DR. HONG YIN 27th June, 2018 Beijing

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1 Researches on Animal Science and Health in CAAS DR. HONG YIN 27th June, 2018 Beijing

2 Outlines of researches Animal science Animal health Veterinary pharmaceutics Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

4 Animal Sciences Beijing Institute of Animal Sciences and Veterinary Medicine Lanzhou Institute of Animal Sciences and Veterinary Pharceutials Enocnomic Animals and Plants Research Institute Feed Reseach Institute. Grassland Research Institute

6 Animal science (IAS, Beijing) National Platform of Animal Resources Conservation and utilization: 3 million animals; 705 breeds;10,000 sperm and embryos per year Biobank: 19,000 blood and tissues samples, and 180 somatic and stem cell lines Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

7 Genomic Evaluation of Animal Resources Goat Fat-tail Sheep Pony Tibetan horse Genome-wide analysis of the genetic diversity, population structure, phylogenetic tree in domestic animals by using NGS and high density SNP arrays Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Published in BBA-Gene Regulatory Mechanisms Published in Journal of Pineal

8 Applied research of stem cells Identification of mirna key to beta cell differentiation Neural cell differentiation and spinal cord injury recovery Published in BBA-Gene Regulatory Mechanisms Published in Journal of Pineal Research Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Markers for Important Economic Traits of

for angle type Lanzhou Veterinary Research

9 Sheep and Goat Genetics and Breeding Identification and Excavation of Molecular Markers for Important Economic Traits of Sheep and Goats Markers for litter size of sheep Markers for year-round estrus Markers for meat production traits Markers for angle type Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

maker assistant breeding technology and hybridization technology were used for the new

10 Development of high throughput detection methods and new species breeding High throughput detection methods focused on Fec B gene of sheep New breed: Luxi black head sheep Molecular maker assistant breeding technology and hybridization technology were used for the new breed development. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

showed learly dou le mus le hara teristi s.

11 Breeding Meishan Pig using Myostatin gene editing technology In 2012, Meishan pig was bred successfully, and the new breed showed learly dou le mus le hara teristi s. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

12 Breeding of new breeds 6 new breeds of livestock and poultry, including Simmental, Jingxing yellow chicken 100, 102, 103 Liyuanyou chicken and Beijing Duck Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

mechanism of yak hypoxia adaptation to high altitude Establishment the cattle and yak molecular

13 Animal science (IHPS, Lanzhou) Genetic resources and breeding of Cattle and Yak Identification Cattle and Yak functional genes of important economical traits Proteomics research on the Molecular mechanism of yak hypoxia adaptation to high altitude Establishment the cattle and yak molecular breeding system Datong Yak Datong Yak Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Breeding of Mutton-wool Strain of Alpine Fine Wool Sheep.

14 Animal science (IHPS, Lanzhou) Resources and Breeding of fine-wool sheep Mmolecular regulation mechanism of fine wool sheep and discovery the important function of gene. Breeding of Mutton-wool Strain of Alpine Fine Wool Sheep. Establishing technology integration model and demonstration base of Green Initiative, high yield and high efficiency of sheep. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

15 Animal Health

16 National Veterinary Research Institutes Ministry of agriculture and rural development China Institute of Veterinary Drug control Lanzhou Veterinary Research Institute Harbin Veterinary Research Institute CADC CAAS Shanghai Veterinary Research Institute China Animal Health and Epidemiology Eenter Lanzhou Institute of husbandry and Parmaceutical Sciences Beijing Institute of Animal Sciences Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Economic Animal Research Institute

18 Centers of Excellence in Animal Diseases National Designations Ministry of Agriculture Designations Gansu Province Designations International Reference Laboratory Designations State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Animal Virology Key Laboratory of Veterinary Parasitology OIE Foot and Mouth Diseases Reference Laboratory National Foot and Mouth Diseases Reference Laboratory Key Laboratory of Eipzootic Diseases Gansu Biological Detection Research Centre OIE Ovine Theileriosis Reference Laboratory Key Laboratory of Zoonosis Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Institutions Affiliated with HVRI Harbin

Reference Laboratory Collaborating Centre

Disease Reference laboratory Reference center

19 Institutions Affiliated with HVRI Harbin Veterinary Research Institute CAAS National Reference Laboratory Collaborating Centre ---Zoonoses of Asia-Pacific Reference Laboratory ---Avian Influenza ---Equine Infectious Anemia ---Infectious Bursal Disease Reference laboratory Reference center --- Avian Influenza --- Animal Influenza ---Contagious Bovine Pleuropneumonia

20 Viral Diseases

21 Viral Diseases FOOT AND MOUTH DISEASE

FMD Etiology and Immunity Team Epidemiology FMD virus (FMDV) Isolation FMDV evolution and distribution study Identifying risk factors for FMD Host tropism of FMDV The virulence and antigenic

22 FMD Etiology and Immunity Team Epidemiology FMD virus (FMDV) Isolation FMDV evolution and distribution study Identifying risk factors for FMD Host tropism of FMDV The virulence and antigenic variation of FMDV The suppressive role of FMDV on host immune system Vaccine development Vaccine process development and manufacture Pathogenic mechanism Prof. Dr: Xiangtao Liu Establishment of vaccine development platform FMD vaccines have been developed: I. FMD O/May-98 inactivated vaccine II. FMD O-Asia1-A trivalent inactivated vaccine III. FMD DNA vaccine FMDV Two of the developed Vaccines were recommended by OIE/FAO for FMD control. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

FMD Prevention and Control Team Main focus: Foot and mouth disease virus, FMDV Porcine epidemic diarrhea virus, PEDV Bovine viral diarrhea virus, BVDV Porcine parvovirus Porcine reproductive and

23 FMD Prevention and Control Team Main focus: Foot and mouth disease virus, FMDV Porcine epidemic diarrhea virus, PEDV Bovine viral diarrhea virus, BVDV Porcine parvovirus Porcine reproductive and respiratory syndrome, PRRSV Swine vesicular disease virus, SVDV Novel technology for disease control and prevention Pathogen etiology, pathogen-host interaction and immunology Disease eradication modelling in industrialized farmers Set up national standard for SVDV diagnosis Set up agriculture industry standard for integrate control of FMD Granted 4 New veterinary medicine certificates Current study: Professor: Yongguang Zhang zhangyongguang@caas.cn Main outcomes: Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Host Antiviral Infection and Immunobiology Team Applied researches Molecular marker vaccines against FMDV type O and A Epitope based vaccine against FMDV type O and A Attenuation of high pathogenic

24 Host Antiviral Infection and Immunobiology Team Applied researches Molecular marker vaccines against FMDV type O and A Epitope based vaccine against FMDV type O and A Attenuation of high pathogenic PRRSV and marker virus strain construction Diagnostic methods for differentiation of FMDV infected from vaccinated animals Development of on site tests for multiple viral diseases Prof. Dr: Zengjun Lu luzengjun@caas.cn infection of pigs Basic researches Dendritic cells phenotypes of cattle and Strategies for antigen targeted presentation Immune regulatory functions of long non-coding RNAs induced by FMDV and PRRSV infection The pathogenic factors of PRRSV and its molecular mechanism Molecular mechanism of FMD virus proteins affect the host tropism Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

25 Veterinary Nanomaterials and Applications Team Main focus: Virus-like particles for FMDV, CPV and PCV Antigen modification of VLPS, FMDV clearance Target tracking, target tropism, target therapy Prof. Dr:Huichen Guo VLPs expression and assembly in E. coli Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

26 Viral Diseases INFLEUZA

basis of the virulence development and host range of AIV Vaccine development, evaluation and update Development of

27 Animal Influenza Research Team To implement the Arbitrative diagnosis of HPAI To provide technical consultation and product to government Active surveillance and analysis of virus variation The exploration of the molecular basis of the virulence development and host range of AIV Vaccine development, evaluation and update Development of diagnostic and surveillance reagents combined with technological training related to its use Chen Hualan Ph.D, Professor

28 Molecular Ecology of Animal Viruses Team Main focus: Influenza Newcastle virus Infectious bronchitis of chicken Prof. Dr. Qiyun Zhu Main Studies: Molecular ecology and genetic evolution of animal Innate immune responses mediated by animal viruses Development of novel vaccines and prophylactic strategies Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Animal influenza pathogenesis and etiology Molecular etiology and

flu viruses in different animal species Pathogenesis and transmission of

vaccines for animal influenza and duck Tembusu virus Pathogenesis on

29 Animal influenza pathogenesis and etiology Molecular etiology and evolution of animal influenza viruses Isolation and characterization of flu viruses in different animal species Pathogenesis and transmission of avian/swine influenza viruses Immune regulation of animal influenza Novel vaccines for animal influenza and duck Tembusu virus Pathogenesis on co-infections of influenza and other viral agents Dr. Zejun Li Professor Chief-scientist

Research Highlights on AIV Basic Virology and Immunology Study The papers on the mechanisms of AIV inter-species transmission were published in major international academic journal.

Science 341, 410 (2013); H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet Ying Zhang et al.

30 Research Highlights on AIV Basic Virology and Immunology Study The papers on the mechanisms of AIV inter-species transmission were published in major international academic journal. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Qianyi Zhang et al. Science 341, 410 (2013); H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet Ying Zhang et al. Science 340, 1459 (2013); Development and Application of AIV vaccine Diagnostic Methods H5N1 Subtype(Re-1) (2004) H5N1 Subtype(Re-4) (2006) H5N1 Subtype(Re-5) (2008) H5N1 Subtype(Re-1+4) (2006) H5N1 Subtype(Re-4+5) (2008) H5+H9 Subtype (2007) Avian influenza and Newcastle Disease Recombinant vaccineδrl-h5ε Avian influenza and Fowlpox virus Recombinant vaccineδh5ε Avian Influenza vaccine develpoed for Egypt DNA vaccine

31 Viral Diseases BOVINE AND OVINE

Viral Diseases in Grazing Animal Team Main focus: Anti-virus immunity Viral pathogenesis

Capsid Vaccine for FMDV O Autophagy induced by FMDV Rapid detection of neutralizing antibody

cn PCR-based endpoint assessment PPRV highlights: Recombinant goatpox virus expressing PPRV

rabies virus and canine distemper virus Bivalent attenuated vaccine against orf virus and

32 Viral Diseases in Grazing Animal Team Main focus: Anti-virus immunity Viral pathogenesis Development of novel vaccine and diagnostic assay FMDV highlights: Thermal stable Empty Capsid Vaccine for FMDV O Autophagy induced by FMDV Rapid detection of neutralizing antibody against FMDV using qrt- Prof. Dr. Zhidong Zhang zhangzhidong@caas.cn PCR-based endpoint assessment PPRV highlights: Recombinant goatpox virus expressing PPRV SP and FMDV Rapid molecular test for PPRV PPR celisa diagnostics Kit Bivalent vaccine against rabies virus and canine distemper virus Bivalent attenuated vaccine against orf virus and sheeppox Other highlights: PPR celisa reagent kit Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Livestock infectious Diseases Research Team Research Interests Etiology, epidemiology, molecular mechanisms of pathogenesis and novel vaccines Focus on: Emerging

33 Livestock infectious Diseases Research Team Research Interests Etiology, epidemiology, molecular mechanisms of pathogenesis and novel vaccines Focus on: Emerging diseases severely affecting livestock Livestock respiratory and digestive diseases Virulence and host tropism of foot-and-mouth disease virus Yu Li, Ph.D, Professor

34 Viral Diseases SWINE

cn Mucosal Immunology: Mechanism of mucosal immune responses in the swine gut and try to boost the gut mucosal immunity (siga).

35 Animal Immunogenetics Team Swine Enteric Viruses: Evolution and co-evolution of PEDV, TGEV, Rotavirus, PDCoV, and etc. Prof. Dr. Guangliang Liu Mucosal Immunology: Mechanism of mucosal immune responses in the swine gut and try to boost the gut mucosal immunity (siga). Novel Control Strategies: Novel vaccines, adjuvants, and immunization strategies to acquire better mucosal immune responses for the prevention and control of swine enteric viruses. Our work model Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

High-consequence Swine viral diseases Research Team Research Interests Etiology and epidemiology Diagnostics and vaccine development Mechanisms of

36 High-consequence Swine viral diseases Research Team Research Interests Etiology and epidemiology Diagnostics and vaccine development Mechanisms of virus replication and virushost interactions Focus on: Classical swine fever Aujeszky s diseases African swine fever et al. Qiu huaji Ph.D, Professor

Swine Digestive System Infectious Diseases Research Team Research Interests Technology of the prevention and control Etiology and epidemiology Diagnostics and vaccine development Pathogenesis,

37 Swine Digestive System Infectious Diseases Research Team Research Interests Technology of the prevention and control Etiology and epidemiology Diagnostics and vaccine development Pathogenesis, mucosal immune mechanism immunology Focus on: TGE Transmissible gastroenteritis of pigs PED Porcine Epizootic Diarrhea PoRV Porcine rotavirus PCV2 Porcine Circovirus PPV Porcine parvovirus PTV Porcine teschovirus Feng Li Ph.D, Professor

Swine infectious diseases: reproductive disorders Porcine

virus (PRV), Classical swine fever virus (CSFV), Porcine Epidemic

Epidemiology and control strategies Development of DIVA vaccines

38 Swine infectious diseases: reproductive disorders Porcine reproductive and respiratory syndrome virus (PRRSV), Pseudorabies virus (PRV), Classical swine fever virus (CSFV), Porcine Epidemic Diarrhea virus (PEDV). Epidemiology and control strategies Development of DIVA vaccines and diagnosis Virus and host interaction Emerging swine diseases Dr. Guangzhi Tong Director-general Professor, Chief-scientist

Swine infectious diseases: respiratory diseases

co-infection Epidemiology and control strategies of

pleuropneumoniae (APP), Streptococcus suis

39 Swine infectious diseases: respiratory diseases Immune pathogenesis of respiratory viral-bacterial co-infection Epidemiology and control strategies of vector-born zoonosis (JE) Antibiotic resistance of bacteria, e.g. Haemophilus parasuis, Actinobacillus pleuropneumoniae (APP), Streptococcus suis Diagnosis of exotic diseases (Ebola virus, Rift Valley Fever) Dr. Zhiyong Ma Deputy Director Professor Chief-scientist

40 Viral Diseases AVIAN

41 Avian Viral Immunosuppressive Disease Research Team Research Interests Epidemiology research Pathogenic Mechanism Research Prevention and Control Technique Research Focus on: Infectious Bursal Disease Marek's Disease Avian Leukosis Wang Xiaomei Ph.D, Professor

Host-pathogen interaction and immunological bases of vaccination Focus on: Newcastle Diseases

42 Avian Respiratory Infectious Diseases Research Team Research Interests 1. Etiology and epidemiology research 2. Animal Disease prevention and control technology 3. Host-pathogen interaction and immunological bases of vaccination Focus on: Newcastle Diseases Avian Infectious Bronchitis Infectious Laryngotracheitis Important Viral Diseases of Water Fowl Liu Shengwang Ph.D, Professor

Waterfowl viral infectious diseases Molecular

virus (NDV) Diagnosis and novel vaccine for duck

for avian mycoplasmas (MG and MS) Innate immune

Virus-host interaction by different signal

43 Waterfowl viral infectious diseases Molecular pathogenesis and evolution of Newcastle disease virus (NDV) Diagnosis and novel vaccine for duck hepatitis virus (DHV) Pathogenesis and vaccine for avian mycoplasmas (MG and MS) Innate immune regulation of viral infections in waterfowls Virus-host interaction by different signal pathways Dr. Chan Ding Deputy Director Professor Chief-scientist

44 Viral Diseases EQUINE

Equine Infectious Diseases and Lentivirus Diseases Research Team Research Interests 1. The interaction between virus and host innate immune system 2.

45 Equine Infectious Diseases and Lentivirus Diseases Research Team Research Interests 1. The interaction between virus and host innate immune system 2. The pathogenesis and immune protection mechanism Wang Xiaojun Ph.D, Professor 3. Diagnostic, epidemiology and vaccine development of equine infectious diseases Focus on: Equine influenza Equine infectious anemia Other Equine infectious diseases

46 Bacterial Diseases

Bacterial Disease in Grazing Animal Team Main

Haemophilus parasuis Salmonella Mycoplasma

47 Bacterial Disease in Grazing Animal Team Main focus: Pathogenesis, vaccine, diagnostics for Haemophilus parasuis Salmonella Mycoplasma Synoviae Mycoplasma bovis Contagious caprine pleuropeunomia Inactivated vaccine for Contagious caprine pleuropeunomia Set up national standards for diagnosis and detection of CCPP Main deliver: Prof. Dr. Yongsheng Liu Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

48 Animal Bacterial Diseases Research Team 1. Animal Tuberculosis 2. Swine Respiratory Bacterial Diseases 3. Liu Siguo Ph.D, Professor Streptococcus Diseases 4. Food-born Bacteria Diseases 5. Drug Resistance and Drug Screening

49 Animal Mycoplasma Diseases Research Team Research Interests 1. Innate immune mechanism 2. Mechanism Research on animal pathogenic and Xin Jiuqing Ph.D, Professor attenuated mycoplasma 3. Diagnostic technology, epidemiology 4. Development of animal animal mycoplasma vaccine

Animal bacterial infectious diseases Pathogenesis, immune response and

of infection and intracellular survival of Brucella abortus Pathogenesis

Pathogenesis and control of Riemerella anatipestifer, Avian pathogenic,

50 Animal bacterial infectious diseases Pathogenesis, immune response and control of zoonotic, food-borne and animal pathogenic bacteria Mechanisms of infection and intracellular survival of Brucella abortus Pathogenesis and diagnosis of Salmenella, Vibrio parahaemolytieus and Streptocococcus Pathogenesis and control of Riemerella anatipestifer, Avian pathogenic, Escherichia coli and Avian Pasteurella multocida Dr. Shengqing Yu Professor Chief-scientist

51 Parasitic Diseases

Ectoparasites and Vector-Borne Diseases Team Main focus: Theileria, Babesia Anaplasma, lyme disease Ticks Bluetongue, BEF, BVD, Africa swine fever Prof. Dr.

52 Ectoparasites and Vector-Borne Diseases Team Main focus: Theileria, Babesia Anaplasma, lyme disease Ticks Bluetongue, BEF, BVD, Africa swine fever Prof. Dr. Hong Yin More than 100 species, strains or isolates of piroplasm Newly designated 3 Theilerias, T. sinensis, T. luwenshuni, T. uilenbergi Newly found but undesignated 2 Babesias, one from sheep and another from cattle Piroplasm collection and identification: Current study: Genome of Babesia, Theileria, Anaplasm Mechanism of Host-tick-babesia interaction Attenuated vaccine for T. annulata VLPs for Blue tone virus Biology and biocontrol of ticks Diagnostics and epidemiology for all the pathogens Piroplasms collection Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Parasitic Diseases of Livestock Team Main focus on Food-borne-parasitic zoonoses Toxoplasmosis Echinococcosis Fasciolosis Porcine Cysticercosis Prof. Dr. Xingquan Zhu Email: zhuxingquan@caas.

53 Parasitic Diseases of Livestock Team Main focus on Food-borne-parasitic zoonoses Toxoplasmosis Echinococcosis Fasciolosis Porcine Cysticercosis Prof. Dr. Xingquan Zhu Research area Sequencing and Annotation of the Genomes and Transcriptomes of Important Parasites Mitochondrial Genomics of Human and Animal Parasites Proteomics Studies of Parasites and Modulations of Host Proteome by Parasite Infection MicroRNAs of Parasites and Modulation of Host MiRNAomes by Parasite Infection CRISPR-Cas9 Technology for Genome Engineering Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Digestive Tract Infection and Mucosal Immunity of Swine and Poultry Team Parasitic disease

Jiangping Cai Phone: +86-931-8342580 E-mail: caijianping@caas.

CSFV: establishment of detection of serum antibody using ELISA.

54 Digestive Tract Infection and Mucosal Immunity of Swine and Poultry Team Parasitic disease Coccidiosis Develop attenuated vaccine Prof. Dr. Jiangping Cai Phone: Viral diseases PEDV: nanobodies against PEDV for development of serological diagnostics CSFV: establishment of detection of serum antibody using ELISA. PCV2: development of detection of IgG and IgM ELISA. Bacterial disease Clostridium CSFV total Ab and PCV2 IgM ELISA reagent kits Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

55 Animal Schistosomiasis National laboratory for animal Schistosomiasis prevention and control Epidemiology and control strategies of animal schistosomiasis Development of diagnosis methods to detect S. Japonicum Pathogenesis and vaccines of S. Japonicum Worm development and sexual maturation of S. Japonicum Dr. Guofeng Cheng Professor, Chief-scientist

Animal protozoon diseases Key Laboratory of

Agriculture China-Japan joint lab for animal

tick-borne protozoon diseases Vaccines for

56 Animal protozoon diseases Key Laboratory of Animal Parasitology of the Ministry of Agriculture China-Japan joint lab for animal protozoon diseases Biology on tick and tick-borne protozoon diseases Vaccines for chicken coccidiosis New diagnosis methods for trypanosomosis and crytosporidiosis Epidemiological studies on novel protozoon diseases Dr. Jinlin Zhou Professor Chief-scientist

57 Zoonotic Diseases

cn Present study: Development of vaccines and diagnostic tools Biology of these pathogens Proteomics of Trichinosis Main

58 Livestock and Poultry Zoonotic Diseases Team Main focus: Echinococcosis Trichinosis Brucellosis Chlamydiosis Prof. Dr. Baoquan Fu Present study: Development of vaccines and diagnostic tools Biology of these pathogens Proteomics of Trichinosis Main achievements: Commercialized vaccine for Chlamydiosis Set up national standard for Chlamydiosis diagnosis E. granulosus larvae in sheep livers Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Important Zoonoses and Exotic Diseases Research Team Research Interests Pathogenic microbe, vaccine and detection technology for zoonoses and exotic animal infectious diseases, Focus

59 Important Zoonoses and Exotic Diseases Research Team Research Interests Pathogenic microbe, vaccine and detection technology for zoonoses and exotic animal infectious diseases, Focus on: Rabies, Brucella, Japanese encephalitis, Peste des Petits Ruminants, Bluetongue, Raft Valley Fever, West Nile Fever, Nipah Diseases, Ebola, SARS, MERS, et al. Bu Zhigao Ph.D, Professor

60 Zoonosis of Natural Foci Research Team Research Interests Epidemiology, pathogenicity and immunology Molecular mechanism of pathogenisis of companion animals, wildlife, and insect vectors Research of preventive and diagnostic agents Qu Liandong Ph.D, Professor

Animal food-borne pathogens and food safety Biohazard Risk

fishes and shrimps) Development of novel vaccine for animal

61 Animal food-borne pathogens and food safety Biohazard Risk Assessment Laboratory of Quality & Safety for Animal Products (Shanghai) Detection of parasites in aquatic products (e.g. fishes and shrimps) Development of novel vaccine for animal parasitology (e.g Cryptosporidium) Biohazard risk assessment of quality & safety for animal products Dr. Zhaoguo Chen Professor Chief-scientist

62 Infectious diseases for small animals Molecular pathogenesis of rabbit hemorrhagic disease virus Pathogenesis, diagnosis and control strategies of canine distemper virus and canine parvovirus Detection methods of norwalk viruses Diagnosis and control coronavirus Dr. Guangqing Liu Professor Chief-scientist

molecular epidemiology The pathogenic mechanisms Infection and immunity mechanisms between host

63 Animal Disease Diagnostic Surveillance and Molecular Epidemiology Research Team Research Interests Establishment monitoring and early-warning technology platform Online variation and molecular epidemiology The pathogenic mechanisms Infection and immunity mechanisms between host and animal pathogen of mutant strain Focus on: Animal emerging infectious diseases Cai Xuehui Ph.D, Professor

Animal Virus Structure and Informatics Research Team Research Interests Virus and biological macromolecules structures Virus entry, assembly and release Viral

64 Animal Virus Structure and Informatics Research Team Research Interests Virus and biological macromolecules structures Virus entry, assembly and release Viral genomics and bioinformatics Epidemiology of infectious animal disease Focus on: EM & Cryo-EM Virome analysis Disease risk modeling Wang Jingfei Ph.D, Professor

65 Veterinary pharmaceutics

Veterinary pharmaceutics (IHPS, Lanzhou) Prevention and

new drugs such as traditional Chinese herbal medicine for

transcription, to searching for potential targets or

66 Veterinary pharmaceutics (IHPS, Lanzhou) Prevention and treatment of dairy cow disease Research and development of new drugs such as traditional Chinese herbal medicine for treating mastitis, reproductive diseases, calf disease and so on in dairy cows. Using techniques of proteomics, metabonomics, and transcription, to searching for potential targets or biomarkers. of cow disease. Gan Nai An Ru Yuan Kang Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

evaluation of TCVM Acupuncture and Evaluation of TCVM Fermentation of TCVM with the strain from animal

67 Veterinary pharmaceutics (IHPS, Lanzhou) Traditional Chinese Veterinary Medicine(TCVM) and Clinical Genome, proteomics and metabonomics of TCVM The Network Pharmacology of TCVM New drugs developing and safety evaluation of TCVM Acupuncture and Evaluation of TCVM Fermentation of TCVM with the strain from animal intestinal flora GMP Workshop for veterinary drugs Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Drug residues detection of antibiotics in animal products.

68 Veterinary pharmaceutics (IHPS, Lanzhou) Veterinary drug innovation and safety assessment Development of antiparasitic drug for sheep and cattle. Safety assessment of antiparasitic drug in food animals. Drug residues detection of antibiotics in animal products. Resistance mechanism and epidemiology of parasitosis in animal. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Veterinary Drug Evaluation Containing Pharmacology and Toxicology Study.

69 Veterinary pharmaceutics (IHPS, Lanzhou) Chemical Veterinary Pharmaceutics Drug Screen Method Study, Drug Design and Synthesis. Development of New Preparations for Animal Use. Veterinary Drug Evaluation Containing Pharmacology and Toxicology Study. Drug Pharmacokinetics and Metabolism Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Research on veterinary drug screening and preparation technology and related basic and

70 Veterinary pharmaceutics (IHPS, Lanzhou) Veterinary natural medicine Research on new efficient crude veterinary drug. Research on new veterinary drug preparations. Research on veterinary drug screening and preparation technology and related basic and applied research. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Research and discovery of new drugs including chemical, biochemical and traditional natural

71 Veterinary pharmaceutics (SVRI, Shanghai) Anti-parasitic, anti-bacterial, anti-viral and anti-fungal drugs. Research and discovery of new drugs including chemical, biochemical and traditional natural medicines. Synthesis of chemical drugs. Vaccine adjuvants and anti-bacterial peptides. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

Cooperation between EU and China on Animal Infectious Diseases and Zoonoses

Cooperation between EU and China on Animal Infectious Diseases and Zoonoses EU-China experts seminar on developing a joint initiative for cooperation in research and innovation on food, agriculture and biotechnologies (FAB), Beijing, 10-11 October, 2013 Cooperation between EU