Danish Diabetes Academy

Transcription

1 Danish Diabetes Academy Summer School on Diabetes & Metabolism - Scientific Programme 3-6 September 2018 Sinatur Hotel Gl. Avernæs Helnæsvej 9, DK-5631 Ebberup

2 Session overview Day 1 Monday 3 September Session I Welcome and Tissue Cross Talk Session II NASH Poster session I Posters no (PI: 1-26) Day 2 Session III Session IV Tuesday 4 September Fetal Programming Precision Medicine Day 3 Wednesday 5 September Session V Metabolism and the Brain Workshop A-F Poster session Il Posters no (PlI: 1-26) Day 4 Session VI Thursday 6 September Insulin Receptors

3 Programme Monday 3 September 09:45 10:30 Check-in and mounting of posters Session I Welcome and Tissue Cross Talk Chair: Professor Louise Dalgaard and Professor Jørgen Wojtaszewski :45 Welcome and introduction Professor Torben Hansen, the NNF Center for Basic Metabolism, University of Copenhagen 10:50 11:20 Action of exosomes in type 1 diabetes Professor Claudiane Guay, University of Lausanne 11:20 11:40 Questions/ discussion 11:45 12:15 Role of extracellular vesicles in tissue cross talk during exercise Professor Mark A Febbraio, Garvan Institute of Medical Research 12:15 12:30 Questions/ discussion 12:30 13:30 Lunch break Session II Nonalcoholic Steatohepatitis (NASH) Chair: Professor Nils Færgeman and Professor Torben Hansen 13: Student presentation (Oll-1): Molecular characterization of steatosis compartments in a diet-induced mouse model of nonalcoholic fatty liver disease PhD stud. Maria Baandrup Kristiansen, University of Copenhagen

4 14: Student presentation (OII-2): Investigating the mechanisms behind thyroid hormone receptor mediated transcriptional regulation Stine M. Præstholm, University of Southern Denmark Fatty liver diseases: The next frontier in clinical hepatology Professor Aleksander Krag, Odense University Hospital Questions/ discussion 15:15 15:30 Coffee break 15:30 16:05 Targeting a Ceramide Double Bond to treat NAFLD/NASH Professor Scott Summers, the University of Utah 16:05 16:25 Questions/ discussion 16:30 17:30 Reflection & discussion Reflection & discussion in groups on the 3 most important issues from previous presentations 17:30 17:45 Short break 17:45 18:10 One-minute poster presentations/ teasers Chair: Rasmus Kjøbsted, University of Copenhagen 18:10 19:10 Poster session I (PI: 1-23) 19:30 Dinner (groups)

5 Programme Tuesday 4 September 07:00 08:30 Morning exercise and breakfast Session III Fetal programming Chair: Professor Louise Dalgaard and Professor Dorte Møller Jensen 08:30 09:00 Of Mice and Men: epigenomics in type 2 diabetes Professor and Associate Director Rebecca A Simmons, Center for Research, Reproduction and Women's Health, University of Pennsylvania School of Medicine 09:00 09:20 Questions/ discussion 09:25 09:55 Metabolic risk and cognitive function in offspring of women with diabetes during pregnancy MD, PhD Tine Dalsgaard Clausen, University of Copenhagen and Nordsjælland Hospital 09:55-10:15 Questions/ discussion 10:15 10:30 Coffee break 10:30 10:50 Student presentation (Olll-1): Body mass index growth in early life and cardiometabolic markers and body composition at 5 years of age a latent class trajectory analysis Rasmus Wibæk Christensen, University of Copenhagen 10:55-11:15 Student presentation (Olll-2): Nampt-mediated nad+ biosynthesis is indispensable for adipose tissue plasticity and development of obesity Karen Nørgaard Nielsen, University of Copenhagen 11:15-13:30 Free time and Lunch break Session IV Precision Medicine Chair: Professor Louise Dalgaard & Professor Torben Hansen

6 13:30-13:50 Student presentation (OIV-1): Lower Insulin Sensitivity in Patients With High Bone Mass due to a LRP5T253I mutation Jens-Jacob Lauterlein, University of Southern Denmark 13:55-14:25 The many faces of diabetes - steps towards precision medicine Professor and principal Investigator Leif Groop, Lund University 14:25-14:45 Questions/ discussion 14:50-15:20 How Will Precision Medicine Change the Pharmaceutical/Biotech Industry PhD Joseph Grimsby, MedImmune, LLC 15: Questions/ discussion 15:40-16:00 Coffee break 16:00 17:00 Reflection & discussion 17:00 18:00 Time off Reflection & discussion in groups on the 3 most important issues from previous presentations & prepare three questions from the plenary session coming up 18:00 19:25 Plenum debate precision medicine 19:30 Dinner Facilitator: Bjørn Quistorff, University of Copenhagen Professor Leif Groop PhD Joseph Grimsby

7 Programme Wednesday 5 September 07:00 08:30 Morning exercise and breakfast Session V Metabolism and the Brain Chair: Professor Louise Dalgaard, Professor Dorte Møller Jensen 08:30 09:00 Effects of Human Brain Insulin Sensitivity on Metabolism and Behavior Professor, Dr. Hubert Preißl, Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen 09:00-09:20 Questions/ discussion 09:25-09:55 Dysregulated Metabolism in the Pathogenesis of Alzheimer s Disease: Type 3 Diabetes Professor, Suzanne De La Monte, Department of Pathology and Medicine, Pierre Galletti Laboratories 09:55-10:15 Questions/ discussion 10:15:10:45 Coffee break 10:45 11:05 Student presentation (OV-1): Follistatin overexpression improves insulin action in skeletal muscle Xiuqing Han, University of Copenhagen 11:05 11:25 Student presentation (OV-2):Uncovering the transcriptional network controlled by lipolysis in brown adipocytes Lasse Kruse Markussen, University of Southern Denmark 11:05 11:35 One-minute poster presentations/teasers Chair: Janne Hingst, University of Copenhagen (KU) 11:55 13:30 Lunch break/ poster lunch (Pll: 1-26) 13:30 15:30 6 table challenge Discussion of questions/challenges in small groups

8 Workshop A What can metabolomics analyses of beta-cells and islets reveal about islet dysfunction in type 2 diabetes? Professor, Principal Investigator Hindrik Mulder, Lund University Workshop B Understanding a bug s life in the fat land Associate Professor, Anandwardhan A. Hardikar, University of Sydney Workshop C Decoding obesity - Long noncoding RNAs and Metabolic Disease Professor Jan-Wilhelm Kornfeld, University of Southern Denmark Workshop D Revisiting dogmas of type 2 diabetes-insulin resistance and hyperglycemia: foes or friends? Professor Marc Prentki, Department of Medicine, McGill University Workshop E Research Similarities & Differences in Academia versus Industry: Considerations for Starting your own Biotech Company Vice President Chris Rhodes & PhD Joseph Grimsby, Medimmune LLC Workshop F Comparing Apples and Oranges 15:30 16:00 Coffee break Director Chittaranjan Yajnik, KEM Hospital, Pune, India 16:00 17:00 Afternoon tea with a brain Network with a senior researcher to talk about their research and career paths. Show up at the meeting point - the coffee buffet outside the plenum room - where an overview of the scheduled professors will be displayed. 17:00 18:30 Finishing your challenge group work and/ or time off 18:30 19:00 Pre-dinner drinks 19:00 Galla dinner

9 Programme Thursday 6 September 07:30 09:30 Morning exercise and breakfast 09:30 10:15 Follow-up on 6 Table Challenge 10:15 10:35 Jeopardy 10:35 10:50 Coffee break The PIs will present the findings of the different groups from the 6 Table Challenge Online game in plenary session Session VI Insulin receptors Chair: Torben Hansen and Nils Færgeman 10:50 11:20 Regulation of peripheral insulin sensitivity by the T2DM susceptibility gene SORCS1 Professor Anders Nykjær, Aarhus University 11:20 11:40 Questions/ discussion 11:45 12:30 The insulin receptor: structure, mechanism of activation and downstream signalling Professor Pierre De Meyts, Visiting Professor, de Duve Institute 12:30 12:50 Questions/ discussion 12:50 13:00 Closing remarks 13:00 Lunch-to-go 13:30 Bus transportation to Odense Central Station

10 Organisers Scientific Programme Professor Torben Hansen, University of Copenhagen Professor Jørgen Wojtaszewski, University of Copenhagen Professor Nils Færgeman, University of Southern Denmark Professor Dorte M. Jensen, University of Southern Denmark Professor Louise T. Dalgaard, Roskilde University Professor Peter Vestergaard, Aalborg University Coordinator Education and Networking Coordinator, Helle Elisabeth Lyngborg, Danish Diabetes Academy

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