Opening Lecture: Vice Rector Research and Innovation: Prof. Eugene Cloete, Stellenbosch University. (South Africa) Cell Death and Diseases Conference location: Protea Hotel, Stellenbosch Wineland district, Cape Province, South Africa DATE: May 8 May 1, 214 Organizers: A.M. Engelbrecht, M.J. Cronjé, R.A. Lockshin, Z.