Resume. Professional Fellowships. Committee of animal model, Chinese Laboratory Animal Association, China

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1 Resume Name: Liu Xinmin Designation: Professor(Neuro-pharmacology); WHO Advisor on Traditional Medicine Professional: Neuro-pharmacology, safety evaluation on medicinal plants; experimental methodology for Behavioral Neuro-pharmacology, as well as innovative research strategy for TCM (Traditional Chinese Medicine) modernization and globalization. Institution: Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) /Peking Union Medical College(PUMC), Beijing, China. Contact information: Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Science, Ma Lianwao, Xibeiwang, Haidian District, Beijing, , China Telephone: Professional Fellowships Chairman 2015-now Committee of animal model, Chinese Laboratory Animal Association, China Executive General Secretary 2014-now China Laboratory Animal Industry and Technology Innovation Strategy Alliance, China Deputy General Secretary 2009-now Committee of Chinese Meterial Medica, World Federation of Chinese Medicine Association Member, 2008-now Advisory Panel on Traditional Medicine, World Health Organization(WHO) 1

2 Consultant &Advisor 2003-now State Administration of Traditional Chinese Medicine, China. EDUCATION & TRAINING Bachelor of Med. Science Hunan Medical University, Changsha, China Master of Medicine (Pharmacology in TCM) Peking Union Medical College, Beijing, China, 1991 Doctor of Medicine (Pharmacology in TCM) Peking Union Medical College, Beijing, China, 1996 WORK EXPERIENCE Dec now Pharmacology Professor on herbal medicine Institute of Medicinal Plant Development, Chinese Sciences/Peking Union Medical College, Beijing, China Academy of Medical Chief scientist Hunan Animal Experimental Center/Hunan Drug Safety Evaluation Center, Changsha, Hunan Province, China Adjunct Prof(Pharmacology on herbal medicine) Hunan University of Traditional Chinese Medicine, Changsha, Hunan Province, China Adjunct Professor(animal behavior experiment) Chinese Astronaut Center, Beijing, China Screening new drugs and health products from herbs for improving learning and memory deficiency, depression, anti-fatigue with mice and rats in vivo and in vitro. Developing techniques for evaluating animal behavior activities, based on computer-vision technology, with high degree of automation and intelligence Guiding foreigner students from Pakistan how to evaluate efficacy and safety on 2

3 herbal plants, based on animal behavior experiments. April,2015 Nov Consultant World Health Organization(WHO), Geneva, Switzerland Developing WHO technical document on interaction of herbal medicines with other medicines, as well as WHO guidelines on good processing practice on election of substance of herbal origin for quality control of herbal medicines. Organizing WHO workshop related on traditional medicine in different countries, under support from WHO regional offices. March, 2013-March, 2015 Professor( Pharmacology) & Deputy Director Academic Committee, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China Chief scientist Hunan Animal Experimental Center/Hunan Drug Safety Evaluation Center, Changsha, Hunan Province, China Adjunct Prof(Pharmacology on herbal medicine) Hunan University of Traditional Chinese Medicine, Changsha, Hunan Province, China Adjunct Professor(animal behavior experiment) Chinese Astronaut Center, Beijing, China Evaluation efficacy and safety of herbal plants on improving learning and memory deficiency, depression, anti-fatigue with mice and rats in vivo and in vitro. Developing methodology for detecting animal behavior activities, based on computer-vision techniques, with high degree of automation and intelligence. Establishing animal models related to neuropsychiatric disorders, as well as cognitive and emotional dysfunction induced by simulated weightlessness, electromagnetic radiation in rats and mice. March, 2009-March, 2013 Professor( Pharmacology) & Deputy Director Academic Committee, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China 3

4 Adjunct Professor(animal behavior experiment) Chinese Astronaut Center, Beijing, China Evaluation efficacy and safety of herbal plants on improving learning and memory deficiency, depression, anti-fatigue with mice and rats in vivo and in vitro. Developing methodology for detecting animal behavior activities, based on computer-vision techniques, with high degree of automation and intelligence. Establishing animal models related to neuropsychiatric disorders, as well as cognitive and emotional dysfunction induced by simulated weightlessness, electromagnetic radiation in rats and mice. Guiding foreigner students from Pakistan, Peru and Luxemburg how to evaluate efficacy and safety of herbal plants, based on animal behavior experiments. Drafting national policy, plan of modernization and globalization of Traditional Chinese medicine, which was organized by Ministry of Science & Technology, Ministry of Health and State Administration of Traditional Chinese medicine of China. March, 2003-March, 2009 Pharmacology Prof. & Director Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China Researching on neuro- pharmacology, anti-cancer with Chinese herbs. Guiding foreigner students from Pakistan, Belgium and Peru how to evaluate efficacy and safety on herbal plants. Screening new drugs for improving learning and memory deficiency, depression, anti-cancer from Chinese herbs with mice and rats in vivo and in vitro. Drafting national policy, plan of modernization and globalization of Traditional Chinese medicine, which was organized by Ministry of Science & Technology, Ministry of Health and State Administration of Traditional Chinese medicine of China. March,1998 March 2003 Researcher Department of Pharmacology and Toxicology, Zayed Complex for Herbal Research & Traditional Medicine Ministry of Health, Abu Dhabi, UAE Setting up the neuro-pharmacological labs. Screening analgesic, sex tonic, anti-inflammatory, hepato-protective and 4

5 gastrointestinal motility drugs from Arab herbs in mice and rats. Safe evaluation of herbal products imported to UAE. Guiding and supervising local staff and students on herbal research and safe evaluation. March, 1997 March,1998 Pharmacology Prof. & Director Department of Pharmacology, Institute of Medicinal Plant Development, Chinese Academy of Medical Science &Peking Union Medical College, P.R. China Screening 20 Chinese herbs for improving learning and memory in mice and rats. Toxicological study and safety evaluation of medicinal plants and herbal decoction on dogs, rats and mice. Drafting national policy, plan of modernization and globalization of Traditional Chinese medicine, which was organized by Ministry of Science & Technology, Ministry of Health and State Administration of Traditional Chinese medicine of China. Aug.,1991-March, 1997 Associate Prof.& Deputy Director Department of Pharmacology, Institute of Medicinal Plant Development, Chinese Academy of Medical Science &Peking Union Medical College, P.R. China Develop the methodology for efficacy evaluation of herbal medicine based on behavioral pharmacology with animal models(memory deficiency, depression, Cerebral ischemia etc.,) with higher degree of automation and intelligent. Screen more than 40 Chinese herbal extracts, components with computer-aided and real-time image analyzing systems. Designing and organize international cooperative programme and project on herbal research, as well as write, edit and summary experimental report. Drafting national policy, plan of modernization and globalization of Traditional Chinese medicine, which was organized by Ministry of Science & Technology, Ministry of Health and State Administration of Traditional Chinese medicine of China. Aug., 1994-Aug.,1991 Assistant Researcher Department of Pharmacology, Institute of Medicinal Plant Development, Chinese Academy of Medical Science &Peking Union Medical College, P.R. China 5

6 Screening and developing new drugs on general tonic, anti-inflammatory, sedative, memory enhancement from Chinese herbs. Toxicological study and safety evaluation with medicinal herbal products on dogs, rats and mice. Other Achievement Organize 2st technical consultation on Improving Data of Traditional Medicine for Western Pacific Region, WHO, as coordinator, in Oct, 2014 Give the presentation on herbal medicine in the international conference as key speaker, which were organized by WHO regional office, international academic association, government agency, etc. More than 20 grants on herbal research have been funded by Chinese government agency, EU FP7 in the past 20 years. International cooperation with University of British Columbia, Canada, Karachi University of Pakistan, and the Centre de Recherche Public de la Santé, Luxembourg on herbal plants Government dossier (as one of principal members) Guideline for Evaluation and Registration about new drugs from Chinese Material Medica. (SATCM, SFDA, China.2007) International Traditional Chinese Medicine Program for Cooperation in Science and Technology (MOST, MOH, SATCM.2006) Guidelines for international cooperation and exchange of Traditional Chinese Medicine ( SATCM.2004) Global Strategy for Chinese Material Medica industry (Develop Center of State Council, MOST, SATCM.2003) National Strategy for Modernization of Traditional Chinese Medicine (MOST, SATCM.2003,1998) Outline of Traditional Chinese Medicine Innovation and Development Plan ( ). Books& Monographs Monograph for toxicity of Chinese Material Medica(Executive editor, 2007) Global Survey Report About Traditional Chinese Medicine (Executive editor, 2006) Introduction about herbal rules &Regulations in European Union(member, Editorial Board, 2005) Survey report about China bio-industry(member, Editorial Board, 2004) Modernization of Chinese Material Medica (Executive editor, 1998) More than 100 academic papers on herbal research have been published in the 6

7 international journals List of some papers published in the past 5 years 1. Haixia Dang Qiong Wang Hainan Wang Ming Yan Xinmin Liu*. The Integration of Chinese Material Medica into the Chinese Health Care Delivery System, an Update Phytotherapy Research ( IF:2.65) 2. Li Feng, Hong-wei Wu, Guang-qing Song, Cong Lu, Ying-hui Li, Li-na Qu,Shan-guang Chen, Xin-min Liu, Qi Chang. Chronical sleep interruption-induced cognitive decline assessed by a metabolomics method. Behavioural Brain Research 302 (2016) IF: Z Shi, C Lu, XP Sun, Q Wang, SG Chen, YH Li, LN Qu, LL Chen, LL Bu, DF Liao, XM Liu*. BMC Complementary and Alternative Medicine 2015, Mar, doi: /s (if:1.88) 4. YM Liu, ZY Li, H Han, SP Xu, Q Chang, RH Liao, RL Pan*, XM Liu*. Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25 35 peptides in vitro and in vivo. Pharmacology, Biochemistry and Behavior. 2015,128: ( IF:2.532) 5. FB Xia, Y Zhong, MQ Li, Q Chang, YH Liao, XM Liu*, RL Pan*. Antioxidant and Anti-Fatigue Constituents of Okra. Nutrients. 2015,7, (IF:3.27). 6. G Zhen, L Zhang, XM Liu, Q Chang, XW Deng, M Xia. De novo assembly and comparative analysis of root transcriptomes from different varieties of Panax ginseng C. A. Meyer grown in different environments. Science China Life Sciences. 2015,58, YM Jiang, ZY Li, YM Liu, XM Liu, Q Chang, YH Liao, RL Pan. Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms.journal of Ethnopharmacology. 2015,159, (IF:3.0) 8. L Gao, XM Peng, SX Huo, XM Liu, M Yan. Memory Enhancement of Acteoside (Verbascoside) in a Senescent Mice Model Induced by a Combination of D-galand AlCl3. PHYTOTHERAPY RESEARCH. 2015, 29(8): (IF:2.66) 9. XM Peng,LGao,SX Huo, XM Liu,M Yan. The Mechanism of Memory Enhancement of Acteoside (Verbascoside) the Senescent Mouse Model Induced by a Combination of D-gal and AlCl3. PHYTOTHERAPY RESEARCH. 2015, 29(8): (IF:2.66) 10. Elizabeth M, Williamson, Kelvin Chan, Qihe Xu, Amandine Nachtergael, Valérian Bunel, L Zhang, Moustapha Ouedraogo, Joëlle Nortier, F Qu, Debbie Shaw, XM Liu,Caroline Stévigny, Joseph Kahumba, Olavi Pelkonen, Pierre Duez. Evaluating the safety of herbal medicines: Integrated toxicological approaches. Science. 2015,347(17): MZ Yan, Q Chang, Y Zhong, BX Xiao, L Feng, FR Cao, RL Pan, ZS Zhang, YH Liao, XM Liu*. Lotus Leaf Alkaloid Extract Displays Sedative-Hypnotic and Anxiolytic Effects through GABAA Receptor. J AGRIC FOOD CHEM. 2015,63(4): (IF: 2.94) 12. J Zhou, M Zhou, FF Yang, CY Liu, RL Pan, Q Chang, XM Liu, YH Liao. Involvement of the Inhibition of Intestinal Glucuronidation in Enhancing the Oral Bioavailability of Resveratrol by Labrasol Containing Nanoemulsions. MOLECULAR PHARMACEUTICS. 2015,12: in 7

8 (IF:4.38) 13. Q Wang, BX Xiao, RL Pan, XM Liu, YH Liao, L Feng, FR Cao, Q Chang. An LC-MS/MS method for simultaneous determination of three Polygala saponin hydrolysates in rat plasma and its application to a pharmacokinetic study. Journal of Ethnopharmacology. 2015,169(6): ( IF:3.0) 14. YM Liu, ZY Li, H Han, SP Xu, Q Chang, RH Liao, RL Pan, XM Liu*. Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25 35 peptides in vitro and in vivo. Pharmacology, Biochemistry and Behavior.2015,128:14-22.( IF:2.532) 15. Haixia Dang, Xiuping Sun, Qiong Wang, Yonghong Liao, Ying Chen, Yi Wang, Lei An, Qi Chang, Ruile Pan, Yihua Sheng, Shanguang Chen, Xinmin Liu*.[Traditional Chinese Medicine A Potential Countermeasure to Stressors Associated with Space Missions] in Human Performance in Space: Advancing Astronautics Researh in China, Science/AAAS, Washington, DC, 2014,p.[21-23]. 16. Zhe Shi, Qiong Wang, Sidi Li, Haixia Dang, Xiuping Sun, Yonghong Liao, Guangqing Song, Cong Lu, Kezhu Wang, Heng Zhang, Shanguang Chen, Xinmin Liu*, [Animal behavior assessment technology for space medicine] in Human Performance in Space: Advancing Astronautics Researh in China, Science/AAAS, Washington, DC, 2014, p. [32-34]. 17. X Hu, FF Yang, LH Quan, CY Liu, XM Liu, YH Liao.Pulmonary delivered polymeric micelles Pharmacokinetic evaluation and biodistribution studies. European Journal of Pharmaceutics and Biopharmaceutics.2014,88: (IF:4.269) 18. YM Liu, SN Shen, ZY Li, YM Jiang, JY Si, Q Chang, XM Liu, RL Pan,.Cajaninstilbene acid protects corticosterone-induced injury in PC12 cells by inhibiting oxidative and endoplasmic reticulum stress-mediated apoptosis. Neurochemistry International.2014,78: (IF:2.857) 19. XM Liu, Q Wang, GQ Song, GP Zhang, ZG Ye, Elizabeth M. Williamson. The Classification and Application of Toxic Chinese Materia Medica. Phytotherapy Research, 2014,28: (IF:2.086) 20. XP Sun, Z Shi, RL Pan, C Qin, YL Zhang, YH Li, LN Qu, TF Li, XM Liu*. Antidepressant-like effects and mechanism of action of SYG in depression model in rats. Neuroendocrinology Letters, 2014, 35(2): (IF:1.296) 21. LH Ye, XX He, LT Kong, YH Liao, RL Pan, BX Xiao, XM Liu, Q Chang. IdentificationandcharacterizationofpotentCYP2D6inhibitorsinlotusleaves. Journal of Ethnopharmacology, 2014,153: (IF:3.014) 22. Li, Zongyang; Liu, Yamin; Wang, Liwei; Liu, Xinmin; Chang, Qi; Guo, Zhi; Liao, Yonghong; Pan, Ruile; Fan, Tai-Ping. Memory-Enhancing Effects of the Crude Ex tract of Polygala tenuifolia on Aged Mice. Evidence-Based Complementary and Alt ernative Medicine, 2014(1), pp 1-11,.(IF:2.801) 23. Wang HM, Wang LW, Liu XM*. Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone(samp8) mice. Pharmacology,Biochemistry and Behavior. 2013;105: ISSN: IF: Shi Z, Chen LL, Liu XM*, et al,. Chronic scopolamine-injection-induced cognitive deficit on reward-directed insrumental learning in rats is associated with CREB signaling activity 8

9 in the cerebral cortex and dorsal hippocampus. Psychopharmacology 2013 May 12;230: ISSN: IF: Li SD, Shi Z, Liu XM*, et al,. Assessing gait impairment after permanet middle cerebral artery occlusion in rats using an automated computer-aided control system.behavioural Brain Research (250): ISSN: IF: Sun XP, Li SD, Liu XM*, et al,. Antidepressant-like effects and memory enhancement of herbal formula in mice exposed to chnonic mild stress. Neuroscience Bulletiu 2012 Dec;29(6): ISSN: IF: Chen Y, Liu XM, Pan RL, et al,. Intestinal Transport of 3,6 -Disinapoylsucrose,A Major Active Component of Polygala tenuifolia,using Caco-2 Cell Monolayer and In Situ Rat Intestinal Perfusion Models. Planta Med 2013;79: ISSN: IF: Li ZY, Guo Z, Liu XM, et al,.neuroprotectiveeffectsoftotalsaikosaponinsof Bupleurum yinchowense on corticosterone-inducedapoptosisinpc12cells. J Ethnopharmacol May 18;148: ISSN: IF: Kong LT, Wang Q, Liu XM, et al,. Different pharmacokinetics of the two structurally similar dammarane sapogenins, protopanaxatriol and protopanaxadiol, in rats. Fitoterapia Feb 4;86: ISSN: X.IF: Shi Z, Sun X, Liu X*, Chen S, Chang Q, Chen L, Song G, Li H. (2012). Evaluation of an Aβ induced cognitive deficit in rat using a reward-directed instrumental learning task. Behavioural Brain Research (IF:3.417), 234(2): Zhang L, Yan J, Liu X, Ye Z, Yang X, Meyboom R, Chan K, Shaw D, Duez P. Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China: Current status and future perspective. J Ethnopharmacol Apr 10;140(3): Bo Peng, Qin Hu, Lihua Sun, Xinmin Liu*, Jianrong Li, Qi Chang, Liwei Wang, Jintian Tang.Duchesnea Phenolic Fraction Inhibits Tumor Growth through Restoring the Th1/Th2 Balance in U14 Cervical Cancer Bearing Mice.Chinese Medicine.Vol.3 No.1, Xiuping Sun,Zhe Shi,Tengfei Li,Ruile Pan,Xinmin Liu*,Lanlan Bu,Lingti Kong,Qi Chang.Antidepressant-like effects of total saikosaponins of Bupleurum yinchouense in mice.2012 April 2:6(26): Journal of Medicinal Plants Research. 34. Xu SP, Yang YY, Xue D, Liu JX, Liu XM*, Fan TP, Pan RL, Li P. ( 2011 ).Cognitive-enhancing effects of polygalasaponin hydrolysate in aβ(25-35)-induced amnesic mice. Evid Based Complement Alternat Med. (IF :4.774) 35. Yanyan Yang,Shuping Xu, Liu XM*,Yue Gao, Andre Steinmeti,Ning Wang,Tianshan Wang and Guosong Qiu.Protective effect of Dammarane Sapogenins against Chemotherapy-induced myelosuppression in mice. Experimental Biology and Medicine.2011 Jun 1,236: Nicholson RA, David LS, Pan RL, Liu XM. (2010). Pinostrobin from Cajanus cajan (L.) Millsp. inhibits sodium channel-activated depolarization of mouse brain synaptoneurosomes. Fitoterapia. (IF: 1.848), 81(7): Hu Q, Pan R, Wang L, Peng B, Tang J, Liu X*. (2010) Platycodon grandiflorum induces apoptosis in SKOV3 human ovarian cancer cells through mitochondrial-dependent pathway. Am J Chin Med. (IF: 1.979), 38(2):

10 38. Qu L, Chen H, Liu X, Bi L, Xiong J, Mao Z, Li Y. Protective effects of flavonoids against oxidative stress induced by simulated microgravity in SH-SY5Y cells. Neurochem Res Sep;35(9): Sun L, Wang Q, Liu X*, Brons NH, Wang N, Steinmetz A, Lv Y, Liao Y, Zheng H. Anti-cancer effects of 20(S)-protopanoxadiol on human acute lymphoblastic leukemia cell lines Reh and RS4;11. Med Oncol Sep;28(3): Epub 2010 Mar Rubio J, Qiong W, Liu X*, Jiang Z, Dang H, Chen SL, Gonzales GF. (2011). Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice. Evid Based Complement Alternat Med.(IF :4.774)2011: An L, Zhang YZ, Liu XM*, Yu NJ, Chen HX, Zhao N, Yuan L, Li YF. (2011). Total flavonoids extracted from Xiaobuxin-Tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. Evid Based Complement Alternat Med.(IF :4.774)2011: Wang Q, Sun LH, Jia W, Liu XM*, Dang HX, Mai WL, Wang N, Steinmetz A, Wang YQ, Xu CJ. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytother Res Dec;24(12): Wei Wang, Qing-Ping Liao, Li-Hui Quan, Chun-Yu Liu, Qi Chang, Xin-Min Liu, Yong-Hong Liao, (2010), The effect of Acorus gramineus on the bioavailabilities and brain concentrations of ginsenosides Rg1, Re and Rb1 after oral administration of Kai-Xin-San preparations in rats, Journal of Ethnopharmacology (IF: 3.014), 131: Chen Y, Liu XM, Pan RL, Wang GN, Fu Y, Chang Q. (2009). An LC-MS/MS method for determination of 3,6'-disinapoylsucrose in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. (IF:1.966), 23(12): Peng B, Hu Q, Liu X*, Wang L, Chang Q, Li J, Tang J, Wang N, Wang Y. (2009). Duchesnea Phenolic Fraction Inhibits in vitro and in vivo Growth of Cervical Cancer Through Induction of Apoptosis and Cell Cycle Arrest. Exp Biol Med (IF:2.526), 234 (1): Peng B, Chang Q, Wang L, Hu Q, Wang Y, Tang J, Liu X*. (2008) Suppression of human ovarian KOV-3 cancer cell growth by Duchesnea phenolic fraction is associated with cell cycle arrest and apoptosis. Gynecol Oncol. (IF:3.888), 108: Dang H, Sun L, Liu X*, Peng B, Wang Q, Jia W, Chen Y, Pan A, Xiao P. Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress. Exp Biol Med (Maywood) Jul;234(7): Epub 2009 May Liu X, Zou J, Sheng Z, Su G, Chen S. The current global status of Chinese materia medica. Phytother Res Oct;23(10): Dang H, Chen Y, Liu X* Wang Q, Wang L, Jia W, Wang Y. Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Prog Neuropsychopharmacol Biol Psychiatry Nov 13;33(8): *corresponding author 10