On Translational Heart Failure Research

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1 HFA WINTER MEETING On Translatinal Heart Failure Research Organized by the Heart Failure Assciatin and the Wrking Grup n Mycardial Functin f the Eurpean Sciety f Cardilgy Les Diablerets, Switzerland January 24 th -27 th, 2018 COORDINATOR: Prf. Rudlf de Ber (NL) Chair f the Basic Science sectin f the HFA T imprve quality f life and lngevity, thrugh better preventin, diagnsis and treatment f heart failure, including the establishment f netwrks fr its management, educatin and research.

2 PRELIMINARY PROGRAMME 08:00 08:10 Welcme t Heart Failure Winter Meeting R.A. De Ber (NL) 08:10 09:50 The hidden secrets f lngevity J-S. Hult (FR) T. Eschenhagen (DE) Cardivascular effects f spermidine. F. Made (AT) Lessns frm a survivr: the naked mle rat G. Lewin (DE) Are adult cardiac stem cells incmpetent? S. Sassn (FR) The redx regulatin f heart regeneratin H. A. Sadek (US) 10:20 Heart and brain, spleen, kidney insights int neur-hrmnal-inflammatry activatin in heart failure Brain and kidney in heart failure - The clinical prblem Linking heart and brain - Mycardial infarctin and left ventricular remdeling assciated with neurinflammatin Heart brain kidney netwrk cntrls adaptatin t cardiac stress thrugh tissue macrphage activatin Cardi-splenic interactin - T cells in mycardial remdelling and aging J. Bauersachs (DE) J-L. Balligand (BE) A. Cats (GB) F. M Bengel (DE) I. Manabe (JP) U. Hfmann (DE) 16:15 17:45 Special wrkshp f the Wrking Grup f Mycardial Functin: tward standards fr the use f US imaging in cardivascular medicine M. Giacca (IT) Ines Falca (PT) Needs and pprtunities t imprve pre-clinical US imaging in cardivascular medicine S. Zacchigna (IT) Use f US imaging in translatinal medicine S. Batkai (DE) What can we learn frm clinical echcardigraphy? P. Lancelltti (BE) Cardivascular US imaging: where are we ging? C. De Krte (NL)

3 17:30 19:45 Pster Sessin Jury D. Dawsn (UK) L. Hein (DE) L. Van Laake (NL) T. Pedrazzini (CH) M. Sterba (CZ) M. Mayr (UK) A. Lyn (UK) L. de Windt (NL) J. van der Velden (NL) N. Hamdani (DE) 08:00 09:40 The cardiac extracellular matrix: beynd a structural scafflding A. Gnzalez Mique (ES) T. Thum (DE) The ever increasing imprtance f fibrsis B. Blaxall (US) Electrical cnnexin between fibrblasts and cardimycytes P. Khl (DE) Paracrine effects f fibrblasts: the plasma membrane calcium ATPase 4 signalling in cardiac D. Oceandy (GB) fibrblasts mediates cardimycyte hypertrphy Matrix as an interstitial transprt system E. Creemers (NL) 11:10 11:50 Frm RNA t prteins - New translatinal cntrl mechanisms J. Backs (DE) E. Van Rij (NL) mrna methylatin as a nvel driver f cardiac hypertrphy F. Accrner (US) RNA binding prteins as regulatrs f translatinal efficiency M. Velkers (DE) RNA editing in endthelial cntrl K. Stells (DE) Lcalized translatin in the sarcmere I. Kehat (IL) 16:45 17:30 Brutsaert Lecture D. Hilfiker-Kleiner (DE) - G. Hasenfuss (DE) 17:30 18:15 Special Lecture David Kass (US) - cgmp/pkg Signaling in the Failing Heart: New Targets and New Therapy Optins C-G. Tcchetti (IT)

4 08:30 10:05 The immune system in cardiac health and disease The quest fr new appraches in mycarditis and Inflammatry cardimypathy T cell cstimulatin blckade blunts pressure verlad-induced heart failure Macrphages facilitate electrical cnductin in the heart Identificatin f a prstaglandin E-induced inflammatry pathway that activates the mycyte enhancer factr 2 in cardiac mycytes. R.T. Smlenski (PL) A. Shah (GB) S. Heymans (NL) G. Cndrelli (IT) M. Nahrendrf (US) A. Tóth (HU) 10:25 Atrial fibrillatin and heart failure: cmmn pathways I-G. Lunde (NO) C. Maack (DE) Atrial fibrillatin and heart failure: clliding epidemics D. Ktecha (GB) Fibrsis S. Nattel (CA) The inflammasme in AF N. Li (US) Calcium signaling in AF D. Dbrev (DE) 12:10 Clsing sessin R.A. De Ber (NL) A. Cats (UK) F. Ruschitzka (CH) P. Sefervic (SRB) S. Bilinski (PL) Clinical Discussants M. Lainscak (SL) S. Frantz (DE) Antni Bayes-Genis (ES)

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