Biological functions: role as tumor suppressor. Growth inhibitor. Inducer of apoptosis. Effects on cell differentiation.
|
|
|
- Janis Maxwell
- 5 years ago
- Views:
Transcription
1 TGF-beta and cancer Isabel Fabregat Departament de Ciències Fisiòlogiques II, Universitat de Barcelona Institut de Investigació Biomèdica de Bellvitge (IDIBELL) Máster en Oncología Molecular, Marzo 2011
2 Index: TGF-β Family. Receptors. Signal transduction. Regulation of Smad family. Biological functions: role as tumor suppressor. Growth inhibitor. Inducer of apoptosis. Effects on cell differentiation. Role of TGF-β in tumor progression. Epithelial to mesenchymal transition. Increase in migration and invasion. Effects on angiogenesis and on the tumor stroma. Summary: Dual role of TGF-β in cancer: Tumor suppression in early stages. Tumor promoter in advanced tumors. Role in metastasis.
3 TGF-β family and their receptors Bernhard Schmierer and Caroline S. Hill Nature 2007
4 Itoh and ten Dijke Current Opinion in Cell Biology, 2007
5 Histone acetylation Histone desacetylation Massagué, Seoane and Wotton Genes & Dev. 2005
6 Shi and Massagué, Cell 2003
7 Molecular mechanisms that attenuate Smad activation by TGF-β Massagué, Seoane and Wotton Genes & Dev. 2005
8 TGF-β inhibits growth, induces apoptosis and mediates cell differentiation It can induce or inhibit Adapted from:
9 TGF-β induces apoptosis in hepatocytes A TGF-β B C M1 CONTROL M1=3.47±0.36 D TGF-β M1 M1=16.2±2.14 Sánchez et al. J. Biol. Chem C T
10 Adaptado de Moustakas and Heldin. J Cell Sci 2005 Proposed mechanisms for TGF-beta-induced apoptosis NADPH oxidasa ROS Cyt c
11 TGF-β, when combined with EGF or HGF, induces hepatocyte differentiation ALB-VIM CK19-CK18 EGF-TGFβ CONTROL Sánchez et al. Exp Cell Res 1998
12 Role of TGF-β as tumor suppressor Bierie and Moses Nature 2006
13 Alterations in TGF-beta signaling in human tumors Levy and Hill. Cytokine & Growth Factor Reviews 2006
14 Massagué, Cell 2008
15 Bierie and Moses Nature 2006
16 TGF-β Caja et al., Cancer Res 2009 MEK/ERKs Hepatocellular carcinoma Glutathione ROS ROS TACE PI3K, ERKs EGFR TGF-α HB-EGF Liver tumor cells Murillo et al., Oncogene 2005 Caja et al., Cell Signal 2007 Caja et al., J Hepatol 2011 Carmona-Cuenca et al., J Cell Physiol 2006, J Hepatol 2008 SURVIVAL APOPTOSIS ΔΨm Herrera et al. FASEB J 2001, Free Radic Biol Med 2004 cit-c Caspase-9 Caspase-3
17 NOX (NADPH Oxidases) family of enzymes NOX family DUOX 1 DUOX 2 NOX 1 NOX 2 NOX 3 NOX 4 NOX 5 O 2 O 2 - NADPH NADP + Brown and Griendling Free Radic Biol Med 2009
18 NADPH oxidases control both survival and apoptosis in liver tumor cells Miguel Murillo TGF-β NOX1 ROS NF-κB Rac1 rac1 Other survival signals egfr ligands Smad3 NOX4 nox4 Nucleus ROS Cell death Patricia Sancho Murillo et al., Biochem J 2007 Carmona-Cuenca et al., J Hepatol 2008 Sancho et al. BBA- Mol Cell Res 2008 Sancho et al. J Biol Chem 2010 Survival Irene Carmona
19 TGF-β treatment induces loss in cell adhesion and confers cell migratory properties Control TGFβ FaO rat hepatoma cells Control Phalloidin TGFβ Esther Bertran
20 TGF-β induces epithelial-mesenchymal transition (EMT) in rat hepatoma cells Control 1 day 3 days DAPI E-CADHERIN alb snail + TGFβ (h) RT FaO hepatoma cells E- cadherin Bertran et al. Cell Signal 2009
21 .. and in human hepatocellular carcinoma cells Laia Caja Caja et al. J Cell Physiol 2011 Dr. Nelson Fausto, Univ. Washington Seattle
22 Proposed models for the molecular mechanisms that mediate EMT by TGF-β in epithelial cells Moustakas and Heldin. J Cell Sci 2005
23 EMT confers invasive and migratory properties FaO TβT-FaO 0 h 4 h 24 h 48 h Bertran et al. Cell Signal 2009
24 EMT confers liver stem cell properties Hep3B cells
25 The TGFβ-induced EMT is a reversible process
26 Anti (A) and pro-(b) tumorigenic effects of TGF-β on cell differentiation Massagué, Cell 2008
27 Sonia Vega Angela Nieto Up-regulation of Snail not only mediates EMT, but also resistance to apoptosis in liver cells Instituto de Neurociencias CSIC/UMH, Alicante Jèssica Mainez Franco et al., J. Cell science 2010
28 Model of transgenic mice expressing Tamoxifen-inducible Snail1
29 Adult hepatocytes from these mice show EMT features..and are completely resistant to TGF-β-induced apoptosis Caspase-3 Activity (% Control) Apoptotic nuclei (%) TGF-β TAM TGF-β TAM
30 Summary TGF-β RI EGFR Ligands Suppressor role RII TACE Smad 2,3 Smad4 EGFR Snail Pro-tumorigenic properties EMT Growth inhibition Apoptosis Migration Invasion Stem cell properties
31
32 TGF-β as a tumor promoter
33 CONCLUSIONS Massagué Cell 2008
34 Biological clues of the metastatic and invasive phenotype IDIBELL Group Fac. Farmacia,UCM, Madrid César Roncero Margarita Fernández Arancha Sánchez TGF-β Liver lab New members: Edgar Baguena Joaquim Moreno Blanca Herrera Straight collaboration with Drs. Àngels Fabra, Angels Sierra, Joan Gil, Emilio Ramos, IDIBELL Laia Caja Patricia Sancho Eva Crosas Joan Fernando Isabel Fabregat Esther Bertran Jèssica Mainez Estanis Navarro
35 Instituto de Neurociencias, CSIC- Univ. Miguel Hernández, Alicante Sonia Vega Ángela M. Nieto Universidad de Extremadura Alberto Álvarez-Barrientos IIB- Alberto Sols (CSIC/UAM) Ángela M. Valverde University of Vienna Austria Wolfgang Mikulits lab CIEMAT, Madrid Jose Carlos Segovia University of Washington, Seattle, USA Nelson Fausto lab Fundación Hospital de Alcorcón, Madrid Conrado Fernández Universitat de Barcelona Gustavo Egea
Transforming growth factor-beta (TGF-b) isan
Overactivation of the TGF-b Pathway Confers a Mesenchymal-Like Phenotype and CXCR4-Dependent Migratory Properties to Liver Tumor Cells Esther Bertran, 1 Eva Crosas-Molist, 1 Patricia Sancho, 1 Laia Caja,
TGF-β. transforming. growth factor. growth factor-β TGF-β. Transforming growth factor-β TGF-β. Smad. DNA Smad Smad cofactor. transcription factor Smad
24 3 65 73 2009 TGF-β Smad cofactors 2 Transforming growth factor-β TGF-β TGF-β Smad Smad DNA Smad Smad cofactor TGF-β Maid Maid Smad cofactor Smad cofactor TGF-β -β signal transduction transcription factor
Cancer and Oncogenes Bioscience in the 21 st Century. Linda Lowe-Krentz
Cancer and Oncogenes Bioscience in the 21 st Century Linda Lowe-Krentz December 1, 2010 Just a Few Numbers Becoming Cancer Genetic Defects Drugs Our friends and family 25 More mutations as 20 you get older
The Hallmarks of Cancer
The Hallmarks of Cancer Theresa L. Hodin, Ph.D. Clinical Research Services Theresa.Hodin@RoswellPark.org Hippocrates Cancer surgery, circa 1689 Cancer Surgery Today 1971: Nixon declares War on Cancer
Virchow s Hypothesis lymphorecticular infiltration of cancer reflected the origin of cancer at sites of inflammation
Virchow s Hypothesis 1863 lymphorecticular infiltration of cancer reflected the origin of cancer at sites of inflammation Barrett s esophagus/ Esophageal adenocarcinoma PSC / Cholangiocarcinoma Viral hepatitis
Contents 1 The Windows of Susceptibility to Breast Cancer 2 The So Called Pre-Neoplastic Lesions and Carcinoma In Situ
Contents 1 The Windows of Susceptibility to Breast Cancer... 1 1.1 Introduction... 1 1.2 Risk Factor and Etiological Agents... 2 1.3 The Concept of the Windows of Susceptibility to Carcinogenesis... 5
ROLE OF TGF-BETA SIGNALING IN PIK3CA-
ROLE OF TGF-BETA SIGNALING IN - DRIVEN HEAD AND NECK CANCER INVASION AND METASTASIS 1,2 Sophia Bornstein, 3 Jingping Shen, 3 Jacob Minor, 3 Frank Hall, 3 Fang Zhang, 4 Sherif Said, 4 Xiao-Jing Wang, 1
Manuel López Cabrera. Modelos experimentales para la investigación en DP
Manuel López Cabrera Modelos experimentales para la investigación en DP Manuel López Cabrera Transición Mesotelio Mesénquima (MMT) como Marcador de Enfermedad y como Diana Terapéutica en Fibrosis Peritoneal
Cancer and Oncogenes Bioscience in the 21 st Century. Linda Lowe-Krentz October 11, 2013
Cancer and Oncogenes Bioscience in the 21 st Century Linda Lowe-Krentz October 11, 2013 Just a Few Numbers Becoming Cancer Genetic Defects Drugs Our friends and family 200 180 160 140 120 100 80 60 40
MASTER EN ONCOLOGÍA MOLECULAR 2011 TGF-BETA
MASTER EN ONCOLOGÍA MOLECULAR 2011 TGF-BETA Joan Seoane ICREA Research Professor Vall d Hebron Institute of Oncology Vall d Hebron University Hospital Barcelona jseoane@vhio.net Glioma Stupp et al. New
Inflammatory Cells and Metastasis
Inflammatory Cells and Metastasis Experimentelle Krebsforschung SS 07 Gerhard Christofori Institute of Biochemistry and Genetics Department of Clinical-Biological Sciences Center of Biomedicine University
IL-24 AND ITS ROLE IN WOUND HEALING
IL-24 AND ITS ROLE IN WOUND HEALING Nancy J. Poindexter, Ryan Williams, Garth Powis, Sunil Chada, and Elizabeth A. Grimm & Introgen Therapeutics, Inc., Houston, TX IL-24/MDA 24/MDA-77 is a Tumor Suppressor
Menachem Elimelech. Science and Technology for Sustainable Water Supply
Menachem Elimelech Science and Technology for Sustainable Water Supply Traditional methods for water purification are chemical and energy intensive. Highly effective, low-cost, robust technologies for
SUPPLEMENTARY FIGURES
SUPPLEMENTARY FIGURES Supplementary Figure S1: Fibroblast-induced elongation of cancer cells requires direct contact with living fibroblasts. A. Representative images of HT29-GFP cultured in the presence
CHAPTER VII CONCLUDING REMARKS AND FUTURE DIRECTION. Androgen deprivation therapy is the most used treatment of de novo or recurrent
CHAPTER VII CONCLUDING REMARKS AND FUTURE DIRECTION Stathmin in Prostate Cancer Development and Progression Androgen deprivation therapy is the most used treatment of de novo or recurrent metastatic PCa.
Alcoholic hepatitis is a drug-induced disorder
Alcoholic hepatitis is a drug-induced disorder Gyongyi Szabo, MD, PhD Professor of Medicine University of Massachusetts Medical School Source: 2 Sobernation.com Clinical Progression of ALD Mortality Acute
Supplementary Figure 1. Identification of tumorous sphere-forming CSCs and CAF feeder cells. The LEAP (Laser-Enabled Analysis and Processing)
Supplementary Figure 1. Identification of tumorous sphere-forming CSCs and CAF feeder cells. The LEAP (Laser-Enabled Analysis and Processing) platform with laser manipulation to efficiently purify lung
1.The metastatic cascade. 2.Pathologic features of metastasis. 3.Therapeutic ramifications
Metastasis 1.The metastatic cascade 2.Pathologic features of metastasis 3.Therapeutic ramifications Sir James Paget (1814-1899) British Surgeon/ Pathologist Paget s disease of bone Paget s disease of the
VIII Curso Internacional del PIRRECV. Some molecular mechanisms of cancer
VIII Curso Internacional del PIRRECV Some molecular mechanisms of cancer Laboratorio de Comunicaciones Celulares, Centro FONDAP Estudios Moleculares de la Celula (CEMC), ICBM, Facultad de Medicina, Universidad
Cigarette Smoke Exposure and HIV-Related Neurologic Disease Progression Basic Mechanisms and Clinical Consequences
Cigarette Smoke Exposure and HIV-Related Neurologic Disease Progression Basic Mechanisms and Clinical Consequences Walter Royal, III, MD Professor of Neurology University of Maryland School of Medicine
Cell Polarity and Cancer
Cell Polarity and Cancer Pr Jean-Paul Borg Email: jean-paul.borg@inserm.fr Features of malignant cells Steps in Malignant Progression Cell polarity, cell adhesion, morphogenesis and tumorigenesis pathways
GENE EXPRESSION AND microrna PROFILING IN LYMPHOMAS. AN INTEGRATIVE GENOMICS ANALYSIS
GENE EXPRESSION AND microrna PROFILING IN LYMPHOMAS. AN INTEGRATIVE GENOMICS ANALYSIS Dra. Margarita Sánchez-Beato Lymphoma Group Molecular Pathology Programme CNIO Agilent Microarray and Sequencing Roadshow,
Quantitative modeling and analysis of the transforming growth factor β signaling pathway
Quantitatie modeling and analysis of the transforming growth factor β signaling pathway Seung-Wook hung, Fayth L. Miles, arlton R. ooper, Mary. Farach-arson, and Babatunde A. Ogunnaike Uniersity of Delaware,
TGF-b signalling and liver disease
STATE-OF-THE-ART REVIEW TGF-b signalling and liver disease Isabel Fabregat 1,2, Joaquim Moreno-Caceres 1,Aranzazu Sanchez 3, Steven Dooley 4, Bedair Dewidar 4,5, Gianluigi Giannelli 6 and Peter ten Dijke
ONCOLOGY LETTERS 5: , 2013
ONCOLOGY LETTERS 5: 149-154, 2013 Epithelial-mesenchymal transition expression profiles as a prognostic factor for disease-free survival in hepatocellular carcinoma: Clinical significance of transforming
Supplementary Figure 1: Func8onal Network Analysis of Kinases Significantly Modulated by MERS CoV Infec8on and Conserved Across All Time Points
A. B. 8 4 Supplementary Figure : Func8onal Network Analysis of Kinases Significantly Modulated by MERS CoV Infec8on and Conserved Across All Time Points Examined. A) Venn diagram analysis of kinases significantly
Type of file: PDF Size of file: 0 KB Title of file for HTML: Supplementary Information Description: Supplementary Figures
Type of file: PDF Size of file: 0 KB Title of file for HTML: Supplementary Information Description: Supplementary Figures Supplementary Figure 1 mir-128-3p is highly expressed in chemoresistant, metastatic
1. The metastatic cascade. 3. Pathologic features of metastasis. 4. Therapeutic ramifications. Which malignant cells will metastasize?
1. The metastatic cascade 3. Pathologic features of metastasis 4. Therapeutic ramifications Sir James Paget (1814-1899) British Surgeon/ Pathologist Paget s disease of Paget s disease of the nipple (intraductal
A Novel CTC-Detecting Technique Using TelomeScan and Its Clinical Applications
A Novel CTC-Detecting Technique Using TelomeScan and Its Clinical Applications Yasuo Urata CEO and President Oncolys BioPharma Inc. February 16, 2013 Telomere Length is a Limiting Factor for Cell Replication
2015 ICDM, 15-17, Jejudob Island, Korea Recent Advances in Diabetic Microvascular Complications. DPP-4 Inhibition and Diabetic Nephropathy
2015 ICDM, 15-17, Jejudob Island, Korea Recent Advances in Diabetic Microvascular Complications DPP-4 Inhibition and Diabetic Nephropathy Daisuke Koya Department of Diabetology & Endocrinology Kanazawa
Comparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa
IJMCM Autumn 2013, Vol 2, No 4 Original Article Comparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa Shima Nafarzadeh 1, Samad Ejtehadi 2, Pouyan Amini Shakib 1, Majid
Cancer Biology Course. Invasion and Metastasis
Cancer Biology Course Invasion and Metastasis 2016 Lu-Hai Wang NHRI Cancer metastasis Major problem: main reason for killing cancer patients, without it cancer can be cured or controlled. Challenging questions:
Abnormally differentiating keratinocytes in the epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S100A9
Abnormally differentiating keratinocytes in the epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S1A9 Joanna Nikitorowicz-Buniak UCL Division of Medicine Systemic sclerosis
Regulation of EMT by TGFb in cancer
FEBS Letters 586 (2012) 1959 1970 journal homepage: www.febsletters.org Review Regulation of EMT by TGFb in cancer Carl-Henrik Heldin a,, Michael Vanlandewijck a, Aristidis Moustakas a,b a Ludwig Institute
Chapter 1: Curcumin is excellent compound for various medicinal usages
Super-Curcumin Story Chapter 1: Curcumin is excellent compound for various medicinal usages Chapter 2: Discovery of Super-Curcumin analog Chapter 3: Anti-tumor activities of Super-Curcumin analog Chapter
Rath, N., and Olson, M. (2016) Regulation of pancreatic cancer aggressiveness by stromal stiffening. Nature Medicine, 22(5), pp. 462-463. There may be differences between this version and the published
mirna Dr. S Hosseini-Asl
mirna Dr. S Hosseini-Asl 1 2 MicroRNAs (mirnas) are small noncoding RNAs which enhance the cleavage or translational repression of specific mrna with recognition site(s) in the 3 - untranslated region
IUBMB Wood Whelan Fellowship - Application Form
IUBMB Wood Whelan Fellowship - Application Form The deadline for submitting an application is April 1, 2019. Your application must be submitted by clicking the submission button on our website. Save this
TGF-β signaling dictates therapeutic targeting in prostate cancer
EDITORIAL TGF-β signaling dictates therapeutic targeting in prostate cancer Natasha Kyprianou University of Kentucky College of Medicine, Departments of Urology, Molecular Biochemistry, Pathology and Toxicology,
CCN1: A NOVEL TARGET FOR PANCREATIC CANCER. Andrew Leask.
CCN1: A NOVEL TARGET FOR PANCREATIC CANCER Andrew Leask CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine
Molecular factors influencing epithelial-mesenchymal transition in breast cancer
Molecular factors influencing epithelial-mesenchymal transition in breast cancer Gisela Nilsson Department of Medical Biochemistry and Cell Biology Institute of Biomedicine Sahlgrenska Academy at University
Protocol for A-549 VIM RFP (ATCC CCL-185EMT) TGFβ1 EMT Induction and Drug Screening
Protocol for A-549 VIM RFP (ATCC CCL-185EMT) TGFβ1 EMT Induction and Drug Screening Introduction: Vimentin (VIM) intermediate filament (IF) proteins are associated with EMT in lung cancer and its metastatic
Tumor microenvironment Interactions and Lung Cancer Invasiveness. Pulmonary Grand Rounds Philippe Montgrain, M.D.
Tumor microenvironment Interactions and Lung Cancer Invasiveness Pulmonary Grand Rounds Philippe Montgrain, M.D. February 26, 2009 Objectives Review epithelial mesenchymal transition (EMT), and its implications
The 6th International Epithelial Mesenchymal Transition Meeting
TEMTIA 2013 The 6th International Epithelial Mesenchymal Transition Meeting 13 16 November 2013 Alicante Spain Organizer and Host: TEMTIA Inc. The Epithelial Mesenchymal Transition International Association
EMT: Epithelial Mesenchimal Transition
EMT: Epithelial Mesenchimal Transition A phenotypic change that is characteristic of some developing tissues and certain forms of cancer. This is a multistep, key process in embryonic development and metastasis
PUBLICATIONS. cells. J. Physiol. (London) 517P:91P (Manchester, England, UK).
277 PUBLICATIONS Abstracts Haddad JJ, Land SC (1999). Differential activation of oxygen-responsive transcription factors over fetal-to-neonatal alveolar oxygen tensions in rat fetal distal lung epithelial
The splicing regulation and clinical significance of epithelial splicing regulatory protein 1 in invasion and metastasis of epithelial ovarian cancer
The splicing regulation and clinical significance of epithelial splicing regulatory protein 1 in invasion and metastasis of epithelial ovarian cancer Jie Tang MD, Ph.D, Professer Vice director of Department
Cancer Biology Dynamical Cell Systems
The Institute of Cancer Research PHD STUDENTSHIP PROJECT PROPOSAL PROJECT DETAILS Project Title: SUPERVISORY TEAM Primary Supervisor: The forces behind pancreatic cancer; and changing them as a therapeutic
Immunological Lung Diseases
Emphysema and Fibrosis Universitätsklinik für Pneumologie Prof. Thomas Geiser Head Div. of Pulmonary Medicine and Laboratory of Lung Research, MU50 thomas.geiser@insel.ch The healthy lung: The pathway
Cell Cell Communication
IBS 8102 Cell, Molecular, and Developmental Biology Cell Cell Communication January 29, 2008 Communicate What? Why do cells communicate? To govern or modify each other for the benefit of the organism differentiate
Sphingosine kinase 1 enables communication between melanoma cells and. fibroblasts that provides a new link to metastasis
Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis Nigel J. Pyne* and Susan Pyne Cell Biology Group, Strathclyde Institute of Pharmacy
Anti-Apoptotic Effects of Cellular Therapy
Anti-Apoptotic Effects of Cellular Therapy Jason Lapetoda 1, Lee K Landeen, PhD 1, George K Michalopoulos, MD 2, Patricia W Bedard, PhD 1 1 Vital Therapies, Inc., San Diego, CA, USA 2 University of Pittsburgh
Mechanisms of Gene Regulation and Signal! Transduction in Hypoxia!
Mechanisms of Gene Regulation and Signal! Transduction in Hypoxia! Lorenz Poellinger! Dept. of Cell and Molecular Biology! Karolinska Institutet, Stockholm, Sweden! Normoxia - O 2 availability is in balance
Transformation of Normal HMECs (Human Mammary Epithelial Cells) into Metastatic Breast Cancer Cells: Introduction - The Broad Picture:
Transformation of Normal HMECs (Human Mammary Epithelial Cells) into Metastatic Breast Cancer Cells: Introduction - The Broad Picture: Spandana Baruah December, 2016 Cancer is defined as: «A disease caused
Flores-Pérez A et al Suppression of cell migration is promoted by mir-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells
Author s response to reviews Title: Suppression of cell migration is promoted by mir-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells Authors: Cesar Lopez-Camarillo (genomicas@yahoo.com.mx)
Neoplasia 18 lecture 8. Dr Heyam Awad MD, FRCPath
Neoplasia 18 lecture 8 Dr Heyam Awad MD, FRCPath ILOS 1. understand the angiogenic switch in tumors and factors that stimulate and inhibit angiogenesis. 2. list the steps important for tumor metastasis
SUPPLEMENTARY INFORMATION
DOI: 10.1038/ncb2607 Figure S1 Elf5 loss promotes EMT in mammary epithelium while Elf5 overexpression inhibits TGFβ induced EMT. (a, c) Different confocal slices through the Z stack image. (b, d) 3D rendering
Seeds and soil theory by Stephen Paget at the end of the XIX century.
Seeds and soil theory by Stephen Paget at the end of the XIX century. In The Distribution Of Secondary Growths In Cancer Of The Breast Paget presents and analyzes 735 fatal cases of breast cancer, complete
PATHOBIOLOGY OF NEOPLASIA
PATHOBIOLOGY OF NEOPLASIA Department of Pathology Gadjah Mada University School of Medicine dr. Harijadi Blok Biomedis, 6 Maret 2009 [12] 3/17/2009 1 The pathobiology of neoplasia Normal cells Malignant
Cell Signaling Regulatory Mechanisms Controlling Epithelial-Mesenchymal Transition in Carcinoma
University of Pennsylvania ScholarlyCommons Publicly Accessible Penn Dissertations 1-1-2015 Cell Signaling Regulatory Mechanisms Controlling Epithelial-Mesenchymal Transition in Carcinoma Janine Marie
EMT and inflammation: inseparable actors of cancer progression
EMT and inflammation: inseparable actors of cancer progression Meggy Suarez-Carmona 1, Julien Lesage 2, Didier Cataldo 3 and Christine Gilles 3 1 National Center for Tumor Diseases (NCT) University Hospital
Tumor Associated Macrophages as a Novel Target for Cancer Therapy
Tumor mass Tumor Associated Macrophage Tumor Associated Macrophages as a Novel Target for Cancer Therapy This booklet contains forward-looking statements that are based on Amgen s current expectations
Therapeutic targeting neuraminidase-1 in multi-stage of tumorigenesis
Therapeutic targeting neuraminidase-1 in multi-stage of tumorigenesis Myron R. Szewczuk Dept. Biomedical and Molecular Sciences, Queen's University, Kingston, K7L 3N6 Ontario, Canada HIGHLIGHTS. An innovative
DOCTOR S DEGREE THESIS
UNIVERSITY OF MEDICINE AND PHARMACY CRAIOVA SUMMARY DOCTOR S DEGREE THESIS THE ROLE OF EPITHELIOMESENCHYMAL TRANSITION IN THYROID CARCINOGENESIS Doctor s Degree Candidate: Mitroi Cristina Mariana (Calangiu)
Therapeutic implications of cancer stem cells. Cédric Blanpain, MD, PhD Laboratory of stem cells and cancer WELBIO, Université Libre de Bruxelles
Therapeutic implications of cancer stem cells Cédric Blanpain, MD, PhD Laboratory of stem cells and cancer WELBIO, Université Libre de Bruxelles Stem cell properties Differentiation Self-renewal Tumor
The Hallmarks of Cancer
The Hallmarks of Cancer This illustration encompasses the six hallmark capabilities originally proposed in our 2000 perspective. The past decade has witnessed remarkable progress toward understanding the
ONCOLOGY LETTERS 11: , 2016
2946 The impact of metformin and salinomycin on transforming growth factor β induced epithelial-to-mesenchymal transition in non small cell lung cancer cell lines STEFAN KOECK 1, ARNO AMANN 1, JULIA M.
EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA RECEPTORS IN NEUROBLASTOMA CELL LINES WITH DIFFERENT TUMORGENICITIES
EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA RECEPTORS IN NEUROBLASTOMA CELL LINES WITH DIFFERENT TUMORGENICITIES Tanmayi Mankame Department of Biology, Fordham University, Bronx, NY Email: tanmayimankame@yahoo.com
mir-509-5p and mir-1243 increase the sensitivity to gemcitabine by inhibiting
mir-509-5p and mir-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer Hidekazu Hiramoto, M.D. 1,3, Tomoki Muramatsu, Ph.D. 1, Daisuke Ichikawa,
From crypt stem cell to colorectal cancer
19 3 2007 6 Chinese Bulletin of Life Sciences Vol. 19, No. 3 Jun., 2007 1004-0374(2007)03-0321-05 ( 510405) Wnt Notch BMP R735.35; R730.21 A From crypt stem cell to colorectal cancer WEN Bin*, CHEN Weiwen
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 4,000 116,000 120M Open access books available International authors and editors Downloads Our
THE HALLMARKS OF CANCER
THE HALLMARKS OF CANCER ONCOGENES - Most of the oncogenes were first identified in retroviruses: EGFR (ErbB), Src, Ras, Myc, PI3K and others (slightly more than 30) - Mutated cellular genes incorporated
Exercise Intolerance in Heart Failure: Significance of Skeletal Muscle Abnormalities
Exercise Intolerance in Heart Failure: Significance of Skeletal Muscle Abnormalities Hokkaido University Graduate School of Medicine Shintaro Kinugawa Survival rate (%) Peak oxygen uptake and prognosis
The expression and significance of tumor associated macrophages and CXCR4 in non-small cell lung cancer
JBUON 2018; 23(2): 398-402 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE The expression and significance of tumor associated macrophages and
Medical Treatment in Marfan Syndrome
Medical Treatment in Marfan Syndrome Julie De Backer, MD, PhD Cardiology and Medical Genetics Ghent University Hospital Belgium Why do we have to treat? Flo Hyman (1954-1986) Captain of the American Women
Concomitant Gain of Function of Notch and Loss of p53 Signalling trigger an EMT Like Programme Driving Metastatic Intestinal Cancers
8 AVRIl 2015 8 Avril 2015 Concomitant Gain of Function of Notch and Loss of p53 Signalling trigger an EMT Like Programme Driving Metastatic Intestinal Cancers Daniel LOUVARD UMR 144 / CNRS - Institut Curie
TGFβ/BMP/Smad signaling pathway
TGFβ/BMP/Smad signaling pathway Dr. Jean Jacques Lebrun Professor of Medicine, McGill University Health Center, Cancer Research Program Associate Dean, Graduate & Postdoctoral Studies McGill University
Distinct mechanisms of TGF-b1 mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
Distinct mechanisms of TGF-b1 mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis Gangwen Han,, Molly Kulesz-Martin, Xiao-Jing Wang J Clin Invest. 2005;115(7):1714-1723.
This article is protected by copyright. All rights reserved.
Coates edited INVITED COMMENTARY Fibroblast Growth Factors and Pulmonary Fibrosis: It s more complex than it sounds Running Title: Pleiotropic actions of FGFs in lung fibrosis Authors: Kevin K. Kim*, Thomas
Thomas Jefferson University Annual Progress Report: 2008 Formula Grant
Thomas Jefferson University Annual Progress Report: 2008 Formula Grant Reporting Period July 1, 2012 December 31, 2012 Formula Grant Overview The Thomas Jefferson University received $3,455,597 in formula
T cell maturation. T-cell Maturation. What allows T cell maturation?
T-cell Maturation What allows T cell maturation? Direct contact with thymic epithelial cells Influence of thymic hormones Growth factors (cytokines, CSF) T cell maturation T cell progenitor DN DP SP 2ry
The biological bases of treatment related cardiac and lung toxicity
The biological bases of treatment related cardiac and lung toxicity Monica Mangoni Cardiopulmonary toxicity of anticancer treatments Chemotherapy TKIs MoAB CARDIAC TOXICITY Radiation effect -------------------------------Early
In vitro scratch assay: method for analysis of cell migration in vitro labeled fluorodeoxyglucose (FDG)
In vitro scratch assay: method for analysis of cell migration in vitro labeled fluorodeoxyglucose (FDG) 1 Dr Saeb Aliwaini 13/11/2015 Migration in vivo Primary tumors are responsible for only about 10%
IVC History, Cancer Research
Riordan Clinic IVC Academy 5 IVC History, Cancer Research O (slides 41-80) Pharmacokinetics of Oral Vitamin C using Liposomal Form* To test whether plasma vitamin C levels, following oral doses in supplemented
The Potential Role of Integrin Regulation by Par6 in TGF-beta-induced. Apoptosis
The Potential Role of Integrin Regulation by Par6 in TGF-beta-induced Apoptosis by Geordon James Avery-Cooper A Thesis presented to The University of Guelph In partial fulfillment of requirements for the
Cancer. Questions about cancer. What is cancer? What causes unregulated cell growth? What regulates cell growth? What causes DNA damage?
Questions about cancer What is cancer? Cancer Gil McVean, Department of Statistics, Oxford What causes unregulated cell growth? What regulates cell growth? What causes DNA damage? What are the steps in
Additional file 2 List of pathway from PID
Additional file 2 List of pathway from PID Pathway ID Pathway name # components # enriched GO terms a4b1_paxdep_pathway Paxillin-dependent events mediated by a4b1 20 179 a4b1_paxindep_pathway Paxillin-independent
Prediction of invasiveness of hepatic tumor cells
Prediction of invasiveness of hepatic tumor cells (Overexpression of Romo1 Promotes Production of Reactive Oxygen Species and Invasiveness of Hepatic Tumor Cells) (Romo1 : Reactive Oxygen Species Modulator
Supplementary Figure S1 Expression of mir-181b in EOC (A) Kaplan-Meier
Supplementary Figure S1 Expression of mir-181b in EOC (A) Kaplan-Meier curves for progression-free survival (PFS) and overall survival (OS) in a cohort of patients (N=52) with stage III primary ovarian
supplementary information
DOI: 10.1038/ncb1875 Figure S1 (a) The 79 surgical specimens from NSCLC patients were analysed by immunohistochemistry with an anti-p53 antibody and control serum (data not shown). The normal bronchi served
Mathematics and Physics of Cancer: Questions. Robijn Bruinsma, UCLA KITP Colloquium May 6, ) Cancer statistics and the multi-stage model.
Mathematics and Physics of Cancer: Questions Robijn Bruinsma, UCLA KITP Colloquium May 6, 2009 1) Cancer statistics and the multi-stage model. 2) Cancer microevolution and clonal expansion. 3) Metastasis:
Award Number: W81XWH mirna Involved in Six1-Induced Breast Cancer TITLE: PRINCIPAL INVESTIGATOR: Anna Smith
AD Award Number: W81XWH-10-1-0296 TITLE: mirna Involved in Six1-Induced Breast Cancer PRINCIPAL INVESTIGATOR: Anna Smith CONTRACTING ORGANIZATION: University of Colorado Anschutz Medical Campus Aurora,
NIH Public Access Author Manuscript Mol Cell. Author manuscript; available in PMC 2010 July 10.
NIH Public Access Author Manuscript Published in final edited form as: Mol Cell. 2009 July 10; 35(1): 26 36. doi:10.1016/j.molcel.2009.06.018. TACE-mediated ectodomain shedding of the type I TGF-β receptor
Supplementary Figure 1. Characterization of NMuMG-ErbB2 and NIC breast cancer cells expressing shrnas targeting LPP. NMuMG-ErbB2 cells (a) and NIC
Supplementary Figure 1. Characterization of NMuMG-ErbB2 and NIC breast cancer cells expressing shrnas targeting LPP. NMuMG-ErbB2 cells (a) and NIC cells (b) were engineered to stably express either a LucA-shRNA
Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial mesenchymal transition
Biochem. J. (2012) 443, 691 700 (Printed in Great Britain) doi:10.1042/bj20111584 691 Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial mesenchymal transition
ト ピ ク ス Khaleque N Khan, Jo Kitawaki Introduction
Adenomyosis is defined by the intramyometrial presence of gland and stroma derived from basalis endometrium surrounded by reactive hyperplastic or hypertrophic myometrium causing either focal or diffuse
Integration of Ras subeffector signaling in TGF-β mediated late stage hepatocarcinogenesis
Carcinogenesis Advance Access published February 10, 2005 The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org
Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer
Cancer Microenvironment (2008) 1:69 83 DOI 10.1007/s12307-008-0007-2 REVIEW PAPER Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer Stéphanie Gout & Jacques Huot Received: 22 December
Pathway Map Reference Guide
Pathway Map Reference Guide Focus Attention-grabber Your Pathway The most popular cell signaling pathways Sample & Assay Technologies Table of contents AKT Signaling 4 camp Signaling 5 Cellular Apoptosis
Review Article Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2015, Article ID 654594, 15 pages http://dx.doi.org/10.1155/2015/654594 Review Article Transforming Growth Factor-Beta and