0290 Cardio/ION Profile

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1 3425 Corporate Way Duluth GA USA Fax: Accession Number: Number: Patient: Age: Date of Birth: Date Collected: Report Date: Telephone: Fax: Reprinted: Comment: Sex: 0290 Cardio/ION Profile

2 Cardiovascular ealth Profile - Serum, Plasma & Erythrocytes Lipoprotein Factors Methodology: Automated Chemistry, Immunometric Assay,Competitive Immunology, PLC, ICP-MS Limits Total Cholesterol 156 < 200 mg/dl DL Cholesterol 62 >= 50 mg/dl LDL Cholesterol (Direct) 101 < 130 mg/dl Triglycerides 70 < 150 mg/dl Lipoprotein (a) 2 <= 37 mg/dl Lipoprotein Ratios LDL/DL 1.6 <= 3.3 Total/DL 2.5 <= 4.5 Chronic Inflammatory Markers Male Female LDL/DL Total/DL LDL/DL Total/DL Risk (*) xAverage xAverage xAverage xAverage *Adapted from the Framingham eart Study Ferritin ng/ml Fibrinogen mg/dl c-reactive Protein (S) 1.8 <= 3.0 mg/l Cardio CRP value (mg/l) CD Risk Level * If the cardio CRP concentration exceeds 10 mg/l after repeat <1 Low testing, the patient should be evaluated for noncardiovascular 1-3 Average etiologies. >3 (up to 10)* igh Other Important Indicators Insulin µiu/ml Testosterone 25 <= 51 ng/dl Sex ormone Binding Globulin nmol/l Free Androgen Index (calc.) 1.6 <= % 44 Magnesium Oxidant Stress Factors ppm omocysteine nmol/ml Coenzyme Q mg/l alpha-tocopherol mg/l gamma-tocopherol mg/l Lipid Peroxides <= 2.60 nmol/ml Fibrinogen performed by Southern Clinical Laboratory 405 West Pike St.,Suite A Lwrenceville, GA Lab Director: Dr. Robert David Page 1

3 Total Cholesterol Triglycerides Lipoprotein (a) LDL/DL Total/DL Ferritin Fibrinogen c-reactive Protein (S) Coenzyme Q10 alpha-tocopherol gamma-tocopherol Lipid Peroxides omocysteine Magnesium Insulin Free Androgen Index (calc.) Better Negative Effect on Cardiovascular ealth Worse Most of the nutritional and metabolic measurements included in the Cardio/ION profile are associated to some degree with your cardiovascular health. owever, those shown on the previous page of this report are ones that most strongly and specifically affect your cardiovascular health. Some factors are favorable for cardiac health when they are high, while others should be low. The chart above helps you to see where the most significant abnormalities are; the longest bars on the chart show the most abnormal results on a scale of increasing negative effects on cardiovascular health. The "Cardiovascular Index" chart below shows your test results with all of the factors summarized as a single index. Depending on your results, some steps that your doctor may want you to take to improve your cardiovascular health are shown in the tables of recommendations at the end of these pages. It is important that you follow your doctor's instructions to achieve the lowest index. Cardiovascular Index = All Factors Favorable All Factors Unfavorable These guidelines are intended as a starting point for the clinician who requested the test and are based only on the laboratory results included in this report. Final recommendations should be implemented by the clinician with consideration of medical history and current clinical observations. These tests are not intended for the diagnosis of specific disorders. Page 2

4 Amino Acids 20 Profile - Plasma Methodology: igh Performance Liquid Chromatography Ranges: Ages 12 and under. Essential Amino Acids Limiting Amino Acids Lysine Methionine Tryptophan µmol/l % Branched Chain Amino Acids Isoleucine Leucine Valine Other Essential Amino Acids Phenylalanine istidine Threonine Conditionally Essential Amino Acids Arginine Taurine Glycine Serine Page 3

5 Amino Acids 20 Profile - Plasma Ranges are for ages 12 and under. Functional Categories Vascular Function µmol/l Arginine Taurine 41 Methodology: igh Performance Liquid Chromatography % Neurotransmitters and Precursors Phenylalanine Tyrosine Tryptophan Glutamic Acid Taurine Sulfur Amino Acids (Glutathione - related) Methionine Taurine Urea Cycle and Ammonia Detoxification 23 Arginine Citrulline Ornithine Glutamine Asparagine Aspartic Acid Ratios Phenyalanine/Tyrosine Glutamic Acid/Glutamine Tryptophan/LNAA* L *Large neutral amino acids (Leu+Ile+Val+Phe+Tyr) <= Page 4

6 omocysteine Assay - Plasma nmol/ml Methodology: Competitive Immunoassay 95% omocysteine Page 5

7 Nutrient & Toxic Elements Profile - Blood Methodology: Inductively Coupled Plasma /Mass Spectroscopy 95% Nutrient Elements Erythrocytes (packed cells) 3,055 1 Potassium 3,809 2,426-4,472 ppm 44 2 Magnesium ppm 44 3 Calcium* ppm Plasma Zinc 1, Copper 926 L Whole Blood Selenium 0.16 Toxic Elements Whole Blood 45 7 Aluminum Arsenic Cadmium Lead Mercury , , <= 140 <= 13.7 <= 1.50 <= 36 <= 13.8 ppb ppb ppm ppb ppb ppb ppb ppb *Relevant to membrane permeability, not nutritional status. Toxic metals are flagged high when the result is above the 95%. for whole blood toxic elements that are within normal limits do not rule out metal accumulation in other tissues. This can be evaluated with urinary porphyrin or urine elements tests. Page 6

8 CoEnzyme Q10 Plus Vitamins Profile - Serum Methodology: igh Performance Liquid Chromatography mg/l 95% Coenzyme Q alpha-tocopherol gamma-tocopherol Vitamin A β-carotene Lipid Peroxide Assay - Serum 6 Methodology: igh Performance Liquid Chromatography nmol/ml 1.72 Lipid Peroxides 1.25 <= 2.60 DNA/Oxidative Stress Markers Assay - Urine Ranges are for ages 12 and under. ng/mg creatinine Methodology: LC/Tandem Mass Spectroscopy, Colorimetric ydroxy-2-deoxyguanosine 2.3 <= 8.7 Vitamin D Profile - Serum ng/ml Methodology: LC/Tandem Mass Spectroscopy Sufficient 8 25-ydroxyvitamin D Optimal 9 25-ydroxyvitamin D ydroxyvitamin D Total 25-ydroxyvitamin D is considered the best assessment of vitamin D status. The test reflects vitamin D from all sources (diet, supplements, and sun exposure). A 2011 Endocrine Society Clinical Practice Guideline suggested vitamin D deficiency be defined as < 20 ng/ml, insuffuciency as ng/ml, and sufficiency as ng/ml.¹ The Vitamin D Council has proposed ng/ml as optimal, and 100 ng/ml as an upper limit.² 25-ydroxyvitamin D3 is from sun exposure, vitamin D-rich foods, or vitamin D3 supplements. 25-ydroxyvitamin D2 is only from fortified foods or supplements. 1. olick MF, Binkley, NC, Bischoff-Ferrari, A, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. July 2011, 96(7): Vitamin D Council Conversion factors: nmol/l = ng/ml x 2.5 ng/ml = nmol/l x 0.4 * <DL = less than detection limit Page 7

9 Fatty Acids Profile - Plasma Ranges: Ages 12 and under. µmol/l Methodology: Capillary Gas Chromatography/Mass Spectrometry 95% Polyunsaturated Omega Alpha Linolenic (18:3n3) 9 L Eicosapentaenoic (20:5n3) Docosapentaenoic (22:5n3) Docosahexaenoic (22:6n3) Polyunsaturated Omega ,560 5 Linoleic (18:2n6) 558 L 773-1, Gamma Linolenic (18:3n6) 3 L Eicosadienoic (20:2n6) 3.6 L Dihomogamma Linolenic (20:3n6) 17 L Arachidonic (20:4n6) Docosadienoic (22:2n6) <0.23 <= Docosatetraenoic (22:4n6) 3.2 L Polyunsaturated Omega Mead (20:3n9) 1.1 <= 7.7 Monounsaturated Myristoleic (14:1n5) Palmitoleic (16:1n7) 36 L Vaccenic (18:1n7) 37 L , Oleic (18:1n9) , Eicosenoic (20:1n9) 3.9 L Nervonic (24:1n9) <1.1 <= 2.1 Page 8

10 Fatty Acids Profile - Plasma Methodology: Capillary Gas Chromatography/Mass Spectrometry Ranges: Ages 12 and under. Saturated 95% µmol/l Capric (10:0) Lauric (12:0) Myristic (14:0) , Palmitic (16:0) 1, , Stearic (18:0) Arachidic (20:0) 1.4 L Behenic (22:0) 0.7 L Lignoceric (24:0) 0.61 L exacosanoic (26:0) <0.27 <= 0.76 Odd Chain Pentadecanoic (15:0) 8.1 <= eptadecanoic (17:0) 11.7 <= Nonadecanoic (19:0) <0.86 <= eneicosanoic (21:0) 32 Tricosanoic (23:0) Trans <0.38 < <= 0.52 <= Palmitelaidic (16:1n7t) <0.4 <= Total C:18 Trans 22 <= 48 Ratios LA/DGLA EPA/DGLA AA/EPA Triene/Tetraene <= Page 9

11 Organix Comprehensive Profile - Urine Ranges: Ages 12 and under. Nutrient Markers mcg/mg creatinine Methodology: LC/Tandem Mass Spectroscopy, Colorimetric 95% Fatty Acid Metabolism (Carnitine & B2) Adipate 6.1 <= Suberate 1.2 <= Ethylmalonate 1.1 <= 9.4 Carbohydrate Metabolism (B1, B3, Cr, Lipoic Acid, CoQ10) Pyruvate <DL* <= L-Lactate β-ydroxybutyrate <DL* <= 7.9 Energy Production (Citric Acid Cycle) (B comp., Q10, Amino acids, Mg) Citrate , Cis-Aconitate Isocitrate a-ketoglutarate <DL* <= Succinate 17.4 <= Fumarate <= Malate 0.5 <= ydroxymethylglutarate 3.6 <= 13.9 B-Complex Vitamin Markers (B1, B2, B3, B5, B6, Biotin) a-ketoisovalerate 0.09 <= a-ketoisocaproate 0.05 <= a-keto-β-methylvalerate 0.12 <= Xanthurenate 0.62 <= β-ydroxyisovalerate 4.6 <= 22.5 Methylation Cofactor Markers (B12, Folate) Methylmalonate 1.3 <= Formiminoglutamate <DL* <= 3.2 Page 10

12 Organix Comprehensive Profile - Urine Ranges: Ages 12 and under. Cell Regulation Markers mcg/mg creatinine Methodology: LC/Tandem Mass Spectroscopy, Colorimetric 95% Neurotransmitter Metabolism Markers (Tyrosine, Tryptophan, B6, antioxidants) 22 Vanilmandelate 2.2 L omovanillate ydroxyindoleacetate 2.0 L Kynurenate <= Quinolinate 2.5 <= Picolinate 2.8 L Oxidative Damage and Antioxidant Markers (Vitamin C and other antioxidants) 28 p-ydroxyphenyllactate <= ydroxy-2-deoxyguanosine 2.3 <= 8.7 (Units for 8-ydroxy-2-deoxyguanosine are ng/mg creatinine). Toxicants and Detoxification Detoxification Indicators (Arg, NAC, Met, Mg and antioxidants) Methylhippurate <= Orotate 0.29 <= Glucarate 2.8 <= a-ydroxybutyrate <DL* <= Pyroglutamate Sulfate 633 L 1,073 3, ,494 Page 11

13 Organix Comprehensive Profile - Urine Methodology: LC/Tandem Mass Spectroscopy, Colorimetric Ranges: Ages 12 and under. mcg/mg creatinine Compounds of Bacterial or Yeast/Fungal Origin Bacterial - general Benzoate <DL* <= ippurate 106 <= 1, Phenylacetate <DL* <= Phenylpropionate <DL* <= p-ydroxybenzoate <DL* <= p-ydroxyphenylacetate 8 <= Indican 9 <= Tricarballylate 0.38 <= 2.00 L. acidophilus / general bacterial D-Lactate 3.3 <= 5.6 Clostridial species 45 3,4-Dihydroxyphenylpropionate <DL* <= 0.12 Yeast / Fungal D-Arabinitol <= 92 Creatinine = 200 mg/dl * <DL = less than detection limit ** >LIN = greater than linearity limit Page 12

14 ION Analyte Pattern Analysis A multi-analyte report can provide greater insight about health risks and special nutrient needs. Patterns of abnormalities can reinforce the degree of significance indicated by a single measurement. Analytes from the various profiles in the ION report are combined below into categories associated with clinical/metabolic conditions. The categories included cover the most common areas of concern relevant to these profiles. Above each thermometer are listed the analytes used to calculate the degree of significance. An or L appears when the patient result is in the fifth quintile (80%) of the population. An additional X next to an analyte indicates that the patient result is outside the 95% reference interval for that analyte. The thermometer advances to the right as the number and severity of relevant abnormalities increases. The longer the filled bar, the greater the degree of significance or likelihood that a health threat may exist in that category. The preceeding laboratory reports provide the detail upon which these thermometers are based. Cardiovascular System Arginine omocysteine Calcium Magnesium CoQ10 a-tocopherol Lipid Peroxide 8-OdG AA/EPA Fatigue Isoleucine X Leucine Phenylalanine Valine Magnesium CoQ10 Adipate Suberate AKG Succinate Malate Xanthurenate X MeMalonate FIGLU Metabolic Syndrome (Syndrome X) Magnesium Palmitic Stearic AB BB BiVal Mental/Emotional Tryptophan Tyrosine Magnesium EPA DA VMA L Xanthurenate X MeMalonate FIGLU 5-IA L X Page 13

15 ION Analyte Pattern Analysis Intestinal Bacterial Metabolites PhAc PhProp pobenz pophac Indican Tricarb D-Lactate 3,4-DPP Intestinal Yeasts / Fungal Metabolites D-Arabinitol Digestion/Absorption Arginine istidine Isoleucine X Leucine Lysine Methionine Phenylalanine Threonine Tryptophan Valine Selenium Toxic Exposure Aluminum Arsenic X Cadmium Lead Mercury Palmitelaidic C18TrFa Citrate Cis-Aconitate Isocitrate Quinolinate 2-Meipp Orotate Glucarate Detoxification Impairment Methionine Glycine Serine Taurine Glutamine Pyroglutamate Sulfate L X Benzoate Page 14

16 ION Analyte Pattern Analysis Oxidative Stress/Antioxidant Insufficiency Taurine Selenium Lead Mercury a-tocopherol g-tocopherol Vitamin A b-carotene Lipid Peroxide 8-OdG pophlac Sulfate L X Mitochondrial Functional Impairment Magnesium CoQ10 Adipate Suberate Ethylmalonate Pyruvate L-Lactate AB BB Succinate Fumarate Malate Amino Acid Insufficiency Arginine istidine Isoleucine X Leucine Lysine Methionine Phenylalanine Threonine Tryptophan Sulfate L X Valine AKG Succinate Essential Fatty Acid Insufficiency AA LA L X Triene/Tetraene ALA L X EPA DA GLA L X DGLA L X Palmitoleic Disordered Methyl Group (Single carbon) Transfer omocysteine Pentadeca eptadeca Nonadecanoic Tricosanoic Kynurenate Xanthurenate X MeMalonate FIGLU Page 15

17 ION Analyte Pattern Analysis Disordered Tryptophan Metabolism Tryptophan Quinolinate Xanthurenate Indican X 5-IA L X Kynurenate Abbreviation 2-Meipp 5-IA 8-OhdG AA/EPA AB AKG akbmeval akicap akival ALA a-tocopherol BB BiVal C18TrFa CoQ10 DGLA DA 3,4-DPP EPA Analyte Name 2-Methylhippurate 5-ydroxyindoleacetate 8-ydroxy-2-deoxyguanosine Arachidonic (20:4n6)/Eicosapentaenoic (20:5n3) a-ydroxybutyrate a-ketoglutarate a-keto-ß-methylvalerate a-ketoisocaproate a-ketoisovalerate Alpha Linolenic (18:3n3) alpha-tocopherol ß-ydroxybutyrate ß-ydroxyisovalerate Total C:18 Trans Coenzyme Q10 Dihomogamma Linolenic (20:3n6) Docosahexanoic (22:6n3) 3,4-Dihydroxyphenylpropionate Eicosapentaenoic (20:5n3) Abbreviation FIGLU g-tocopherol GLA eptadeca cys VA MG LA MeMalonate Pentadeca PhAc PhProp pbenz pphac pphlac Total C:18 Tricarb Triene/Tetraene VMA Analyte Name Formiminoglutamate gamma-tocopherol Gamma Linoleic (18:3n6) eptadecanoic (17:0) omocysteine omovanillate ydroxymethylglutarate Linoleic (18:2n6) Methylmalonate Pentadecanoic (15:0) Phenylacetate Phenylpropionate p-ydroxybenzoate p-ydroxyphenylacetate p-ydroxyphenyllactate Total c:18 Trans Tricarballylate Mead/Arachidonic Ratio Vanilmandelate Page 16

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