MRC-NIHR NPC Assay Portfolio
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- Irma Norma Doyle
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1 MRC-NIHR NPC Assay Portfolio No one technology platform or assay can provide the comprehensive coverage of the metabolome needed to provide insight into complex biological processes which is why the MRC-NIHR National Phenome Centre has developed and implemented two distinct but customisable research offerings. The Centre is embedded in the Division of Computational and Systems Medicine at Imperial College London ensuring it has a strong research and development pipeline driving innovation in metabolic phenotyping. New technological opportunities are quickly evaluated and further developed into routine platforms. The MRC-NIHR National Phenome Centre assay portfolio is therefore continuously improving and expanding. Comprehensive Discovery Service Assay Chemical Class Matrix & Volume NMR (Profiling & Targeted) (210 Metabolites, 105 Lipoprotein components & chylomicron content) Abundant metabolites (µm-mm) Urine annotation: Profiling with annotation against a database of up to 600 compounds. Quantified Urine: Creatinine, Creatine, D-Glucose-beta, Alanine, Lactic Acid, Acetic Acid, Succinic Acid, Citric Acid, Dimethylamine, Trimethylamine, Betaine, Glycine, Fumaric Acid, Formic Acid, 1-Methylnicotinamide, N,N- Dimethylglycine, Myo-Inositol, Taurine, Trigonelline, Hippuric Acid, D- Lactose, Paracetamol, Paracetamol-glucuronide, Benzoic Acid, Ethanol, Orotic Acid, Methylmalonic Acid, 2-Hydroxyisovaleric Acid, Ethylmalonic Acid, N- Acetylaspartic Acid, Glutaric Acid, Xantine, Uridine, Acetone, 3- Hydroxybutyric Acid, Acetoacetic Acid, Propionic Acid, L-Isoleucine, Allo- Standard Volumes: Urine (600 µl) Plasma/ (350 µl) Tailored microscale assays: Urine (60 µl) Plasma/ (50 µl) 1
2 Metabolite Profiling - UPLC-MS Reverse Phase chromatography, + ionisation Reverse Phase chromatography, - ionisation Isoleucine, Leucine, Valine, Citrulline, 3-Hydrxypropionic Acid, Phenylalanine, Phenylpyruvic Acid, N-Acetylphenulalanine, Neopterin, Phenylacetic Acid, 2- Hydroxyphenylacetic Acid, 2-Phenyllactic Acid, 3-Phenyllactic Acid, 4- Hydroxyphenyllactic Acid, 3-Methyl-2-Oxovaleric Acid, 2-Hydroxy-4- Methylvaleric Acid, D-Galactonic Acid, 3-Methylcrotonylglycine, Uracil, Galactitol, Isovaleroyglycine, 5-Aminoleuvulinic Acid, 2-Oxoisocaproic Acid, Propionylglycine, 4-Hydroxyphenylacetic Acid, 3-Hydroxyvaleric Acid, D- Sorbitol, 3-Hydroxyglutaric Acid, E-Glutaconic Acid, 2-Oxoisovaleric Acid, L- pyroglutamic Acid. Plasma annotation: Profiling and annotation against a database of up to 600 compounds. Quantified Plasma: TPTG, TPCH, TPFC, TPA1, TPA2, TPAB, VLTG, VLCH, VLFC, VLPL, VLAB, IDTG, IDCH, IDFC, IDPL, IDAB, LDTG, LDCH, LDFC, LDPL, LDAB, HDTG, HDCH, HDFC, HDPL, HDA1, HDA2, V1TG, V1CH, V1FC, V1PL, V2TG, V2CH, V2FC, V2PL, V3TG, V3CH, V3FC, V3PL, V4TG, V4CH, V4FC, V4PL, V5TG, V5CH, V5FC, V5PL, V6TG, V6CH, V6FC, V6PL, L1TG, L1CH, L1FC, L1PL, L1AB, L2TG, L2CH, L2FC, L2PL, L2AB, L3TG, L3CH, L3FC, L3PL, L3AB, L4TG, L4CH, L4FC, L4PL, L4AB, L5TG, L5CH, L5FC, L5PL, L5AB, L6TG, L6CH, L6FC, L6PL, L6AB, H1TG, H1CH, H1FC, H1PL, H1A1, H1A2, H2TG, H2CH, H2FC, H2PL, H2A1, H2A2, H3TG, H3CH, H3FC, H3PL, H3A1, H3A2, H4TG, H4CH, H4FC, H4PL, H4A1, H4A2. Broad and deep metabolite coverage of moderately polar to moderately apolar species. Urine (100 µl) 2
3 High Polarity Metabolite Profiling - UPLC-MS HILIC chromatography, + ionisation Lipid Analysis - UPLC-MS Reverse Phase chromatography, + ionisation Reverse Phase chromatography, - ionisation Broad and deep metabolite coverage of highly polar analytes. Broad and deep metabolite lipid species coverage. Urine (50 µl) Plasma/ (50 µl) Plasma/ (100 µl) Guided Monitoring Services Amino Compounds (38 Analytes Monitored) Acylcarnitines (26 Analytes Monitored) Assay Biochemicals Matrix Quantified: L-Alanine, L-Arginine, L-Asparagine, L-Aspartic acid, L-Cystine, L-Glutamic acid, L- Urine Glutamine, Glycine, L-Histidine, L-Isoleucine, L-Leucine, L-Lysine, L-Methionine, L-Phenylalanine, Plasma L-Proline, L-Serine, L-Threonine, L-Tryptophan, L-Tyrosine, L-Valine Targeted: 3-Methyl-L-histidine, 1-Methyl-L-histidine, Cystathionine, DL-β-Aminoisobutryic acid, Ethanolamine, Homoserine, Hydroxy-L-proline, Hydroxylysine, L-Carnosine, L-Citrulline, L- Ornithine, L-α-aminoadipic acid, L-α-Amino-n-butyric acid, Phosphoserine, Sarcosine, Taurine, β-alanine,γ-amino-n-butyric acid Quantified: Carnitine, Acetylcarnitine, Propionylcarnitine, Malonylcarnitine, Butyryl-L-carnitine, Isobutyryl-L-carnitine, Succinylcarnitine, Methylmalonylcarnitine, Valeryl-L-carnitine, Isovaleryl- L-carnitine, Tiglylcarnitine (3-Methylcrotonylcarnitine), 3-hydroxyisovalerylcarnitine, Glutarylcarnitine, Hexanoylcarnitine, Octanoylcarnitine, 3-hydroxyoctanoylcarnitine, Decanoylcarnitine, Dodecanoylcarnitine (Lauroylcarnitine), Myristoylcarnitine (tetradecanoylcarnitine), Palmitoylcarnitine (hexadecanoylcarnitine), 3- Plasma 3
4 Bile Acids (100 Analytes Monitored) hydroxypalmitoylcarnitine, Stearoylcarnitine (octadecanoylcarnitine), Oleylcarnitine (oleoylcarnitine), Linoleylcarnitine, 3-hydroxystearoylcarnitine, 3-hydroxyoleylcarnitine Quantified: Chenodeoxycholic acid, Cholic acid, Deoxycholic acid, Glycochenodeoxycholic acid, Glycocholic acid, Glycodeoxycholic acid, Glycolithocholic acid, Glycoursodeoxycholic acid, Hyodeoxycholic acid, Lithocholic acid, Taurochenodeoxycholic acid, Taurocholic acid, Taurodeoxycholic acid, Taurolithocholic acid, Ursodeoxycholic acid Targeted: 12-Dehydrocholic acid, 3-Dehydrocholic acid, 3-Ketocholanic acid, 3,12- Diketocholanic acid, 3,6-Diketocholanic acid, 3,7-Diketocholanic acid, 3,7,12-Dehydrocholic acid, 3,7,12-Glycodehydrocholic acid, 3,7,12-Taurodehydrocholic acid, 3α-Hydroxy-12- ketolithocholic acid, 3α-Hydroxy-6,7-diketocholanic acid, 3α-Hydroxy-7-ketolithocholic acid, 3α- Hydroxy-7,12-diketocholanic acid, 3α,12α,23-Nordeoxycholic acid, 5-Cholenic acid-3β-ol, 5α- Cholanic acid-3, 6-dione, 5α-Cholanic acid-3α-ol-6-one, 5β-Cholanic acid-3α, 6α-diol-7-one, 5β- Cholanic Acid-3β, 12α-diol,5β-Cholenic acid-7α-ol-3-one, 8(14),(5β)-Cholenic acid-3α,12α-diol, 9(11),(5β)-Cholenic acid-3α-ol-12-one, Allolithocholic acid, Glyco-ursocholanic acid, Glycohyocholic acid, Glycohyodeoxycholic acid, Hyocholic acid, Isodeoxycholic acid, Isolithocholic acid, Lithocholenic acid, Murocholic acid, Lithocholenic acid-3-sulphate, 5- Cholenic acid-3β-ol-3-sulphate, Isolithocholic Acid-3-sulphate, Allolithocholic acid-3-sulphate, Lithocholic acid-3-sulphate, 3α,12α,23-Nordeoxycholic acid-3-sulphate, 3α,12α,23- Nordeoxycholic acid-12-sulphate, 9(11),(5β)-Cholenic acid-3α-ol-12-one-3-sulphate, 5β-Cholenic acid-7α-ol-3-one-7-sulphate, 5α-Cholanic acid-3α-ol-6-one-3-sulphate, 3α-Hydroxy-7- ketolithocholic acid-3-sulphate, 3α-Hydroxy-12-ketolithocholic acid-3-sulphate, 8(14),(5β)- Cholenic acid-3α,12α-diol-3-sulphate, 8(14),(5β)-Cholenic acid-3α,12α-diol-12-sulphate, Murocholic acid-3-sulphate, Murocholic acid-6-sulphate, Isodeoxycholic acid-7-sulphate, Isodeoxycholic acid-12-sulphate, 5β-Cholanic acid-3β,12α-diol-3-sulphate, 5β-Cholanic acid- 3β,12α-diol-12-sulphate, Chenodeoxycholic acid-3-sulphate, Chenodeoxycholic acid-7-sulphate, Hyodeoxycholic acid-3-sulphate, Hyodeoxycholic acid-6-sulphate, Ursodeoxycholic acid-3- sulphate, Ursodeoxycholic acid-7-sulphate, Deoxycholic acid-3-sulphate, Deoxycholic acid-12- sulphate, 3α-Hydroxy-7,12-diketocholanic acid-3-sulphate, 3α-Hydroxy-6,7-diketocholanic acid- Urine Plasma 4
5 Glutathione Pathway Biochemicals (23 Analytes Monitored) Phenols (43 Analytes Monitored) 3-sulphate, 5β-Cholanic acid-3α,6α-diol-7-one-3-sulphate, 5β-Cholanic acid-3α,6α-diol-7-one-6- sulphate, 3-Dehydrocholic acid-7-sulphate, 3-Dehydrocholic acid-12-sulphate, 12-Dehydrocholic acid-3-sulphate, 12-Dehydrocholic acid-7-sulphate, Cholic acid-3-sulphate, Cholic acid-7- sulphate, Cholic acid-12-sulphate, Hyocholic acid-3-sulphate, Hyocholic acid-7-sulphate, Hyocholic acid-12-sulphate, Glycolithocholic acid-3-sulphate, Glycoursodeoxycholic acid-3- sulphate, Glycoursodeoxycholic acid-7-sulphate, Glycohyodeoxycholic acid-3-sulphate, Glycohyodeoxycholic acid-6-sulphate, Glycochenodeoxycholic acid-3-sulphate, Glycochenodeoxycholic acid-7-sulphate, Glycodeoxycholic acid-3-sulphate, Glycodeoxycholic acid-12-sulphate, Tauro-ursocholanic acid-3-sulphate, Glycocholic acid-3-sulphate, Glycocholic acid-7-sulphate, Glycocholic acid-12-sulphate, Glycohyocholic acid-3-sulphate, Glycohyocholic acid-6-sulphate, Glycohyocholic acid-7-sulphate, Tauro-ursodeoxycholic acid-3-sulphate, Tauroursodeoxycholic acid-7-sulphate, Taurohyodeoxycholic acid-3-sulphate, Taurohyodeoxycholic acid-6-sulphate, Taurochenodeoxycholic acid-3-sulphate, Taurochenodeoxycholic acid-7- sulphate, Taurodeoxycholic acid-3-sulphate, Taurodeoxycholic acid-12-sulphate, Taurohyocholic acid-3-sulphate, Taurohyocholic acid-6-sulphate, Taurohyocholic acid-7-sulphate, Taurocholic acid-3-sulphate, Taurocholic acid-7-sulphate, Taurocholic acid-12-sulphate, Taurohyocholic acid, Taurohyodeoxycholic acid, Ursocholanic acid, Tauro-ursocholanic acid, Tauroursodeoxycholic acid Cystine, Cysteine, Adenosyl-homocysteine, Glutathione, Glutathione disulfide, Glycine, Glutamate (glutamic acid), Methionine, Ophthalmic acid, 5-Oxoproline, Taurine, Hypotaurine, Homocysteine, Cystathionine, Cysteine sulphate, Cysteate, 2-Aminobutyrate, γ- Gutamylcysteine, Adenosyl-methionine, Betaine, Choline, Cysteamine, Cys-gly Hippuric acid, Phenol, p-cresol, Phenylacetic acid, Benzoic acid, Mandelic acid, Cinnamic acid, Phenylpropionic acid (hydrocinnamic acid), Phenyllactic acid (2-Hydroxy-3-phenylpropionic acid), Phenylpyruvic acid, 2-Hydroxybenzoic acid (salicylic acid), 3-, 4-, 2-Hydroxyhippuric acid, 3-, 4-, 2-Hydroxyphenylacetic acid, 3-, 4-, 2-Hydroxymandelic acid, 3-, 4-, 2- Hydroxyphenylpropionic acid, 3-, 4-, 2-Hydroxycinnamic acid (o-coumaric acid), 3-, 4-, 2- Hydroxyphenylpyruvic acid, 3-, 4-, 2-Hydroxyphenyllactic, 3-, 4-, 4-Hydroxy-3-Methoxybenzoic Plasma Urine 5
6 Biocrates AbsoluteIDQ p150 Metabolomics Kit (158 Analytes Monitored) acid (vanillic acid), 4-Hydroxy-3-Methoxyhippuric acid, 4-Hydroxy-3-Methoxyphenylacetic acid (homovanillic acid), 4-Hydroxy-3-Methoxymandelic acid, 4-Hydroxy-3-Methoxyphenylpropionic acid (Dihydroferulic acid), 4-Hydroxy-3-Methoxycinnamic acid (Ferulic acid), 4-Hydroxy-3- Methoxyphenylpyruvic acid, 4-Hydroxycinnamoylglycine, Feruloylglycine, 3,4-Dihydrobenzoic acid (Protocatechuic acid), 2,5-Dihydrobenzoic acid (Gentisic acid) 3,5 Dihydrobenzoic acid (α- Resorcylic acid), 2,4-Dihydrobenzoic acid (β-resorcylic acid), 2,6-Dihydrobenzoic acid (γ- Resorcylic acid), 2,3-Dihydrobenzoic acid (Hypogallic acid, Pyrocatechuic acid), 3,4,5- Trihydrobenzoic acid (Gallic acid), 4-Hydroxy-3,5-dimethoxybenzoic acid (Syringic acid), 3,4- Dihydroxyphenylacetic acid (Homoprotocatechuic acid), 2,5-Dihydroxyphenylacetic acid (Homogentisic acid), 3,4-Dihydroxycinnamic acid (Caffeic acid), 4-Hydroxyquinoline-2-carboxylic acid (Kynurenic acid), 3-Hydroxyanthranilic acid, 5-Hydroxyindoleacetic acid, Valinoylglycine, 5- (dihydroxyphenyl)-γ-valerolactones, 5-(hydroxyl-methoxy-phenyl)-γ-valerolactones, Indole-3- pyruvic acid, Indole-3-lactic acid, Indole-3-carboxylic, Indole-3-acetic, Indoxyl sulfate, Shikimate (shikimic acid), 4-vinylphenol, 4-ethylphenol, 1,2-dihydroxybenzene (catechol, pyrocatechol), 1,3-dihydroxybenzene (resorcinol, resorcin), 1,4-dihydroxybenzene (hydroquinone, benzene- 1,4-diol, quinol) Quantified: C0: acylcarnitines, C10: acylcarnitines, C12: acylcarnitines, C14: acylcarnitines, C16: acylcarnitines, C18: acylcarnitines, C2: acylcarnitines, C3: acylcarnitines, C4: acylcarnitines, C6 / C4:1-DC: acylcarnitines, C5: acylcarnitines, C8: acylcarnitines, Arginine: aminoacids,, Glycine: aminoacids, Histidine: aminoacids, Methionine: aminoacids, Ornithine: aminoacids, Phenylalanine: aminoacids, Proline: aminoacids, Serine: aminoacids, Threonine: aminoacids, Tryptophan: aminoacids, Tyrosine: aminoacids, Valine: aminoacids, xleucine: aminoacids, PC ae C38:1: glycerophospholipids, H1_pos_198_180: sugars Monitored: C10:1: acylcarnitines, C10:2: acylcarnitines, C12-DC: acylcarnitines, C12:1: acylcarnitines, C14:1: acylcarnitines, C14:1-OH: acylcarnitines, C14:2: acylcarnitines, C14:2-OH: acylcarnitines, C16-OH: acylcarnitines, C16:1: acylcarnitines, C16:1-OH: acylcarnitines, C16:2: acylcarnitines, C16:2-OH: acylcarnitines, C18:1: acylcarnitines, C18:1-OH: acylcarnitines, C18:2: acylcarnitines, C3-DC / C4-OH: acylcarnitines, C3-OH: acylcarnitines, C3:1: acylcarnitines, C4:1: Plasma 6
7 acylcarnitines, C5-M-DC: acylcarnitines, C3-DC-M / C5-OH: acylcarnitines, C5:1: acylcarnitines, C5:1-DC: acylcarnitines, C5-DC / C6-OH: acylcarnitines, C6:1: acylcarnitines, C7-DC: acylcarnitines, C8:1: acylcarnitines, C9: acylcarnitines, Glutamine: aminoacidslysopc a C14:0: glycerophospholipids, lysopc a C16:0: glycerophospholipids, lysopc a C16:1: glycerophospholipids, lysopc a C17:0: glycerophospholipids, lysopc a C18:0: glycerophospholipids, lysopc a C18:1: glycerophospholipids, lysopc a C18:2: glycerophospholipids, lysopc a C20:3: glycerophospholipids, lysopc a C20:4: glycerophospholipids, lysopc a C24:0: glycerophospholipids, lysopc a C26:0: glycerophospholipids, lysopc a C26:1: glycerophospholipids, lysopc a C28:0: glycerophospholipids, lysopc a C28:1: glycerophospholipids, PC aa C24:0: glycerophospholipids, PC aa C26:0: glycerophospholipids, PC aa C28:1: glycerophospholipids, PC aa C30:0: glycerophospholipids, PC aa C32:0: glycerophospholipids, PC aa C32:1: glycerophospholipids, PC aa C32:2: glycerophospholipids, PC aa C32:3: glycerophospholipids, PC aa C34:1: glycerophospholipids, PC aa C34:2: glycerophospholipids, PC aa C34:3: glycerophospholipids, PC aa C34:4: glycerophospholipids, PC aa C36:0: glycerophospholipids, PC aa C36:1: glycerophospholipids, PC aa C36:2: glycerophospholipids, PC aa C36:3: glycerophospholipids, PC aa C36:4: glycerophospholipids, PC aa C36:5: glycerophospholipids, PC aa C36:6: glycerophospholipids, PC aa C38:0: glycerophospholipids, PC aa C38:3: glycerophospholipids, PC aa C38:4: glycerophospholipids, PC aa C38:5: glycerophospholipids, PC aa C38:6: glycerophospholipids, PC aa C40:1: glycerophospholipids, PC aa C40:2: glycerophospholipids, PC aa C40:3: glycerophospholipids, PC aa C40:4: glycerophospholipids, PC aa C40:5: glycerophospholipids, PC aa C40:6: glycerophospholipids, PC aa C42:0: glycerophospholipids, PC aa C42:1: glycerophospholipids, PC aa C42:2: glycerophospholipids, PC aa C42:4: glycerophospholipids, PC aa C42:5: glycerophospholipids, PC aa C42:6: glycerophospholipids, PC ae C30:0: glycerophospholipids, PC ae C30:1: glycerophospholipids, PC ae C30:2: glycerophospholipids, PC ae C32:1: glycerophospholipids, PC ae C32:2: glycerophospholipids, PC ae C34:0: glycerophospholipids, PC ae C34:1: glycerophospholipids, PC ae C34:2: glycerophospholipids, PC ae C34:3: glycerophospholipids, PC ae C36:0: glycerophospholipids, PC 7
8 ae C36:1: glycerophospholipids, PC ae C36:2: glycerophospholipids, PC ae C36:3: glycerophospholipids, PC ae C36:4: glycerophospholipids, PC ae C36:5: glycerophospholipids, PC ae C38:0: glycerophospholipids, PC ae C38:2: glycerophospholipids, PC ae C38:3: glycerophospholipids, PC ae C38:4: glycerophospholipids, PC ae C38:5: glycerophospholipids, PC ae C38:6: glycerophospholipids, PC ae C40:1: glycerophospholipids, PC ae C40:2: glycerophospholipids, PC ae C40:3: glycerophospholipids, PC ae C40:4: glycerophospholipids, PC ae C40:5: glycerophospholipids, PC ae C40:6: glycerophospholipids, PC ae C42:0: glycerophospholipids, PC ae C42:1: glycerophospholipids, PC ae C42:2: glycerophospholipids, PC ae C42:3: glycerophospholipids, PC ae C42:4: glycerophospholipids, PC ae C42:5: glycerophospholipids, PC ae C44:3: glycerophospholipids, PC ae C44:4: glycerophospholipids, PC ae C44:5: glycerophospholipids, PC ae C44:6: glycerophospholipids, SM (OH) C14:1: sphingolipids, SM (OH) C16:1: sphingolipids, SM (OH) C22:1: sphingolipids, SM (OH) C22:2: sphingolipids, SM (OH) C24:1: sphingolipids, SM C16:0: sphingolipids, SM C16:1: sphingolipids, SM C18:0: sphingolipids, SM C18:1: sphingolipids, SM C20:2: sphingolipids, SM C24:0: sphingolipids, SM C24:1: sphingolipids, SM C26:0: sphingolipids, SM C26:1: sphingolipids 8
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