Essential Amino Acids
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1 3425 Corporate Way Duluth, GA Patient: SAMPLE PATIENT DOB: Sex: MRN: 3100 ION Profile - Blood / Urine Amino Acids 20 Profile - Plasma Methodology: High Performance Liquid Chromatography s: Ages 13 and over. Limiting Amino Acids Essential Amino Acids Lysine Methionine Tryptophan 25 L Branched Chain Amino Acids Isoleucine 30 L Leucine 57 L Valine Other Essential Amino Acids μmol/l Phenylalanine Histidine Threonine Conditionally Essential Amino Acids Arginine Taurine Glycine 474 H Serine C0090.1
2 Amino Acids 20 Profile - Plasma Methodology: High Performance Liquid Chromatography s: Ages 13 and over. Vascular Function Neurotransmitters and Precursors Sulfur Amino Acids (Glutathione - related) μmol/l Arginine Taurine Phenylalanine Tyrosine Tryptophan 25 L Glutamic Acid 180 H Taurine Methionine Taurine Urea Cycle and Ammonia Detoxification Arginine Citrulline 48 H Ornithine Asparagine 25 L Aspartic Acid 13.1 H Ratios 29. Phenylalanine/Tyrosine 1.40 <= Functional Categories Glutamine Glutamic Acid/Glutamine 0.53 H Page Tryptophan/LNAA* L *Large neutral amino acids (Leu+Ile+Val+Phe+Tyr) NR = Not Reportable C0090.2
3 Page 3 Methodology: Enzymatic Assay s: Ages 13 and over. Homocysteine Assay - Plasma Homocysteine 20.7 H nmol/ml Nutrient & Toxic Elements Profile - Blood Methodology: Inductively Coupled Plasma/Mass Spectrometry Erythrocytes (packed cells) Nutrient Elements Potassium 2,519 2,303-3,374 ppm 44 Magnesium ppm 44 Calcium* ppm Plasma Zinc ,594 ppb Copper ,920 ppb Whole Blood Selenium ppm 2,672 Whole Blood Toxic Elements 7. Aluminum 26 <= 113 ppb Arsenic 11.5 H <= 10.0 ppb Cadmium 0.21 <= 1.10 ppb Lead 22 <= 29 ppb Mercury 3.8 <= 9.8 ppb 45 *Relevant to membrane permeability, not nutritional status. for whole blood toxic elements that are within normal limits do not rule out metal accumulation in other tissues. NR = Not Reportable C0090.3
4 Page 4 Methodology: High Performance Liquid Chromatography s: Ages 13 and over. mg/l Coenzyme Q10 Plus Vitamins Profile - Serum Coenzyme Q alpha-tocopherol 42.6 H gamma-tocopherol Vitamin A (Retinol) 1.39 H β-carotene Lipid Peroxides Assay - Serum Methodology: High Performance Liquid Chromatography nmol/ml Lipid Peroxides 1.47 <= 2.60 Methodology: LC/Tandem Mass Spectrometry, Colorimetric s: Ages 13 and over. ng/mg creatinine 7. DNA/Oxidative Stress Marker (8-OHdG) Assay - Urine 8-Hydroxy-2-deoxyguanosine 4.9 <= Vitamin D Profile - Serum Methodology: Chemiluminescent Reference ng/ml Hydroxyvitamin D ng/m Deficiency: Insufficiency: Sufficient: Recommended: Excessive: <20 ng/ml ng/ml ng/ml ng/ml >100 ng/ml There is no consensus in the literature regarding optimal levels of 25-Hydroxyvitamin D. Higher levels of 25-Hydroxyvitamin D may be concerning in some patient populations, such as renal failure. Levels below 30 ng/ml are considered insufficient by most medical associations.treatment is at the discretion of the treating clinician. Holick MF, et al. J Clin Endocrinol Metab. 2011;96(7): Vitamin D Council: <DL = less than detection limit NR = Not Reportable 25-Hydroxyvitamin D testing performed by Genova Diagnostics, Inc. 63 Zillicoa St., Asheville, NC A. L. Peace-Brewer, PhD, D(ABMLI), Lab Director - CLIA Lic. #34D Medicare Lic. # C0090.5
5 Fatty Acids Profile- Plasma Methodology: Capillary Gas Chromatography/Mass Spectrometry s: Ages 13 and over μmol/l Polyunsaturated Omega-3 20 Alpha Linolenic (18:3n3) Eicosapentaenoic (20:5n3) Docosapentaenoic (22:5n3) Docosahexaenoic (22:6n3) Page Polyunsaturated Omega ,669 Linoleic (18:2n6) 1, , Gamma Linolenic (18:3n6) Eicosadienoic (20:2n6) Dihomogamma Linolenic (20:3n6) Arachidonic (20:4n6) Docosadienoic (22:2n6) 0.8 <= Docosatetraenoic (22:4n6) Polyunsaturated Omega Mead (20:3n9) 2.3 <= 8.3 Monounsaturated Myristoleic (14:1n5) Palmitoleic (16:1n7) Vaccenic (18:1n7) ,182 Oleic (18:1n9) 1, , Eicosenoic (20:1n9) Nervonic (24:1n9) C0090.7
6 Page 6 Fatty Acid Profile - Plasma Methodology: Capillary Gas ChromatographyMass Spectrometry s: Ages 13 and over μmol/l Saturated Capric (10:0) Lauric (12:0) Myristic (14:0) ,794 Palmitic (16:0) 1, , Stearic (18:0) Arachidic (20:0) Behenic (22:0) Lignoceric (24:0) Hexacosanoic (26:0) 0.35 <= 0.43 Odd Chain 14.5 Pentadecanoic (15:0) 9.5 <= Heptadecanoic (17:0) 18.3 <= Nonadecanoic (19:0) 1.83 <= Heneicosanoic (21:0) 0.38 <= Tricosanoic (23:0) 0.80 H <= Trans 0.4 Palmitelaidic (16:1n7t) 1.0 <= Total C:18 Trans 21 <= 59 Ratios 30 LA/DGLA EPA/DGLA AA/EPA Triene/Tetraene <= NR = Not Reportable C0090.9
7 Organix Comprehensive Profile - Urine Methodology: LC/Tandem Mass Spectrometry, Colorimetric This report is not intended for the diagnosis of neonatal inborn errors of metabolism. s: Ages 13 and over mcg/mg creatinine Nutrient Markers Fatty Acid Metabolism (Carnitine & B2) Adipate 7.8 <= Suberate 0.9 <= Ethylmalonate 7.9 H <= 6.3 Carbohydrate Metabolism (B1, B3, Cr, Lipoic Acid, CoQ10) Pyruvate <DL <= L-Lactate β-hydroxybutyrate 2.5 <= 9.9 Energy Production (Citric Acid Cycle) (B comp., CoQ10, Amino Acids, Mg) Citrate Cis-Aconitate Isocitrate α-ketoglutarate <DL <= Succinate 21.0 H <= Fumarate <DL <= Malate 1.1 <= Hydroxymethylglutarate 3.6 <= 5.1 B-Complex Vitamin Markers (B1, B2, B3, B5, B6, Biotin) 15. α-ketoisovalerate α-ketoisocaproate α-keto-β-methylvalerate 0.25 <DL <= <DL <= <DL <= Xanthurenate <DL <= β-hydroxyisovalerate 4.5 <= 11.5 Page 7 C
8 Organix Comprehensive Profile - Urine Methodology: LC/Tandem Mass Spectrometry, Colorimetric This report is not intended for the diagnosis of neonatal inborn errors of metabolism. s: Ages 13 and over mcg/mg creatinine Methylation Cofactor Markers (B12, Folate) Neurotransmitter Metabolism Markers (Tyrosine, Tryptophan, B6, Antioxidants) Cell Regulation Markers Vanilmandelate Homovanillate Hydroxyindoleacetate Kynurenate 1.1 <= Quinolinate 2.6 <= Picolinate Oxidative Damage and Antioxidant Markers (Vitamin C and Other Antioxidants) p-hydroxyphenyllactate 0.47 <= Hydroxy-2-deoxyguanosine 4.9 <= 7.6 (Units for 8-hydroxy-2-dexoyguanosine are ng/mg creatinine) Detoxification Indicators (Arg, NAC, Met, Mg, Antioxidants) Toxicants and Detoxification Methylhippurate <= Orotate 0.57 <= Glucarate 9.9 <= 10.7 α-hydroxybutyrate Nutrient Markers Methylmalonate 0.6 <= Formiminoglutamate 0.5 <= Pyroglutamate ,347 Sulfate 1, , <DL <= Page 8 C
9 Organix Comprehensive Profile - Urine Methodology: LC/Tandem Mass Spectrometry, Colorimetric This report is not intended for the diagnosis of neonatal inborn errors of metabolism. s: Ages 13 and over mcg/mg creatinine Bacterial - General Compounds of Bacterial or Yeast/Fungal Origin Benzoate <DL <= Hippurate 709 <= 1, Phenylacetate 0.17 <= Page Phenylpropionate <DL <= p-hydroxybenzoate 0.5 <= p-hydroxyphenylacetate 10 <= Indican 93 H <= Tricarballylate <DL <= 1.41 L. acidophilus / General Bacterial 44. D-Lactate 0.2 <= Clostridial Species 45. 3,4-Dihydroxyphenylpropionate <DL <= 0.05 Yeast / Fungal 46. D-Arabinitol 40 <= Creatinine = 48 mg/dl <DL = less than detection limit >UL = greater than upper linearity limit NR = Not reportable C
10 Page 10 Commentary The Diasorin Liaison 25-Hydroxyvitamin D Total Assay is certified by the CDC Vitamin D Standardization-Certification Program (CDC VDSCP). The performance characteristics of all assays have been verified by Genova Diagnostics, Inc. Unless otherwise noted with, the assay has not been cleared by the U.S. Food and Drug Administration. COVAT
11 Page ION Profile - Blood / Urine ION Analyte Pattern Analysis A multi-analyte report can provide greater insight about health risks and special nutrient needs. Patterns of abnormalities can reinforce the degree of significance indicated by a single measurement. Analytes from the various profiles in the ION report are combined below into categories associated with clinical/metabolic conditions. The categories included cover the most common areas of concern relevant to these profiles. Above each thermometer are listed the or appears when the patient result is outside the fourth quintile of the analytes used to calculate the degree of significance. An population. The thermometer advances to the right as the number and severity of relevant abnormalities increases. The longer the filled bar, the greater the degree of significance or likelihood that a health threat may exist in that category. The preceeding laboratory results provide the detail upon which these thermometers are based. Arginine Coenzyme Q10 Homocysteine alpha-tocopherol Cardiovascular System Calcium gamma-tocopherol Magnesium Lipid Peroxides 8-OHdG* AA/EPA Isoleucine Magnesium α-ketoglutarate Methylmalonate Leucine Coenzyme Q10 Succinate Formiminoglutamate Fatigue Phenylalanine Adipate Malate Valine Suberate Xanthurenate Magnesium Palmitic (16:0) β-hydroxybutyrate Metabolic Syndrome (Syndrome X) β-hydroxyisovalerate Stearic (18:0) α-hydroxybutyrate *8-OHdG = 8-Hydroxy-2-deoxyguanosine C
12 3100 ION Profile - Blood / Urine Mental/Emotional Tryptophan Docosahexaenoic Vanilmandelate Tyrosine Xanthurenate 5-Hydroxyindoleacetate Magnesium Methylmalonate Eicosapentanoic Formiminoglutamate Page 12 Phenylacetate Phenylpropionate Indican Intestinal/Bacterial Metabolites p-hydroxybenzoate Tricarballylate D-Lactate p-hydroxyphenylacetate 3,4-DHPP* D-Arabinitol Intestinal Yeasts/FungalMetabolites Arginine Lysine Tryptophan Histidine Methionine Valine Digestion/Absorption Isoleucine Phenylalanine Selenium Leucine Threonine *3,4-DHPP = 3,4-Dihydroxyphenylpropionate C
13 3100 ION Profile - Blood / Urine Page 13 Toxic Exposure Aluminum Arsenic Mercury Palmitelaidic (16:1n7t) Cis-Aconitate Isocitrate Orotate Glucarate Cadmium Lead Total C:18 Trans Citrate Quinolinate 2-Methylhippurate Methionine Glycine Glutamine Pyroglutamate Detoxification Impairment Serine Sulfate Taurine Benzoate Taurine alpha-tocopherol Lipid Peroxides Oxidative Stress/Antioxidant Insufficiency Selenium Lead gamma-tocopherol Vitamin A (Retinol) 8-OHdG* p-hydroxyphenyllactate Mercury β-carotene Sulfate Magnesium Ethylmalonate β-hydroxybutyrate Coenzyme Q10 Pyruvate Succinate Mitochondrial Functional Impairment Adipate L-Lactate Fumarate Suberate α-hydroxybutyrate Malate *8-OHdG = 8-Hydroxy-2-deoxyguanosine C
14 3100 ION Profile - Blood / Urine Page 14 Arginine Lysine Tryptophan Histidine Methionine Valine Amino Acid Insufficiency Isoleucine Phenylalanine Sulfate Leucine Threonine Essential Fatty Acid Insufficiency Arachidonic Alpha Linoleic Eicosapentaenoic Docosahexaenoic Linoleic Gamma Linolenic Dihomogamma Linolenic Palmitoleic Triene/Tetraene Homocysteine Tricosanoic Kynurenate Disordered Methyl Group (Single Carbon) Transfer Pentadecanoic Heptadecanoic Nonadecanoic Xanthurenate Methylmalonate Formiminoglutamate Tryptophan Xanthurenate Quinolinate Indican Disordered Tryptophan Metabolism 5-Hydroxyindoleacetate Kynurenate C
15 Page ION Profile - Blood / Urine Additional Considerations This page is provided as a starting point that may guide decisions about medical treatment based on the test results. It is derived only from the laboratory results included in this report. Final recommendations should be based on consideration of the patient's medical history and current clinical condition. Nutrient Nutrient Need Clinician Recommendations Vitamin C Vitamin B-1 (Thiamin) Vitamin B-2 (Riboflavin) Vitamin B-3 (Niacin) Vitamin B-5 (Pantothenic Acid) Vitamin B-6 (Pyridoxine) Vitamin B-12 (Cobalamin) Folic Acid Magnesium Zinc Black Current Oil/Evening Primrose Oil Carnitine Coenzyme Q10 Lipoic Acid N-Acetylcysteine Need for other antioxidants L-Glutamine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Tryptophan L-Tyrosine Low: mg Optional: 0-10 mg Low: mg Optional: 0-10 mg Optional: 0-10 mg Moderate: mg Moderate: mcg Low: mcg Moderate: mg Optional: 0-10 mg Optional Low: mg Moderate: mg Optional: mg Optional: mg Optional Low: mg Moderate: mg Moderate: mg Low: mg Low: mg Low: mg Moderate: mg Low: mg Various conditionally essential nurients and other potentially beneficial interventions appear in this section only if relevant abnormalities are present. C
Essential Amino Acids
3425 Corporate Way Duluth, GA 30096 3102 ION Profile with Amino Acids 40 - Blood/Urine Amino Acids 40 Profile - Plasma Methodology: High Performance Liquid Chromotography s: Ages 13 and over. Limiting
0091 Organix Comprehensive Profile - Urine
3425 Corporate Way Duluth GA 30096 USA 770.446.5483 Fax: 770.441.2237 www.gdx.net/www.metametrix.com Ordering Physician: Accession #: Reference #: Patient: Date of Birth: Age: Sex: Reprinted: 07/04/2001
0091 Organix Comprehensive Profile - Urine
Accession #: Order #: Reference #: Patient: Date of Birth: Age: Sex: Date Collected: Date Received: Telephone: Fax: Organix Interpretation Organix Interpretive Guide is downloadable at: www.metametrix.com/files/test-menu/interpretive-guides/organix-ig.pdf
0490 ION with Amino Acids 40 Profile
Accession Number: Order Number: Number: Patient: Age: Sex: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0490 ION with Amino Acids 40 Profile Amino Acids 40 Profile -
0091 Organix Comprehensive Profile Summary of abnormal results:
Ordering Physician: 255252-279741 Via Borin 48 31100 Treviso Number: Age: 43 Sex: F Date of Birth: 03/01/1964 Date Collected: 12/12/07 Date Received: 12/17/07 Telephone: Fax: Summary of abnormal results:
0490 ION with Amino Acids 40 Profile
Metametrix 1234 Main St. Anywhere, GA 30096 Accession Number: Order Number: G1234567 Number: Patient: Age: 51 Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: Sex: 4/3/13 Date Received:
0490 ION with Amino Acids 40 Profile
Accession Number: Order Number: Number: Patient: Age: Sex: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0490 ION with Amino Acids 40 Profile Amino Acids 40 Profile -
0291 Organix Basic Profile - Urine
Accession #: Order #: Reference #: Patient: G1234567 Date Collected: Date Received: Date of Report: 04/03/2012 Date of Birth: 02/05/1962 Telephone: 7704464583 Ordering Physician: Age: Sex: 50 Female Fax:
0290 Cardio/ION Profile
Accession Number: Order Number: Reference Number: Patient: Age: Sex: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0290 Cardio/ION Profile Date Reported: Cardiovascular
0410 Triad Bloodspot Profile
Accession Number: Order Number: Reference Number: Patient: Age: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: 0410 Triad Bloodspot Profile This report contains the following:
0290 Cardio/ION Profile
3425 Corporate Way Duluth GA 30096 USA 770.446.5483 Fax: 770.441.2237 www.gdx.net/www.metametrix.com Accession Number: Number: Patient: Age: Date of Birth: Date Collected: Report Date: Telephone: Fax:
0291 Organix Basic Profile Summary of abnormal results:
Ordering Physician: 250200-274226 Reference Number: Age: 57 Sex: F Date of Birth: 12/25/1949 Date Collected: 11/18/07 Date Received: 11/18/07 Report Date: Telephone: Fax: Reprinted: 12/5/07 7704465483
4146 Women's Health Profile
Ordering Physician: Metametrix 1234 Main St. Anywhere, GA 30096 Reference Number: Age: 50 Sex: Female Date of Birth: 02/05/1962 Date Collected: 6/12/12 Date Received: 6/13/12 Report Date: Telephone: Fax:
4315 NY Designs for Health Metabolic Profile
Ordering Physician: Metametrix Staff & Family 3425 Corporate Way Duluth, NY 30096 Accession Number:A0909030008 Reference Number: Age: 47 Sex: Female Date of Birth: 02/05/1962 Date Collected: 9/2/09 Date
4320 Designs for Health Metabolic Profile plus FA
Ordering Physician: Metametrix 3425 Corporate Way Duluth, GA 30096 Accession Number:A0909030010 Reference Number: Age: 47 Sex: Female Date of Birth: 02/05/1962 Date Collected: 9/2/09 Date Received: 9/3/09
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0010 Amino Acids 40 Profile - Plasma
Accession #: Order #: G1234567 Date Collected: Date Received: 01/22/2013 Reference #: Patient: Date of Birth: 02/05/1962 Date of Report: Telephone: 7704464583 Ordering Physician: 1234 Main St. Anywhere,
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