CELL AND TISSUE INJURY COURSE-II PATHOLOGY LABORATORY. PATHOLOGY of MASS LESIONS and TISSUE DEFECTS -MACROSCOPY Assoc. Professor Rengin Ahıskalı

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1 CELL AND TISSUE INJURY COURSE-II PATHOLOGY LABORATORY PATHOLOGY of MASS LESIONS and TISSUE DEFECTS -MACROSCOPY Assoc. Professor Rengin Ahıskalı

2 M1 - RENAL TUBERCULOSIS cavitary areas caseous necrosis fibrous tissue

3 M2 - SPERMATOCELE thickened, fibrotic wall small compressed testis irregular internal surface with accumulated cellular debris

4 M3 - CHRONIC NON - SPESIFIC CERVICITIS WITH NABOTHIAN CYSTS Ovaries & tubes cervix sectioned cyst cysts are visible as bluish bumps under the epithelium

5 M4 - HYDATID CYSTS hydatid cysts fibrous host capsule cuticular membrane of a ruptured hydatid cyst

6 M5 - SEROUS PAPILLARY CYSTADENOMA OF THE OVARY unilocular cyst with a very thin wall smooth inner surface (compare with spermatocele) coarse papillary structures fine papillary structures

7 M6 - SEROUS PAPILLARY CYSTADENOCARCINOMA OF THE OVARY multiple cystic compartments (multilocular cyst) solid areas papillary structures

8 M7 - BENIGN CYSTIC TERATOMA OF THE OVARY (DERMOID CYST) hair and sebaceous material remnants of yellowish colored sebaceous material predominantly solid area with smaller cysts skin-like inner surface

9 M8 - TRANSlTIONAL CELL CARCINOMA OF URINARY BLADDER exophitic tumors with papillary appearance thick (hypertrophic) bladder wall prostate close-up view of the tiny, slender papillary structures

10 M9 - ENDOMETRIAL POLYPS F F C C C F C F: Fundus, C: Cervix solid polyp predominantly solid polyp with small cystic areas dark color due to bleeding at the tip of polyp

11 M10 - MULTIPLE (INFLAMMATORY) POLYPS COLON Distal part of colon and close up of same area : elongated polypoid growths of mucosa. Notice various sizes and shapes, all with smooth surfaces.

12 M11 - COLON CANCER central ulceration (ulceroinfiltrative area) heaped up borders (exophytic part) small, sessile polyp exophytic (vegetating) tumor, causing dilatation of colon

13 M12 - LEIOMYOMA NODULES UTERUS Two histerectomy specimens with solid, white, firm, nodular tumors. Notice fibrillary appearance on cut surface. They are well demarcated, but not encapsulated.

14 M13 - RENAL CELL CARCINOMA yellow solitary nodular tumor in one pole normal kidney in other pole fibrosis within tumor multiple yellowish tumor nodules tumor invading perinephric tissue

15 This sample was omitted from your lab. guide as the original specimen had detoriorated, but there are two new specimens with the following description: M14 - BREAST CANCER These are mastectomy specimens. (Black color is due to indian ink which is used to mark the surgical margins. The nipples are removed for microscopic sampling).you can see breast tissue which has abundant fat tissue and the skin on it. On cut section white colored, infiltrative cancers are visible. One is a very large tumor, both have irregular borders the smaller one has a spiculated border. The tumors are much firmer than the surrounding breast tissue, such tumors are called schirrous carcinomas. This extreme firmness is due to marked desmoplasia in the tumor stroma.

16 M14 - BREAST CANCER white colored, infiltrative tumor very irregular borders F: fat tissue F F F F

17 M15 - MALIGNANT FIBROUS HISTIOCYTOMA coarsely nodular tumor on the skin surface fungating growth tumor infiltrating the deep soft tissues on cut surface

18 M16 - TUMOR METASTASES -PERITONEUM peritoneal fat tissue multiple nodular masses of different sizes variegated cut surface

19 M18 - TERATOMA OF TESTIS Tunica albuginea surrounding testis very large tumor (compare with small seminoma sample) predominantly solid tumor with small cystic areas, variegated cut surface Notice bluish white color of cartilage areas

20 M19 - SEMINOMA OF TESTIS large homogenous, lobulated, white solid tumor Tunica albuginea not invaded by tumor tiny area of residual testicular tissue a smaller tumor with similar cut surface

21 M20 - TERATOCARCINOMA OF TESTIS large tumor replacing the entire testis variegated appearence, cystic and solid areas tumor invading the testicular tunics area of necrosis

Female Genital Tract Lab. Dr. Nisreen Abu Shahin Assistant Professor of Pathology University of Jordan

Female Genital Tract Lab. Dr. Nisreen Abu Shahin Assistant Professor of Pathology University of Jordan Female Genital Tract Lab Dr. Nisreen Abu Shahin Assistant Professor of Pathology University of Jordan Ovarian Pathology A 20-year-old female presented with vague left pelvic pain. Pelvic exam revealed