SCIENTIFIC PROGRAM SATURDAY, AUGUST 3. Registration / Poster Set-Up SUNDAY, AUGUST 4

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1 SCIENTIFIC PROGRAM SATURDAY, AUGUST 3 1-5pm Registration / Poster Set-Up SUNDAY, AUGUST 4 8am-5pm Registration 8:15am Welcome and Introduction Carol Black & Robert Lafyatis SESSION 1 Integrative Medicine Chairs Michael Whitfield & Shervin Assassi 8:25 Introduction 8:30 The application of bioinformatics to autoimmune Atul Butte disease 9:30 The genetic basis for tsk2 Elizabeth Blankenhorn 10:00 Discussion 10:30 COFFEE BREAK SESSION 2 Biomarkers Chairs Luc Mouthon & John Varga 10:55 Introduction 11:00 Biomarkers of interstitial lung disease Naftali Kaminski 11:30 Alterations in angiogenesis in systemic sclerosis Marco Matucci-Cerinic and clinical biomarkers 12:00pm Discussion 12:30 LUNCH

2 SESSION 3 ER Stress Chairs Maria Trojanowska & David Abraham 1:55 Introduction 2:00 Unfolded protein response and oxidative stress Randall Kaufman 2:30 Mechanotransduction and redox regulation in lung Victor Thannickal fibrosis 3:00 Discussion 3:30 TEA BREAK SESSION 4 Environmental & Infectious Disease Triggers Chairs Armando Gabrielli & Carol Black 3:55 Introduction 4:00 Identifying environmental factors in autoimmune Fred Miller diseases 4:30 Microbial pathogens in skin disease Sarah Arron 5:00 Discussion 5:30 END of SESSION 5:45 WELCOME RECEPTION AGGANIS ARENA MONDAY, AUGUST 5 SESSION 5 Molecular Genetics and Fibrosis Chairs Maureen Mayes & Michael Whitfield 7:55am Introduction 8:00 Non-coding RNAs in skin disease Howard Chang 8:30 Epigenetics and liver fibrosis Derek Mann 9:00 Discussion SESSION 6 High Throughput Proteomics Chair Monique Hinchcliff & Thomas Medsger 9:15 Introduction 9:20 Systems-level analysis of proteolytic events Chris Overall in increased vascular permeability and complement activation in skin inflammation 9:50 Biomarker studies in lupus nephritis Chandra Mohan 10:20 Discussion 10:35 COFFEE BREAK

3 SESSION 7 Matrisomal Proteins and Adipose in Fibrosis Chairs Kristofer Rubin & Thomas Krieg 10:55 Introduction 11:00 Decoding the matrix Richard Hynes 11:30 Advances in understanding adipogenesis and links Stephen Farmer to fibrosis 12:00pm Discussion 12:15 LUNCH SESSION 8 Angiogenesis & Pericytes Chairs Jeff Browning & Robert Lafyatis 1:25 Introduction 1:30 Pericytes Annika Keller 2:00 Mesenchymal cells and pericytes in lymph node Theresa Lu architecture 2:30 Pericytes in injury and fibrosis Lucie Peduto 3:00 Discussion 3:15 TEA BREAK SESSION 9 Vascular Disease Applications to Scleroderma Chairs Peter Merkel & Armando Gabrielli 3:40 Introduction 3:45 Pathophysiology of giant cell arteritis Cornelia Weyand 4:00 Vascular capillary leak in systemic sclerosis Tracy Frech 4:15 Biomarkers of vasculitis Paul Monach 4:30 Discussion 5:00 END of SESSION

4 TUESDAY, AUGUST 6 SESSION 10 Breakthroughs in Therapy Chairs Virginia Steen & Robert Simms 7:55am Introduction 8:00 Autologous hematopoietic stem cell treatment of scleroderma lessons learned over 15 years SESSION 11 PAH & Vascular Remodeling Chairs Marlene Rabinovitch & Hap Farber 8:40am Introduction 8:45 Cell therapy approaches for pulmonary arterial hypertension 9:15 Inflammation and hypoxia in pulmonary arterial hypertension 9:45 Discussion 10:15 COFFEE BREAK SESSION 12 Industry Presentations Chairs David Abraham & Robert Lafyatis Alan Tyndall Duncan Stewart Kurt Stenmark 10:40 Introduction 10:45 Evaluation of the anti-fibrotic properties of CCNs R Lemaire - Medimmune in pulmonary fibrosis 11:00 TLR blockade in autoimmune disease R Arbeit Idera 11:15 Dasatinib in systemic sclerosis B Ganguly Bristol Myers 11:30 Pharmaceutical development of anti-fibrotic medicines for the 21 st century: Enhancing our chances of success 11:45 Molecular diagnostics for systemic sclerosis: Towards personalized medicine 12:00pm Lunch Squibb D Budd GlaxoSmithKline Y Nesbeth - Celdara

5 SESSION 13 Selected Abstract Presentation Chairs Luc Mouthon & Maria Trojanowska 1:25 Introduction 1:30 Interleukin-33 is an upstream regulator of Irina Luzina Inflammation and fibrosis 1:45 RNA-seq and mir-seq analysis of SSc skin across Zhenghui Li intrinsic gene expression subsets shows differential expression of non-coding RNAs regulating SSc gene expression 2:00 Ephrin B2 is overexpressed in human scleroderma David Lagares skin and mediates fibroblast to myofibroblast differentiations, and induces fibrosis in mice 2:15 SSc intrinsic subset classification in patients that Monique Hinchcliff demonstrate clinical improvement during treatment 2:30 JNK-1 shows an association with systemic sclerosis Sandra Guerra 2:45 Pulmonary hypertension in patients with U1-RNP antibodies Vincent Sobanski 3 5pm ~ Poster Viewing ~ 18 th Floor Lounge 10 Buick Street 6PM ~ BANQUET ~ Metcalf Trustee Center Ballroom ~ One Silber Way ~ 9 th Floor Banquet Speaker: Joseph Loscalzo, MD, PhD, Chairman, Department of Medicine; Physicianin-Chief, Brigham & Women s Hospital; Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School WEDNESDAY, AUGUST 7 SESSION 14 Innate Immunity & Inflammation in Fibrosis I Chairs Carol Feghali-Bostwick & John Varga 7:55am Introduction 8:00 The inflammasome in interstitial lung disease Augustine Choi 8:30 Lipid mediators in inflammation and fibrosis Charles Serhan

6 SESSION 15 Innate Immunity & Inflammation in Fibrosis II Chairs Carol Feghali-Bostwick & John Varga 9:00 Sterile injury & inflammation Richard Flavell 9:30 Inflammasomes in systemic sclerosis Carol Artlett 10:00 Discussion 10:30 COFFEE BREAK SESSION 16 Monocytes/Macrophages in Fibrotic Disease Chairs Romy Christmann & Christopher Denton 10:55 Introduction 11:00 Macrophage heterogeneity and alternative Siamon Gordon activation 11:30 Macrophage activation in fibrosis Tom Wynn 12:00pm Discussion 12:15pm LUNCH 1:15 Meeting SCAR and SScores SESSION 17 Scleroderma Clinical Trials Consortium Chairs Virginia Steen & Dan Furst 2:15 Introduction Should there be a paradigm shift in clinical trials Moderator: D Furst for SSc? 2:20 CRISS protocol P Merkel 2:30 2:40 Case selection for stem cell transplantation in systemic sclerosis Discussion C Denton Furst, Merkel, Denton Biomarkers and patient samples Moderator: M Mayes 3:00 Use of biomarkers as outcome measures R Lafyatis 3:10 3:20 Control of patient samples from clinical trials Discussion R Simms Mayes, Lafyatis, Simms Use of observational cohorts in clinical trials Moderator: V Steen 3:40 ESOS study A Herrick 3:50 EUSTAR activities Y Allanore 4:00 Discussion: REVEAL Registry, PHAROS and CSRG V Steen, L Chung, A Herrick Y Allanore, M Baron 4:20 Statistical challenges of observational trials S Johnson END OF WORKSHOP

SCIENTIFIC PROGRAM. 8:15am Welcome and Introduction Carol Black & Robert Lafyatis

SCIENTIFIC PROGRAM. 8:15am Welcome and Introduction Carol Black & Robert Lafyatis SCIENTIFIC PROGRAM SATURDAY, AUGUST 3 1-5pm Registration / Poster Set-Up SUNDAY, AUGUST 4 8am-6pm Registration 8:15am Welcome and Introduction Carol Black & Robert Lafyatis SESSION 1 Integrative Medicine