UNIVERSITAS AIRLANGGA DIREKTORAT PENDIDIKAN Tim Pengembangan Jurnal Universitas Airlangga Kampus C Mulyorejo Surabaya

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2 EDITORIAL BOARD EDITORIAL BOARD OF DENTAL JOURNAL (MAJALAH KEDOKTERAN GIGI), January 2nd, 2014 December 31st, 2014 SK: 166/H3.1.2/KD/2014 January 2 nd, 2014 December 31 st, 2014 Chief Editor : Udijanto Tedjosasongko, drg., Ph.D.,Sp.KGA(K) (Department of Pediatric Dentistry Universitas Airlangga ) Editorial Boards : 1. Prof. Nairn Hutchinson Fulton Wilson, MSc. Ph.D., FDS. (Department of Conservative Dentistry - University of Guy s Dental School, London) 2. Prof. W.J. Spitzer, DMD., MD. (Department of Cranio & Oral Maxillofacial Surgery Hamburg University, Germany) 3. Prof. Edward C. Combe. M.Sc. Ph.D. D.D.Sc. (Department of Biomaterial Minnesota University, U.S.A) 4. Prof. Madya. H. AB. Rani Samsudin D.D.S., FDSRC, AM. (Department of Oral and Maxillofacial Surgery -University Science Malaysia, Malaysia) 5. Prof. Taizo Hamada, D.D.S., Ph.D. (Department of Prosthodontic - Tohoku University, Japan) 6. Prof. Yukio Kato, D.D.S., Ph.D. (Department of Oral Bio Chemistry-University of Hiroshima, Japan) 7. Prof. dr. A.G.M. Tielens (Department of Medical Microbiology and Infections Disease - Erasmus University Medical centre, Rotterdam, the Netherlands) 8. Prof. Lakshman Samaranayake (Department of Oral Microbiology The University of Hongkong) 9. Prof. Kozai Katsuyuki, DDS.,Ph.D. (Department of Pediatric - University of Hiroshima, Japan) 10. Prof. dr. A.G.M. Tielens (Department of Medical Microbiology - University and Infections Diseases - erasmus University Medical Centre, Rotterdam, The Netherlands) 11. Kok Van Kessel (Department of Medical Microbiology and Infections Disease - Erasmus University Medical centre, Rotterdam, the Netherlands) 12. Dr. Leslie Ang (Department of Restorative Dentistry National Dental Centre of Singapore) 13. Prof. Widowati Witjaksono, drg., Ph.D. (Kulliyah of Dentistry, International Islamic University Malaysia) 14. Prof. Dr. M. Suharsini, drg, M.S., Sp. KGA. (Department of Pediatric Dentistry - Universitas Indonesia) 15. Achmad Gunadi, drg, M.S., Ph.D. (Department of Prosthodontic Universitas Jember) Managing Editors : 1. Prof. Dr. M Rubianto, drg, M.S., Sp. Perio. (Department of Periodontic Universitas 2. Prof. Dr. Latief Mooduto, drg, M.S., Sp. KG. (Department of Conservative Dentistry Univ. 3. Prof. RM. Coen Pramono, drg., SU., Sp.BM(K) (Department of Oral and Maxillofacial Surgery - Univ. 4. Prof. Dr. Mieke Sylvia M. A. R., drg, M.S.,Sp.Ort. (Department of Ortodontic Univ. 5. Prof. Dr. Istiati, drg, M.S. (Department of Oral Pathology and Maxillofacial Univ. 6. Prof. Dr. Anita Yuliati, drg, M.Kes. (Department of Dental Material Univ. page 2 / 5

3 7. Prof. Seno Pradopo, drg, S.U., Ph.D. Sp. KGA. (Department of Pediatric Dentistry Univ. 8. Prof. Dr. Diah Savitri Ernawati, drg., M.Si. (Department of Oral Medicine Univ. 9. Prof. Thalca I. Agusni, drg, MHPEd. Ph.D.,Sp.Ort. (Department of Orthodontic Univ. 10. Dr. R. Darmawan Setijanto, drg.,m.kes. (Department of Dental Public Health Univ. 11. Dr. Elly Munadziroh, drg.,ms (Department of Dental Material Universitas 12. Ketut Suardita, drg., Ph.D., Sp.KG(Department of Conservative Dentistry-Univ. 13. Priyawan Rachmadi, drg, Ph.D. (Department of Dental Material Univ. 14. Dr. Retno Pudji Rahayu, drg., M.Kes. (Department of Oral Pathology and Maxillofacial Univ. 15. Dr. Eha Renwi Astuti, drg., M.Kes (Department of Dental Radiology Univ. 16. Bagus Soebadi, drg, MHPEd. (Department of Oral Medicine Univ. 17. Markus Budi Rahardjo, drg.,m.kes. (Department of Oral Biology Univ. 18. Dr. Susy Kristiani, drg., M.Kes. (Department of Odontology Forensic Univ. 19. Dr. Ira Widjiastuti, drg, M.Kes.Sp.KG. (Department of Conservative Dentistry Univ. 20. Sianiwati Goenharto, drg., M.S. (Department of Ortodontic Univ. 21. Devi Rianti, drg, M.Kes. (Department of Dental Material Univ. 22. Dr. Chiquita Prahasanti, drg.,sp.perio. (Department of Periodontic Univ. 23. Rostiny, drg.,m.kes.,sp.pros. (Department of Prosthodontic Univ. 24. An nissa Chusida, drg.,m.kes (Department of Odontology Forensic Univ. 25. Eric Priyo Prasetyo, drg., Sp.KG. (Department of Conservative Dentistry Univ. 26. Els Sunarsih Budipramana, drg., MS.,Sp.KGA.(K). (Department of Pediatric Dentistry Univ. 27. Dr. Hendrik Setiabudi, drg., M.Kes (Department of Oral Biology Univ. 28. Anis Irmawati, drg.,m.kes. (Department of Oral biology Univ. 29. Yuliati, drg.,m.kes. (Department of Oral Biology Univ. 30. Retno Palupi, drg.,m.kes. (Department of Dental Public Helath Univ. 31. Eka Augustina, drg.,sp.perio. (Department of Periodonsia Univ. 32. Febriastuti, drg.,sp.kg. (Department of Conservative Dentistry Univ. 33. Mega M. Puteri, drg.,sp.kga. (Department of Pediatric Dentistry Univ. Administrative Assistant : Novi Dian Prastiwi (Faculty of Dentistry Airlangga University) page 3 / 5

4 Table of Contents No Title Page 1 The role of calcium on enamel hypoplasia prevention The correlation of micronucleus formation and 8-oxo-dG expression due to the panoramic radiography exposure 0-0 page 4 / 5

5 Powered by TCPDF ( UNIVERSITAS AIRLANGGA Vol No. 3 / TOC : 2, and page : 0-0 The correlation of micronucleus formation and 8-oxo-dG expression due to the panoramic radiography exposure Korelasi antara jumlah mikronukleus dan ekspresi 8-oxo-dG akibat paparan radiografi panoramic Author : Rurie Ratna Shantiningsih rr_shantin@yahoo.com Department of Dentomaxillofacial, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta Indonesia Suwaldi - Faculty of Pharmacy; Universitas Gadjah Mada, Yogykarta Indonesia Indwiani Astut - Departement Pharmacology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta Indonesia Munakhir Mudjosemedi - Department of Dentomaxillofacial, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta Indonesia Abstract Background: The expression of 8-oxo-dG is defined as one form of damaged DNA occuring as the result of oxidation reaction due to X ray exposure. Panoramic radiography exposure has been widely known to be able to increase micronucleus which are signing the early stage and as biomarker in carsinogenesis mechanism. Purpose:The purpose of this research was to study the correlation between micronucleus number and 8-oxo-dG expression as a result of panoramic radiography exposure. Methods:Twelve New Zealand male rabbits aging 6 months were divided into 4 groups. Group I were rabbits that represented 0 day, group II represented 3th day, group III represented 6th day, and group IV represented 9th day after the panoramic radiography exposure. Respectively samples were swabbed at mandibular anterior gingival mucosa before and after the panoramic radiography exposure. The swabbed samples were coloured by using Feulgen-Rossenbeck staining for calculating the amount of micronucleus formation. Expression of 8-oxo-dG was detected using immunohistochemical of rabbit s gingival mucosa epithelium. Statistical analysis were carried out on pearson correlation. Results: There was a highest increasing of micronucleus on the 9th day after panoramic radiography exposure. Meanwhile, there was significant correlation (p=0,049) of the increasing amount of micronucleus and 8-oxo-dG expression in negatively correlation (r = -0,578). The increasing of micronucleus formation on the 9th day after panoramic radiography exposure was accordance with some previous studies. The expression score of 8-oxo-dG decreases as the day goes by. Conclusion:There was a correlation between the number of micronucleus and expression score of 8-oxo-dG. Keyword : Micronucleus, 8-oxo-dG, radiography, panoramic, exposure,, Daftar Pustaka : 1. Whaites E, (2002). Essentials of dental radiography and radiology. London : Churchill Livingstone Empty Fullpaper page 5 / 5