CHEMISTRY, BIOLOGY & MEDICINE

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1 C B M 06 INTERNATIONAL SYMPOSIUM ON CHEMISTRY, BIOLOGY & MEDICINE Organized on the Occasion of the 60th Birthday of Prof. K.C. Nicolaou CYPRUS / MAY 28 JUNE 01, 2006 Elysium Beach Resort, Paphos All information will be updated regularly on the symposium website:

2 Welcome It is a pleasure to invite you to attend the International Symposium on Chemistry, Biology & Medicine, which will be held in Cyprus, an island of history and legends, that in the past 10,000 years has witnessed the heroics of many historical figures, including Alexander the Great, and the rise and fall of many civilizations. The symposium will feature lectures by several prestigious chemists from many parts of the world, who are coming together to celebrate Professor Nicolaou s 60th birthday. All of the participants in this symposium have been influenced by Professor Nicolaou s warmth and personal charm, his gifts as a student and teacher of organic chemistry, and his magnificent accomplishments in the fields of chemical synthesis and chemical biology. The program will include plenary lectures, major talks by guest speakers, and poster sessions. A scientific exhibition as well as cultural sightseeing and entertainment will also be available. This occasion will allow young scientists to meet established chemists and younger rising stars for stimulating discussions. The symposium will highlight a variety of emerging fields, covering fundamental concepts as well as novel applications. Posters will be showcased in a central location to facilitate the exchange of ideas and information. This exciting conference should encourage scientists to report their latest accomplishments in the form of poster presentations. Lunch will be in the same surroundings facilitating further opportunity for interactions. The Organizing Committee of the symposium encourages the establishment of contacts between academia and industry in a spirit of constructive globalization. We also invite you to enjoy Cyprus beaches, mountains, citrus groves, picturesque villages and excellent wine. The symposium will give attendees the opportunity to become familiar with the enchanted birthplace of K.C. Nicolaou, which has been an inspiration to him throughout his life. The Organizing Committee wishes you a wonderful sojourn in Cyprus and experiences leading to lifelong happy memories. We look forward to meeting you in Paphos, Cyprus. The Organizing Committee Magid ABOU-GHARBIA, Wyeth Mark E. DUGGAN, Merck Madeleine M. JOULLIÉ, University of Pennsylvania Ronald MAGOLDA, Wyeth Philippe NANTERMET, Merck Nicos A. PETASIS, Univ. of Southern California Erik J. SORENSEN, Princeton University

3 Conference program: The topics to be covered during this symposium include: Total Synthesis of Natural Products New Synthetic Methodology Combinatorial Chemistry Diversity and Target-Oriented Synthesis Medicinal Chemistry Drug Discovery & Development Confirmed speakers: Dr Magid ABOU-GHARBIA (Wyeth Research) Professor Phil BARAN (The SCRIPPS Research Institute) Professor Stefan BRÄSE (University of Karlsruhe) Professor Elias COREY J. (Harvard University) Professor François DIEDERICH (ETH-Hoenggerberg) Professor Peter J. GARRATT (University College London) Professor Madeleine JOULLIÉ (University of Pennsylvania) Professor Steven LEY (University of Cambridge) Professor Nicos A. PETASIS (University of Southern California) Professor Floris RUTJES (Radboud University Nijmegen) Professor Masakatsu SHIBASAKI (University of Tokyo) Professor Nigel SIMPKINS (University of Nottingham) Professor Erik SORENSEN (Princeton University) Professor David TANNER (The Technical University of Denmark) Professor Emmanuel THEODORAKIS (University of California San Diego) Professor Jun ichi UENISHI (Kyoto Pharmaceutical University) Professor Nicolas WINSSINGER (ISIS/ULP) Professor Yang ZHEN (Institute of Chemistry & Cell Biology) Business-symposium: The Conference program will include a mini business symposium dedicated to «New Trends in Chemistry and Biology Outsourcing», which will provide an ideal platform for any companies offering outsourcing services in drug discovery, bioprocessing/biomanufacturing and pharma chemicals. The aim is to offer through the use of lectures and stimulating discussions a unique opportunity for an in-depth understanding of how industry leaders are using outsourcing to achieve high performance across their businesses. This business symposium will cover the strategies, best practices, success stories and future trends in outsourcing. Commercial exhibition: The commercial exhibition will form an integral part of the Symposium and will represent a unique opportunity for companies to present and promote their products to the large, highly qualified audience attending the meeting. It will be located centrally and

4 Preliminary program schedule: refreshment breaks will be held in the exhibition area to ensure a high level of attendance by the delegates. All information about the exhibition and sponsoring opportunities is available through the symposium secretariat. Poster communications: All delegates are invited to participate in the scientific program by submitting abstracts of scientific communications to be presented in the poster sessions. All submitted abstracts will be peer-reviewed for their acceptance. Participants wishing to contribute should submit their abstract via the online submission tool on the symposium website www. cbmcyprus06.com where a template for the abstract with further details is also available. Please note that registration is required to submit an abstract. Deadline for poster submission: February 28, 2006 Poster authors should confirm their registration by paying the registration fee prior to April 15, 2006, to ensure the inclusion of their poster in the final program and book of abstracts. Social program: The social program of CBM 06 includes the welcome reception on Sunday May 28th and the banquet on Thursday May 31st, celebrating Professor K.C. Nicolaou s 60th birthday. Accompanying persons program: Accompanying persons can register for participation in the social program (welcome reception and banquet during the symposium). An additional sightseeing program during conferences will be available.

5 Exhibition open Exhibition open Sunday May 28, :00 pm - 6:00 pm Registration 6:00 pm - 8:00 pm Welcome reception mixer Monday May 29, :00 am - 8:30 am Opening Ceremony of CBM Cyprus 2006 Opening Remarks Remarks 8:30 am - 9:30 am KEYNOTE LECTURE E.J. Corey 9:30 am - 10:20 am P 1 10:20 am - 10:50 am Coffee break + poster session 10:50 am - 11:40 am P 2 11:40 am - 12:10 pm IL-1 12:10 pm - 2:00 pm Lunch + poster session Symposium/Panel discussion on «New Trends in Chemistry and Biology Outsourcing» 1:55 pm - 6:00 pm Tuesday May 30, :00 am - 8:50 am P 3 8:50 am - 9:30 am AL-1 9:30 am - 10:00 am Coffee break + poster session 10:00 am - 10:40 am AL-2 10:40 am - 11:20 am AL-3 11:20 am - 12:00 pm AL-4 12:00 pm - 2:00 pm Lunch + poster session 2:00 pm - 2:50 pm P 4 2:50 pm - 3:20 pm IL-2 3:20 pm - 3:50 pm IL-3 3:50 pm - 4:30 pm AL-5 4:30 pm Free evening Wednesday May 31, :00 am - 8:50 am P 5 8:50 am - 9:30 am AL-6 9:30 am - 10:00 am Coffee break + poster session 10:00 am - 10:40 am AL-7 10:40 am - 11:10 am IL-4 11:10 am - 11:50 am AL-8 11:50 am - 12:20 pm IL-5 12:00 pm - 2:00 pm Lunch + poster session 2:00 pm Excursion 1/2 day trip Thursday June 1, :00 am - 8:50 am P 6 8:50 am - 9:30 am AL-9 9:30 am - 10:00 am Coffee break 10:00 am - 10:50 am P 7 10:50 am - 11:20 am IL-6 11:20 am - 12:00 pm AL-10 12:00 pm - 2:00 pm Lunch 2:00 pm - 2:40 pm AL-11 2:40 pm - 3:40 pm LECTURE K.C. NICOLAOU 3:40 pm - 4:00 pm CLOSING 7:00 pm BANQUET

6 Exhibition open Venue: The venue chosen for the symposium is the Elysium Beach Resort, a 5 star deluxe hotel, which offers leisure and business visitors to Cyprus an entirely unique experience. The Resort is located adjacent to the ancient Tombs of Kings in Paphos. The Elysium enjoys uninterrupted views of the Mediterranean Sea and has been sensitively designed in a palatial style primarily influenced by the Byzantine era. The cultural references of its architecture evoke the rich history of Cyprus and combine elements from Greek, Roman, Medieval and Venetian eras. Weather in Cyprus Cyprus enjoys a Mediterranean climate, with abundant sunshine year round. The average temperature in May is 26 C climbing to 30 C in June and as a rule, it hardly ever rains during the period of the symposium. Very light-weight summer clothing, possibly a long sleeved cotton top for the evenings is the most you will need to stay comfortably warm. This time of the year is already ideal for swimming and all beach/ water activities. Travel opportunities Post symposium tours to Athens, the Greek Islands, Egypt or Israel can also be arranged with the symposium secretariat. Accommodation: Accommodation is available at a range of hotels across Paphos, from 2 and 3 star hotels to luxury 5 star resorts as the Elysium. Transportation to the Elysium will be organized from the other hotels. We have reserved a block of rooms in each of the hotels. To reserve a room under the CBM 06 block and take advantage of the group rates please make your reservation online via the symposium website no later than April 15th.

7 Registration form: (Please fill out one form per participant. Accompanying persons should fill out a separate form, but indicate the name of the person with whom they are attending in the appropriate field of the registration form.) Mr Ms Mrs Dr Prof. First Name: Name: Company: Job Title: Department: Address: City/Postcode/ZIP: State: Country: Telephone: Fax: Accompanying person: Selected hotel: double/twin single Arrival date: Departure date: Transportation from & to the aiport: Paphos 17,5 Larnaca 25 Excursion on Wednesday afternoon: 25 Registration information: Two easy ways to register: on-line via or fill in the registration form and return it by mail or fax to: LD Organisation Symposium Secretariat Route de Blocry 55 B 1348 Louvain-la-Neuve Belgium Fax: You will always receive an acknowledgement of your registration. If you do not receive anything, please call us on or send us an at secretariat@ldorganisation.com to make sure we have received your booking. Registration rates: Early Bird Standard Registration Registration before February 28 after February 28 Industry affiliated Academic Students Accompanying person The participant fee includes entry to the symposium and exhibition, the handbook, lunches, coffee breaks and refreshments, as well as the welcome reception and the symposium banquet. The accompanying person fee includes the welcome reception and the banquet dinner. Accompanying persons should make a separate registration, but indicate the name of the person with whom they attend in the appropriate field of the registration form.

8 General information: Language: The official symposium language is English. Symposium Website: For more information about the Symposium and on-line registration please see under www. cbmcyprus06.org. Confirmation: Please note that final confirmations will be mailed only after receipt of full payment. If you do not receive any confirmation 7 days prior to the event, please contact the Symposium Secretariat. Cancellations: Substitutions may be made at any time, but please advise the Symposium Secretariat of a change of name. In case of cancellation prior to April 15, 2006, by written notice, registration fees will be refunded, less $125 processing charges. Unfortunately, after this date, no further refunds can be made. In the unlikely event that the Organizing Committee shall deem it necessary to cancel the symposium, all pre-paid registration fees will be reimbursed. Neither LD Organisation, nor the Organizing Committee shall be liable for reimbursing travel costs or accommodation arrangements made by individual delegates. Payment: If possible, please use the on-line payment opportunity while registering on-line for the Symposium via the website org. Otherwise, payments should be made to the Symposium Secretariat By payment to account n (in Euros) IBAN: BE BIC: BBRUBEBB (ING - Rue des Wallons 2 B-1348 Louvain-la-Neuve) mentioning CBM06 and our references. or By Eurocard/Mastercard or Visa credit card by sending the card details by Fax to Collective remittances should be accompanied by a list of names. Acknowledgements will be mailed after receipt of full payment. Please notify any corrections to this registration immediately. Please note that your registration is only effective after receipt of the full payment. Liability and insurance: Neither the Organizers nor LD Organisation will assume any responsibility whatsoever for any damage or injury to persons or property during the Symposium. The participants are recommended to arrange for their personal travel and health insurance. Local transportation upon arrival: Transportation from Larnaca and Paphos Airport to Paphos and the Hotels can be arranged. Registered participants will receive all relevant information via the symposium secretariat. LD Organisation sprl Route de Blocry, 55 B-1348 LOUVAIN-LA-NEUVE Belgium Tel.: Fax: CBM@LDOrganisation.com

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