Signaling in cell death survival, proliferation and degeneration. Conference location:são Paulo Brazil. June 10 13, 2011.

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1 Signaling in cell death survival, proliferation and degeneration Conference location:são Paulo Brazil June 10 13, 2011 Organizers: Soraya Smaili, Sergio Lavandero, Richard Lockshin, Roya Khosravi Far and Zahra Zakeri June 10 th 2:00pm 6:00pm: Signaling in cell death survival, proliferation and degeneration Conference location: São Paulo Brazil June 10 13, 2011 Organizers: Soraya Smaili, Sergio Lavandero, Richard Lockshin, Roya Khosravi Far and Zahra Zakeri June 10 th 2:00pm 6:00pm: Welcome Introduction and awards Chair: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA 2:00 2:15pm Introduction and welcome Zahra Zakeri: Queens College, U.S.A. 2:15 2:30pm Presenting Award to Dr. Guido Kroemer Richard A. Lockshin: St. Johns University, U.S.A 2:30 3:30pm Cancer cell death; killing the immortal Guido Kroemer. Institut Gustave Roussy, France

2 3:30 4:00pm Coffee Break Pathways to cell death and cell survival Chair: Marie Lise Gougeon, Institut Pasteur, France 4:00 4:30pm protein BAD Integration of glucose metabolism and apoptosis by the BCL 2 family Nika Danial, Dept. of Pathology, Harvard University, USA 4:30 5:00pm New functions of the BCL 2 protein family on ER physiology Claudio Hetz, Inst. of Biomedical Sciences, Univ. of Chile, Chile 5:00 5:30pm Physiological mechanisms mediated by the prion protein in the control of cell death and survival Rafael Linden, Instituto de Biofisica da UFRJ, Brazil 5:30 5:45pm Increased ER mitochondrial coupling stimulates mitochondrial metabolism during early stages of ER stress. Roberto Bravo, Univ. Chile, Santiago, Chile 5:45 6:00pm Analysis of apoptosis regulatory genes controlled by histone deacetylase inhibitors in chronic lymphocytic leukemia cells, Joan Gil, University of Barcelona IDIBELL, Spain 7:00pm Social hour Dinner June 11 th 9:00am 7:30pm Regulation of cell death in cancer I Chair: Marianne J Cronje, Univ. Johannesburg, South Africa 9:00 9:30am Desirable off target effects of anticancer agents Laurence Zitvogel, INSERM and Institut Gustave Roussy, Villejuif, France

3 9:30 10:00am Sensitivity and resistance in preclinical cancer model Klaus Michel Debatin, Children s Cancer Center, Ulm, Germany 10:00 10:30am Novel cell death regulatory pathways in cancer Gustavo Amarante Mendes, Universidade de São Paulo, São Paulo, Brazil 10:30 11:00am Coffee Break Regulation of cell death in cancer II Chair: Katharina D'Herde, Dept. Human Anatomy and Embryology, Fac. Medicine, Univ. Gent, Belgium 11:00 11:30am Cell death pathways to cancer Roya Khosravi Far, Dept. of Pathology, Harvard U. Med. School, USA 11:30 12:00am microenvironment A dual role for galectin 3 in cell death within specialized tissue Roger Chammas University of São Paulo, Brazil 12:00 12:15pm colon cancer cells Enhancement of TRAIL induced apoptosis by Homoharringtonine in human Jarmila Stremenova Charles University in Prague, Prague, Czech Republic 12:15 12:30pm MicroRNA 10b is down regulated in head and neck cancer and could impact cancer development through kfl4 signaling Flavia Maziero Andreghetto, Albert Einstein Research and Education Institute, São Paulo, Brazil 12:30 2:00pm Lunch Regulation of cell death in cancer III Chair: Andrew Quest, University of Chile, Chile 2:00 2:30pm Exploiting cell death signaling pathways to overcome cancer resistance Simone Fulda. Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt 2:30 3:00pm Redox regulation of cell fate in cancer cells

4 Shazib Pervaiz, National University Health System, Singapore 3:00 3:30pm The p53 family between development, cell death and cancer Gerry Melino, Univ. di Roma Tor Vergata, Italy and MRC, Univ. of Leicester, UK Not confirmed by registration 3:30 4:00pm Coffee Regulation of Death in Neurodegeneration and Neuroprotection I Chair: Maria de Fatima Leite, Federal University of Minas Gerais, Brazil 4:00 4:30pm The prion protein as a survival target in Alzheimer s disease Vilma Martins Cancer Hospital, São Paulo, Brazil 4:30 5:00pm S100B releasing as a signal of astrocyte activation to survival or death Carlos Alberto S. Gonçalves Federal University of Minas Gerais Brazil 5:00 5:15am Study of calcium signalling in a rat model of sporadic Alzheimer's Disease Leticia Rodrigues, Federal University of São Paulo 5:15 5:30am p53 protein directly regulates the mitochondrial PTP pore during oxidative stress induced necrosis and ischemic stroke Ute Moll Dept. of Pathology, Stony Brook University, Stony Brook NY 5:30 7:30pm Poster Session 8:00pm Dinner June 12 th 9:00am 7:30pm Regulation of Death Chair: Sergio Lavandero, Univ. of Chile School of Medicine, Santiago,Chile

5 9:00 9:30am Role of TRPM4 in cell death Andres Stutzin, Univ. of Chile, Santiago, Chile 9:30 10:00am Prostate epithelial cell apoptosis: new approaches to an old model Hernandes Carvalho University of Campinas, São Paulo, Brazil 10:00 10:15 A natural cytotoxic peptide from the venom of South American rattlesnake targets tumor cells in vivo, triggers cell death by calcium dependent pathway and shows significant efficacy in melanoma tumor in vivo model Mirian Hayashi, Universidade Federal de São Paulo (UNIFESP) 10:15 10:30am complex formation Apoptotic and non apoptotic roles of caspases in embryonic tooth bone Eva Matalová, Czech Academy of Sciences Prague, Czech Republic 10:30 11:00am Coffee Break Regulation of Death Chair: Nader Maghsoudi, Neuroscience Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran 11:00 11:30am The survivin/cox2 connection to tumor suppression by caveolin 1 Andrew Quest, University of Chile, Chile 11:30 12:00pm Intracellular pathogens and cell death Marisa Isabel Colombo, Universidad Nacional de Cuyo Mendoza Argentina 12:00 12:15pm Combining cell death and immune stimulation using p19arf and IFNb in a B16F10 tumor vaccine model Ruan Medrano, InCor HCFM USP, São Paulo, Brazil

6 12:15 12:30pm Overcoming tumor and virus strategies to keep cells alive: translation of mouse models into a human disease Julian Pardo, Univ. of Zaragoza, Spain 12:30 2:00pm Lunch Young scientist Mentoring Workshop: How the young scientists in the field can survive, network and excel. Moderator: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA 2:15 2:45pm What are the obstacles holding back scientists? Soraya Smaili, Departamento de Farmacologia, Universidade Federal de São Paulo (UNIFESP/EPM), São Paulo, SP, Brazil. 2:45 3:45pm Panel discussion: Panelists : Roya Khosravi Far; Marie Lise Gougeon; Guido Kroemer ; Simone Fulda; Eileen White; Marianne J Cronje; Soraya Smaili; Marisa Isabel Colombo, Gerry Melino, Simone Fulda Regulation of Death Chair: Simone Fulda, Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt 4:00 4:30pm Double stranded DNA virus tools to cope with cell stress and death Covadonga Alonso: Dpt. Biotecnologia, Universidad Autónoma de Madrid, Spain 4:30 5:00pm TAM Receptors in Immune Modulation and Clearance of Apoptotic Cells Raymond Birge: UMDNJ New Jersey Medical School, Newark, NJ USA 5:00 5:15am Flavivirus NS4A induced autophagy protects cells against death and enhances virus replication Emmanuel Datan, Queens College of CUNY, New York, NY USA

7 5:15 5:30am Dengue virus infection upregulates cell death markers in human monocytes and caspase inhibitor modulates virus load Amanda Torrentes Carvalho, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 5:30 7:30pm 8:00pm Poster Session Dinner June 13 th 9:00am 2:00pm Targeting autophagic cell death pathways Chair: Mauro Piacentini, National Institute for Infectious Diseases IRCCS L. Spallanzani, and Univ. de Roma Tor Vergata, Rome, Italy 9:00 9:30am The role of bec 1 in C. elegans development and aging Alicia Melendez Queens College, U.S.A. 9:30 10:00am Role of Ambra1 in autophagy regulation: far beyond Beclin 1 interaction Gian Maria Fimia, National Institute for Infectious Diseases IRCCS L. Spallanzani, Rome, Italy 10:00 10:15am The role pf MKP 1 in autophagy and apoptosis during ischaemia/reperfusion injury in the heart Anna Mart Engelbrecht Stellenbosch University, Stellenbosch, South Africa 10:15 10:30am The dual PI3K/mTOR inhibitor NVP BEZ235 and chloroquine synergize to trigger apoptosis through lysosomal membrane permeabilisation in neuroblastoma cells Christian Seitz, Goethe University Frankfurt am Main,Germany 10:30 11:00am Coffee Pathways to cell death and cell survival II Chair: Soraya Smaili, Departamento de Farmacologia, Universidade Federal de São Paulo (UNIFESP/EPM), São Paulo, SP, Brazil.

8 11:00 11:30am DOR: a new regulator of autophagy Antonio Zorzano, Institute for Research in Biomedicine (IRB Barcelona), Spain 11:30 12:00pm Wrap up Richard Lockshin, St. John s Univ., Jamaica NY, USA 12:00 2:00pm Lunch and End of Meeting

Conference Program. The Sixth International Cell Death. Society Symposium. Angra dos Reis, Hotel do Frode. Brazil 2006

Conference Program. The Sixth International Cell Death. Society Symposium. Angra dos Reis, Hotel do Frode. Brazil 2006 Conference Program The Sixth International Cell Death Society Symposium Angra dos Reis, Hotel do Frode Brazil 2006 Friday 2 nd June 2006 I. Cell cycle, Cell Death and Aging Welcome and Introduction, Award