Biology 5357: Membranes
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1 Biology 5357: Membranes Introduction, Plausibility, Reality and Some Physics Paul H. MD, PhD Lipid Department of Cell Biology and Physiology
2 Lipid lography They represent a low energy and presumably stable molecular state while providing atomic scale structural information. Membranes are fluid Membranes are hydrated Membranes are anisotropic Lipid Glycerophosphate s Stereochemistry of lipid structures
3 Lipid lography Fatty Acids e.g. Potassium Palmitate Maxmize favorable packing Headgroups are hydrogen bonded Chains are anti-, torsion angle < 30 Lipid Glycerophosphate s Stereochemistry of lipid structures
4 Acylglycerol 1-acyl chain two acyl chains Lipid Glycerophosphate s Stereochemistry of lipid structures
5 Acylglycerol Trans Leaflet H-Bonding No Trans Leaflet H bonds Lipid Glycerophosphate s Stereochemistry of lipid structures
6 Acylglycerol Glycerol Glycerol Lipid Glycerophosphate s Stereochemistry of lipid structures
7 Triacylglycerol Nonlamellar Lipid Relatively weak headgroup polarity Lateral packing in a single layer Polar region in the single layer Jensen & Mabis (1966) Lipid Glycerophosphate s Stereochemistry of lipid structures
8 Analysis Φ = cos 1 ( n S ) Lipid Glycerophosphate s Stereochemistry of lipid structures
9 Glycerophosphate DiLauryl- Glycerol- Phosphate Hitchcock (1974) Lipid Glycerophosphate s Stereochemistry of lipid structures
10 Glycerophosphate Lysophosphatidylethanolamine ( n S ) = Lipid Glycerophosphate s Stereochemistry of lipid structures
11 Glycerophosphate 3-Laurylpropanediol-1-phosphocholine based thickness of bilayer Lipid Glycerophosphate s Stereochemistry of lipid structures
12 Membrane Leaflets Stereochemical Leaflet Segregation Lipid Glycerophosphate s Stereochemistry of lipid structures
13 Lipid Glycerophosphate s Stereochemistry of lipid structures
14 A. Cornish-Bowden and M. Luz Cardenas. Life before luca. Journal of Theoretical Biology, C von Nageli. Wachstumsgeschichte von pterothamnion plumula und floccosum. ln: C. von Nageli & C. Cramer (eds.), Pjlanzenphysiologische Untersuchungen. Friedrich Schulthess: Zurich, pages 54 68, claimed to observe separating membrane formation during cell division. Lipid
15 Die Lehre von der Pflanzenzelle Hofmeister. Handb. d. physiol. Botanik. I. Leipzig, John E. Heuser. The origins and evolution of freeze-etch electron microscopy. Journal of Electron Microscopy, 60(suppl 1):S3 S29, August Lipid R. Milo, R. Phillips, and N. Orme. Cell Biology by the Numbers. Garland Science, 2016.
16 Henri Dutrochet. Nouvelles recherches sur l endosmose et l exosmose... de l irritabilité végétale... JB Baillière, Jacobus H. van t Hoff, M. Perouansky. The overton in MeyerOverton: a biographical sketch commemorating the 150th anniversary of charles ernest overton s birth. British Journal of Anaesthesia, 114(4): , April Lipid
17 T Heimburg. Thermal Biophysics of Membranes, chapter Anesthesia, pages Wiley-VHC, Weinheim, Ellyn Gray, Joshua Karslake, Benjamin B. Machta, and Sarah L. Veatch. Liquid general anesthetics lower critical temperatures in plasma membrane vesicles. Biophysical Journal, 105(12): , Lipid Thomas Heimburg. Nerves and anesthesia: A physics perspective on medicine. arxiv, September 2014.
18 Kaare Grasboll, Henrike Sasse-Middelhoff, and Thomas Heimburg. The thermodynamics of general and local anesthesia. Biophysical Journal, 106(10): , Linus Pauling. A molecular theory of general anesthesia. Science, 134:15 21, The hydrate-microcrystal theory of anesthesia by non-hydrogen-bonding agents differs from most earlier theories in that it involves primarily the interaction of the molecules of the anesthetic agent with water molecules in the brain, rather than with molecules of lipid. Lipid
19 Leonard L Firestone, Andrew S Janoff, and Keith W Miller. Lipid-dependent differential effects of stereoisomers of anesthetic alcohols. Biochimica et Biophysica Acta (BBA) - Biomembranes, 898(1):90 96, E. Gorter and F. Grendel. On the bimolecular layers of lipoids on the chromocytes of the blood. J. Exp. Med., 41: , Lipid A. Pockel. Surface tension. Nature, 43: , 1891.
20 K. A. Dill and S. Bromberg. Molecular Driving Forces, chapter Adsorption, Binding & Catalysis, pages Garland Science, Tao Ni, Antreas C. Kalli, Fiona B. Naughton, Luke A. Yates, Omar Naneh, Mirijam Kozorog, Gregor Anderluh, Mark S.P. Sansom, and Robert J.C. Gilbert. and lipid-binding properties of the kindlin-3 pleckstrin homology domain. Biochemical Journal, 474(4): , Lipid
21 Hyunju Cho, Ming Wu, Betul Bilgin, S. Patrick Walton, and Christina Chan. Latest developments in experimental and computational approaches to characterize proteinlipid interactions. PROTEOMICS, 12(22): , H. Hauser and G. Poupart. The of Biological Membranes, pages CRC Press, 2 edition, Lipid T Heimburg. Thermal Biophysics of Membranes, chapter Introduction to Thermodynamics, pages Wiley-VHC, Weinheim, 2007.
22 K.E. van Holde, W.C. Johnson, and P.S. Ho. Principles of Physical Biochemistry, chapter Macromolecules in Solution: Thermodynamics and Equilibrium, pages Prentice Hall, Upper Saddle River, New Jersey USA, S Blundell and K Blundell. Concepts in Thermal Physics, chapter 28. Phase transitions. Oxford University Press, Lipid
23 Emiliano Brini, Christopher J. Fennell, Marivi Fernandez-Serra, Barbara Hribar-Lee, Miha Luksic, and Ken A. Dill. How water s properties are encoded in its molecular structure and energies. Chemical Reviews, 0(0):null, 0. PMID: T. Heimburg. Thermal Biophysics of Membranes, chapter Phase Diagrams, pages Wiley-VHC, Weinheim, Lipid
24 W. Helfrich. Elastic properties of lipid bilayers: theory and possible experiments. Z. Naturforsch., 28: , H. A. Pinnow and W. Helfrich. Effect of thermal undulations on the bending elasticity and spontaneous curvature of fluid membranes. The European Physical Journal E, 3(2): , Lipid
25 Michael F. Brown. Curvature forces in membrane Lipid-Protein interactions. Biochemistry, 51(49): , December S Blundell and K Blundell. Concepts in Thermal Physics, chapter 17. Rods Bubbles and Magnets, pages Oxford University Press, Lipid
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