Ovarian spermatogenesis in Haliotis madaka
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1 Ovarian spermatogenesis in Haliotis madaka Average butyltin concentrations in muscle of the giant abalone TBT DBT MBT ** ) Concentration ng/g wet wt Site A (reference) Site B(population decline) n=125 n=83 Spermatogenesis in ovary of the giant abalone (H. madaka) from Site B, Japan April 1996 Percentage composition of masculinized females of the giant abalone specimens from Site B (a site representative of population decline) 0% spermatogenesis within 9% proliferated epithelium of 2% mantle 6% spermatogenesis within newly formed tissues over epithelium 4% of mantle testis-like structure in ovary seminiferous tubules-like structure formation spermatogenesis around ovarian tubes in ovary Horiguchi et al. (2000) 79% normal structure
2 In situ exposure experiment nearby a shipyard in Site B, Japan Concentration (ng/g wet wt.) ** ** TBT TPT Before After Significant accumulation of TBT and TPT in muscle of abalone from Site A (reference), after 7-month7 in situ exposure experiment (June 1998 Jan. 1999) Ovarian spermatogenesis was observed in 90% of females in situ exposed nearby a shipyard in Site B Horiguchi et al. (2000)
3 Laboratory flow-through exposure experiments of TBT and TPhT with abalone, H. gigantea Concentration (ng/g wet wt.) Triorganotin concentrations in muscle of Haliotis gigantea after 2-month flow-through exposure TBT TPhT ± Control TBT100ng/L TPhT100ng/L Ovarian spermatogenesis in female H. gigantea exposed to 100 ng/l of TBT for 2 months Horiguchi et al. (2002)
4 Reproductive Cycles in the Giant Abalone (January 1998 March 1999) 5 Site A 4 5 Site B No specimen collected Jan-98 Mar-98 May-98 Jun-98 Jul-98 Aug-98 Sep-98 Oct-98 Nov-98 Dec-98 Jan-99 Feb-99 Mar Jan-98 Mar-98 May-98 Jun-98 Jul-98 Aug-98 Sep-98 Oct-98 Nov-98 Jan-99 Feb-99 Mar-99 Ovarian spermatogenesis: 0 % (Site A) 19 % (Site B) Horiguchi et al. (2005) 1
5 Conclusions Imposex has been observed in 39 species of gastropods from Japan. Reproductive failure involved by imposex is thought to have led some Japanese gastropod populations to population decline/mass extinction. Causal substances of gastropod imposex are TBT and/or TPhT from antifouling paints. Similar endocrine disruption to gastropod imposex was also observed in abalone from Japan. Ovarian spermatogenesis was also induced by TBT and TPhT in abalone. TBT is still used worldwide in antifouling paints despite of the AFS Convention, which may bring about delayed recovery of gastropods from imposex.
6 Hypotheses on Induction Mechanism of Imposex Caused by TBT in Gastropods Aromatase inhibition (Bettin( et al., 1996) Testosterone excretion-inhibition inhibition (Ronis( & Mason, 1996) Interfering with the release by female cerebropleural ganglia of a retrogressive factor for penis growth (Féral & Le Gall, 1983) Promotion of APGWamide as a penis morphogenetic factor (Oberd( Oberdörsterrster & McClellan- Green, 2000)
7 Identification of Steroid Hormones & Metabolism 7696 a-1) 7472 b-1) Standard Sample (Thais clavigera ) testosterone m/z estradiol m/z a-2) b-2) Standard a-1) testosterone m/z b-1) estradiol m/z Sample ( Babylonia japonica ) a-2) b-2) Time (min) Time (min) c-1) androsterone m/z c-2) d-1) estrone m/z e-1) ethynylestradiol m/z Time (min) d-2) e-2) Time (min) 21
8 Structure of Estrogen Receptor rock shell C D E F human mouse alligator chicken zebrafish Iguchi et al. (2007)
9 Comparison of ER Homology among Species human beta mouse beta 89.0% 77.8% chicken beta 53.9% zebrafish beta chicken alpha 91.6% 47.4% alligator alpha 82.1% human alpha mouse alpha 90.7% 51.8% 26.4% zebrafish alpha rock shell ER-like Iguchi et al. (2007)
10 Aromatase Inhibitor and Testosterone: Less Effective on the Development of Imposex Injection experiments Control Fadrozole Fadrozole + Testosterone TPTCl Incidence ** (%) Penis Length * *** (mm) VDS Index *** * p<0.05 ; ** p<0.01 ; *** p< day flow through exposure experiments of only Fadrozole (0.3 mg/l) and Fadrozole (0.3 mg/l) in combination with 3 conc. of Testosterone (0.1, 1 and 10 g/l) did NOT result in significant promotion of imposex symptoms (Sugimoto, Horiguchi, Shiraishi, Morita, Takahashi & Miura, unpublished data), either.
11 Hypotheses on Induction Mechanism of Imposex Caused by TBT in Gastropods Aromatase inhibition (Bettin( et al., 1996) X Testosterone excretion-inhibition inhibition (Ronis( & Mason, 1996) X Interfering with the release by female cerebropleural ganglia of a retrogressive factor for penis growth (Féral & Le Gall, 1983) X? Promotion of APGWamide as a penis morphogenetic factor (Oberd( Oberdörsterrster & McClellan- Green, 2000) X NOT supported in the experiments with Thais clavigera
12 From Nishikawa, J., Mamiya, S., Kanayama, T., Nishikawa, T., Shiraishi, F., Horiguchi, T.: Environ. Sci & Technol. 38: , We know TBT and TPhT cause imposex in T. clavigera.
13 Retinoid X Receptor (RXR) One of nuclear receptors Ligand-dependent dependent transcriptional activation 9-cis retinoic acid (9CRA): the natural ligand to human RXR (hrxr( hrxr) Heterodimer coupled with non-steroid nuclear receptors Three subtypes: hrxr, hrxr and hrxr TBT and TPhT are agonists for hrxr,, having strong affinity, comparable to 9CRA Phylogenetically well conserved
14 Homology of RXR among Species Nishikawa, J., Mamiya, S., Kanayama, T., Nishikawa, T., Shiraishi, F., Horiguchi, T.: Environ. Sci & Technol. 38: , 2004.
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