SCIENTIFIC PROGRAM. 8:45am Welcome and Introduction Carol Black & Robert Lafyatis

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1 SCIENTIFIC PROGRAM SATURDAY, AUGUST 3 1-5pm Registration / Poster Set-Up SUNDAY, AUGUST 4 8am-6pm Registration 8:45am Welcome and Introduction Carol Black & Robert Lafyatis SESSION 1 Integrative Medicine 8:55 Introduction 9:00 The application of bioinformatics to autoimmune disease 10:30 COFFEE BREAK SESSION 2 Biomarkers Atul Butte 11:00 Biomarkers of interstitial lung disease Naftali Kaminski 11:30 Alterations in angiogenesis in systemic sclerosis Marco Matucci-Cerinic and clinical biomarkers

2 SESSION 3 ER Stress 2:00 Unfolded protein response and oxidative stress Randall Kaufman 2:30 Oxidative and mechanical stress in pulmonary Victor Thannickal fibrosis 3:00 Discussion 3:30 TEA BREAK SESSION 4 Environmental & Infectious Disease Triggers 3:55 Introduction 4:00 Identifying environmental factors in connective Fred Miller tissue disease 4:30 Microbial pathogens in skin disease Sarah Arron 5:00 Discussion 5:30 END of SESSION 5:45 WELCOME RECEPTION AGGANIS ARENA MONDAY, AUGUST 5 SESSION 5 High Throughput Sequencing Applications to Scleroderma/Epigenetics 7:55am Introduction 8:00 Non-coding RNAs in skin disease Howard Chang 8:30 Epigenetics and liver fibrosis Derek Mann 9:00 Discussion 9:30 COFFEE BREAK

3 SESSION 6 High Throughput Proteomics 9:55 Introduction 10:00 Matrisomes in fibrotic disease Richard Hynes 10:30 High throughput proteomics Chris Overall 11:00 Proteomic approaches in autoimmune disease Chandra Mohan 11:30 Development of fibrosis in obese adipose tissues Stephen Farmer SESSION 7 Angiogenesis & Pericytes 1:25 Introduction 1:30 Pericytes Annika Keller 2:00 Mesenchymal cells and pericytes in lymph node Theresa Lu architecture 2:30 Pericytes and ADAM12 Lucie Peduto 3:00 Discussion 3:30 TEA BREAK SESSION 8 Vascular Disease Applications to Scleroderma Chairs - 3:55 Introduction 4:00 Vascular disease in systemic sclerosis Cornelia Weyand 4:15 Vascular capillary leak in systemic sclerosis Tracy Frech 4:30 Biomarkers of vasculitis Paul Monach 4:45 Discussion 5:00 END of SESSION

4 TUESDAY, AUGUST 6 SESSION 9 PAH & Vascular Remodeling 8:55am Introduction 9:00 Cell therapy approaches for pulmonary arterial hypertension 9:30 Inflammation and hypoxia in pulmonary arterial hypertension 10:30 COFFEE BREAK SESSION 10 Industry Presentations Duncan Stewart Kurt Stenmark 11:00 TBA R Lemaire - Medimmune 11:15 TLR blockade in autoimmune disease T Sullivan/R Arbeit Idera 11:30 Mesenchymal stem cells as therapeutics Celltex 11:45 Dasatinib in systemic sclerosis B Ganguly Bristol Myers Squibb 12:15 TBA R Marshall GlaxoSmithKline SESSION 11 Young Investigators Selected Abstract Presentation Carol Black & Robert Lafyatis 2:00 2:10 2:20 2:30 2:40 3 5pm ~ Poster Viewing ~ 6PM ~ BANQUET ~ Metcalf Trustee Center Ballroom ~ One Silber Way ~ 9 th Floor

5 WEDNESDAY, AUGUST 7 SESSION 12 Innate Immunity & Inflammation in Fibrosis I 7:55am Introduction 8:00 The inflammasome in interstitial lung disease Augustine Choi 8:30 Lipid mediators in inflammation and fibrosis Charles Serhan SESSION 13 Innate Immunity & Inflammation in Fibrosis II 9:00 Sterile injury & inflammation Richard Flavell 9:30 Inflammasomes in Systemic Sclerosis Carol Artlett 10:30 TEA BREAK SESSION 14 Monocytes/Macrophages in Fibrotic Disease 11:00 Monocyte heterogeneity & alternative activation Siamon Gordon In fibrotic disease 11:30 Macrophage activation in fibrosis Tom Wynn SESSION 15 Scleroderma Clinical Trials Consortium 2:00 2:30 3:00 3:30 END OF WORKSHOP