SUPPLEMENTARTY TABLES

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1 SUPPLEMENTARTY TABLES

2 Table S1. Descriptive statistics and questionnaire data for female (16) and male (16) Variable Sex Mean Std. Error Gender Diff. t-test Age Female t(30) = 0.79 Male n.s., P = 0.43 Education Female t(30) = Male n.s., P = 0.17 Pain Intensity Low Female t(30) = 1.63 Male n.s., P = 0.11 Pain Intensity High Female t(30) = Male n.s., P = 0.43 Fair Player Female t(30) =0.39 How reasonable/fair Male n.s., P = 0.70 Unfair Player Female t(30) = How reasonable/fair Male n.s., P = 0.33 Fair Player Female t(30) = 0.00 How pleasant/agreeable Male n.s., P = 1.00 Unfair Player Female t(30) = -.35 How pleasant/agreeable Male n.s., P = 0.73 Fair Player Female t(30) = 0.67 How much you liked Male n.s., P = 0.49 Unfair Player Female t(30) = How much you liked Male n.s., P = 0.43 Fair Player Female t(30) = 0.65 How attractive Male n.s., P = 0.52 Unfair Player Female t(30) = 1.30 How attractive Male n.s., P = 0.20 Empathic Concern Female t(30) = Scale, Davis Male P = n.s., 0.12 Note. The range of the scale for pain intensity ratings was from 0 (no feeling) to 10 (unbearable pain); for all other ratings from -2 (not at all) to +2 (very much).

3 Table S2. Foci of pain-related activation when women experience pain in the self Brain regions Pain-Related Activation in Self [Pain no pain in Self] ( Pain Matrix ) ACC * ACC * ACC * ACC * ACC * o ACC * Right AI * Right AI/FI * Right AI * Left mid-anterior insula * o mid-anterior insula * o AI/FI * o AI * Left posterior insula/sii * o * o * Right SII * SI/MI * o SI * o SI * Thalamus * Brainstem/dorsal pons * o substantia nigra * Note. ACC, anterior cingulate cortex; AI, anterior insula; FI, fronto-insular cortex; SI, primary; SII, secondary somatosensory cortex; MI, primary motor cortex; All values, P < uncorrected; * P < 0.05 whole-brain corrected (FDR); = Sub-maxima within of a cluster.

4 Table S3. Cerebral foci of pain-related activation when men experience pain in the self Brain regions Pain-Related Activation in Self [Pain no pain in Self] ( Pain Matrix ) ACC (anterior) * ACC (posterior) * o ACC * o ACC * Right mid-anterior insula * o * Right anterior insula * Left anterior insula/fi * Left mid-anterior insula * Left posterior insula/sii * SI/MI * o SI * o SI * Thalamus * Left midbrain/substantia nigra * Right midbrain/substantia nigra * Brainstem/dorsal pons * Note. ACC, anterior cingulate cortex; AI, anterior insula; FI, fronto-insular cortex; SI, primary; SII, secondary somatosensory cortex; MI, primary motor cortex; All values, P < uncorrected; * P < 0.05 whole-brain corrected (FDR); = Sub-maxima within a cluster.

5 Table S4a. Pain-related activation when women observe pain in fair player Coordinates of peak activation (mm) Z scores Pain-related Activation in Fair [Pain no Pain in Fair] ACC (anterior) ACC (posterior) Left AI/FI o Right FI/OFC Right AI/FI Right AI/OFC Right SII Inclusive Masking [Pain no Pain] in Self masked with [Pain no Pain] in Fair ACC Left AI o AI Right FI/OFC Right AI/FI Left SII/supramarginal gyrus Note. ACC, anterior cingulate cortex; AI, anterior insula; FI, fronto-insular cortex; OFC, orbito-frontal cortex; SI, primary; SII, secondary somatosensory cortex; All values, P < uncorrected; * P < 0.05 whole-brain corrected (FDR); = Sub-maxima within of a cluster.

6 Table S4b. Pain-related activation for women common to self and fair player Conjunction Analysis [Pain no Pain] in Self and Fair ACC * o ACC * Left AI * o AI/FI/OFC * o AI * Right AI/FI * o FI/OFC o AI/FI Left SII/supramarginal gyrus * o * Right SII/supramarginal gyrus * o * o * Brainstem/dorsal pons * Note. ACC, anterior cingulate cortex; AI, anterior insula; FI, fronto-insular cortex; OFC, orbito-frontal cortex; SI, primary; SII, secondary somatosensory cortex; All values, P < uncorrected; * P < 0.05 whole-brain corrected (FDR); = Sub-maxima within of a cluster.

7 Table S5. (a) Pain-related activation when men observe pain in the fair player and (b, c) common activation to the self and fair player conditions. (a) Pain-related Activation in Fair [Pain no Pain in Fair] Left FI Left AI Right mid-insula Right AI/FI (b) Inclusive Masking [Pain no Pain] in Self masked with [Pain no Pain] in Fair Left AI o FI Mid insula Right FI/OFC Brainstem/dorsal pons (c) Conjunction Analysis (P < 0.001) [Pain no Pain] in Self and Fair Left AI * o * Right FI Right mid insula Right FI o o Right SII/STS * Brainstem/dorsal pons Note. ACC, anterior cingulate cortex; AI, anterior insula; FI, fronto-insular cortex; SI, primary; SII, secondary somatosensory cortex; All values, P < uncorrected; * P < 0.05 whole-brain corrected (FDR); = Sub-maxima within a cluster.

8 Table S6. Pain-related activation when women observe unfair player in pain Coordinates of peak activation (mm) Z scores Pain-Related Activation in Unfair [Pain no Pain Unfair] Left AI/FI Right AI/FI o FI Inclusive Masking [Pain no Pain] in Unfair masked with [Pain no Pain] in Self Left AI Right AI/FI o FI Conjunction Analysis (P < 0.001) [Pain no Pain] in Self and Unfair ACC Left AI * Right AI/FI * o FI Right FI Left SII/STS Left SII/supramarginal gyrus Note. ACC, anterior cingulate cortex; AI, anterior insula; FI, fronto-insular cortex; SII, secondary somatosensory cortex. All values, * P < 0.05 whole-brain corrected (FDR); = Sub-maxima within of a cluster.

9 Table S7. Common pain-related activation when women observe fair and unfair players Conjunction Analysis [Pain no Pain] in Self, Fair, Unfair ACC * ACC * Left AI * o AI * Right AI/FI * o AI * Right AI * Left SII/STS * o SII * Conjunction Analysis [Pain no Pain] in Fair and Unfair masked by [Pain no Pain] in Self Left AI Right AI/FI Right AI Left SII/STS Note. ACC, anterior cingulate cortex; AI, anterior insula; FI, fronto-insular cortex; STS, superior temporal sulcus; All values, P < uncorrected; * P < 0.05 whole-brain corrected (FDR); = Sub-maxima within of a cluster.

10 Table S8. Cerebral activity specific to women observing fair or unfair player in pain Pain-Related Activity Specific to Fair [Pain Fair Pain Unfair] Left mid-insula Right posterior insula/sii Interaction [Pain no Pain] Fair - [Pain no Pain] Unfair Right mid-insula Right posterior insula/sii Pain-related Activity Specific to Unfair [Pain Unfair Pain Fair] n.s. Interaction [Pain no Pain] Unfair - [Pain no Pain] Fair n.s Note. SII, secondary somatosensory cortex. All values, P < uncorrected.

11 S9. Pain-related activation when men observe unfair player in pain Coordinates of peak activation (mm) Z scores Pain-Related Activation in Unfair [Pain no Pain] in Unfair Midbrain/dorsal pons Inclusive Masking [Pain no Pain] in Unfair masked with [Pain no Pain] in Self n.s. Conjunction Analysis (P < 0.001) [Pain no Pain] in Self and Unfair Right middle insula Brainstem/dorsal pons Note. All values, P < uncorrected Table S10. Common pain-related activation when men observe fair and unfair players Conjunction Analysis [Pain no Pain] in Self, Fair, Unfair Player Brainstem/dorsal pons Conjunction Analysis [Pain no Pain] in Fair and Unfair masked with [Pain no Pain] in Self n.s. Note. P < uncorrected

12 Table S11. Cerebral activity specific to men observing fair or unfair player in pain Pain-Related Activity Specific to Fair [Pain Fair Pain Unfair] Left FI Right FI Right FI Interaction [Pain no Pain] Fair - [Pain no Pain] Unfair Left FI Right FI Pain-Related Activity Specific to Unfair [Pain Unfair Pain Fair] Right posterior insula/sii Nucleus accumbens Interaction [Pain no Pain] Unfair - [Pain no Pain] Fair Nucleus accumbens Left OFC Left OFC Note. SII, secondary somatosensory cortex; OFC, orbito-frontal cortex. All values, P < uncorrected

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